Symptom Provocation in Irritable Bowel Syndrome Effects of Differing Doses of Fructose-Sorbitol
Abstract
The role of fructose and sorbitol, when ingested together, in the aetiology of irritable bowel syndrome (IBS) is controversial. The aims of this study in IBS patients, therefore, were to compare differences in symptom provocation with various doses of fructose-sorbitol and to relate differences in the extent of colonic hydrogen production after each dose to such symptom provocation. Two different mixtures of fructose and sorbitol--20 g fructose plus 3.5 g sorbitol ('lower' dose) and 25 g fructose plus 5 g sorbitol ('higher' dose)--were administered to 15 patients with IBS and to 24 healthy controls. Breath hydrogen concentrations were determined at 10-min intervals for 3 h after ingestion of each mixture, and the presence and severity of a range of gastrointestinal symptoms were recorded on a standard form before, during, and after the study. Total symptom score in IBS patients, but not controls, was greater (p < 0.05) after the higher than after the lower dose of fructose-sorbitol mixture, and, for the higher dose, symptoms were significantly greater in IBS patients than in controls (p < 0.05). Moreover, the increase in total symptom score between the higher and lower dose mixtures was of a greater magnitude (p = 0.01) in IBS patients than in controls. No significant correlation was observed between the increase in symptom score and the increase in peak hydrogen concentration or the increase in integrated hydrogen response between lower and higher dose mixtures, although these latter increases were at times substantial.(ABSTRACT TRUNCATED AT 250 WORDS)
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Fructose and sorbitol mixtures produce a modest increase in stool weight but often increase flatulence and bloating in both healthy volunteers and IBS patients.
“fructose and sorbitol mixtures produce a modest increase in stool weight, they often increase flatulence and bloating in both healthy volunteers and IBS patients [272,273]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [273]
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- Authors
- Symons, P., Jones, M. P., & Kellow, J. E.
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- Royal North Shore Hospital (AU)
- ORCID
- Jones, M. P.
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- Scandinavian Journal of Gastroenterology
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- Informa UK Limited
- Published
- 1992-01
- Volume
- 27
- Issue
- 11
- Pages
- 940-944
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2012532703
- Cited by
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- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- irritable bowel syndrome, fructose, sorbitol, symptom provocation, breath hydrogen, sugar consumption, dose-response relationship, gastrointestinal symptoms
- MeSH terms
- Administration, Oral, Adult, Breath Tests, Colonic Diseases, Functional, Dose-Response Relationship, Drug, Female, Fructose, Humans, Hydrogen, Male, Middle Aged, Sorbitol
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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