Self-injection of amphetamine directly into the brain

Hoebel, Bartley G.; Monaco, Anthony P.; Hernandez, Luis; Aulisi, Edward F.; Stanley, B. Glenn; Lenard, Laszlo

doi:10.1007/bf00429012

Cited by 367Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Self-injection of amphetamine directly into the brain

Hoebel, Bartley G., Monaco, Anthony P., Hernandez, Luis, Aulisi, Edward F., Stanley, B. Glenn, Lenard, Laszlo·1983·Psychopharmacology

DOI 10.1007/bf00429012

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Abstract

Rats learned to self-administer d-amphetamine (10 micrograms/microliter) through a cannula implanted in the nucleus accumbens. They responded more frequently for 65 +/- 15 nl of amphetamine than for equal amounts of saline. When presented with two levers (one amphetamine, one blank) they responded more on the correct lever for amphetamine. They would also switch levers, when necessary, to maintain access to the drug. When half the usual drug intake was given automatically, animals reduced their response rate by half, thus self-regulating the total amount of amphetamine they received. In tests for leakage into the ventricles, eight rats that self-injected with an accumbens cannula showed response extinction when switched to a ventricular cannula. We conclude that amphetamine self-injected into the accumbens is a positive reinforcer. This localization of 'amphetamine reward' suggests that the nucleus accumbens contains a synaptic mechanism underlying amphetamine abuse and, perhaps, also natural reinforcement of behavior.

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Rats learn to lever-press for amphetamine delivery directly into the accumbens.
“In addition, rats learn to lever-press for amphetamine delivery directly into the accumbens”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Hoebel et al., 1983

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Authors: Hoebel, B. G., Monaco, A. P., Hernandez, L., Aulisi, E. F., Stanley, B. G., & Lenard, L.
Affiliations: Princeton University (US)
ORCID: Monaco, Anthony P.
Stanley, B. Glenn
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1983-09
Volume: 81
Issue: 2
Pages: 158-163
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf00429012
OpenAlex: W1982641194
Cited by: 367
References: 31
Citations by year: 2023: 1 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 8 · 2012: 3
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: amphetamine self-administration, nucleus accumbens, positive reinforcement, reward, amphetamine abuse
MeSH terms: Animals, Caudate Nucleus, Dextroamphetamine, Discrimination, Psychological, Female, Injections, Injections, Intraventricular, Nucleus Accumbens, Rats, Inbred Strains, Reinforcement, Psychology, Self Administration, Rats

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