Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature
Abstract
The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of mesenchymal stromal cells (MSCs). The ISCT MSC committee continues to support the use of the acronym "MSCs" but recommends this be (i) supplemented by tissue-source origin of the cells, which would highlight tissue-specific properties; (ii) intended as MSCs unless rigorous evidence for stemness exists that can be supported by both in vitro and in vivo data; and (iii) associated with robust matrix of functional assays to demonstrate MSC properties, which are not generically defined but informed by the intended therapeutic mode of actions.
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MSCs demonstrate immunomodulatory properties.
“MSCs demonstrate multifaceted advantages, including immunomodulatory properties, anti-fibrotic effects (via hepatic stellate cell inhibition and ECM remodeling), promotion of hepatocyte regeneration, and mitigation of oxidative stress.”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [27]
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Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766 · see citing works
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · see citing works
Sacchetti, B., Funari, A., Michienzi, S., Di Cesare, S., Piersanti, S., Saggio, I., Tagliafico, E., Ferrari, S., Robey, P. G., Riminucci, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.025 · Cited by 2,226 · see citing works
Stem Cell Properties of Human Dental Pulp Stem Cells
Gronthos, S., Brahim, J. S., Li, W., Fisher, L. W., Cherman, N., BOYDE, A., DenBesten, P., Robey, P. G., & Shi, S. (2002) · Journal of Dental Research · doi:10.1177/154405910208100806 · Cited by 2,115 · see citing works
Horwitz, E. M., Blanc, K. L., Dominici, M., Mueller, I., Slaper‐Cortenbach, I., Marini, F. C., Deans, R. J., Krause, D. S., & Keating, A. (2005) · Cytotherapy · doi:10.1080/14653240500319234 · Cited by 2,074 · see citing works
Caplan, A. I., & Correa, D. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.06.008 · Cited by 1,682 · see citing works
Mechanisms involved in the therapeutic properties of mesenchymal stem cells
da Silva Meirelles, L., Fontes, A. M., Covas, D. T., & Caplan, A. I. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.002 · Cited by 1,436 · see citing works
Kinnaird, T. D., Stabile, E., Burnett, M. S., Shou, M., Lee, C. W., Barr, S., Fuchs, S., & Epstein, S. E. (2004) · Circulation · doi:10.1161/01.cir.0000124062.31102.57 · Cited by 1,304 · see citing works
Mesenchymal Stem Cells: Time to Change the Name!
Caplan, A. I. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0051 · Cited by 1,130 · see citing works
Panés, J., García‐Olmo, D., Assche, G. V., Colombel, J., Reinisch, W., Baumgart, D. C., Dignass, A. U., Nachury, M., Ferrante, M., Kazemi-Shirazi, L., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31203-x · Cited by 1,094 · see citing works
MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease
Kordelas, L., Rebmann, V., Ludwig, A., Radtke, S., Ruesing, J., Doeppner, T. R., Epple, M., Horn, P., Beelen, D. W., & Giebel, B. (2014) · Leukemia · doi:10.1038/leu.2014.41 · Cited by 1,086 · see citing works
Muraglia, A., Cancedda, R., & Quarto, R. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.7.1161 · Cited by 1,025 · see citing works
Multipotent mesenchymal stromal cells and the innate immune system
Blanc, K. L., & Mougiakakos, D. (2012) · Nature reviews. Immunology · doi:10.1038/nri3209 · Cited by 1,019 · see citing works
Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers
Friedenstein, A. J., Chailakhyan, R. K., & Gerasimov, U. V. (1987) · Cell Proliferation · doi:10.1111/j.1365-2184.1987.tb01309.x · Cited by 984 · see citing works
