Gut Microbiome in Psoriasis: An Updated Review
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(1) Background: A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis. The gut–skin axis is the novel concept of the interaction between skin diseases and microbiome through inflammatory mediators, metabolites and the intestinal barrier. The objective of this study was to synthesize current data on the gut microbial composition in psoriasis. (2) Methods: We conducted a systematic review of studies investigating intestinal microbiome in psoriasis, using the PRISMA checklist. We searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2000–2020). (3) Results: All of the 10 retrieved studies reported alterations in the gut microbiome in patients with psoriasis. Eight studies assessed alpha- and beta-diversity. Four of them reported a lack of change in alpha-diversity, but all confirmed significant changes in beta-diversity. At the phylum-level, at least two or more studies reported a lower relative abundance of Bacteroidetes, and higher Firmicutes in psoriasis patients versus healthy controls. (4) Conclusions: There is a significant association between alterations in gut microbial composition and psoriasis; however, there is high heterogeneity between studies. More unified methodological standards in large-scale studies are needed to understand microbiota’s contribution to psoriasis pathogenesis and its modulation as a potential therapeutic strategy.
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Abnormal changes in the number of different types of bacteria in the intestinal tract caused by intestinal microbial dysbiosis are one of the causes of the development of psoriasis.
“abnormal changes in the number of different types of bacteria in the intestinal tract caused by intestinal microbial dysbiosis are one of the causes of the development of psoriasis [103].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [103]
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A Multifaced Approach on Psoriasis PathogenesisPreprint
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- Authors
- Sikora, M., Stec, A., Chrabaszcz, M., Knot, A., Waskiel-Burnat, A., Rakowska, A., Olszewska, M., & Rudnicka, L.
- Affiliations
- Medical University of Warsaw (PL)
- Department of Dermatology, Medical University of Warsaw, 02-091 Warsaw, Poland
- Corresponding author
- Sikora, Mariusz
- Venue
- Pathogens
- Publisher
- MDPI AG
- Published
- 2020-06-12
- Volume
- 9
- Issue
- 6
- Pages
- 463
- ISSN
- 2076-0817 (ISSN-L)
- PMC
- PMC7350295
- OpenAlex
- W3034348811
- Cited by
- 118
- References
- 53
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 29 · 2023: 26 · 2022: 15 · 2021: 19
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministerstwo Nauki i Szkolnictwa Wyższego (MNiSW/2019/32/DIR/NN4)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- psoriasis, gut microbiota, gut dysbiosis, gut-skin axis, microbial diversity, Bacteroidetes, Firmicutes, intestinal barrier, psoriasis pathogenesis, microbiota-based therapy
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