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Cited by 92Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

Effect of weight loss and antiandrogenic therapy on sex hormone blood levels and insulin resistance in obese patients with polycystic ovaries

Pasquali, Renato, Fabbri, Raffaella, Venturoli, Stefano, Paradisi, Roberto, Antenucci, Daniela, Melchionda, Nazario·1986·American Journal of Obstetrics and Gynecology
DOI 10.1016/0002-9378(86)90410-2
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Abstract

This study was performed in two randomly defined groups of obese patients with polycystic ovaries to investigate the overall effects of hypocaloric diet combined (group 2) or not combined (group 1) with an antiandrogenic therapy (cyproterone acetate, 50 mg/day, plus ethinyl estradiol, 0.05 mg/day) on sex hormone plasma levels, insulin secretion and resistance, and body weight loss and on their reciprocal interrelationships. All obese patients with polycystic ovaries showed elevated luteinizing hormone and androgen levels, hyperinsulinemia, and marked insulin resistance. After an average period of 3 months both groups showed a similar weight loss and a similar reduction in the insulin-resistant state. During treatment in group 1 three patients had a greater frequency of menstrual bleeding, and in one of them an ovulatory cycle was documented. Whereas, no changes in gonadotropin and sex steroid levels were found in group 1, a significant fall was observed in group 2. No relationships were observed between these changes and those which occurred on insulin levels. We conclude that hyperandrogenism in obese patients with polycystic ovaries does not appear to be a primary factor leading to the insulin-resistant state.

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Crossref · 10.1016/0002-9378(86)90410-2

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15 of 15 references verified0 citation errors · 0 not checkable

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  • Androgens in association with increased free fatty acid levels reduce insulin excretion in the liver and insulin-dependent glucose uptake in skeletal muscles, contributing to insulin resistance and compensatory hyperinsulinemia.

    “Moreover, androgens in association with increased free fatty acids (FFA) levels (a common feature in women with PCOS) reduce insulin excretion in the liver and insulin-dependent glucose uptake in skeletal muscles contributing to IR and compensatory hyperinsulinemia [22].”

    From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [22]

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Authors
Pasquali, R., Fabbri, R., Venturoli, S., Paradisi, R., Antenucci, D., & Melchionda, N.
Affiliations
University of Bologna (IT)
Corresponding author
Pasquali, Renato
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
1986-01
Volume
154
Issue
1
Pages
139-144
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/0002-9378(86)90410-2
OpenAlex
W1998630269
Cited by
92
References
15
Citations by year
2025: 1 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2012: 1
FWCI
6.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, obesity, weight loss, hypocaloric diet, antiandrogen therapy, cyproterone acetate, ethinyl estradiol, insulin resistance, hyperinsulinemia, hyperandrogenism, luteinizing hormone, sex hormone levels, menstrual bleeding, ovulation
MeSH terms
Adolescent, Adult, Androgen Antagonists, Body Weight, C-Peptide, Energy Intake, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Obesity, Polycystic Ovary Syndrome, Gonadal Steroid Hormones

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