Stem cells in tissue engineering
Bianco, P., & Robey, P. G. (2001) · Nature · doi:10.1038/35102181 · Cited by 969 · see citing works
Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
Ranganath, S. H., Levy, O., Inamdar, M. S., & Karp, J. M. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.005 · Cited by 808 · see citing works
Kuznetsov, S. A., Krebsbach, P. H., Satomura, K., Kerr, J. M., Riminucci, M., Benayahu, D., & Robey, P. G. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.9.1335 · Cited by 723 · see citing works
Covas, D. T., Panepucci, R. A., Fontes, A. M., Silva, W. A., Orellana, M. D., Freitas, M. C. C., Neder, L., Santos, A. R. D., Peres, L. C., Jamur, M. C., et al. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2007.12.015 · Cited by 610 · see citing works
Collino, F., Deregibus, M. C., Bruno, S., Sterpone, L., Aghemo, G., Viltono, L., Tetta, C., & Camussi, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011803 · Cited by 608 · see citing works
Identification of the Human Skeletal Stem Cell
Chan, C. K. F., Gulati, G. S., Sinha, R., Vincent-Tompkins, J., Lopez, M., Carter, A. C., Ransom, R. C., Reinisch, A., Wearda, T. L., Murphy, M. P., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.029 · Cited by 602 · see citing works
Zannettino, A. C. W., Paton, S., Arthur, A., Khor, F., Itescu, S., Gimble, J. M., & Gronthos, S. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21210 · Cited by 553 · see citing works
Galipeau, J., Krampera, M., Barrett, J., Dazzi, F., Deans, R., de Bruijn, J. D., Dominici, M., Fibbe, W. E., Gee, A. P., Gimble, J. M., et al. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.11.008 · Cited by 521 · see citing works
Self-citationMSC-Based Product Characterization for Clinical Trials: An FDA Perspective
Mendicino, M., Bailey, A. M., Wonnacott, K., Puri, R. K., & Bauer, S. R. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.013 · Cited by 500 · see citing works
Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo
Guimarães‐Camboa, N., Cattaneo, P., Sun, Y., Moore‐Morris, T., Gu, Y., Dalton, N. D., Rockenstein, E. M., Masliah, E., Peterson, K. L., Stallcup, W. B., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.12.006 · Cited by 491 · see citing works
Clonal analysis of the differentiation potential of human adipose‐derived adult stem cells
Guilak, F., Lott, K. E., Awad, H. A., Cao, Q., Hicok, K. C., Fermor, B., & Gimble, J. M. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20463 · Cited by 491 · see citing works
Krampera, M., Galipeau, J., Shi, Y., Tarte, K., & Sensebé, L. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.02.010 · Cited by 465 · see citing works
Self-citationMelief, S. M., Zwaginga, J. J., Fibbe, W. E., & Roelofs, H. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0184 · Cited by 442 · see citing works
Russell, K. C., Phinney, D. G., Lacey, M. R., Barrilleaux, B. L., Meyertholen, K., & O’Connor, K. C. (2010) · Stem Cells · doi:10.1002/stem.312 · Cited by 439 · see citing works
Self-citationSacchetti, B., Funari, A., Remoli, C., Giannicola, G., Kogler, G., Liedtke, S., Cossu, G., Serafini, M., Sampaolesi, M., Tagliafico, E., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.05.011 · Cited by 428 · see citing works
The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells
Corselli, M., Chen, C.-W., Sun, B., Yap, S., Rubin, J. P., & Péault, B. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0200 · Cited by 393 · see citing works
The Pericyte as a Possible Osteoblast Progenitor Cell
Brighton, C. T., Lorich, D. G., Kupcha, R., REILLY, T. M., JONES, A. R., & WOODBURY, R. A. (1992) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199202000-00043 · Cited by 299 · see citing works
