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Cited by 102Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityHeart Failure Treatment and Management

Myocardial contractility and left ventricular function in obese patients with essential hypertension

Garavaglia, Guillermo E., Messerli, Franz H., Nunez, Boris D., Schmieder, Roland E., Grossman, Ehud·1988·The American Journal of Cardiology
DOI 10.1016/0002-9149(88)90662-5
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Abstract

Although the risk of developing congestive heart failure increases in parallel with the degree of obesity, load-dependent indexes of left ventricular function are found to be reduced in patients with morbid obesity only. We used the ratio of end-systolic wall stress to end-systolic volume index, which is load-independent, to assess myocardial contractility in 23 nonobese, 28 mildly obese and 26 moderately obese patients with mild to moderate essential hypertension. Although load-dependent indexes (i.e., ejection fraction, fractional fiber shortening and velocity of circumferential fiber shortening) were similar in the 3 groups, end-systolic wall stress to end-systolic volume index was lower in the moderately obese group (2.63 +/- 0.4, p less than 0.002) and even in the mildly obese group (2.88 +/- 0.8, p less than 0.05) than in the nonobese group (3.27 +/- 0.7). Further, there was a significant inverse relation between end-systolic wall stress to end-systolic volume index and body mass index (r = -0.34, p less than 0.005), diastolic diameter (r = -0.56, p less than 0.001) and left ventricular mass index (r = -0.55, p less than 0.001). Some obese patients have depressed myocardial contractility when compared with lean patients despite well-preserved pump function.

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Crossref · 10.1016/0002-9149(88)90662-5

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  • Findings on LV ejection fraction in obese subjects are variable, with studies reporting depressed, normal, or supernormal EF.

    “Various authors have reported depressed LV ejection fraction (EF) (15, 68, 100), normal EF (22, 111, 116, 191, 242, 266, 279, 377), and supernormal EF (28, 155, 274, 375) in obese subjects.”

    From Cardiac remodeling in obesity (2008) · cites this paper as [111]

  • Invasive studies have led to the conclusion that myocardial contractility is reduced in obese subjects.

    “Invasive studies have also led to the conclusion that myocardial contractility is reduced (111).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [111]

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Authors
Garavaglia, G. E., Messerli, F. H., Nunez, B. D., Schmieder, R. E., & Grossman, E.
Affiliations
Ochsner Medical Center (US)
Corresponding author
Messerli, Franz H.
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1988-09
Volume
62
Issue
9
Pages
594-597
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(88)90662-5
OpenAlex
W2046553029
Cited by
102
References
34
Citations by year
2024: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
1.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords
cardiac contractility, left ventricular function, obesity, essential hypertension, end-systolic wall stress, end-systolic volume index, left ventricular mass, body mass index, ejection fraction
MeSH terms
Adult, Echocardiography, Female, Heart, Humans, Hypertension, Male, Middle Aged, Myocardial Contraction, Obesity, Stroke Volume

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