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Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice
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“The SCN express a robust circadian rhythm of electrophysiologic activity, even when isolated from the rest of the brain (3,4).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [4]
Citations
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“Complex interactions among SCN neurons and astrocytes generate tissuelevel synchrony of circadian rhythms in SCN firing rates (Green and Gillette, 1982; Herzog et al., 1998; Albus et al., 2002; Kudo et al., 2015), which convey solar timing information to nearby brain regions (Abrahamson and Moore,…”
BackgroundKlett, N. J., Cravetchi, O., & Allen, C. N. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304211059770 · Cited by 7
“SCN neurons display a circadian rhythm in action potential firing frequency with a peak in the middle of the day (Inouye and Kawamura, 1979; Green and Gillette, 1982).”
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“Electrophysiological evidence, accrued over the past dec- ade, has indicated that SCN neurons express an internal pacemaker that endows and controls rhythmic regular burst firing rates (Green & Gillette, 1982; Meijer & Rietveld, 1989; Cloues & Sather, 2003; Yamaguchi et al. 2003).”
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“Body temperature is also found to achieve peak value in the evening [7, 16], increase in temperature could also result in improving performance due to facilitation in nerve conduction velocity, elevated blood supply [5, 16] or due to higher carbohydrate uptake [17].”
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“uptake, suggesting that neurons of the SCN possess an intrinsic pacemaker (Green and Gillette, 1982).”
GENERATION AND ENTRAINMENT OF ORCADIAN RHYTHMS
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“Coupling to this input, spontaneous neuronal activity of SCN neurons is commonly higher during the day than during night-time, regardless of whether a species is nocturnal or diurnal (Inouye and Kawamura, 1979; Green and Gillette, 1982; Bano-Otalora et al., 2021; Morioka et al., 2023).”
Wegner, S., Belle, M. D. C., Chang, P., Hughes, A. T. L., Conibear, A. E., Muir, C., Samuels, R. E., & Piggins, H. D. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16590 · Cited by 3
“Since the SCN network is viable and readily accessible ex vivo (Green & Gillette, 1982; Groos & Hendriks, 1982; Shibata & Moore, 1988), we assessed neuronal state and gating to excitatory inputs by comparing whole-cell current clamp and voltage-clamp recordings from SCN-containing brain slices…”
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“The SCN itself produces oscillations of electrical activity with a circadian period even when acutely dissociated in vitro (Green & Gillette, 1982), solidifying the clock concept.”
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“Moreover, this rhythm is maintained in SCN slices (Green and Gillette, 1982; Shibata et al., 1982) as well as in isolated SCN cells (Welsh et al.”
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“SCN neurons cultured in vitro displayed circadian electrical activity (Green & Gillette, 1982; Groos & Hendriks, 1982; Shibata, Oomura, Kita, & Hattori, 1982) This clock operates independently of environmental cues but is capable of entraining to the external cycle via such cues (Aronson et al.,…”
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Metadata
- Authors
- Green, D. J., & Gillette, R.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1982-08
- Volume
- 245
- Issue
- 1
- Pages
- 198-200
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2083497067
- Cited by
- 503
- References
- 10
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 7 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 14
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian rhythm, suprachiasmatic nucleus, neuronal firing rate, single-unit recording, brain slices, light-dark cycle, rats, circadian pacemaker
- MeSH terms
- Action Potentials, Animals, Circadian Rhythm, Female, Hypothalamus, Anterior, Rats, In Vitro Techniques
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