Cited by 754Aging and Gerontology ResearchGenetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

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Admission criteria for immunogerontological studies in man: The senieur protocol

Ligthart, Gerard J., Corberand, Joël X., Fournier, Catherine, Galanaud, Pierre, Hijmans, Willy, Kennes, Bernard, Müller-Hermelink, Hans K., Steinmann, Gerhard G.·1984·Mechanisms of Ageing and Development

DOI 10.1016/0047-6374(84)90152-0

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Abstract

Immunogerontological studies in man have often led to conflicting results. One of the main reasons is the selection of the subjects to be studied. Admission criteria such as "apparently healthy" or "without overt disease" seem insufficient to exclude underlying disease which might influence the immune system and thereby the results. In an attempt to solve this problem, the SENIEUR protocol described in this paper was developed by a working party in the framework of the EURAGE Concerted Action Programme on Ageing of the European Community. This protocol establishes strict admission criteria for immunogerontological studies in man based on clinical information and laboratory data, and it sets limits to pharmacological interference. The use of this protocol will lead to standardization between centers and also to a closer study of the influence of age as such on the immune system. These findings in the immunologically "optimally aged" can also serve as reference values for immunogerontological studies in subjects who do not meet the SENIEUR criteria. In this way the use of this protocol can contribute to the dissection of the influence of disease versus ageing on the immune system.

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Background
Interleukin-7 is associated with monocyte chemoattractant protein-1 and soluble E-selectin levels in peripheral blood of newly post-menopausal women
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Method
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Method
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Result
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Method
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“The healthy women were volunteers from the community who fulfilled the stringent criteria of the SENIEUR protocol (14).”
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“To this end, the SENIEUR protocol was established, containing donor admission criteria for immunogerontology studies [11].”
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“This is one of the conclusions from the so-called SENIEUR collaborative study focusing on immunology and ageing (Ligthart et al. 1984).”
Background
Age-related studies of SIg, Leu-4 and concanavalin a receptor densities and capping in human lymphocytes
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Age‐Related Decline of Influenza A Virus‐Specific Cytotoxic T Lymphocyte Activity
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Self-citation
Lymphocyte clones from old subjects: growing rate and functional activity
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Changes in Immunologic Function
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Immunosenescence
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In reply
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“However, when SENIUR guidelines (guidelines that only ensure the healthiest elderly are included in a study) are strictly adhered to in human studies, there is an increase in NK cell numbers among the aged [171, 172].”

Authors: Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G.
Affiliations: Leiden University (NL)
Hôpital Necker-Enfants Malades (FR)
Université Paris-Sud (FR)
Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author: Ligthart, Gerard J.
ORCID: Galanaud, Pierre
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 1984-11
Volume: 28
Issue: 1
Pages: 47-55
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/0047-6374(84)90152-0
OpenAlex: W2037412303
Cited by: 754
References: 9
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 11 · 2018: 13 · 2017: 8 · 2016: 17 · 2015: 11 · 2014: 11 · 2013: 22 · 2012: 18
FWCI: 13.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mechanisms of Ageing and Development (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: healthy aging, reference values, age-related immune changes
MeSH terms: Adult, Aged, Aging, Cardiovascular Diseases, Humans, Immunity, Infections, Inflammation, Lymphoproliferative Disorders, Neoplasms, Research Design

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Admission criteria for immunogerontological studies in man: The senieur protocol

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