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Cited by 123Gastrointestinal motility and disordersGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Role of fructose-sorbitol malabsorption in the irritable bowel syndrome

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Nelis, G.Fritz, Vermeeren, Marja A.P., Jansen, Wim·1990·Gastroenterology
DOI 10.1016/0016-5085(90)90621-7
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Abstract

Because even after low doses of fructose and sorbitol, fructose-sorbitol malabsorption has been found in a high number of patients with the irritable bowel syndrome, an etiological role of fructose-sorbitol malabsorption in the irritable bowel syndrome has been suggested. However, these studies have been uncontrolled. Therefore, a controlled study of fructose-sorbitol malabsorption in the irritable bowel syndrome compared with healthy controls was performed. Seventy-three patients, 23 men and 50 women with a mean age 43.1 +/- 1.7 years (range, 18-66 years) with the irritable bowel syndrome were compared with 87 age- and sex-matched control subjects. Fructose-sorbitol malabsorption was determined by a breath-hydrogen test (Lactoscreen, Hoek Loos, Schiedam, The Netherlands) following an oral load of 25 g fructose and 5 g sorbitol after a 10-hour fast. Fructose-sorbitol malabsorption, as shown by an H2 peak of 20 ppm over basal values, was found in 22 (30.1%) of the patients and 35 (40.2%) of the control subjects. With a lower peak level of 10 ppm over basal values, these percentages were 45.2% and 57.5%, respectively. Also, the highest H2 peak values (15.2 +/- 2.3 ppm vs. 21.5 +/- 2.6 ppm), time to reach peak levels (110.7 +/- 5.4 min vs. 107.1 +/- 5.9 min), and area under the H2 curve (1310 +/- 219 ppm.min vs. 1812 +/- 255 ppm.min) did not discriminate between patients and controls. During the test, symptoms developed in 31 of 70 patients and in 3 of 85 control subjects (P less than 0.0001). Symptomatic patients did not differ from asymptomatic patients regarding the presence or absence of fructose-sorbitol malabsorption, H2 peak values, and area under the curve. No differences could be identified between male and female patients or controls. In conclusion, fructose-sorbitol malabsorption is frequently seen in patients with irritable bowel syndrome, but this is not different from observations in healthy volunteers. Therefore, fructose-sorbitol malabsorption does not seem to play an important role in the etiology of irritable bowel syndrome.

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  • Fructose and sorbitol mixtures produce a modest increase in stool weight but often increase flatulence and bloating in both healthy volunteers and IBS patients.

    “fructose and sorbitol mixtures produce a modest increase in stool weight, they often increase flatulence and bloating in both healthy volunteers and IBS patients [272,273]”

    From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [272]

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Research works printed but not linked: 4

  1. VonNoorden KH. Sionon in der Diabetesbehandlung. Deutsch Med Wochenschr 1929;55:483.
  2. Levinsky NG, Alexander EA. Acute renal failure. In: Brenner BM, Rector FC, eds. The Kidney. Volume 2. Philadelphia: Saunders, 1976:806-837.
  3. Douwes AC, Fernandes J. Degenhart HJ. Improved accuracy of lactose tolerancy test in children using expired H, measure- ments. Arch Dis Child 1978;53:939-942.
  4. Whitehead WE, Engel BT, Schuster MM. Irritable bowel syn- drome. Physiological and psychological differences between diarrhea-predominant and constipation-predominant patients. Dig Dis Sci 1980;25:404-413.

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Authors
Nelis, G. F., Vermeeren, M. A. P., & Jansen, W.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1990-10
Volume
99
Issue
4
Pages
1016-1020
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/0016-5085(90)90621-7
OpenAlex
W1898816935
Cited by
123
References
33
Citations by year
2023: 1 · 2020: 1 · 2018: 1 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 6 · 2012: 4
FWCI
6.12
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
fructose malabsorption, hydrogen breath test, fructose intolerance, healthy controls comparison, sex differences, age differences, disease severity, symptom duration
MeSH terms
Adult, Breath Tests, Colonic Diseases, Functional, Female, Fructose, Humans, Hydrogen, Intestinal Absorption, Malabsorption Syndromes, Male, Sorbitol

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