Cited by 1,096Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementCardiac electrophysiology and arrhythmias

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Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study)

Furberg, Curt D., Psaty, Bruce M., Manolio, Teri A., Gardin, Julius M., Smith, Vivienne E., Rautaharju, Pentti M.·1994·The American Journal of Cardiology

DOI 10.1016/0002-9149(94)90363-8

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Abstract

Atrial fibrillation (AF) is a common arrhythmia in elderly persons and a common cause of embolic stroke. Most studies of the prevalence and correlates of AF have used selected, hospital-based populations. The Cardiovascular Health Study is a population-based, longitudinal study of risk factors for coronary artery disease and stroke in 5,201 men and women aged > or = 65 years. AF was diagnosed in 4.8% of women and in 6.2% of men at the baseline examination, and prevalence was strongly associated with advanced age in women. Prevalence of AF was 9.1% in men and women with clinical cardiovascular disease, 4.6% in patients with evidence of subclinical but no clinical cardiovascular disease, and only 1.6% in subjects with neither clinical nor subclinical cardiovascular disease. A history of congestive heart failure, valvular heart disease and stroke, echocardiographic evidence of enlarged left atrial dimension, abnormal mitral or aortic valve function, treated systemic hypertension, and advanced age were independently associated with the prevalence of AF. The low prevalence of AF in the absence of clinical and subclinical cardiovascular disease calls into question the existence and clinical usefulness of the concept of so-called "lone atrial fibrillation" in the elderly.

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Authors: Furberg, C. D., Psaty, B. M., Manolio, T. A., Gardin, J. M., Smith, V. E., & Rautaharju, P. M.
Affiliations: Atrium Health Wake Forest Baptist (US)
ORCID: Psaty, Bruce M.
Manolio, Teri A.
Gardin, Julius M.
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 1994-08
Volume: 74
Issue: 3
Pages: 236-241
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/0002-9149(94)90363-8
OpenAlex: W2029045834
Cited by: 1,096
References: 28
Citations by year: 2026: 2 · 2025: 4 · 2024: 10 · 2023: 16 · 2022: 26 · 2021: 26 · 2020: 27 · 2019: 24 · 2018: 30 · 2017: 34 · 2016: 40 · 2015: 42 · 2014: 57 · 2013: 56 · 2012: 58
FWCI: 11.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc085081-021, n01hc085079-024, n01hc085080-026)
National Heart, Lung, and Blood Institute (N01-HC-85081, N01HC85080, N01-HC85079)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: atrial fibrillation, prevalence, older adults, Cardiovascular Health Study, cardiovascular disease, subclinical cardiovascular disease, congestive heart failure, valvular heart disease, stroke, left atrial enlargement, systemic hypertension, age differences, lone atrial fibrillation
MeSH terms: Aged, Aged, 80 and over, Anti-Arrhythmia Agents, Anticoagulants, Atrial Fibrillation, Blood Glucose, Cardiovascular Diseases, Coronary Disease, Electrocardiography, Female, Humans, Male, Regression Analysis, Sampling Studies, Prevalence, Chi-Square Distribution

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Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study)

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