Interferon-γ-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell
Stagg, J., Pommey, S., Eliopoulos, N., & Galipeau, J. (2005) · Blood · doi:10.1182/blood-2005-07-2793 · Cited by 290 · see citing works
Self-citationCD34 expression by stromal precursors in normal human adult bone marrow
Simmons, P., & Torok‐Storb, B. (1991) · Blood · doi:10.1182/blood.v78.11.2848.2848 · Cited by 288 · see citing works
Sipp, D., Robey, P. G., & Turner, L. G. (2018) · Nature · doi:10.1038/d41586-018-06756-9 · Cited by 286 · see citing works
Mazurier, F., Doedens, M., Gan, O. I., & Dick, J. E. (2003) · Nature Medicine · doi:10.1038/nm886 · Cited by 282 · see citing works
Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies
Iyer, S. S., & Rojas, M. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.5.569 · Cited by 269 · see citing works
Immunoregulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles on T Lymphocytes
Fattore, A. D., Luciano, R., Pascucci, L., Goffredo, B. M., Giorda, E., Scapaticci, M., Fierabracci, A., & Muraca, M. (2015) · Cell Transplantation · doi:10.3727/096368915x687543 · Cited by 266 · see citing works
Human Mesenchymal Stem Cells Self-Renew and Differentiate According to a Deterministic Hierarchy
Sarugaser, R., Hanoun, L., Keating, A., Stanford, W. L., & Davies, J. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006498 · Cited by 261 · see citing works
Is CD34 truly a negative marker for mesenchymal stromal cells?
Lin, C.-S., Ning, H., Lin, G., & Lue, T. F. (2012) · Cytotherapy · doi:10.3109/14653249.2012.729817 · Cited by 239 · see citing works
Immunosuppression by mesenchymal stromal cells: From culture to clinic
Jones, B. J., & McTaggart, S. J. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.03.006 · Cited by 226 · see citing works
Romieu, R., François, M., Boivin, M., Stagg, J., & Galipeau, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1549 · Cited by 221 · see citing works
Self-citationPotency Analysis of Mesenchymal Stromal Cells Using a Combinatorial Assay Matrix Approach
Chinnadurai, R., Rajan, D., Qayed, M. D., Arafat, D., Garcia, M. A., Liu, Y., Kugathasan, S., Anderson, L. J., Gibson, G. C., & Galipeau, J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.013 · Cited by 204 · see citing works
Self-citationFavaro, E., Carpanetto, A., Caorsi, C., Giovarelli, M., Angelini, C., Cavallo‐Perin, P., Tetta, C., Camussi, G., & Zanone, M. M. (2015) · Diabetologia · doi:10.1007/s00125-015-3808-0 · Cited by 164 · see citing works
Challenges for mesenchymal stromal cell therapies
Martín, I., Galipeau, J., Kessler, C., Blanc, K. L., & Dazzi, F. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat2189 · Cited by 164 · see citing works
Self-citationMcKenzie, J. L., Gan, O. I., Doedens, M., & Dick, J. E. (2005) · Blood · doi:10.1182/blood-2005-03-1081 · Cited by 147 · see citing works
Blocki, A. M., Wang, Y., Koch, M. K., Peh, P., Beyer, S., Law, P., Hui, J. H. P., & Raghunath, M. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0415 · Cited by 143 · see citing works
Gruber, R., Kandler, B., Holzmann, P., Vögele-Kadletz, M., Losert, U. M., Fischer, M. B., & Watzek, G. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.896 · Cited by 138 · see citing works
Viswanathan, S., Keating, A., Deans, R., Hematti, P., Prockop, D. J., Stroncek, D. F., Stacey, G., Weiss, D. J., Mason, C., & Rao, M. S. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0591 · Cited by 128 · see citing works
Self-citationMesenchymal stromal cells: misconceptions and evolving concepts
Phinney, D. G., & Sensebé, L. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2012.11.005 · Cited by 125 · see citing works
