CoChat
Sign Up
Cited by 156Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismIron Metabolism and Disorders

The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.

Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study

Oestreicher, E., Sengstock, G.J., Riederer, P., Olanow, C.W., Dunn, A.J., Arendash, G.W.·1994·Brain Research
DOI 10.1016/0006-8993(94)90833-8
Open this paper in CoChat — free account

Abstract

Parkinson's-diseased (PD) brains have increased levels of iron in the zona compacta of the substantia nigra (SNc). To determine whether these elevated nigral iron levels may be caused secondarily by degeneration of nigrostriatal dopaminergic (NS-DA) neurons, the NS-DA pathway was unilaterally lesioned in rats through 6-hydroxydopamine (6-OHDA) infusion and nigral iron levels evaluated three weeks later. A significant increase was observed in both iron concentration (+35%) and iron content (+33) within the substantia nigra (SN) ipsilateral to comprehensive 6-OHDA lesions. Moreover, ferric iron staining was dramatically increased within the SNc following 6-OHDA lesions, primarily due to the appearance of iron-positive SNc neurons and infiltrating reactive glial cells. Iron staining in the SN zona reticularis was modestly increased after 6-OHDA lesions, but staining in the neostriatum and globus pallidus was unaffected. These results indicate that loss of NS-DA neurons is associated with increased iron levels in the SN. This suggests that increased nigral iron levels in PD may be secondary to some neurodegenerative process. Nonetheless, even a secondary increase in nigral iron levels may be of pathogenic importance in PD because of iron's ability to catalyze neurotoxic free radical formation and perpetuate neurodegeneration.

Overview

Integrity signals

Registry

Crossref · 10.1016/0006-8993(94)90833-8

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Antonini, 1993, Brain iron uptake in patients with Parkinson's disease (PD) measured by positron emmission tomography (PET), J. Cereb. Blood Flow Metab., 13, S364

Cited by

Sorted by citations

See all 156

Related

See all

Metadata

Authors
Oestreicher, E., Sengstock, G. J., Riederer, P., Olanow, C. W., Dunn, A. J., & Arendash, G. W.
Affiliations
  • University of Würzburg (DE)
  • University of South Florida (US)
  • Louisiana State University (US)
Corresponding author
Arendash, G.W.
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
1994-10
Volume
660
Issue
1
Pages
8-18
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(94)90833-8
OpenAlex
W2049800884
Cited by
156
References
47
Citations by year
2026: 1 · 2025: 1 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 7 · 2012: 4
FWCI
3.39
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
Parkinson's disease, nigrostriatal dopaminergic neurons, substantia nigra, iron accumulation, 6-hydroxydopamine lesion, neurodegeneration, reactive glial cells
MeSH terms
Amphetamine, Animals, Behavior, Animal, Corpus Striatum, Histocytochemistry, Iron, Male, Medial Forebrain Bundle, Nerve Degeneration, Neurons, Stereotyped Behavior, Substantia Nigra, Oxidopamine, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review