Body composition and prognosis in chronic systolic heart failure: the obesity paradox
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The 'obesity paradox' has been described in a variety of disease processes, including other gynecologic cancers.
“The “obesity paradox”, which suggest a positive association between increasing BMI as it pertains to a specific disease, was firstly reported in heart failure31, but has since been described in a variety of disease processes, including other gynecologic cancers32–34.”
From Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation (2021) · cites this paper as [31]
A paradoxical survival advantage with higher BMI exists in the elderly and in a broad range of illnesses, including diabetes mellitus, chronic heart failure, acute heart failure, coronary artery disease, and percutaneous coronary artery interventions.
“the case is strong that such a paradoxical relation exists in the elderly, 7 and accompanying a broad range of illnesses, including diabetes mellitus, 8 chronic heart failure, 9,10 acute heart failure, 11 coronary artery disease, 12 and percutaneous coronary artery interventions.13”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [10]
A growing number of recent reports document a statistically significant survival benefit in obese patients once they have been diagnosed with cardiovascular diseases.
“While it is widely accepted that obesity increases the risk of developing heart disease, a growing number of recent reports document a statistically significant survival benefit in obese patients once they have been diagnosed with cardiovascular diseases (128, 144, 145, 200, 201, 211, 244).”
From Cardiac remodeling in obesity (2008) · cites this paper as [201]
In a stable outpatient cohort, obese patients had better survival than normal-weight patients with comparable severity of heart failure.
“For example, follow-up examination of a stable outpatient cohort showed that obese patients had better survival than normal-weight patients with comparable severity of heart failure (201).”
From Cardiac remodeling in obesity (2008) · cites this paper as [201]
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- Authors
- Lavie, C. J., Osman, A. F., Milani, R. V., & Mehra, M. R.
- Affiliations
- Ochsner Medical Center (US)
- Corresponding author
- Lavie, Carl J.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 91
- Issue
- 7
- Pages
- 891-894
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2081209712
- Cited by
- 486
- References
- 21
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 5 · 2023: 13 · 2022: 9 · 2021: 12 · 2020: 17 · 2019: 19 · 2018: 17 · 2017: 16 · 2016: 37 · 2015: 18 · 2014: 42 · 2013: 40 · 2012: 26
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity paradox, chronic systolic heart failure, body composition, body fat percentage, body mass index, survival, prognosis, NYHA functional class
- MeSH terms
- Adult, Age Factors, Aged, Body Composition, Chronic Disease, Female, Follow-Up Studies, Heart Failure, Humans, Louisiana, Male, Middle Aged, Obesity, Oxygen Consumption, Predictive Value of Tests, Prognosis, Retrospective Studies, Severity of Illness Index, Stroke Volume, Systole, Cohort Studies, Body Mass Index, Incidence, Multivariate Analysis, Disease-Free Survival
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