A review of the cost of atrial fibrillation
Open accessAbstract
Objectives To systematically review and synthesize the literature on the costs of atrial fibrillation (AF) with attention to study design and costing methods, geography, and intervention approaches.Methods A systematic search for previously published studies reporting the costs for AF patients was conducted. Data were analyzed in three steps: first by evaluating overall system costs; second by evaluating the relative contribution of specific cost components; and third by examining variations across study designs, across primary treatment approach, and by geography. Finally, a specific review of the treatment costs associated with anticoagulation treatment was examined given the clinical importance and attention given to these costs in the literature.Results The literature search resulted in 115 articles. On review of the abstracts or full text of these articles, 21 articles met all study criteria and reported on health system AF-related direct costs. A further six articles focused exclusively on anticoagulation costs for patients with AF. The overall average annual system cost across 27 estimates obtained from the literature was $5450 (SD = $3624) in 2010 Canadian dollars and ranged from a low of $1,632 to a high of $21,099. About one-third of these costs could be attributed to anticoagulation management. The largest cost component was acute care, followed by outpatient and physician and then medication-related costs.Conclusion AF-related medical costs are high, reflecting resource-intensive and long-term treatments including anticoagulation treatment. These costs, accompanied with increasing prevalence, justify increased attention to the management of patients with AF. Future studies of AF cost should ensure a broad assessment of the incremental direct medical and societal cost associated with this diagnosis.
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Heart failure and AF coincide in many patients.
“Heart failure and AF coincide in many patients.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [217]
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- Authors
- Wodchis, W. P., Bhatia, R. S., Leblanc, K., Meshkat, N., & Morra, D.
- Affiliations
- University of Toronto (CA)
- Harvard University (US)
- University Health Network (CA)
- Corresponding author
- Wodchis, Walter P.
- Venue
- Value in Health
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 15
- Issue
- 2
- Pages
- 240-248
- ISSN
- 1098-3015 (ISSN-L)
- OpenAlex
- W2029111709
- Cited by
- 109
- References
- 56
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 10 · 2023: 8 · 2022: 13 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 6 · 2013: 8 · 2012: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Value in Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- atrial fibrillation, health care costs, direct medical costs, anticoagulation costs, cost components, acute care costs, drug costs, physician costs, economic burden
- MeSH terms
- Atrial Fibrillation, Costs and Cost Analysis, Humans, Research Design, Health Care Costs, Cost of Illness
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