The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Abstract
We have previously demonstrated that astrocytes synthesize and secrete apolipoprotein E in situ. In the present work, primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro. The astrocytes in culture contained immunoreactive apolipoprotein E in the area of the Golgi apparatus. Incubation of the astrocytes with [35S]methionine resulted in the secretion of labeled immunoprecipitable apolipoprotein E, which constituted 1-3% of the total secreted proteins. The apolipoprotein E secreted in culture and the apolipoprotein E in rat brain extracts differed from serum apolipoprotein E in two respects: both had a slightly higher apparent molecular weight (approx. 36,000) and more acidic isoforms than serum apolipoprotein E. Sialylation of the newly secreted apolipoprotein accounted for the difference in both the apparent molecular weight and isoelectric focusing pattern of newly secreted apolipoprotein E and plasma apolipoprotein E. The astrocytes possessed apolipoprotein B,E(LDL) receptors capable of binding and internalizing apolipoprotein E-containing lipoproteins. The uptake of lipoproteins by the cells led to a reduction in the number of cell surface receptors and to the intracellular accumulation of cholesteryl esters. Since apolipoprotein E is present within the brain, and since brain cells can express apolipoprotein B,E(LDL) receptors, apolipoprotein E-containing lipoproteins may function to redistribute lipid and regulate cholesterol homeostasis within the brain.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the brain and neuronal cultures, ApoE is synthesized in astrocytes.14,15”
From Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain (2013) · cites this paper as [14]
In the citing paper
“How tau and apoE together influence tau-mediated neurodegeneration is not clear, although recent data suggest that microglia are required (Mancuso et al., 2019; Shi et al., 2019), despite the main producers of apoE in the brain being astrocytes (Pitas et al., 1987).”
From Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia (2021) · cites this paper as Pitas et al., 1987
In the citing paper
“In the central nervous system, this 34-kDa protein is mainly produced by microglia and astrocytes (Pitas et al., 1987) and delivers cholesterol-rich lipoproteins to neurons to support synaptogenesis and maintenance of synaptic connections (Mauch et al., 2001).”
From The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain (2013) · cites this paper as Pitas et al., 1987
In the citing paper
“Moreover, incubation with LDL has been shown to alter astrocyte morphology, although the specific consequences and mechanisms by which LDL cholesterol affects astrocytes remain incompletely understood (Dehouck et al. 1994; Engel et al. 2019; Pitas et al. 1987).”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Pitas et al. 1987
In the citing paper
“Moreover, incubation with LDL has been shown to alter astrocyte morphology, although the specific consequences and mechanisms by which LDL cholesterol affects astrocytes remain incompletely understood (Dehouck et al. 1994; Engel et al. 2019; Pitas et al. 1987).”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Pitas et al. 1987
In the citing paper
“Like other cells in the body, astrocytes possess an apo (B, E) receptor, and at the cellular level, this receptor provides a regulated mechanism for supplying cells with cholesterol (Volpe et al., 1978; Pitas et al., 1987).”
From Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. (1994) · cites this paper as Pitas et al., 1987
In the citing paper
“Pitas et al. (1987) have proposed a model for cholesterol transport and homeostasis within the central nervous sys- tem.”
From Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. (1994) · cites this paper as Pitas et al. (1987)
In the citing paper
“Astrocytes are the primary source of apoE in the brain [23, 24].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [24]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724
Bolton, A. E., & Hunter, W. M. (1973) · Biochemical Journal · doi:10.1042/bj1330529 · Cited by 3,240
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 1,906
[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
Goldstein, J. L., Basu, S. K., & Brown, M. S. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)98152-1 · Cited by 1,629
Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts
Goldstein, J. L., & Brown, M. S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42341-7 · Cited by 1,123
Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829
Self-citationLipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 756
Self-citationRegulation of Plasma Cholesterol by Lipoprotein Receptors
Brown, M. S., Kovanen, P. T., & Goldstein, J. L. (1981) · Science · doi:10.1126/science.6261329 · Cited by 702
Research works printed but not linked: 12
- Roheim, 1979, 76, 4646
- Pitas, 1986, 45, 587
- Elshourbagy, 1985, 82, 203
- Ignatius, 1986, 83, 1125
- Snipes, 1986, 83, 1130
- Skene, 1983, 80, 4169
- Rudling, 1983, Cancer Res., 43, 4600
- Mahley, 1977, Am. J. Pathol., 87, 205
- Pitas, 1979, 76, 2311
- Basu, 1981, 78, 7545
- Horrocks, 1983, Vol. 3, 1
- Mahley, 1983, Arch. Pathol. Lab. Med., 107, 393
Cited by
Sorted by citations
Items 501–600 of 695
Polidori, M. C., Pientka, L., Nelles, G., & Griffiths, H. R. (2010) · PubMed Central · Cited by 9
Kawasaki, K., Ogiwara, N., Sugano, M., Okumura, N., & Yamauchi, K. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.12.018 · Cited by 9
DeKroon, R. M., & Armati, P. J. (2002) · Cell Biology International · doi:10.1006/cbir.2002.0868 · Cited by 9
Effect of apolipoprotein E (apoE) phenotype on the apoE content of CSF-HDL in children
Hirayama, S., Miida, T., Obayashi, K., Yamazaki, F., Yamazaki-Sakurai, M., Ito, M., Saito, Y., Hanyu, O., Suzuki, K., & Aizawa, Y. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.01.004 · Cited by 9
Is Apolipoprotein E Required for Cognitive Function in Humans?
Lane‐Donovan, C., & Herz, J. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2013 · Cited by 8
Lipid Dyshomeostasis and Inherited Cerebellar Ataxia
Zhao, J., Zhang, H., Fan, X., Yu, X., & Huai, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02826-2 · Cited by 9
Berntsson, E., Friedemann, M., Noormägi, A., Jarvet, J., Roos, P. M., Tõugu, V., Gräslund, A., Palumaa, P., & Wärmländer, S. K. T. S. (2022) · ACS Omega · doi:10.1021/acsomega.2c02254 · Cited by 8
Hirschberg, Y., Boonen, K., Schildermans, K., van Dam, A., Pintelon, I., Vandendriessche, C., Velimirović, M., Jacobs, A., Vandenbroucke, R. E., Nelissen, I., et al. (2022) · Journal of Extracellular Biology · doi:10.1002/jex2.55 · Cited by 8
The potential of apolipoprotein E4 to act as a substrate for primary cultures of hippocampal neurons
Kim, K.-M., Vicenty, J., & Palmore, G. T. R. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.012 · Cited by 8
Bernstock, J. D., Verheyen, J., Huang, B. Y., Hallenbeck, J. M., & Pluchino, S. (2014) · InTech eBooks · doi:10.5772/58599 · Cited by 9
FGF-1-Induced Reactions for Biogenesis of apoE-HDL are Mediated by Src in Rat Astrocytes
Nishida, T., Ito, J.-I., Nagayasu, Y., & Yokoyama, S. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp135 · Cited by 8
APOE-ε3 and APOE-219G Haplotypes Increase the Risk for Schizophrenia in Sibling Pairs
Tovilla‐Zárate, C. A., Camarena, B., Fresán, A., Apiquián, R., Dassori, A. M., Rolando, M., Escamilla, M., & Nicolini, H. (2009) · Journal of Neuropsychiatry · doi:10.1176/jnp.2009.21.4.440 · Cited by 8