Self-citationWang, C., Yang, H., Hsu, H., Chen, L., Tsai, C., Tsai, K., Yew, T., Kao, Y., & Hung, S. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.461 · Cited by 98 · see citing works
The changing cellular environments of hematopoiesis in human development in utero
Tavian, M., & Péault, B. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.06.025 · Cited by 84 · see citing works
Hoffmann, J. C., Glassford, A. J., Doyle, T. C., Robbins, R. C., Schrepfer, S., & Pelletier, M. P. (2010) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/s-0029-1240758 · Cited by 83 · see citing works
Gupta, P. K., Krishna, M., Chullikana, A., Desai, S., Rajkumar, M., Dutta, S., Sarkar, U. N., Raju, R., Dhar, A., Parakh, R., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0237 · Cited by 79 · see citing works
Linard, C., Brachet, M., L’Homme, B., Strup-Perrot, C., Busson, É., Bonneau, M., Lataillade, J., Bey, É., & Benderitter, M. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1051-6 · Cited by 69 · see citing works
Clonal analysis and hierarchy of human bone marrow mesenchymal stem and progenitor cells
Lee, C. C. I., Christensen, J. E., Yöder, M. C., & Tarantal, A. F. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.11.001 · Cited by 63 · see citing works
Canfield, A. E., Doherty, M. J., Kelly, V., Newman, W. G., Farrington, C., Grant, M. E., & Boot-Handford, R. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02363-2 · Cited by 47 · see citing works
Winkler, T., von Roth, P., Schumann, M. R., Sieland, K., Stoltenburg, G., Taupitz, M., Perka, C., Duda, G. N., & Matziolis, G. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0179 · Cited by 43 · see citing works
Homing properties of mesenchymal stromal cells
Kallmeyer, K., & Pepper, M. S. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.997204 · Cited by 43 · see citing works
Response to Nature commentary “Clear up this stem-cell mess”
Galipeau, J., Weiss, D. J., & Dominici, M. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2018.11.007 · Cited by 20 · see citing works
Self-citationAdvances in mesenchymal stem cell biology
Dennis, J. E., & Caplan, A. I. (2004) · Current Opinion in Orthopedics · doi:10.1097/01.bco.0000134430.30813.f7 · Cited by 17 · see citing works
Induction of Expression of CD271 and CD34 in Mesenchymal Stromal Cells Cultured as Spheroids
Bellagamba, B. C., Grudzinski, P. B., Ely, P. B., Nader, P. D. J. H., Nardi, N. B., & Meirelles, L. D. S. (2018) · Stem Cells International · doi:10.1155/2018/7357213 · Cited by 16 · see citing works
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Levy, O., Kuai, R., Siren, E. M. J., Bhere, D., Milton, Y., Nissar, N., De Biasio, M., Heinelt, M., Reeve, B., Abdi, R., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba6884 · Cited by 694 · see citing works
Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X. M., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05034-x · Cited by 654 · see citing works
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Wu, X., Jiang, J., Gu, Z., Zhang, J., Chen, Y., & Liu, X. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01855-9 · Cited by 343 · see citing works
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Battafarano, G., Rossi, M., Martino, V. D., Marampon, F., Borro, L., Secinaro, A., & Fattore, A. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031128 · Cited by 299 · see citing works
Liu, J., Ding, Y., Liu, Z., & Liang, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00258 · Cited by 272 · see citing works
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Xu, X., Jiang, W., Chen, L., Xu, Z., Zhang, Q., Zhu, M., Ye, P., Li, H., Yu, L., Zhou, X., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.297 · Cited by 122 · see citing works
