The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
The Role of the Skin and Gut Microbiome in Psoriatic Disease
Open accessAbstract
Purpose To understand the changes in the microbiome in psoriatic disease, we conducted a systematic review of studies comparing the skin and gut microbiota in psoriatic individuals and healthy controls.Findings Our review of studies pertaining to the cutaneous microbiome showed a trend towards an increased relative abundance of Streptococcus and a decreased level of Propionibacterium in psoriasis patients compared to controls. In the gut microbiome, the ratio of Firmicutes and Bacteroidetes was perturbed in psoriatic individuals compared to healthy controls. Actinobacteria was also relatively underrepresented in psoriasis patients relative to healthy individuals.Summary Although the field of the psoriatic microbiome is relatively new, these first studies reveal interesting differences in microbiome composition that may be associated with the development of psoriatic comorbidities and serve as novel therapeutic targets.
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“An increased Firmicutes/Bacteroidetes ratio was also found in patients with psoriasis.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [102]
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“the prevalence of psoriasis was negatively correlated with the concentration of actinomycetes by the Psoriasis Activity and Severity Index (PASI) score.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [102]
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1 retracted
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RetractedStructure, function and diversity of the healthy human microbiome
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Diet rapidly and reproducibly alters the human gut microbiome
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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
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Cited by
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Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
Wang, X., Zhang, P., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26196076 · Cited by 529
Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 513
Effects of Probiotics on Gut Microbiota: An Overview
Chandrasekaran, P., Weiskirchen, S., & Weiskirchen, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116022 · Cited by 382
Gut microbiota dysbiosis in a cohort of patients with psoriasis
Hidalgo‐Cantabrana, C., Gómez, J., Delgado, S., Requena‐López, S., Queiro‐Silva, R., Margolles, A., Coto, E., Sánchez, B., & Coto‐Segura, P. (2019) · British Journal of Dermatology · doi:10.1111/bjd.17931 · Cited by 236
The microbiome and autoimmunity: a paradigm from the gut–liver axis
Li, B., Selmi, C. F., Tang, R., Gershwin, M. E., & Ma, X. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2018.7 · Cited by 237
Metadata
- Authors
- Yan, D., Issa, N., Afifi, L., Jeon, C., Chang, H.-W., & Liao, W.
- Affiliations
- University of California, San Francisco (US)
- Georgetown University (US)
- Corresponding author
- Yan, Di
- Venue
- Current Dermatology Reports
- Published
- 2017-04-22
- Volume
- 6
- Issue
- 2
- Pages
- 94-103
- ISSN
- 2162-4933 (ISSN-L)
- PMC
- PMC5552074
- OpenAlex
- W2606499437
- Cited by
- 135
- References
- 72
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 20 · 2023: 18 · 2022: 15 · 2021: 22 · 2020: 13 · 2019: 18 · 2018: 9 · 2017: 2
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Dermatology Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Psoriasis Foundation Translational Research Award (NIH R01 AR065174, NIH U01 AI119125)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- psoriasis, psoriatic arthritis, skin microbiome, gut microbiota, Streptococcus, Propionibacterium, Firmicutes, Bacteroidetes, actinobacteria, dysbiosis, therapeutic target
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