Cited by 754Aging and Gerontology ResearchGenetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

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Admission criteria for immunogerontological studies in man: The senieur protocol

Ligthart, Gerard J., Corberand, Joël X., Fournier, Catherine, Galanaud, Pierre, Hijmans, Willy, Kennes, Bernard, Müller-Hermelink, Hans K., Steinmann, Gerhard G.·1984·Mechanisms of Ageing and Development

DOI 10.1016/0047-6374(84)90152-0

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Abstract

Immunogerontological studies in man have often led to conflicting results. One of the main reasons is the selection of the subjects to be studied. Admission criteria such as "apparently healthy" or "without overt disease" seem insufficient to exclude underlying disease which might influence the immune system and thereby the results. In an attempt to solve this problem, the SENIEUR protocol described in this paper was developed by a working party in the framework of the EURAGE Concerted Action Programme on Ageing of the European Community. This protocol establishes strict admission criteria for immunogerontological studies in man based on clinical information and laboratory data, and it sets limits to pharmacological interference. The use of this protocol will lead to standardization between centers and also to a closer study of the influence of age as such on the immune system. These findings in the immunologically "optimally aged" can also serve as reference values for immunogerontological studies in subjects who do not meet the SENIEUR criteria. In this way the use of this protocol can contribute to the dissection of the influence of disease versus ageing on the immune system.

