Cited by 503Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

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Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice

Green, Daniel J., Gillette, Rhanor·1982·Brain Research

DOI 10.1016/0006-8993(82)90361-4

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Kita, 1981, Circadian rhythmic changes of SCN neuronal activity in the rat hypothalamic slice, Neurosci. Abstr., 7, 858

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“…rhythmicity in SCN multiunit electrical activity even after surgical isolation of the SCN within a “hypothalamic island” (Inouye and Kawamura, 1979), while in vitro recordings demonstrated circadian rhythmicity in SCN single-unit activity in hypothalamic tissue slices (Green and Gillette, 1982).”
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“…but not of other tested brain areas including the cerebral cortex and arcuate nucleus, display robust circadian oscillations in firing rate in vitro, suggesting that the rhythmicity of the SCN is autonomous and self-sustaining (Green & Gillette 1982, Groos & Hendriks 1982, Shibata et al. 1982).”
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“SCN neurons exhibit a cell-autonomous circadian rhythm in spontaneous firing (Bos and Mirmiran 1990; Bouskila and Dudek 1993; Green and Gillette 1982; Groos and Hendriks 1982; Inouye and Kawamura 1979; Welsh et al. 1995), which is transmitted to target areas and may impose a circadian rhythm on a…”
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Background
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BackgroundMethod
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Background
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Immunocytochemical characterization of the suprachiasmatic nucleus and the intergeniculate leaflet in the diurnal ground squirrel, Spermophilus lateralis
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Baño‐Otálora, B., & Piggins, H. D. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.007 · Cited by 66
“…day (Sakhi et al., 2014b; Zhao and Rusak, 2005) further suggests that rhythmic neuronal activity in the LHb is coincident with or phase-delayed with respect to the firing rate rhythms of SCN neurons which peak around mid-day (Cutler et al., 2003; Green and Gillette, 1982; Groos and Hendriks, 1982).”
The suprachiasmatic nucleus; a responsive clock regulating homeostasis by daily changing the setpoints of physiological parameters
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Leptin Modulates Spike Coding in the Rat Suprachiasmatic Nucleus
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Tetrodotoxin does not affect circadian rhythms in neuronal activity and metabolism in rodent suprachiasmatic nucleus in vitro.
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Inward rectifier and low-threshold calcium currents contribute to the spontaneous firing mechanism in neurons of the rat suprachiasmatic nucleus
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“Earlier electrophysiological studies for the SCN using extracellular recordings of multiple- or single-unit activity demonstrated that specific firing patterns of neuronal activity are maintained in a brain slice preparation of the SCN [4, 7, 27] and even in an organotypic explant of SCN, which had been cultured for s…”
Background
Transplantation: a new tool in the analysis of the mammalian hypothalamic circadian pacemaker
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In vitro electrical activity in the suprachiasmatic nucleus following splitting and masking of wheel-running behavior
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Cyclic AMP Signaling Control of Action Potential Firing Rate and Molecular Circadian Pacemaking in the Suprachiasmatic Nucleus
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“The firing peak rhythm matched that reported from acute slices (Green and Gillette, 1982; Cutler et al., 2003), and additionally, we identified a”
Result
Principles of Clinical Chronobiology
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Electrophysiological responses of hamster suprachiasmatic neurones to neuropeptide Y in the hypothalamic slice preparation
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Defined Cell Groups in the Rat Suprachiasmatic Nucleus Have Different Day/Night Rhythms of Single-Unit Activity In Vivo
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“The absolute value of the mean firing rate of the SCN at its peak, however, was lower than the value reported by some studies in vitro (mean peak rate of 8-9 Hz; Groos and Hendriks, 1982; Green and Gillette, 1982; Shibata and Moore, 1988).”
MethodResult
Chapter 9 Regulation of entrainment pathways by the suprachiasmatic circadian clock: sensitivities to second messengers
Gillette, M. U. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)60404-5 · Cited by 59
Gap junctions couple astrocytes but not neurons in dissociated cultures of rat suprachiasmatic nucleus
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Chapter 8 – The organization of the human circadian timing system
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GABAergic mechanisms in the suprachiasmatic nucleus that influence circadian rhythm
Ono, D., Honma, K., & Honma, S. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15012 · Cited by 59
“The importance of the SCN for circadian rhythms as a central circadian clock has also been verified using acute SCN brain slice culture (Green & Gillette, 1982; Groos & Hendriks, 1982; Shibata, Oomura, Kita, & Hattori, 1982).”
Method
Development of Hamster Circadian Rhythms: Prenatal Entrainment of the Pacemaker
Davis, F. C., & Gorski, R. A. (1986) · Journal of Biological Rhythms · doi:10.1177/074873048600100108 · Cited by 58
Serotonergic phase shifts of the mammalian circadian clock: effects of tetrodotoxin and high Mg2+
Prosser, R. A., Heller, H. C., & Miller, J. D. (1992) · Brain Research · doi:10.1016/0006-8993(92)90784-7 · Cited by 58
Circadian rhythm of [3H]imipramine binding in the rat suprachiasmatic nuclei
Wirz‐Justice, A., Kräuchi, K., Morimasa, T., Willener, R., & Feer, H. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90348-5 · Cited by 58
Effects of tetrodotoxin on the circadian pacemaker mechanism in suprachiasmatic explants in vitro
Earnest, D. J., DiGiorgio, S., & Sladek, C. D. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90160-l · Cited by 57
Effects of partial destruction of the suprachiasmatic nuclei on two circadian parameters: wheel-running activity and short-day induced testicular regression
Pickard, G. E., & Turek, F. (1985) · Journal of Comparative Physiology · doi:10.1007/bf00610832 · Cited by 22
The response of suprachiasmatic neurons of the rat hypothalamus to photic and serotonergic stimulation
Miller, J. D., & Fuller, C. A. (1990) · Brain Research · doi:10.1016/0006-8993(90)90590-8 · Cited by 56
Effects of 17β-Estradiol on Neuronal Cell Excitability and Neurotransmission in the Suprachiasmatic Nucleus of Rat
Fatehi, M., & Fatehi-Hassanabad, Z. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301523 · Cited by 55
“It has already been shown that the SCN neurons under in vitro conditions, fire spontaneous action potentials (Inouye and Kawamura, 1979; Green and Gillette, 1982; Jackson et al, 2004; Kononenko and Dudek, 2004).”
Background

Authors: Green, D. J., & Gillette, R.
Affiliations: University of Illinois Urbana-Champaign (US)
ORCID: Green, Daniel J.
Gillette, Rhanor
Venue: Brain Research
Publisher: Elsevier BV
Published: 1982-08
Volume: 245
Issue: 1
Pages: 198-200
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(82)90361-4
OpenAlex: W2083497067
Cited by: 503
References: 10
Citations by year: 2025: 1 · 2024: 4 · 2023: 7 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 14
FWCI: 7.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian rhythm, suprachiasmatic nucleus, neuronal firing rate, single-unit recording, brain slices, light-dark cycle, rats, circadian pacemaker
MeSH terms: Action Potentials, Animals, Circadian Rhythm, Female, Hypothalamus, Anterior, Rats, In Vitro Techniques

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Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice

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