Takacs, C. N., Andreo, U., Belote, R. L., Pulupa, J., Scull, M. A., Gleason, C. E., Rice, C. M., & Simon, S. M. (2017) · Traffic · doi:10.1111/tra.12467 · Cited by 10
Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels
den Hoedt, S., Janssen, C. I. F., Astarita, G., Piomelli, D., Leijten, F. P. J., Crivelli, S. M., Verhoeven, A. J. M., de Vries, H. E., Walter, J., Martínez‐Martínez, P., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160739 · Cited by 8
Gene expression of apolipoprotein E in human brain tumors
Lichtor, T. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90935-z · Cited by 8
Astrocytes and Memory: Implications for the Treatment of Memory-related Disorders
Wang, J., Cheng, P., Qu, Y., & Zhu, G. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240128102039 · Cited by 7
Rodríguez, A., Calero, O., Veiga, S., Menacho-Román, M., Arribas, I., Cano, L., García-Ribas, G., & Calero, M. (2025) · Alzheimer's Research & Therapy · doi:10.1186/s13195-025-01811-w · Cited by 8
Pinchaud, K., Masson, C., Dayre, B., Mounier, C., Gilles, J.-F., Vanhoutte, P., Caboche, J., & Bétuing, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311001 · Cited by 8
Zhang, X., Gao, R., Yang, L., Zhu, Y., Zhang, T., Shen, X., Gu, W., Yang, L., & Peng, S. (2024) · Clinical and Translational Discovery · doi:10.1002/ctd2.287 · Cited by 8
Bánáti, D., Hellmann‐Regen, J., Mack, I., Young, H. A., Benton, D., Eggersdorfer, M. L., Rohn, S., Dulińska-Litewka, J., Krężel, W., & Rühl, R. (2024) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000808 · Cited by 7
Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation
Ng, S. S., Park, J. E., Meng, W., Chen, C., Kalaria, R. N., McCarthy, N. E., & Sze, S. K. (2020) · ACS Omega · doi:10.1021/acsomega.9b04439 · Cited by 9
Lipid Metabolism and Oxidation in Neurons and Glial Cells
Fantini, J., & Yahi, N. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800111-0.00003-5 · Cited by 7
Disruption of cholesterol homeostasis in developmental neurotoxicity
Guizzetti, M., Chen, J., & Costa, L. G. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382032-7.10065-7 · Cited by 7
Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?
Sporiš, D. (2017) · Acta Clinica Croatica · doi:10.20471/acc.2017.56.01.02 · Cited by 7
An Integrative Overview of Non-Amyloid and Non-Tau Pathologies in Alzheimer’s Disease
Menta, B. W., & Swerdlow, R. H. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2603-y · Cited by 7
Suesca, E., Alejo, J. L. P., Bolaños, N. I., Ocampo, J., Leidy, C., & González, J. M. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22305 · Cited by 7
Regulation and Physiological Function of Insulin-Like Growth Factors in the Central Nervous System
Lauterio, T. J. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5949-4_37 · Cited by 7
Sulfation of Rat Apolipoprotein E
Gebicke‐Haerter, P. J., & Shooter, E. M. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb11791.x · Cited by 7
Apolipoprotein E and Alzheimer’s disease
Mahley, R. W. (1995) · Developments in cardiovascular medicine · doi:10.1007/978-94-011-6585-3_6 · Cited by 7
Self-citationFat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease
Hone, E., Lim, F., & Martins, I. J. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch7 · Cited by 8
Nedelkov, D., Tsokolas, Z. E., Rodrigues, M. S., Sible, I. J., Han, S. D., Kerman, B. E., Renteln, M., Mack, W. J., Pascoal, T. A., Yassine, H. N., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01795-7 · Cited by 6
Patwekar, M., Patwekar, F., Shaikh, D., Fatema, S. R., Aher, S. J., & Sharma, R. (2023) · Applied Chemical Engineering · doi:10.24294/ace.v6i3.2338 · Cited by 8
Alz-Disc: A Tool to Discriminate Disease-causing and Neutral Mutations in Alzheimer's Disease
Gromiha, M. M., Kulandaisamy, A., & Dharshini, S. A. P. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207325666220520102316 · Cited by 6
Advances in the Study of APOE and Innate Immunity in Alzheimer’s Disease
Li, Y., Chang, J., Chen, X., Liu, J., & Zhao, L. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230179 · Cited by 6
Martinez, R., Chunjing, W., Geffin, R., & McCarthy, M. (2012) · Journal of NeuroVirology · doi:10.1007/s13365-012-0079-0 · Cited by 6
Nagayasu, Y., Ito, J.-I., Nishida, T., & Yokoyama, S. (2008) · The Journal of Biochemistry · doi:10.1093/jb/mvn008 · Cited by 6
Apolipoprotein E polymorphism and dendritic shape in hippocampal interneurons
Schönheit, B., Glöckner, F., & Ohm, T. G. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.03.016 · Cited by 6
Isoforms of rat apolipoproteins and changes induced by insulin deficiency and fasting
Callow, M. J., & Redgrave, T. G. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90182-9 · Cited by 6
Association between Apolipoprotein E Polymorphisms and Epilepsy in Children
Kukuruzović, M. (2021) · Acta Clinica Croatica · doi:10.20471/acc.2021.60.04.05 · Cited by 6
Cholesterol—A Janus-Faced Molecule in the Central Nervous System
Wood, W. G., Igbavboa, U., Eckert, G. P., & Müller, W. E. G. (2007) · Springer eBooks · doi:10.1007/978-0-387-30380-2_7 · Cited by 5
Mahley, R. W., Nathan, B. P., Bellosta, S., & Pitas, R. E. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_5 · Cited by 5
Self-citationGenetics of Alzheimer's Disease
Bekris, L. M., Yu, C., Bird, T. D., & Tsuang, D. W. (2010) · Wiley eBooks · doi:10.1002/9780470669600.ch43 · Cited by 6
Arnaud, L., Benech, P. D., Greetham, L., Stephan, D., Jimenez, A., Jullien, N. D., García‐González, L., Tsvetkov, P. O., Devred, F., Sancho-Martinez, I., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.16.440108 · Cited by 5
Non-Anticoagulant Actions of Glycosaminoglycans (GAGs)
Cornelli, U. (1996) · Springer eBooks · doi:10.1007/978-1-4613-0371-8_20 · Cited by 5
Protective ApoE variants support neuronal function by extracting peroxidated lipids
Ralhan, I., Do, A. D., Bae, J.-Y., Feringa, F. M., Cai, W., Chang, J., Chik, K., Lee, N. Y., Gerry, C., van der Kant, R., et al. (2025) · bioRxiv · doi:10.1101/2025.03.05.641722 · Cited by 4
Trudel, L., Therriault, J., Macedo, A. C., Woo, M. S., Rahmouni, N., Aumont, É., Servaes, S., Hosseini, S. A., Ferrari‐Souza, J. P., Bellaver, B., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-01171-4 · Cited by 6
Tripodi, D., Vitarelli, F., Spiti, S., & Leoni, V. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-43883-7_17 · Cited by 5
Brousseau, V., Caron, P., Trottier, J., Paolo, T. D., Milkiewicz, P., & Barbier, O. (2022) · Journal of Mass Spectrometry · doi:10.1002/jms.4827 · Cited by 5
Seeger, D. R., Murphy, C. C., & Murphy, E. J. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.05.003 · Cited by 5
The Impact of Apolipoprotein E Allelic Variants on Alzheimer’s Disease
Serrano, E., Sanz, P. G., & Barrantes, F. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-61721-9_29 · Cited by 4
Key Enzymes and Proteins in Amyloid-Beta Production and Clearance
Santos, C. R. A., Cardoso, I., & Gonçalves, I. (2011) · InTech eBooks · doi:10.5772/17646 · Cited by 5
Methods for the study of lipid metabolism in neurons
Hayashi, H., Karten, B., Vance, D. E., Campenot, R. B., Maue, R. A., & Vance, J. E. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.04.002 · Cited by 4
Apolipoprotein-E genotypes and myasthenia gravis
Behari, M., Suhail, H., Soundararajan, C. C., Vivekanandhan, S., & Singh, S. (2010) · Neurology India · doi:10.4103/0028-3886.65533 · Cited by 4
O’Toole, D., & Love, W. C. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms784oa · Cited by 4
Human, but not bovine, oxidized cerebral spinal fluid lipoproteins disrupt neuronal microtubules
Neely, M. D., Swift, L. L., & Montine, T. J. (2000) · Lipids · doi:10.1007/s11745-000-0641-8 · Cited by 4
Sykes, J. E., & Lores-Cardozo, M. (1988) · Neurochemistry International · doi:10.1016/0197-0186(88)90030-7 · Cited by 4
Low cholesterol and violent death
Corrigan, F. M., Gray, R. F., & SKINNER, E. R. (1993) · Irish Journal of Psychological Medicine · doi:10.1017/s0790966700012660 · Cited by 4
Leys, D., Englund, E. M., & Erkinjuntti, T. (2003) · Wiley eBooks · doi:10.1002/9780470752340.ch20 · Cited by 4
Jiraanont, P., Wang, J. Y., Durbin-Johnson, B., Hwang, Y. H., Hessl, D. R., Rivera, S. M., Hagerman, R. J., & Tassone, F. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107292 · Cited by 3
Freudenberg‐Hua, Y., Giliberto, L., d’Abramo, C., Li, W., Ma, Y., Goate, A., & Koppel, J. L. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03098-7 · Cited by 4
Apolipoproteína E e Doença de Alzheimer
Prado, D., & Cardoso, I. L. (2013) · Revista Neurociências · doi:10.4181/rnc.2013.21.775.8p · Cited by 3
Cholesterol and late-life cognition. An epidemiological and clinical approach
Solomon, A. (2009) · Cited by 2
Pathology, Neurobiology, and Animal Models of Alzheimer's Disease
Sisodia, S. S., Price, D. D., Crain, B. J., & Troncoso, J. C. (1996) · Informa Healthcare eBooks · doi:10.1201/9781420048407.ch12 · Cited by 3
Aging, cognitive decline, apolipoprotein E and docosahexaenoic acid metabolism
Plourde, M. (2018) · OCL · doi:10.1051/ocl/2018032 · Cited by 5
Jasmin, S. B. (2011) · eScholarship@McGill (McGill) · doi:10.82308/52384 · Cited by 3
Liu, G., Men, P., Perry, G. L., & Smith, M. A. (2003) · Wiley eBooks · doi:10.1002/9783527610419.ntls0122 · Cited by 3
The rat, a useful animal model for pharmacological studies on apolipoprotein E
Leininger‐Muller, B., & Siest, G. (1996) · Life Sciences · doi:10.1016/0024-3205(95)02245-7 · Cited by 3
Yamauchi, K., Tozuka, M., Hidaka, E., Ueno, I., Matsuda, K., & Katsuyama, T. (2003) · PubMed · Cited by 3
Effects of apolipoprotein E polymorphism on the development of stroke.
Ahmad, U., Mahmood, M. S., Siddiqui, S., & Pm, F. (2004) · PubMed · Cited by 3
ApoE expression across the CNS: Who, What, Where, When, and How (much)?
Nolt, G. L., Lucido, C. C., Smith, L. M., & Johnson, L. A. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00028-x · Cited by 2
The Mevalonate Pathway in the Radiation Response of Cancer
Azizi, L., Hausman, H., Meyer, A. K., Wong, M., & Pajonk, F. (2025) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2025.03.059 · Cited by 2
Iacono, D. (2025) · Neuroethics · doi:10.1007/s12152-025-09624-2 · Cited by 2
Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders
Kuan, J. H., Raghavan, R., Koh, D. L. W., Tan, W. Y., Iezhitsa, I. N., & Agarwal, R. (2026) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70026 · Cited by 4
Using iPSC models to examine neuron–glia interactions in neurodegenerative diseases
Lopez, D. M., Keavey, L., & Bowles, K. R. (2026) · Bioscience Reports · doi:10.1042/bsr20250131 · Cited by 2
Yuan, N. Y., Richards, W. D., Parham, K. T., Clark, S. G., & Lebakken, C. S. (2026) · Cells · doi:10.3390/cells15141266 · Cited by 2
Zhang, X., Rawal, P., Wu, L., & Zhao, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818000-6.00007-x · Cited by 2
Cholesterol Trafficking in the Brain
Lütjohann, D., Vanmierlo, T., & Mulder, M. T. (2009) · Springer eBooks · doi:10.1007/978-3-642-00300-4_5 · Cited by 2
Cerebrospinal fluid apolipoprotein e levels in subacute sclerosing panencephalitis
Yüksel, D., Ichiyama, T., Yilmaz, D., & Anlar, B. (2011) · Brain and Development · doi:10.1016/j.braindev.2011.07.001 · Cited by 2
Li, J., Zhang, F., Wang, Y., Wang, Y., Qin, W. D., Xing, Q., Qian, X., Guo, T., Gao, X., He, L., et al. (2014) · BioMed Research International · doi:10.1155/2014/236702 · Cited by 2
Dehouck, B., Dehouck, M., Fruchart, J., & Cecchelli, R. (1987) · Review & Expositor · doi:10.1177/003463738708400125 · Cited by 2
