The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide: Implications for neurodegenerative diseases
Abstract
Incubation of rat skeletal muscle mitochondria with the nitric oxide generator, S-nitrosoglutathione (GSNO) reversibly inhibited oxygen utilisation with all substrates tested. The visible absorption spectra of the inhibited mitochondria showed that cytochromes c+c1, b and a+a3 were reduced, indicating a block at the distal end of the respiratory chain. Analysis of the respiratory chain enzyme activities in the presence of GSNO localised the site of inhibition of cytochrome c oxidase alone. These results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of nitric oxide in the CNS and other tissues.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In competition with oxygen, nitric oxide binds to cytochrome c oxidase in the mitochondrial electron transport chain, which leads to inhibition of mitochondrial respiration.[93][94][95]”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [94]
In the citing paper
“Furthermore, S-nitrosation of mitochondrial targets can modify mitochondrial function (97, 98, 474).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [97]
In the citing paper
“other studies have found a role for NO· in the inhibition of complex IV (cytochrome c oxidase) (97, 474) or in the ATPase complex (405).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [97]
In the citing paper
“indicating that there was no ‘compensatory’ increased contribution of anaerobic glycolysis to energy turnover as may be the case if, for example, nitrate supplementation had resulted in an inhibition of respiration [62, 63].”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [63]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Mitochondrial Complex I Deficiency in Parkinson's Disease
Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283
Self-citationNitric oxide: A cytotoxic activated macrophage effector molecule
Hibbs, J. B., Taintor, R. R., Vavrin, Z., & Rachlin, E. M. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80015-9 · Cited by 2,034
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Bredt, D. S., & Snyder, S. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9030 · Cited by 1,849
Stuehr, D. J., & Nathan, C. F. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1543 · Cited by 1,744
The cell biology of macrophage activation.
Adams, D. O., & Hamilton, T. A. (1984) · Annual Review of Immunology · doi:10.1146/annurev.iy.02.040184.001435 · Cited by 1,628
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
Turrens, J. F., & Boveris, A. (1980) · Biochemical Journal · doi:10.1042/bj1910421 · Cited by 1,601
[45] Cytochrome oxidase from beef heart mitochondria
Wharton, D. C., & Tzagoloff, A. (1967) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(67)10048-7 · Cited by 1,264
Inhibition of Mitochondrial Electron Transport by Peroxynitrite
Radi, R., Rodriguez, M., Castro, L., & Telleri, R. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1013 · Cited by 693
Schapira, A. H. V., Mann, V. M., Cooper, J. A. D., Dexter, D. T., Daniel, S. E., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb05809.x · Cited by 673
Self-citation
Research works printed but not linked: 1
- 1986 The Rockerfeller University Press New York C.F. Nathan R.M. Steinman R.J. North Mechanisms of Host Resistance to Infective Agents Tumors and Allografts 165 184
Cited by
Sorted by citations
Items 101–107 of 107
Mitochondria and Cellular Redox State on the Route from Ageing to Alzheimer's Disease
Abate, G., Vezzoli, M., Sandri, M., Rungratanawanich, W., Memo, M., & Uberti, D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111385 · Cited by 41
Jaber, S. M., Bordt, E. A., Bhatt, N. M., Lewis, D. M., Gerecht, S., Fiskum, G., & Polster, B. M. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.09.003 · Cited by 40
ORSI, A., BELTRÁN, B., CLEMENTI, E., HALLÉN, K., FEELISCH, M., & MONCADA, S. (2000) · Biochemical Journal · doi:10.1042/bj3460407 · Cited by 37
Self-citationPresley, T., Kuppusamy, P., Zweier, J. L., & Ilangovan, G. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.090175 · Cited by 34
Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide
Brookes, P. S., Shiva, S., Patel, R. P., & Darley-Usmar, V. M. (2002) · Methods in Enzymology · doi:10.1016/s0076-6879(02)59194-1 · Cited by 33
Self-citationRodríguez-Juárez, F., Aguirre, E., & Cadenas, S. (2007) · Biochemical Journal · doi:10.1042/bj20070033 · Cited by 31
Nitrite reduction: a ubiquitous function from a pre-aerobic past
Cutruzzolà, F., Rinaldo, S., Castiglione, N., Giardina, G., Pecht, I., & Brunori, M. (2009) · BioEssays · doi:10.1002/bies.200800235 · Cited by 13
Metadata
- Authors
- Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V.
- Affiliations
- Royal Free London NHS Foundation Trust (GB)
- Wellcome Trust (GB)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-05-23
- Volume
- 345
- Issue
- 1
- Pages
- 50-54
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1528220495
- Cited by
- 1,241
- References
- 32
- Citations by year
- 2026: 21 · 2025: 14 · 2024: 24 · 2023: 14 · 2022: 15 · 2021: 26 · 2020: 27 · 2019: 27 · 2018: 28 · 2017: 32 · 2016: 31 · 2015: 37 · 2014: 41 · 2013: 33 · 2012: 49
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- nitric oxide, cytochrome c oxidase, reversible inhibition, mitochondrial respiratory chain, S-nitrosoglutathione, skeletal muscle mitochondria, oxygen utilisation, cytochrome reduction
- MeSH terms
- Animals, Electron Transport Complex IV, Electron Transport, Glutathione, Mitochondria, Muscle, Nitric Oxide, Nitroso Compounds, Parkinson Disease, S-Nitrosoglutathione, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
