The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.
Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study
Abstract
Parkinson's-diseased (PD) brains have increased levels of iron in the zona compacta of the substantia nigra (SNc). To determine whether these elevated nigral iron levels may be caused secondarily by degeneration of nigrostriatal dopaminergic (NS-DA) neurons, the NS-DA pathway was unilaterally lesioned in rats through 6-hydroxydopamine (6-OHDA) infusion and nigral iron levels evaluated three weeks later. A significant increase was observed in both iron concentration (+35%) and iron content (+33) within the substantia nigra (SN) ipsilateral to comprehensive 6-OHDA lesions. Moreover, ferric iron staining was dramatically increased within the SNc following 6-OHDA lesions, primarily due to the appearance of iron-positive SNc neurons and infiltrating reactive glial cells. Iron staining in the SN zona reticularis was modestly increased after 6-OHDA lesions, but staining in the neostriatum and globus pallidus was unaffected. These results indicate that loss of NS-DA neurons is associated with increased iron levels in the SN. This suggests that increased nigral iron levels in PD may be secondary to some neurodegenerative process. Nonetheless, even a secondary increase in nigral iron levels may be of pathogenic importance in PD because of iron's ability to catalyze neurotoxic free radical formation and perpetuate neurodegeneration.
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“Moreover, in the 6-hydroxydopamine model of Parkinson’s disease the degeneration of nigrostriatal dopaminergic neurons is associated with increased iron accumulation.155”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [155]
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Cites
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The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819
Iron, brain ageing and neurodegenerative disorders
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Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein
Uversky, V. N., Li, J., & Fink, A. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105343200 · Cited by 1,103
Metadata
- Authors
- Oestreicher, E., Sengstock, G. J., Riederer, P., Olanow, C. W., Dunn, A. J., & Arendash, G. W.
- Affiliations
- University of Würzburg (DE)
- University of South Florida (US)
- Louisiana State University (US)
- Corresponding author
- Arendash, G.W.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-10
- Volume
- 660
- Issue
- 1
- Pages
- 8-18
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2049800884
- Cited by
- 156
- References
- 47
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 7 · 2012: 4
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- Parkinson's disease, nigrostriatal dopaminergic neurons, substantia nigra, iron accumulation, 6-hydroxydopamine lesion, neurodegeneration, reactive glial cells
- MeSH terms
- Amphetamine, Animals, Behavior, Animal, Corpus Striatum, Histocytochemistry, Iron, Male, Medial Forebrain Bundle, Nerve Degeneration, Neurons, Stereotyped Behavior, Substantia Nigra, Oxidopamine, Rats, Sprague-Dawley, Rats
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