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Background
The immune S ystem in the elderly
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“The questionnaire was adapted from the SENIEUR protocol for immunogerontological studies (Ligthart et al., 1984).”
Method
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“elderly subjects [37].”
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Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults
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“To focus specifically on the target subjects and render the results easier to understand, a healthy population was selected.(26) This also allowed confounders, such as chronic disease and medication, which could alter immune status and, consequently, mask the aging effect, to be avoided.”
Background
Quality and Quantity of the Humoral Immune Response in Healthy Elderly and Young Subjects after Annually Repeated Influenza Vaccination
de Bruijn, I. A., Remarque, E. J., der Zijde, C. M. J., van Tol, M. J. D., Westendorp, R. G. J., & Knook, D. L. (1999) · The Journal of Infectious Diseases · doi:10.1086/314540 · Cited by 110
“A series of 54 elderly (median age, 78 years; range, 71-85) and 24 young adults (median age, 22; range, 18-29) were selected on health criteria according to the SENIEUR protocol [6].”
Method
The process of aging changes the interplay of the immune, endocrine and nervous systems
Straub, R. H., Cutolo, M., Zietz, B., & Schölmerich, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00289-5 · Cited by 110
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Pietschmann, P., Gollob, E., Brosch, S., Hahn, P., Kudlacek, S. T., Willheim, M., Woloszczuk, W., Peterlik, M., & Tragl, K. H. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00189-x · Cited by 109
“, 1984) (D) 38 elderly (age: 82 ^ 12 years) males according to the SENIEUR protocol (Ligthart et al., 1984).”
MethodInfluential
Cytokines and hormones as possible links between endocrinosenescence and immunosenescence
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Untitled work
(2002) · doi:10.1002/1521-4141(200206)32:6
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“Although chronic stress is a risk factor for bad health outcomes in the elderly, some individuals may preserve their healthy status during such conditions.In the present article, we assessed the neuroendocrine and immunological correlates of chronic stress in populations judged to be ‘strictly healthy’ by the SENIEUR…”
Method
Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data
Lugli, E., Pinti, M., Nasi, M., Troiano, L., Ferraresi, R., Mussi, C., Salvioli, G., Patsekin, V., Robinson, J. P., Durante, C., et al. (2007) · Cytometry Part A · doi:10.1002/cyto.a.20387 · Cited by 105
HEMATOPOIESIS AND CYTOKINES
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MethodResult
Humoral immunity in aging
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Re-epithelialization of normal human excisional wounds is associated with a switch from αvβ5 to αvβ6 integrins
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APP Peptides Stimulate Lymphocyte Proliferation in Normals, But Not in Patients With Alzheimer's Disease
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Method
Biochemical changes in response to intensive resistance exercise training in the elderly
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Nutritional influences on immune response in healthy aged persons
Mazari, L., & Lesourd, B. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00047-5 · Cited by 99
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Huang, H. W. (2005) · Frontiers in bioscience · doi:10.2741/1521 · Cited by 98
Investigations of the lymphokine system in elderly individuals
Sindermann, J. R., Kruse, A., Frercks, H.-J., Schütz, R., & Kirchner, H. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90066-z · Cited by 98
Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged
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Overproduction of monokines by leukocytes after stimulation with lipopolysaccharide in the elderly
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Schröder, A., & Rink, L. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00017-4 · Cited by 96
Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55–70 years
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“Individuals were screened based on defined exclusion criteria, adapted from the SENIOR protocol (Ligthart et al. 1984) which included: body mass index (BMI; !”
Method
Blood Micronutrient and Thyroid Hormone Concentrations in the Oldest-Old
Ravaglia, G., Forti, P., Maioli, F., Nesi, B., Pratelli, L., Savarino, L., Cucinotta, D., & Cavalli, G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6627 · Cited by 95
“Briefly, to exclude the confounding effects of chronic or acute diseases on levels of circulating thyroid hormones, subjects were considered eligible for the study only if they fulfilled the health criteria selection of the SENIEUR protocol (18).”
Re-epithelialization of normal human excisional wounds is associated with a switch from alpha v beta 5 to alpha v beta 6 integrins.
Clark, R. A. F., Ashcroft, G. S., Spencer, M., Larjava, H., & Ferguson, M. W. J. (1996) · PubMed · Cited by 95
Aging and Neutrophils: There Is Still Much To Do
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Biological age—what is it and can it be measured?
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Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status
Mariani, E., Cattini, L., Neri, S., Malavolta, M., Mocchegiani, E., Ravaglia, G., & Facchini, A. (2006) · Biogerontology · doi:10.1007/s10522-006-9060-8 · Cited by 94