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Qin, L., Liu, N., Bao, C.-L.-M., Yang, D.-Z., Ma, G.-X., Yi, W.-H., Xiao, G.-Z., & Cao, H.-L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00952-0 · Cited by 114 · see citing works
Jimenez-Puerta, G., Marchal, J. A., López‐Ruiz, E., & Gálvez‐Martín, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020445 · Cited by 106 · see citing works
Frisbie, L. G., Buckanovich, R. J., & Coffman, L. G. (2022) · Stem Cells · doi:10.1093/stmcls/sxac036 · Cited by 107 · see citing works
Renesme, L., Cobey, K. D., Lalu, M. M., Bubela, T. M., Chinnadurai, R., Vos, J. D., Dunbar, P. R., Fergusson, D. A., Freund, D., Galipeau, J., et al. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.10.008 · Cited by 99 · see citing works
Self-citationKulus, M., Sibiak, R., Stefańska, K., Zdun, M., Wieczorkiewicz, M., Piotrowska‐Kempisty, H., Jaśkowski, J. M., Bukowska, D., Ratajczak, K., Zabel, M., et al. (2021) · Cells · doi:10.3390/cells10123278 · Cited by 98 · see citing works
Therapeutic Mesenchymal Stem/Stromal Cells: Value, Challenges and Optimization
Najar, M., Melki, R., Khalife, F., Lagneaux, L., Bouhtit, F., Agha, D. M., Fahmi, H., Lewalle, P., Fayyad‐Kazan, M., & Merimi, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716853 · Cited by 93 · see citing works
Galipeau, J. (2021) · Stem Cells · doi:10.1002/stem.3380 · Cited by 89 · see citing works
Self-citationCellular expansion of MSCs : Shifting the regenerative potential
Miclau, K. R., Hambright, W. S., Huard, J., Stoddart, M. J., & Bahney, C. S. (2022) · Aging Cell · doi:10.1111/acel.13759 · Cited by 88 · see citing works
Barrère‐Lemaire, S., Vincent, A., Jørgensen, C., Piot, C. A., Nargeot, J., & Djouad, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00009.2023 · Cited by 86 · see citing works
Single-Cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells
Zhang, C., Han, X., Liu, J., Chen, L., Lei, Y., Chen, K., Si, J., Wang, T.-Y., Zhou, H. F., Zhao, X., et al. (2022) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2022.01.005 · Cited by 87 · see citing works
Cell culture‐derived extracellular vesicles: Considerations for reporting cell culturing parameters
Shekari, F., Alibhai, F. J., Baharvand, H., Börger, V., Bruno, S., Davies, O. G., Giebel, B., Gimona, M., Salekdeh, G. H., Jaular, L. M., et al. (2023) · Journal of Extracellular Biology · doi:10.1002/jex2.115 · Cited by 89 · see citing works
Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering
Shafiee, S., Shariatzadeh, S., Zafari, A., Majd, A., & Niknejad, H. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.745314 · Cited by 80 · see citing works
Tieu, A., Hu, K., Gnyra, C., Montroy, J. R., Fergusson, D. A., Allan, D., Stewart, D. J., Thébaud, B., & Lalu, M. M. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12141 · Cited by 77 · see citing works
Zhou, H., Li, X., Yin, Y., He, X., An, Y., Tian, B., Hong, Y., Wu, L., & Chen, F. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01614-w · Cited by 75 · see citing works
Li, C., Zhao, H., & Wang, B. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100948 · Cited by 73 · see citing works
Jayaraman, P., Lim, R., Ng, J., & Vemuri, M. C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.648472 · Cited by 72 · see citing works
Galipeau, J., Krampera, M., LeBlanc, K., Nolta, J. A., Phinney, D. G., Shi, Y., Tarte, K., Viswanathan, S., & Martín, I. (2021) · Cytotherapy · doi:10.1016/j.jcyt.2020.11.007 · Cited by 71 · see citing works
Self-citationPanteli, M., Vun, J. S. H., Pountos, I., Howard, A. J., Jones, E., & Giannoudis, P. V. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17096 · Cited by 70 · see citing works
