Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study
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Plasma insulin is a risk factor for diabetes mellitus and cardiovascular disease in men. We investigated the association between plasma testosterone and plasma insulin in an occupational sample of 1292 healthy adult men. Total plasma testosterone decreased with each decade of age and insulin increased with each decade of age. In these cross-sectional data, this significant graded inverse association between testosterone and insulin was independent of age. The association was reduced but not explained by the addition of obesity and subscapular skinfold to the model. Adjustment for alcohol consumption, cigarette smoking and plasma glucose did not materially alter the association. These results are the reverse of the positive association of androgens with insulin in women and suggest alternative possible explanations for the effect of hyperinsulinaemia on cardiovascular disease risk. Prospective studies will be necessary to determine the direction and causal nature of this association.
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An inverse relationship exists between testosterone levels and insulin concentrations in healthy men.
“An inverse relationship ex-ists between testosterone levels and insulin concentrations in healthy men (2).”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [2]
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- Authors
- Simon, D., Preziosi, P., Barrett-Connor, E., Roger, M., Saint-Paul, M., Nahoul, K., & Papoz, L.
- Affiliations
- Inserm (FR)
- University of California San Diego (US)
- Venue
- Diabetologia
- Published
- 1992-02
- Volume
- 35
- Issue
- 2
- Pages
- 173-177
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2037112420
- Cited by
- 157
- References
- 44
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 9 · 2012: 8
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- plasma testosterone, plasma insulin, hyperinsulinemia, androgens, age-related decline, healthy men, cardiovascular risk, diabetes risk, obesity, skinfold thickness, sex differences
- MeSH terms
- Adult, Age Factors, Alcohol Drinking, Blood Glucose, Blood Pressure, Diabetes Mellitus, Fasting, Humans, Insulin, Middle Aged, Reference Values, Risk Factors, Smoking, Testosterone, Body Mass Index
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