“The population was selected by Mocchegiani’s group (Ancona, Italy), within the framework of EU ZINCAGE Project, according to the SENIEUR protocol, which describes the admission criteria to immunogerontological studies based on clinical information, laboratory data and pharmacological interference (Ligthart et al. 1984…”
BackgroundMethod
Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease
Wick, G., & Grubeck‐Loebenstein, B. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01037.x · Cited by 92
Immunosenescence of Polymorphonuclear Neutrophils
Weßels, I., Jansen, J., Rink, L., & Uciechowski, P. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.14 · Cited by 89
“To separate age-related changes from alterations due to nutrition, lifestyle, medications, or underlying diseases, elderly donors for the study of immunosenescence need to be recruited according to the SENIEUR protocol, which discriminates between healthy and frail elderly people[2].”
Background
The clinical impact of systemic low-level inflammation in elderly populations. With special reference to cardiovascular disease, dementia and mortality.
Brüünsgaard, H. (2006) · PubMed · Cited by 90
Extracellular and immunological actions of zinc
Rink, L., & Gabriel, P. (2001) · BioMetals · doi:10.1023/a:1012986225203 · Cited by 90
“However, zinc deficient patients, like elderly and hemodialysis patients, showed a reduced response to vaccination (Fraker et al. 1986; Lighart et al. 1984; Bonomini et al. 1993; Sandstead et al. 1982; Cakman et al. 1996).”
Background
The Role of Nutrition in Immunity in the Aged
Lesourd, B., Mazari, L., & Ferry, M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01628.x · Cited by 92
The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T-cell and NK-cell subsets in human blood.
Ligthart, G. J., Pc, V. V., Hr, S., & Hijmans, W. (1986) · PubMed Central · Cited by 90
Self-citation
Age-related changes of heat shock protein gene transcription in human peripheral blood mononuclear cells
Deguchi, Y., Negoro, S., & Kishimoto, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80289-4 · Cited by 89
Dehydroepiandrosterone Sulphate (DHEAS) in the Oldest Old, Aged 85 and Overa
Birkenhäger‐Gillesse, E. G., Derksen, J. J. L., & Lagaay, A. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb56858.x · Cited by 89
Coagulation and inflammatory markers in Alzheimer's and vascular dementia
Gupta, A., Watkins, A., Thomas, P., Majer, R., Habubi, N., Morris, G., & Pansari, K. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2004.00143.x · Cited by 87
Influence of menstrual cycle on NK activity
de Souza, S. S., de Castro, F. A., Mendonça, H. C., Palma, P. V. B., de Morais, F. R., Ferriani, R. A., & Voltarelli, J. C. (2001) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(00)00091-7 · Cited by 88
“, 1989) when they included only individuals who were in good health as described by the SENIEUR protocol (Ligthart et al., 1984).”
MethodInfluential
RANTES and MIP-1α production by T lymphocytes, monocytes and NK cells from nonagenarian subjects
Mariani, E., Pulsatelli, L., Neri, S., Dolzani, P., Meneghetti, A., Silvestri, T., Ravaglia, G., Forti, P., Cattini, L., & Facchini, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00187-5 · Cited by 88
Circulating Human Antibody-Secreting Cells during Vaccinations and Respiratory Viral Infections Are Characterized by High Specificity and Lack of Bystander Effect
Lee, F. E.-H., Halliley, J. L., Walsh, E. E., Moscatiello, A. P., Kmush, B. L., Falsey, A. R., Randall, T. D., Kaminiski, D. A., Miller, R. K., & Sanz, I. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002932 · Cited by 83
“Subjects were considered immunologically “healthy” as defined by a modified Senieur clinical survey (20).”
Background
Specific and nonspecific immune responses to fasting and refeeding differ in healthy young adult and elderly persons
Walrand, S., Moreau, K., Caldefie, F., Tridon, A., CHASSAGNE, J., Portefaix, G., Cynober, L., Beaufrère, B., Vasson, M., & Boirie‌, Y. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.5.670 · Cited by 87
Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols
Nilsson, B.-O., Ernerudh, J., Johansson, B. E. A., Evrin, P., Löfgren, S., Ferguson, F. G., & Wikby, A. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00024-1 · Cited by 87
Impact of psychological and endocrine factors on cytokine production of healthy elderly people
Luz, C., Dornelles, F. N., Preissler, T., Collaziol, D., da Cruz, I. B. M., & Bauer, M. E. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00148-9 · Cited by 87
Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians
Mariani, E., Ravaglia, G., Forti, P., Meneghetti, A., Tarozzi, A., Maioli, F., Boschi, F., Pratelli, L., Pizzoferrato, A., PIRAS, F., et al. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00855.x · Cited by 86
Cell mediated immunity changes in ageing, relative importance of cell subpopulation switches and of nutritional factors
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Nutrition, diet and immunosenescence
Maijó, M., Clements, S. J., Ivory, K., Nicoletti, C., & Carding, S. R. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.003 · Cited by 85
“Subsequently, the SENIEUR protocol was defined to better characterize ‘‘healthiness’’ (Ligthart et al., 1984) and excludes subjects who have”
Method
Von Willebrand factor in Italian centenarians.
Coppola, R., Mari, D., Lattuada, A., & Franceschi, C. (2003) · PubMed · Cited by 85
Cytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity
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Age-associated changes in human T cell phenotype and function
Jackola, D. R., Ruger, J. K., & Miller, R. A. (1994) · Aging Clinical and Experimental Research · doi:10.1007/bf03324210 · Cited by 85
Age‐Related Decline in Interleukin 2 Production in Response to Influenza Vaccine