Rheumatoid arthritis: the old issue, the new therapeutic approach
Babaahmadi, M., Tayebi, B., Gholipour, N. M., Kamardi, M. T., Heidari, S., Baharvand, H., Eslaminejad, M. B., Hajizadeh‐Saffar, E., & Hassani, S. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03473-7 · Cited by 67 · see citing works
Zhao, B., Zhang, X., Zhang, Y., Lu, Y., Zhang, W., Lu, S., Fu, Y., Zhou, Y., Zhang, J., & Zhang, J. (2021) · Stem Cells and Development · doi:10.1089/scd.2021.0100 · Cited by 66 · see citing works
Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells
Novoseletskaya, E. S., Evdokimov, P. V., & Efimenko, A. Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01252-8 · Cited by 66 · see citing works
Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem Cells
Nikolits, I., Nebel, S., Egger, D., Kreß, S., & Kasper, C. (2021) · Cells · doi:10.3390/cells10040886 · Cited by 68 · see citing works
Banimohamad‐Shotorbani, B., Kahroba, H., Sadeghzadeh, H., Wilson, D. M., Maadi, H., Samadi, N., Hejazi, M. S., Farajpour, H., Nemati-Anari, B., & Sadeghi, M. R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101125 · Cited by 64 · see citing works
Schultz, I. C., Bertoni, A. P. S., & Wink, M. R. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10122-0 · Cited by 62 · see citing works
Renesme, L., Pierro, M., Cobey, K. D., Mital, R., Nangle, K., Shorr, R., Lalu, M. M., & Thébaud, B. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szab009 · Cited by 63 · see citing works
Mesenchymal stromal cell therapy: Progress to date and future outlook
Lu, W., & Allickson, J. G. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.02.003 · Cited by 67 · see citing works
Wruck, W., Graffmann, N., Spitzhorn, L., & Adjaye, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.717772 · Cited by 62 · see citing works
Importance of lymphocyte–stromal cell interactions in autoimmune and inflammatory rheumatic diseases
Noack, M., & Miossec, P. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00665-4 · Cited by 61 · see citing works
Huang, P., Russell, A. L., Lefavor, R., Durand, N., James, E. D., Harvey, L., Zhang, C., Countryman, S. M., Stodieck, L., & Zubair, A. C. (2020) · npj Microgravity · doi:10.1038/s41526-020-0106-z · Cited by 61 · see citing works
Lyu, Z., Xin, M., Oyston, D. R., Xue, T., Kang, H., Wang, X., Wang, Z., & Wang, Z. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155354 · Cited by 58 · see citing works
Laloze, J., Fiévet, L., & Desmoulière, A. (2020) · Advances in Wound Care · doi:10.1089/wound.2020.1175 · Cited by 58 · see citing works
Alzahrani, F. A., Saadeldin, I. M., Ahmad, A., Kumar, D., Azhar, E. I., Siddiqui, A. J., Kurdi, B., Sajini, A. A., Alrefaei, A. F., & Jahan, S. (2020) · Stem Cells International · doi:10.1155/2020/8835986 · Cited by 57 · see citing works
Adipose‐derived stromal cells for nonhealing wounds: Emerging opportunities and challenges
Deptuła, M., Brzezicka, A., Skoniecka, A., Zieliński, J., & Pikuła, M. (2021) · Medicinal Research Reviews · doi:10.1002/med.21789 · Cited by 56 · see citing works
Padinharayil, H., Varghese, J., Wilson, C. M., & George, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122542 · Cited by 56 · see citing works
Ryan, S. T., Beheshti, E. H., Afrose, D., Ding, X., Xia, B., Grau, G. E., Little, C. B., McClements, L., & Li, J. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063023 · Cited by 54 · see citing works
Engineered mesenchymal stem/stromal cells against cancer
Shi, Y., Zhang, J., Li, Y., Feng, C., Shao, C., Shi, Y., & Fang, J. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07443-0 · Cited by 60 · see citing works
