Evaluation of neuroprotective effects of Canna indica L against aluminium chloride induced memory impairment in rats
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Canna indica extracts at 200 mg/kg significantly reduced AChE levels in the cortex and hippocampus (p<0.001) and BChE levels in the cortex (p<0.0001) in AlCl3-induced models.
“oral administration of three Canna indica extracts (derived from aerial parts, roots, and a combination of both) at 200 mg/kg significantly reduced AChE levels in the cortex and hippocampus (p < 0.001) and BChE levels in the cortex (p < 0.0001) [64].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [64]
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“For instance, oral administration of three Canna indica extracts (derived from aerial parts, roots, and a combination of both) at 200 mg/kg significantly reduced AChE levels in the cortex and hippocampus ( p 0.001) and BChE levels in the cortex ( p 0.0001) [64].”
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- Authors
- Ojha, P. S., Biradar, P. R., Tubachi, S., & Patil, V. S.
- Affiliations
- KLE Academy of Higher Education and Research (IN)
- Indian Council of Medical Research (IN)
- Corresponding author
- Biradar, Prakash R.
- Venue
- Advances in Traditional Medicine
- Published
- 2022-01-07
- Volume
- 23
- Issue
- 2
- Pages
- 539-556
- ISSN
- 1598-2386 (ISSN-L)
- 2662-4052
- 2662-4060
- PMC
- PMC8853014
- OpenAlex
- W4206287178
- Cited by
- 24
- References
- 51
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 5
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Oriental Pharmacy and Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Canna indica, memory impairment, Alzheimer's disease, neuroprotection, acetylcholinesterase inhibition, butyrylcholinesterase, antioxidant activity, oxidative stress, hippocampal pathology, flavonoids, phlobatannins, saponins, aerial parts, root extract, donepezil
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