McElhaney, J. E., Beattie, B. L., Devine, R. D. O., Grynoch, R., Toth, E. L., & Bleackley, R. C. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb01424.x · Cited by 85
Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAS and proteins in acute cutaneous wounds of healthy humans
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Hemopoietic Reserve in the Older Cancer Patient: Clinical and Economic Considerations
Balducci, L., Hardy, C. L., & Lyman, G. H. (2000) · Cancer Control · doi:10.1177/107327480000700605 · Cited by 83
Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors
Phelouzat, M.-A., Laforge, T., Arbogast, A., Quadri, R. A., Boutet, S. C., & Proust, J. J. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)01883-6 · Cited by 83
Cytokine production by stimulated mononuclear cells did not change with aging in apparently healthy, well-nourished women
Ahluwalia, N., Mastro, A. M., Ball, R., Miles, M. P., Rajendra, R., & Handte, G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00266-4 · Cited by 82
“Women between the ages of 41–60 years were not included due to the potentially confounding effects of hormonal changes during menopause on immune parameters (Ligthart et al., 1984; Murasko et al., 1987).”
BackgroundMethodResultInfluential
Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy
Deguchi, K., Kamada, M., Irahara, M., Maegawa, M., Yamamoto, S., Ohmoto, Y., Murata, K., Yasui, T., Yamano, S., & Aono, T. (2001) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200107000-00008 · Cited by 82
“Subjects suspected of having infectious diseases, inflammatory disorders, malignancy, or autoimmune diseases, of being undernourished, or of abusing alcohol or drugs were excluded according to the SENIEUR protocol.(19) Premenopausal women with a regular menstrual cycle were classified into four categories (in their 10…”
Method
Age-related quantitative alterations in lymphocyte subsets and immunoglobulin isotypes in healthy horses
McFarlane, D., Sellon, D. C., & Gibbs, S. A. (2001) · American Journal of Veterinary Research · doi:10.2460/ajvr.2001.62.1413 · Cited by 82
“This problem has been addressed in studies of human aging by establishing strict selection criteria, which requires results of clinical and laboratory tests be within reference range.(20) In our study, admission criteria included normal physical examination findings and CBC and serum biochemical analysis results withi…”
Postmenopausal changes in serum cytokine levels and hormone replacement therapy
Kamada, M., Irahara, M., Maegawa, M., Ohmoto, Y., Takeji, T., Yasui, T., & Aono, T. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.109940 · Cited by 82
Natural killer cell function is not diminished in the healthy aged and is proportional to the number of NK cells in the peripheral blood.
Ligthart, G. J., Schuit, H. R. E., & Hijmans, W. (1989) · PubMed Central · Cited by 82
Self-citation
Comorbidity Is a Better Predictor of Impaired Immunity than Chronological Age in Older Adults
Castle, S. C., Uyemura, K., Rafi, A., Akande, O., & Makinodan, T. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53512.x · Cited by 81
“For the past 17 years, the SENIEUR protocol has been effectively used to isolate the effect of aging on changes in immunity by excluding extrinsic factors such as concomitant disease and medications to treat those diseases.(17) The findings of more than 200 papers that have applied this protocol have shown only a mode…”
Method
Approach to define “normal aging” in man. Immune function, serum lipids, lipoproteins and neopterin levels
Reibnegger, G. J., Huber, L. A., Jürgens, G., Schönitzer, D., Werner, E. R., Wächter, H., Wick, G., & Traill, K. N. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90115-7 · Cited by 81
Immunological changes in the elderly
Ginaldi, L., Martinis, M. D., D’Ostilio, A., Marini, L., Loreto, M. F., & Quaglino, D. (1999) · Aging Clinical and Experimental Research · doi:10.1007/bf03339801 · Cited by 81
Immune response during disease and recovery in the elderly
Lesourd, B. (1999) · Proceedings of The Nutrition Society · doi:10.1079/pns19990013 · Cited by 81
+647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications
Giacconi, R., Bonfigli, A. R., Testa, R., Sirolla, C., Cipriano, C., Marra, M., Muti, E., Malavolta, M., Costarelli, L., Piacenza, F., et al. (2008) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.12.006 · Cited by 80
Immunodeficiency of Aging
Burns, E. A., & Goodwin, J. S. (1997) · Drugs & Aging · doi:10.2165/00002512-199711050-00005 · Cited by 80
Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants
Rea, I. M., Ross, O. A., Armstrong, M., McNerlan, S., Alexander, D. H., Curran, M. D., & Middleton, D. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00036-8 · Cited by 80
“Subjects were free-living, mentally competent and approximated Senieur protocol (Ligthart et al., 1984).”
Method
Spontaneous and Fas-Induced Apoptotic Cell Death in Aged Neutrophils
Tortorella, C., Piazzolla, G., Spaccavento, F., Pece, S., Jirillo, E., & Antonaci, S. (1998) · Journal of Clinical Immunology · doi:10.1023/a:1023286831246 · Cited by 80
“Twenty-five volunteers (14 males and 11 females) over 65 years old (mean age, 77; range, 72-90) free of diseases affecting the immune system, cancer, or infections and taking no antiinflammatory drugs or corticosteroids were selected according to SENIEUR protocol (31).”
Method
Possible correlation between gut microbiota and immunity among healthy middle-aged and elderly people in southwest China
Shen, X. P., Miao, J., Wan, Q., Wang, S., Li, M., Pu, F., Wang, G., Qian, W. P., Yu, Q., Marotta, F., et al. (2018) · Gut Pathogens · doi:10.1186/s13099-018-0231-3 · Cited by 80
Titers of Herpes Simplex Virus Type 1 Antibodies Positively Correlate with Grey Matter Volumes in Alzheimer's Disease