Self-citationArzi, B., Peralta, S., Fiani, N., Vapniarsky, N., Taechangam, N., Delatorre, U., Clark, K. C., Walker, N. J., Loscar, M. R., Lommer, M. J., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01623-9 · Cited by 55 · see citing works
Massa, M., Croce, S., Campanelli, R., Abbà, C., Lenta, E., Valsecchi, C., & Avanzini, M. A. (2020) · Diagnostics · doi:10.3390/diagnostics10120999 · Cited by 53 · see citing works
Mesenchymal stromal cells for systemic sclerosis treatment
Farge, D., Loisel, S., Lansiaux, P., & Tarte, K. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102755 · Cited by 55 · see citing works
Hackel, A. M., Vollmer, S., Bruderek, K., Lang, S., & Brandau, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1078551 · Cited by 54 · see citing works
Anti-Tumor Effects of Exosomes Derived from Drug-Incubated Permanently Growing Human MSC
Melzer, C., von der Ohe, J., & Hass, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197311 · Cited by 54 · see citing works
Fibroblasts as Turned Agents in Cancer Progression
Wieder, R. (2023) · Cancers · doi:10.3390/cancers15072014 · Cited by 54 · see citing works
Yang, H., Fierro, F. A., So, M., Yoon, D. J., Nguyen, A. V., Gallegos, A., Bagood, M. D., Rojo-Castro, T., Alex, A., Stewart, H., et al. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0380 · Cited by 52 · see citing works
Self-citationGonzález-Fernández, P., Rodríguez‐Nogales, C., Jordan, O., & Allémann, É. (2022) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2022.01.003 · Cited by 51 · see citing works
Brozovich, A., Sinicrope, B. J., Bauza, G., Niclot, F. B., Lintner, D. M., Taraballi, F., & McCulloch, P. C. (2021) · Orthopaedic Journal of Sports Medicine · doi:10.1177/23259671211058459 · Cited by 50 · see citing works
Lach, M., Rosochowicz, M. A., Richter, M., Jagiełło, I., Suchorska, W. M., & Trzeciak, T. (2022) · Cells · doi:10.3390/cells11030529 · Cited by 51 · see citing works
HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation
Steens, J., & Klein, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1002909 · Cited by 50 · see citing works
Maiso, P., Mogollón, P., Ocio, E. M., & Garayoa, M. (2021) · Cancers · doi:10.3390/cancers13112542 · Cited by 48 · see citing works
Sávio-Silva, C., Beyerstedt, S., Soinski-Sousa, P. E., Casaro, E. B., Balby-Rocha, M. T. A., Simplício-Filho, A., Alves-Silva, J., & Rangel, É. B. (2020) · Stem Cells International · doi:10.1155/2020/8833725 · Cited by 52 · see citing works
Loussouarn, C., Pers, Y., Bony, C., Jørgensen, C., & Noël, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623973 · Cited by 46 · see citing works
Immunogenicity of mesenchymal stromal/stem cells
Chen, W., Lv, L., Chen, N., & Cui, E. (2023) · Scandinavian Journal of Immunology · doi:10.1111/sji.13267 · Cited by 52 · see citing works
Improving mesenchymal stem/stromal cell potency and survival
Nolta, J. A., Galipeau, J., & Phinney, D. G. (2020) · Cytotherapy · doi:10.1016/j.jcyt.2020.01.004 · Cited by 47 · see citing works
Self-citationMesenchymal Stem Cell/Multipotent Stromal Cell Augmentation of Wound Healing
Sylakowski, K., Bradshaw, A. M., & Wells, A. H. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.03.017 · Cited by 50 · see citing works
Mesenchymal stromal cells for the treatment of ocular autoimmune diseases
Oh, J. Y., & Lee, R. H. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100967 · Cited by 47 · see citing works
Behm, C., Blufstein, A., Gahn, J., Nemec, M., Moritz, A., Rausch‐Fan, X., & Andrukhov, O. (2020) · Cells · doi:10.3390/cells9051222 · Cited by 45 · see citing works
Zupan, J., Stražar, K., Kocijan, R., Nau, T., Grillari, J., & Marolt, D. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111539 · Cited by 49 · see citing works
