Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle
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Key Points: The human circadian system causes a morning peak in circulating levels of PAI-1, independent of any behavioral or environmental influences. The circadian system determines to a large extent the PAI-1 rhythm observed during a regular sleep/wake cycle.
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A forced desynchrony protocol revealed that PAI-1 is rhythmic and peaks in the biological morning, suggesting a role for the circadian clock in reducing fibrinolytic activity in the morning, especially since this circadian rhythm was approximately 8 times larger than changes in PAI-1 induced by behaviors such as mild exercise.
“A forced desynchrony protocol revealed that PAI-1 is rhythmic and peaks in the biological morning, suggesting a role for the circadian clock in reducing fibrinolytic activity in the morning, especially since this circadian rhythm was approximately 8 times larger than changes in PAI-1 induced by behaviors such as mild exercise (111).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [111]
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- Authors
- Scheer, F. A. J. L., & Shea, S. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-01-23
- Volume
- 123
- Issue
- 4
- Pages
- 590-593
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3901072
- OpenAlex
- W2054542782
- Cited by
- 172
- References
- 23
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 14 · 2023: 15 · 2022: 15 · 2021: 17 · 2020: 9 · 2019: 23 · 2018: 12 · 2017: 8 · 2016: 13 · 2015: 14 · 2014: 9
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K24HL076446, R01HL076409, P30HL101299)
- National Center for Research Resources (UL1RR025758)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- plasminogen activator inhibitor-1, circadian rhythm, morning peak, prothrombotic factors, fibrinolysis, sleep-wake cycle, cardiovascular events, head-up tilt, physical activity, posture, circadian system
- MeSH terms
- Adult, Behavior, Blood Coagulation, Circadian Rhythm, Female, Fibrinolysis, Gene Expression Regulation, Humans, Male, Risk Factors, Sleep, Temperature, Time Factors, Wakefulness, Exercise, Plasminogen Activator Inhibitor 1, Young Adult
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