Mancuso, R., Baglio, F., Cabinio, M., Calabrese, E., Hernis, A., Nemni, R., & Clerici, M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130977 · Cited by 79
“AD patients meet the diagnosis of probable AD according to the NINCDS-ADRDA criteria [15] and to the updated guidelines for AD of the National Institute on Aging [16].”
SARCOPENIA AND FUNCTIONAL DECLINE: PATHOPHYSIOLOGY, PREVENTION AND THERAPY
Bautmans, I., Puyvelde, K. V., & Mets, T. F. (2009) · Acta Clinica Belgica · doi:10.1179/acb.2009.048 · Cited by 78
Antinuclear antibodies in healthy aging people: a prospective study
Xavier, R. M., Yamauchi, Y., Nakamura, M., Tanigawa, Y., Ishikura, H., Tsunematsu, T., & Kobayashi, S. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)01532-q · Cited by 77
Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence
Phelouzat, M.-A., Arbogast, A., Laforge, T., Quadri, R. A., & Proust, J. J. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01714-9 · Cited by 77
Klotho—a Common Link in Physiological and Rheumatoid Arthritis-Related Aging of Human CD4+ Lymphocytes
Witkowski, J. M., Soroczyńska‐Cybula, M., Bryl, E., Smoleńska, Ż., & Jóźwik, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.771 · Cited by 76
“Healthy people above the age of 65 years conformed to the SENIEUR Protocol criteria (31).”
Method
Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects
Biasi, D., Carletto, A., Dell’Agnola, C., Caramaschi, P., Montesanti, F., Zavateri, G., Zeminian, S., Bellavite, P., & Bambara, L. M. (1996) · Inflammation · doi:10.1007/bf01488803 · Cited by 76
“36 years, range 68-100 years), were selected according to SENIEUR protocol (18).”
Method
IL-33 and its decoy sST2 in patients with Alzheimer’s disease and mild cognitive impairment
Saresella, M., Marventano, I., Piancone, F., La Rosa, F., Galimberti, D., Fenoglio, C., Scarpini, E., & Clerici, M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01806-4 · Cited by 75
Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets
Schindowski, K., Fröhlich, L. O., Maurer, K., Müller, W. E., & Eckert, A. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00396-7 · Cited by 75
“In addition, subjects with pathological distribution of lymphocyte subpopulations in flow cytometric analysis ac- cording to the Senieur protocol (Ligthart et al., 1984) were rejected from the study.”
Method
Exercise, immunity and aging
Venkatraman, J. T., & Fernandes, G. (1997) · Aging Clinical and Experimental Research · doi:10.1007/bf03340127 · Cited by 75
MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice
Higgins, D. A., Carlson, J. R., & Nest, G. V. (1996) · Vaccine · doi:10.1016/0264-410x(95)00240-2 · Cited by 74
Immunosenescence in Humans: Deterioration or Remodelling?
Franceschi, C., Monti, D., Barbieri, D., Grassilli, E., Troiano, L., Salvioli, S., Negro, P., Capri, M., Guido, M., Azzi, R., et al. (1995) · International Reviews of Immunology · doi:10.3109/08830189509056702 · Cited by 74
Different IL-8 production by T and NK lymphocytes in elderly subjects
Mariani, E., Pulsatelli, L., Meneghetti, A., Dolzani, P., Mazzetti, I., Neri, S., Ravaglia, G., Forti, P., & Facchini, A. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00270-6 · Cited by 74
Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis
Mariani, E., Roda, P., Mariani, A. R., Vitale, M., Degrassi, A., Papa, S., & Facchini, A. (1990) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1990.tb05359.x · Cited by 74
Distinct macrophage phenotypes skewed by local granulocyte macrophage colony‐stimulating factor (GM‐CSF) and macrophage colony‐stimulating factor (M‐CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis
Jiemy, W. F., van Sleen, Y., van der Geest, K. S. M., ten Berge, H., Abdulahad, W. H., Sandovici, M., Boots, A. M. H., Heeringa, P., & Brouwer, E. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1164 · Cited by 73
“HCs were screened by health assessment questionnaires, physical examination and laboratory tests for past and actual morbidities and excluded when they were not healthy according to the adapted Senieur criteria.(44)”
Method
Decreased proliferative capability of CD4+ cells of elderly people is associated with faster loss of activation-related antigens and accumulation of regulatory T cells
Bryl, E., & Witkowski, J. M. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.029 · Cited by 73
IL-4-Producing CD8+ T Cells with a CD62L++(bright) Phenotype Accumulate in a Subgroup of Older Adults and Are Associated with the Maintenance of Intact Humoral Immunity in Old Age
Schwaiger, S., Wolf, A. M., Robatscher, P., Jenewein, B., & Grubeck‐Loebenstein, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.613 · Cited by 73

Authors: Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G.
Affiliations: Leiden University (NL)
Hôpital Necker-Enfants Malades (FR)
Université Paris-Sud (FR)
Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author: Ligthart, Gerard J.
ORCID: Galanaud, Pierre
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 1984-11
Volume: 28
Issue: 1
Pages: 47-55
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/0047-6374(84)90152-0
OpenAlex: W2037412303
Cited by: 754
References: 9
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 11 · 2018: 13 · 2017: 8 · 2016: 17 · 2015: 11 · 2014: 11 · 2013: 22 · 2012: 18
FWCI: 13.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mechanisms of Ageing and Development (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: healthy aging, reference values, age-related immune changes
MeSH terms: Adult, Aged, Aging, Cardiovascular Diseases, Humans, Immunity, Infections, Inflammation, Lymphoproliferative Disorders, Neoplasms, Research Design

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Admission criteria for immunogerontological studies in man: The senieur protocol

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