Specific changes of gut commensal microbiota and TLRs during indomethacin-induced acute intestinal inflammation in rats
Abstract
BACKGROUND AND AIMS: Gut microbiota is a contributing factor in the development and maintenance of intestinal inflammation, although precise cause-effect relationships have not been established. We assessed spontaneous changes of gut commensal microbiota and toll-like receptors (TLRs)-mediated host-bacterial interactions in a model of indomethacin-induced acute enteritis in rats. METHODS: Male Spague-Dawley rats, maintained under conventional conditions, were used. Enteritis was induced by systemic indomethacin administration. During the acute phase of inflammation, animals were euthanized and ileal and ceco-colonic changes evaluated. Inflammation was assessed through disease activity parameters (clinical signs, macroscopic/microscopic scores and tissue levels of inflammatory markers). Microbiota (ileal and ceco-colonic) was characterized using fluorescent in situ hybridization (FISH) and analysis of 16s rDNA polymorphism. Host-bacterial interactions were assessed evaluating the ratio of bacterial adherence to the intestinal wall (FISH) and expression of TLRs 2 and 4 (RT-PCR). RESULTS: After indomethacin, disease activity parameters increased, suggesting an active inflammation. Total bacterial counts were similar in vehicle- or indomethacin-treated animals. However, during inflammation the relative composition of the microbiota was altered. This dysbiotic state was characterized by an increase in the counts of Bacteroides spp., Enterobacteriaceae (in ileum and cecum-colon) and Clostridium spp. (in ileum). Bacterial wall adherence significantly increased during inflammation. In animals with enteritis, TLR-2 and -4 were up-regulated both in the ileum and the ceco-colonic region. CONCLUSIONS: Gut inflammation implies qualitative changes in GCM, with simultaneous alterations in host-bacterial interactions. These observations further support a potential role for gut microbiota in the pathophysiology of intestinal inflammation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In intestinal biopsies from patients with Parkinson's disease, the immune response of TLR4, cytokines and chemokines, as well as the number of CD3+ T cells, increased in the lamina propria of colonic tissue.
“intestinal biopsies from patients with Parkinson's disease, it was reported that the immune response of TLR4, cytokines and chemokines, as well as the number of CD3 + T cells, increased in the lamina propria of colonic tissue.120”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [120]
Section 3.7 reports increased TLR-4 expression in the ceco-colonic tissue of rats with indomethacin-induced inflammation. It does not establish this finding in biopsies from patients with Parkinson’s disease, and our copy does not report increased cytokines, chemokines, or CD3+ T cells in the colonic lamina propria. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIncreased expression of TLRs can increase the permeability of the intestinal epithelial barrier and increase the susceptibility of host colonic inflammation.
“The increased expression of TLRs can increase the permeability of the intestinal epithelial barrier and increase the susceptibility of host colonic inflammation, indicating that they play a crucial role in maintaining intestinal immune homeostasis.119,120”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [120]
Section 3.7 reports increased TLR-2 and TLR-4 expression in inflamed ileal and ceco-colonic tissue. The Discussion suggests this up-regulation might help aggravate or perpetuate inflammation, but it does not say that increased TLR expression raises epithelial barrier permeability or establish that it increases susceptibility to colonic inflammation. Page numbers were not available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMicroarray analysis of sigmoid mucosa samples illustrated that the expression of TLR4 mRNA was significantly higher compared with that in controls.
“Microarray analysis of sigmoid mucosa samples illustrated that the expression of TLR4 mRNA was significantly higher compared with that in controls.”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [120]
Section 3.7 (page unavailable) reports increased TLR-4 expression in inflamed rat ileal and ceco-colonic tissue compared with controls. But the Methods (section 2.10, page unavailable) describe semi-quantitative RT-PCR, not microarray analysis, and the samples were not sigmoid mucosa. The text does not establish that the specific TLR-4 comparison claimed was statistically significant. (LLM, conf=0.88)
Experimental — accuracy not yet measuredGut microbiota may trigger immune activation of the colonic mucosa through the TLR4 signalling pathway, leading to neuroinflammation and subsequent neurodegeneration in Parkinson's disease.
“These findings suggest that gut microbiota may trigger immune activation of the colonic mucosa through the TLR4 signalling pathway, leading to neuroinflammation and subsequent neurodegeneration in Parkinson's disease.”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [120]
The Discussion reports altered gut microbiota and increased ileal and ceco-colonic TLR-4 expression during indomethacin-induced inflammation in rats, and suggests that altered host–bacterial interactions may perpetuate intestinal inflammation. It does not connect this pathway to neuroinflammation, neurodegeneration, or Parkinson’s disease; it also does not establish that microbiota triggered the observed inflammation. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe increase in Bacteroides spp., Enterobacteriaceae and Clostridium in rats with acute colitis mediates the occurrence of intestinal inflammation by upregulating TLR2 and TLR4.
“In addition, the increase in Bacteroides spp., Enterobacteriaceae and Clostridium in rats with acute colitis mediates the occurrence of intestinal inflammation by upregulating TLR2 and TLR4.120”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [120]
The Results (section 3.7) report increased TLR-2 and TLR-4 expression during inflammation, and the Discussion reports increases in the named bacterial groups. But the Discussion describes TLR upregulation as possibly associated with dysbiosis and says these changes coincide during indomethacin-induced acute enteritis; it does not establish that the bacteria cause inflammation by upregulating TLRs. (LLM, conf=0.88)
Experimental — accuracy not yet measured
TLR4 gene knockout significantly alleviated the effects of rotenone on intestinal barrier destruction, reduced the expression of GFAP in the myenteric plexus and colonic alpha-synuclein aggregation, decreased microglial activation in the substantia nigra and the loss of dopaminergic cells and alleviated the impairment of motor function.
“Intriguingly, TLR4 gene knockout significantly alleviated the effects of rotenone on intestinal barrier destruction, reduced the expression of GFAP in the myenteric plexus and colonic a-synuclein aggregation, decreased microglial activation in the substantia nigra and the loss of dopaminergic cells and alleviated the impairment of motor function.120”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [120]
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166 · see citing works
Amann, R., Binder, B. J., Olson, R. J., Chisholm, S. W., Devereux, R., & Stahl, D. A. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.6.1919-1925.1990 · Cited by 3,998 · see citing works
Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., & NAKAYA, R. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90290-h · Cited by 2,405 · see citing works
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927 · see citing works
Immune adaptations that maintain homeostasis with the intestinal microbiota
Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,455 · see citing works
Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., FERNÁNDEZ-SUEIRO, J. L., Balish, E., & Hammer, R. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2359 · Cited by 1,156 · see citing works
Gut Microbiota and Its Possible Relationship With Obesity
DiBaise, J. K., Zhang, H., Crowell, M. D., Krajmalnik‐Brown, R., Decker, G. A., & Rittmann, B. E. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.4.460 · Cited by 598 · see citing works
Heimesaat, M. M., Bereswill, S., Fischer, A., Fuchs, D., Struck, D., Niebergall, J., Jahn, H.-K., Dunay, I. R., Moter, A., Gescher, D. M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8785 · