The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Abstract
We have previously demonstrated that astrocytes synthesize and secrete apolipoprotein E in situ. In the present work, primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro. The astrocytes in culture contained immunoreactive apolipoprotein E in the area of the Golgi apparatus. Incubation of the astrocytes with [35S]methionine resulted in the secretion of labeled immunoprecipitable apolipoprotein E, which constituted 1-3% of the total secreted proteins. The apolipoprotein E secreted in culture and the apolipoprotein E in rat brain extracts differed from serum apolipoprotein E in two respects: both had a slightly higher apparent molecular weight (approx. 36,000) and more acidic isoforms than serum apolipoprotein E. Sialylation of the newly secreted apolipoprotein accounted for the difference in both the apparent molecular weight and isoelectric focusing pattern of newly secreted apolipoprotein E and plasma apolipoprotein E. The astrocytes possessed apolipoprotein B,E(LDL) receptors capable of binding and internalizing apolipoprotein E-containing lipoproteins. The uptake of lipoproteins by the cells led to a reduction in the number of cell surface receptors and to the intracellular accumulation of cholesteryl esters. Since apolipoprotein E is present within the brain, and since brain cells can express apolipoprotein B,E(LDL) receptors, apolipoprotein E-containing lipoproteins may function to redistribute lipid and regulate cholesterol homeostasis within the brain.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the brain and neuronal cultures, ApoE is synthesized in astrocytes.14,15”
From Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain (2013) · cites this paper as [14]
In the citing paper
“How tau and apoE together influence tau-mediated neurodegeneration is not clear, although recent data suggest that microglia are required (Mancuso et al., 2019; Shi et al., 2019), despite the main producers of apoE in the brain being astrocytes (Pitas et al., 1987).”
From Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia (2021) · cites this paper as Pitas et al., 1987
In the citing paper
“In the central nervous system, this 34-kDa protein is mainly produced by microglia and astrocytes (Pitas et al., 1987) and delivers cholesterol-rich lipoproteins to neurons to support synaptogenesis and maintenance of synaptic connections (Mauch et al., 2001).”
From The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain (2013) · cites this paper as Pitas et al., 1987
In the citing paper
“Moreover, incubation with LDL has been shown to alter astrocyte morphology, although the specific consequences and mechanisms by which LDL cholesterol affects astrocytes remain incompletely understood (Dehouck et al. 1994; Engel et al. 2019; Pitas et al. 1987).”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Pitas et al. 1987
In the citing paper
“Moreover, incubation with LDL has been shown to alter astrocyte morphology, although the specific consequences and mechanisms by which LDL cholesterol affects astrocytes remain incompletely understood (Dehouck et al. 1994; Engel et al. 2019; Pitas et al. 1987).”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Pitas et al. 1987
In the citing paper
“Like other cells in the body, astrocytes possess an apo (B, E) receptor, and at the cellular level, this receptor provides a regulated mechanism for supplying cells with cholesterol (Volpe et al., 1978; Pitas et al., 1987).”
From Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. (1994) · cites this paper as Pitas et al., 1987
In the citing paper
“Pitas et al. (1987) have proposed a model for cholesterol transport and homeostasis within the central nervous sys- tem.”
From Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. (1994) · cites this paper as Pitas et al. (1987)
In the citing paper
“Astrocytes are the primary source of apoE in the brain [23, 24].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [24]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724
Bolton, A. E., & Hunter, W. M. (1973) · Biochemical Journal · doi:10.1042/bj1330529 · Cited by 3,240
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 1,906
[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
Goldstein, J. L., Basu, S. K., & Brown, M. S. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)98152-1 · Cited by 1,629
Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts
Goldstein, J. L., & Brown, M. S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42341-7 · Cited by 1,123
Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829
Self-citationLipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 756
Self-citationRegulation of Plasma Cholesterol by Lipoprotein Receptors
Brown, M. S., Kovanen, P. T., & Goldstein, J. L. (1981) · Science · doi:10.1126/science.6261329 · Cited by 702
Research works printed but not linked: 12
- Roheim, 1979, 76, 4646
- Pitas, 1986, 45, 587
- Elshourbagy, 1985, 82, 203
- Ignatius, 1986, 83, 1125
- Snipes, 1986, 83, 1130
- Skene, 1983, 80, 4169
- Rudling, 1983, Cancer Res., 43, 4600
- Mahley, 1977, Am. J. Pathol., 87, 205
- Pitas, 1979, 76, 2311
- Basu, 1981, 78, 7545
- Horrocks, 1983, Vol. 3, 1
- Mahley, 1983, Arch. Pathol. Lab. Med., 107, 393
Cited by
Sorted by citations
Items 601–695 of 695
Potential Biological Mechanisms of ApoE in Alzheimer’s Disease
Rebeck, G. W. (1997) · Humana Press eBooks · doi:10.1007/978-1-59259-471-9_2 · Cited by 1
Gaillard, O., Delattre, P., Akli, J., & Schuller, E. (1999) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/s0923-2532(99)80037-4 · Cited by 1
Glial Changes in Aging and Alzheimer’s Disease
Morán, M. A., & Gómez‐Ramos, P. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5737-1_19 · Cited by 1
Coagulation-fibrinolysis abnormalities in poststroke patients.
Oztürk, S., Bruck, D. C., & Feinberg, W. M. (1994) · Stroke · doi:10.1161/01.str.25.8.1702 · Cited by 1
Apolipoprotein E4 Phenotype in Alzheimer's Disease
Takagi, Y., Mon Son, C. H. O. I., KIMURA, S., Fukuchi, K., Miya, T., Baba, K., Sugita, K., & Gomi, K. (1996) · The Showa University Journal of Medical Sciences · doi:10.15369/sujms1989.8.197 · Cited by 1
Apolipoprotein E: Structural and Functional Interactions with Amyloid β
Stine, W. B., & LaDu, M. J. (2005) · Wiley eBooks · doi:10.1002/9783527619344.ch10 · Cited by 1
Ueki, A., Kawano, M., Namba, Y., Kawakami, M., Matsumura, M., Fukushima, Y., Otsuka, M., & Ikeda, K. (1995) · Advances in behavioral biology · doi:10.1007/978-1-4757-9145-7_28 · Cited by 1
Role of Amyloid Protein Precursor and Apolipoprotein E in Stroke
Hall, E. D., Oostveen, J. A., Dunn, E., & Carter, D. B. (1995) · Elsevier eBooks · doi:10.1016/b978-0-7506-9603-6.50027-6 · Cited by 1
Reverse genetics of familial combined hyperlipidaemia.
Worsley, A. P. (1993) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 1
Metabolic Abnormalities in Alzheimer Disease
Gebhardt, F. M., & Dodd, P. R. (2008) · Springer eBooks · doi:10.1007/978-0-387-79112-8_22 · Cited by 1
AAV-Delivered Anti-PC-OxPL Antibody Fragments: A Novel Therapeutic Approach to Target ALSPreprint
Gomes‐Duarte, A., Wong, J. K., Pasteuning-Vuhman, S., Pos, W., Haselberg, R., Sogorb-González, M., Pascoal, S., van Dijk, R. E., Sharifi, F., Giera, M. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.634350 · Cited by 1
Freudenberg‐Hua, Y., Giliberto, L., d’Abramo, C., Li, W., Ma, Y., Goate, A., & Koppel, J. L. (2025) · medRxiv · doi:10.1101/2025.02.24.25322783 · Cited by 1
Glycosaminoglycans as Potential Future Treatment of Alzheimer’s Disease
Cornelli, U. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-661-4_36 · Cited by 1
Schmechel, D. E., Xu, P., Gilbert, J. R., & Roses, A. D. (1999) · Springer eBooks · doi:10.1007/978-1-4615-4887-4_10 · Cited by 1
Mutka, A. (2009) · Työväentutkimus Vuosikirja
Cholesterol Metabolism in Huntington’s Disease
Leoni, V., Caccia, C., & Bjrkhem, I. (2012) · InTech eBooks · doi:10.5772/32654
Simmons, C. R. (2011) · UKnowledge (University of Kentucky)
Regulierung und Verfügbarkeit von Apolipoprotein E in Astrozyten
Hamker, U. (2005) · edoc Publication server (Humboldt University of Berlin) · doi:10.18452/15272
Zannis, V. I., Laccotripe, M., Makrides, S. C., Kardassis, D., & Zanni, E. E. (1996) · Springer eBooks · doi:10.1007/978-1-4613-0355-8_7
Abad‐Rodríguez, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.12.002
Cholesterol: nieuw therapeutisch target bij de ziekte van Alzheimer?
Mulder, M. T., & van Mierlo, T. (2007) · Neuropraxis · doi:10.1007/bf03079128
Bibliography NIA/AlzA Conference on Apolipoprotein E Genotyping in Alzheimer's Disease
Kwon, Y. J., Tsai, J., & Relkin, N. R. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32609.x
van den Kommer, T. N. (2011) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Molecular interactions underlying neuronal ceroid lipofuscinoses CLN1 and CLN5
Lyly, A. (2008) · Työväentutkimus Vuosikirja
Björkhem, I., Leoni, V., Meaney, S., & Besta, C. (2010)
Cholesterol Disturbances in Inherited Neurodegenerative Diseases
Mutka, A. (2009)
Aufnahme, Abbau und Bindung von ApoE(3/3)- versus ApoE(4/4)-Liposomen in hippokampalen Zellen
Medizin, E., & Beisiegel†, U. (2004)
Danik, M., & Poirier, J. (2002) · New comprehensive biochemistry · doi:10.1016/s0167-7306(02)35033-6
Bowirrat, A. (2010) · The Open Complementary Medicine Journal · doi:10.2174/1876391x01002010090
EXPLORING THE ROLE OF MITOCHONDRIAL CHOLESTEROL IN NIEMANN-PICK TYPE C DISEASE
Kennedy, B. E. (2016) · DalSpace (Dalhousie University)
Depressão em doentes com Lúpus: o papel da variabilidade genética do sistema monoaminérgico.
Tavares, A. I. G. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/d9h9-rj26
da Silva, I. M. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Apolipoprotein E and Mitochondria-associated Endoplasmic Reticulum Dysfunction
Tambini, M. D. (2016)
Alzheimer’s Disease Therapeutics Targeting Apolipoprotein E
Liao, F., & Holtzman, D. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00010-1
Alteration of cholesterol homeostasis in the Huntington's disease brain
Kreilaus, F. (2015) · Research Online (University of Wollongong)
DEAFFERENTATION IN THE RAT AND IN ALZHEIMER'S DISEASE
Poirier, J., Hess, M. A., May, P. C., Pasinetti, G. M., & Finch, C. E. (1990)
Apolipoproteins in the Treatment of Vascular and Nonvascular Disease
Sirtori, C. R. (1995) · Medical science symposia series · doi:10.1007/978-94-011-0039-7_8
Deciphering the role of 27-hydroxycholesterol in neurodegeneration
Ismail, M. A. M. (2016) · Figshare
Munger, E. L. (2016) · OhioLink ETD Center (Ohio Library and Information Network)
Tirniceriu, A. (2009) · DuEPublico (University of Duisburg-Essen)
Genes, Aging, and Parkinson’s Disease
Milanese, C., & Mastroberardino, P. G. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622888-00389
Gümüş, E. (2018) · Dicle Medical Journal / Dicle Tip Dergisi · doi:10.5798/dicletip.457243
Castranio, E. L. (2018) · D-Scholarship@Pitt (University of Pittsburgh)
A study of the global effects of Apolipoprotein E using lipidomics
Hawksworth, J. I. (2019) · ORCA Online Research @Cardiff (Cardiff University)
Disruption of Cholesterol Homeostasis in Developmental Neurotoxicity
Guizzetti, M., & Costa, L. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804239-7.00057-3
The need for traumatic brain injury markers
Than, M. P., Fatovich, D. M., Fitzgerald, M., Gozt, A., McKinlay, A., & Snell, D. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816346-7.00002-6
Yu, T., Tensaouti, Y., Stephanz, E. P., Rafikian, E. E., Yang, M., & Kernie, S. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.13.425890
Strattan, L. E. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.097
Modelling of ischemic stroke : focus on co-morbidities and therapeutic intervention
Dhungana, H. (2014) · UEF eRepo (University of Eastern Finland)
Kumar, A. (2021) · International Journal of Bioinformatics and Biological Science · doi:10.30954/2319-5169.1.2021.3
Mann, D. M. A. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6001-2_4
Pathogenesis of Alzheimer Disease: Metabolic Factors
(2004) · Springer eBooks · doi:10.1007/0-306-48529-x_15
Cellular Mechanisms of Dementia
Gan, L. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0054
Roberts, A. P., Dec, K., McAllister, B., Tyrrell, V. J., O’Donnell, V. B., Harwood, A. J., & Williams, J. H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.19.537428
Apolipoprotein E Isoform-Related Translational Measures in PTSD Research
Torres, E. R. S., DeBarber, A. E., & Raber, J. (2023) · Neuromethods · doi:10.1007/978-1-0716-3218-5_8
Horkulak, N. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10060
Chan, D., Spires‐Jones, T. L., Provenzano, F. A., Glennon, E. B. C., & Duff, K. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0020
Ashford, B., Simpson, J. E., Dawson, C., Boche, D., Cooper‐Knock, J., Heath, P. R., Fillingham, D. J., Appleby‐Mallinder, C., Wei, W., Dunning, M., et al. (2025) · medRxiv · doi:10.1101/2025.02.07.25321850
Microglial glutathione and glutamate: regulation mechanisms
Fry, V. A. H. (2009) · UCL Discovery (University College London)
Correas, Á. G., Stromsnes, K., Lupu, R. I., & González, G. O. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_29-1 · Cited by 1
APOE, Pesticides, Environmental Pollutants, and Epigenetics
Biosca-Brull, J., Colomina, M. T., Cabré, M., & Guardia-Escote, L. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_50-1
Katzman, R. (1994) · Comprehensive physiology · doi:10.1002/j.2040-4603.1994.tb01684.x
The Christchurch point mutation in mouse APOE reduces Aβ-induced tau and α-synuclein pathologiesPreprint
Soto-Faguás, C. M., O’Niel, A., Mueller, P. A., Sanchez-Molina, P., Woltjer, R. L., Raber, J., & Unni, V. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.05.686857
Behavioral Aspects of Apolipoprotein E Knockout Mice
Litherland, M. T. (2003)
REGULATION OF LOW DENSITY LIPOPROTEIN RECEPTOR SPLICING EFFICIENCY
Ling, I. (2009) · UKnowledge (University of Kentucky)
Meuret, C. J., Hu, Y., Smadi, S., Bantugan, M. A., Xian, H., Martinez, A. E., Krauss, R. M., Ma, Q. L., Nedelkov, D., & Yassine, H. N. (2024) · Figshare · doi:10.6084/m9.figshare.26591264
Glial-Derived Substances Associated with CNS Regeneration
Schwartz, M., Harel, A., Cohen, A., Stein‐Izsak, C., FAINARU, M., Rubinstein, M., Belkin, M., & Solomon, A. (1988) · Springer eBooks · doi:10.1007/978-3-642-73148-8_36
Kapoor, M., Shekhar, A., Verma, V., Sibin, M. K., Partikar, S., Jaipurkar, R., Rajagopal, S., & Ruchira, G. (2026) · Medical Journal Armed Forces India · doi:10.1016/j.mjafi.2025.12.003
Molecular mechanism of Alzheimer’s disease using integrated multi-omics
Alhusaini, M., Mussa, B. M., İlçe, B. Y., Alhaj, H. A., & Hamoudi, R. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1735696
Triglyceride-sensing in the mesocorticolimbic system and reward-driven behaviour control
Berland, C. (2018) · theses.fr (ABES) · doi:10.70675/3a1dc076z7d5az413czbc66z525614a40de5
Freyssin, A. (2020) · theses.fr (ABES) · doi:10.70675/0db2e37dz547bz4731z852dz9b843c062cba
Characterization of cellular heterogeneity in Diffuse Low Grade Glioma
Augustus, M. (2020) · theses.fr (ABES) · doi:10.70675/037c23a4z44ddz4bb7z999ezb0c178c35170
Mahley, R. W. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_2
Self-citationVecino, R., Díaz‐Guerra, E., Arribas-González, E., Gil, D. S., Acosta, F. J. F., Serra, I., Moreno‐Jiménez, E. P., Moratalla, R., Navarrete, M., & Vicario‐Abejón, C. (2026) · Research Square · doi:10.21203/rs.3.rs-10968101/v1
BindingDB Entry 50018264: Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.
BindingDB (2024) · UC San Diego · doi:10.7270/q27p93md
Effects Of Apolipoprotein E On Olfactory Neuron Plasticity In Mice
Nisar, R. (2000) · Journal of Collective Bargaining in the Academy
Effects of Apolipoprotein E on Neurite Outgrowth from Adult Mice Cortical Neurons
Jiang, Y. (2000) · Journal of Collective Bargaining in the Academy
Regional Specific Brain ApoE Modulation by the Estrous Cycle and Exogenous Estrogen
Rosario, E. R. (2002) · Journal of Collective Bargaining in the Academy
Effects of E2 on ApoE Secretion and Neurite Outgrowth in Cultured Adult Mouse Cortical Neurons
Shen, F. (2002) · Journal of Collective Bargaining in the Academy
Saul, A. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3915
ApoE4 impairs astrocyte lipid droplet formation via endolysosomal dysfunction
Ralhan, I., Bae, J.-Y., Lee, N. Y., Cai, W., Chang, J., Jarad, S., Gu, H., Zhang, D., & Ioannou, M. S. (2026) · doi:10.64898/2026.09.01.748585
Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis
Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.008 · Cited by 298
The Role and Metabolism of Sulfatide in the Nervous System
Eckhardt, M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8022-3 · Cited by 193
Novel Role for Apolipoprotein E in the Central Nervous System
Han, X., Cheng, H., Fryer, J. D., Fagan, A. M., & Holtzman, D. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212340200 · Cited by 126
Cole (2000) · doi:10.1002/1097-0029(20000815)50:4
Genetic Mutations Affecting Human Lipoproteins, Their Receptors, and Their Enzymes
Zannis, V. I., Kardassis, D., & Zanni, E. E. (1993) · Advances in Human Genetics 21 · doi:10.1007/978-1-4615-3010-7_3 · Cited by 78
Flowers, S. A., Grant, O. C., Woods, R. J., & Rebeck, G. W. (2020) · Glycobiology · doi:10.1093/glycob/cwz084 · Cited by 52
A unifying hypothesis of alzheimer’s disease: III—Risk factors
Heininger, K. (2000) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/(sici)1099-1077(200001)15:1
Metadata
- Authors
- Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Pitas, Robert E.
- ORCID
- Mahley, Robert W.
- Venue
- Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 917
- Issue
- 1
- Pages
- 148-161
- ISSN
- 0005-2760 (ISSN-L)
- OpenAlex
- W2067064610
- Cited by
- 693
- References
- 39
- Citations by year
- 2026: 9 · 2025: 24 · 2024: 11 · 2023: 16 · 2022: 19 · 2021: 22 · 2020: 15 · 2019: 17 · 2018: 9 · 2017: 11 · 2016: 24 · 2015: 19 · 2014: 12 · 2013: 16 · 2012: 19
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- astrocytes, apolipoprotein E, sialylation, Golgi apparatus, cholesterol esters, cholesterol homeostasis, brain lipids
- MeSH terms
- Animals, Animals, Newborn, Apolipoproteins E, Astrocytes, Brain, Cells, Cultured, Female, Fetus, Fibroblasts, Humans, Immunoenzyme Techniques, Kinetics, Macrophages, Microscopy, Fluorescence, Molecular Weight, Pregnancy, Rats, Inbred Strains, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