Umbilical cord mesenchymal stromal cells—from bench to bedside
Chetty, S. S., Yarani, R., Swaminathan, G., Primavera, R., Regmi, S., Rai, S., Zhong, J., Ganguly, A., & Thakor, A. S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1006295 · Cited by 47 · see citing works
Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control
Mukkala, A. N., Jerkic, M., Khan, Z., Szaszi, K., Kapus, A., & Rotstein, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115788 · Cited by 45 · see citing works
la Torre, R. S.-D., Quiñones-Vico, M. I., Fernández‐González, A., Sánchez‐Díaz, M., Montero‐Vílchez, T., Sierra-Sánchez, Á., & Arias‐Santiago, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132991 · Cited by 47 · see citing works
Mesenchymal Stem Cell-Derived Exosomes as a Treatment Option for Osteoarthritis
Vadhan, A., Gupta, T., & Hsu, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179149 · Cited by 44 · see citing works
Banking on teeth – Stem cells and the dental office
Zeitlin, B. D. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.02.003 · Cited by 44 · see citing works
Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges
Parfejevs, V., Sagini, K., Buss, A., Soboļevska, K., Llorente, A., Riekstiņa, U., & Ābols, A. (2020) · Cells · doi:10.3390/cells9051171 · Cited by 46 · see citing works
Srinivasan, A., Sathiyanathan, P., Yin, L., Liu, T. M., Lam, A., Ravikumar, M., Smith, R. A. A., Loh, H. P., Zhang, Y., Ling, L., et al. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2021.11.009 · Cited by 44 · see citing works
Riedl, J., Popp, C. M., Eide, C. R., Ebens, C. L., & Tolar, J. (2021) · Cytotherapy · doi:10.1016/j.jcyt.2021.06.004 · Cited by 43 · see citing works
Modifying MSC Phenotype to Facilitate Bone Healing: Biological Approaches
Goodman, S. B., & Lin, T. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00641 · Cited by 43 · see citing works
The vascular nature of lung-resident mesenchymal stem cells
Steens, J., Klar, L., Hansel, C., Slama, A., Hager, T., Jendrossek, V., Aigner, C., & Klein, D. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0191 · Cited by 43 · see citing works
Anti-fibrotic mechanisms of exogenously-expanded mesenchymal stromal cells for fibrotic diseases
Rockel, J. S., Rabani, R., & Viswanathan, S. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.10.014 · Cited by 42 · see citing works
Self-citationMarrazzo, P., Pizzuti, V., Zia, S., Sargenti, A., Gazzola, D., Roda, B., Bonsi, L., & Alviano, F. (2021) · Antibiotics · doi:10.3390/antibiotics10070750 · Cited by 43 · see citing works
- Authors
- Viswanathan, S., Shi, Y., Galipeau, J., Krampera, M., Leblanc, K., Martin, I., Nolta, J., Phinney, D. G., & Sensebe, L.
- Affiliations
- University Health Network (CA)
- Chinese Academy of Sciences (CN)
- University of Wisconsin–Madison (US)
- University of Verona (IT)
- Karolinska Institutet (SE)
- University of California Davis Medical Center (US)
- Scripps Research Institute (US)
- Corresponding author
- Viswanathan, S.
- Shi, Y.
- Venue
- Cytotherapy
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 21
- Issue
- 10
- Pages
- 1019-1024
- ISSN
- 1465-3249 (ISSN-L)
- OpenAlex
- W2973068260
- Cited by
- 839
- References
- 61
- Citations by year
- 2026: 109 · 2025: 127 · 2024: 124 · 2023: 128 · 2022: 137 · 2021: 136 · 2020: 75 · 2019: 2
- FWCI
- 48.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- mesenchymal stem cells, stemness, functional assays, cell therapy
- MeSH terms
- Cell Differentiation, Humans, Terminology as Topic, Societies, Medical, Genetic Therapy, Stromal Cells, Cell Culture Techniques, Internationality, Mesenchymal Stem Cells, Cell- and Tissue-Based Therapy
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