Apolipoproteína E e Doença de Alzheimer
Prado, D., & Cardoso, I. L. (2013) · Revista Neurociências · doi:10.34024/rnc.2013.v21.8211 · Cited by 2
Etiology, Genetics, and Pathogenesis of Alzheimer's Disease
McKeon‐O'Malley, C., & Tanzi, R. E. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50024-x · Cited by 3
Blank-Stein, N., Mayer, M., & Mass, E. (2021) · Advances in immunology · doi:10.1016/bs.ai.2021.08.001 · Cited by 2
Poirier, J., Hess, M. A., May, P. C., Pasinetti, G. M., & Finch, C. E. (1990) · Advances in behavioral biology · doi:10.1007/978-1-4684-5844-2_38 · Cited by 2
Apolipoproteins as “Drugs”: Current Status
Sirtori, C. R. (1993) · Springer eBooks · doi:10.1007/978-3-642-84634-2_12 · Cited by 2
Glial/axonal pattern formation in the fish optic nerve
Scholes, J., Maggs, A., & Dowding, A. J. (1992) · Springer eBooks · doi:10.1007/978-94-011-2348-8_8 · Cited by 2
Ng, S. S., Park, J. E., Meng, W., Chen, C., Kalaria, R. N., McCarthy, N. E., & Sze, S. K. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/643783 · Cited by 2
Baumart, G. J., Rodrigues, M. S., Sholl, J. N., de Sousa, A. C., Weber, A. F., Costa‐Beber, L. C., Farias, H. R., Costa, M. V., Peres, A. M., de Camargo, P. R., et al. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70403 · Cited by 2
Ramsden, C. E., Cutler, R. G., Li, X., & Keyes, G. S. (2025) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2025.102681 · Cited by 1
Mahley, R. W. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_2-1 · Cited by 1
Self-citationA new lens on Alzheimer's disease: Insights into the Edinger-Westphal nucleus and its circuits
Zhou, Y., Su, T., Yuan, M., Li, W., Zhou, Y., Kou, J., Chang, J.-S., Liu, D., Chen, L., Zhan, K., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251372587 · Cited by 1
LOW DENSITY LIPOPROTEIN RECEPTOR AND ALZHEIMERS DISEASE
Gopalraj, R. K. (2009) · UKnowledge (University of Kentucky) · Cited by 1
Role of Apolipoprotein E in Alzheimer’s Disease: Clues from its Structure
Weisgraber, K. H., & Dong, L. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_2 · Cited by 1
Zhang, D., Guo, Z., Yang, Y., & Chang, J. (2022) · Journal of Holistic Integrative Pharmacy · doi:10.1016/s2707-3688(23)00061-4 · Cited by 2
Cholesterol in the Central Nervous System in Health and Disease
Skowronek, R. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-41192-2_21 · Cited by 1
Searcy, J. L. (2009) · UKnowledge (University of Kentucky) · Cited by 1
Gümüş, E. (2019) · Van Medical Journal · doi:10.5505/vtd.2019.24571 · Cited by 1
Biswal, R. A., Riyaz Sharif, S., & Pazhamalai, V. (2020) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2020.120113 · Cited by 1
Hyman, B. T., Rebeck, G. W., Christie, R. H., Page, K. J., Irizarry, M. C., & Strickland, D. K. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_8 · Cited by 1
Metadata
- Authors
- Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Pitas, Robert E.
- ORCID
- Mahley, Robert W.
- Venue
- Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 917
- Issue
- 1
- Pages
- 148-161
- ISSN
- 0005-2760 (ISSN-L)
- OpenAlex
- W2067064610
- Cited by
- 693
- References
- 39
- Citations by year
- 2026: 9 · 2025: 24 · 2024: 11 · 2023: 16 · 2022: 19 · 2021: 22 · 2020: 15 · 2019: 17 · 2018: 9 · 2017: 11 · 2016: 24 · 2015: 19 · 2014: 12 · 2013: 16 · 2012: 19
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- astrocytes, apolipoprotein E, sialylation, Golgi apparatus, cholesterol esters, cholesterol homeostasis, brain lipids
- MeSH terms
- Animals, Animals, Newborn, Apolipoproteins E, Astrocytes, Brain, Cells, Cultured, Female, Fetus, Fibroblasts, Humans, Immunoenzyme Techniques, Kinetics, Macrophages, Microscopy, Fluorescence, Molecular Weight, Pregnancy, Rats, Inbred Strains, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
