Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats
Abstract
Intraventricular injections of 6-hydroxydopamine produced 95 percent depletion of telencephalic norepinephrine and 62 percent depletion of striatal dopamine in rats. Treated rats maintained body weight at subnormal levels and failed to increase food intake in response to a short-term decrease in glucose utilization. After treatment with the monoamine oxidase inhibitor pargyline, 6-hydroxydopamine produced no further norepinephrine depletion but increased the dopamine depletion to 95 percent and produced complete aphagia. These effects are comparable to events that follow bilateral electrolytic lesions of the lateral hypothalamus.
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DA release in the striatum is required to integrate relevant signals for sustained feeding.
“These results suggest that DA release in the striatum is required to integrate relevant signals for sustained feeding [301,314,315].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [315]
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Self-citationOrr, W. B., Gardiner, T. W., Stricker, E. M., Zigmond, M. J., & Berger, T. W. (1986) · Brain Research · doi:10.1016/0006-8993(86)90895-4 · Cited by 70 · see citing works
Self-citationFunctional development of prefrontal cortex in rats continues into adolescence.
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Preoptic knife cuts and sexual behavior in male rats
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Chemical and Immunochemical Lesions by Specific Neurotoxic Substances and Antisera
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Spatial learning in rats is impaired after degeneration of the nigrostriatal dopaminergic system
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Many mouths to feed: the control of food intake during lactation.
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Regulation of male rat copulatory behavior by preoptic incertohypothalamic dopamine neurons
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The Psychopharmacology of Feeding
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Self-citationApomorphine-induced restoration of drinking to thirst challenges in 6-hydroxydopamine-treated rats
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Deficits in consummatory responses to regulatory challenges following basal ganglia lesions in rats
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Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice
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- Authors
- Zigmond, M. J., & Stricker, E. M.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Science
- Published
- 1972-09-29
- Volume
- 177
- Issue
- 4055
- Pages
- 1211-1214
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091764078
- Cited by
- 296
- References
- 31
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 3 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 3 · 2012: 6
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- 6-hydroxydopamine, feeding behavior, dietary intake, norepinephrine depletion, dopamine depletion, intraventricular injection, pargyline, monoamine oxidase inhibition, aphagia, lateral hypothalamus, glucose utilization, body weight
- MeSH terms
- Animals, Behavior, Animal, Body Weight, Brain Chemistry, Cerebral Ventricles, Dopamine, Feeding Behavior, Hexoses, Hydroxylamines, Hypothalamus, Injections, Male, Norepinephrine, Pargyline, Telencephalon, Thalamus, Rats
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