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The dopaminergic innervation of the supraoptic and paraventricular nucleus. A light and electron microscopical study
Open accessAbstract
An antiserum that has been raised against glutaraldehyde-conjugated dopamine was used to demonstrate specifically dopamine in the rat hypothalamus. This dopamine antiserum permitted an optimal fixation with glutaraldehyde and therefore enabled the simultaneous light and electron microscopic immunocytochemical localization of dopamine. It was demonstrated that the paraventricular and supraoptic nuclei of the hypothalamus were innervated by thin dopaminergic fibers, in contrast to the suprachiasmatic nucleus, which hardly received any dopaminergic input. Ultrastructural observations revealed that the dopamine fibers terminated synaptically on the magnocellular neurons and their processes. It is concluded that the present results may explain the effect of centrally injected dopamine on vasopressin and oxytocin release. In the dopamine-containing terminals the reaction product was frequently observed in 90 nm dense core vesicles and around clear vesicles.
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“Additionally, the PVN and the SON express DA receptors and receive dopaminergic innervations, possibly from the VTA (Buijs et al., 1984; Decavel et al., 1987; He et al., 2021; Rivkees and Lachowicz, 1997).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Buijs et al., 1984
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“In addition, the VTA, NAc, and AMY express both OXTR and DA receptors (Baskerville et al., 2009; Buijs et al., 1984; Roeling et al., 1993).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Buijs et al., 1984
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Metadata
- Authors
- Buijs, R. M., Geffard, M., Pool, C. W., & Hoorneman, E. M. D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Buijs, R.M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1984-12
- Volume
- 323
- Issue
- 1
- Pages
- 65-72
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2126473406
- Cited by
- 226
- References
- 31
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 20.68
- Type
- journal article
- Language
- en
- Open access
- green
- pure.knaw.nl
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- dopaminergic innervation, supraoptic nucleus, paraventricular nucleus, hypothalamus, magnocellular neurons, vasopressin release, oxytocin release, suprachiasmatic nucleus, synaptic terminals, dense core vesicles, clear vesicles, ultrastructure
- MeSH terms
- Animals, Dopamine, Immunoenzyme Techniques, Male, Microscopy, Electron, Oxytocin, Paraventricular Hypothalamic Nucleus, Rats, Inbred Strains, Supraoptic Nucleus, Vasopressins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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