Cited by 296Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormones

Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats

Zigmond, Michael J., Stricker, Edward M.·1972·Science

Abstract

Intraventricular injections of 6-hydroxydopamine produced 95 percent depletion of telencephalic norepinephrine and 62 percent depletion of striatal dopamine in rats. Treated rats maintained body weight at subnormal levels and failed to increase food intake in response to a short-term decrease in glucose utilization. After treatment with the monoamine oxidase inhibitor pargyline, 6-hydroxydopamine produced no further norepinephrine depletion but increased the dopamine depletion to 95 percent and produced complete aphagia. These effects are comparable to events that follow bilateral electrolytic lesions of the lateral hypothalamus.

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Crossref · 10.1126/science.177.4055.1211

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31 of 31 references verified0 citation errors · 0 not checkable

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Authors
Zigmond, M. J., & Stricker, E. M.
Affiliations
University of Pittsburgh (US)
Venue
Science
Published
1972-09-29
Volume
177
Issue
4055
Pages
1211-1214
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2091764078
Cited by
296
References
31
Citations by year
2026: 1 · 2022: 2 · 2021: 3 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 3 · 2012: 6
FWCI
13.82
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
6-hydroxydopamine, feeding behavior, dietary intake, norepinephrine depletion, dopamine depletion, intraventricular injection, pargyline, monoamine oxidase inhibition, aphagia, lateral hypothalamus, glucose utilization, body weight
MeSH terms
Animals, Behavior, Animal, Body Weight, Brain Chemistry, Cerebral Ventricles, Dopamine, Feeding Behavior, Hexoses, Hydroxylamines, Hypothalamus, Injections, Male, Norepinephrine, Pargyline, Telencephalon, Thalamus, Rats

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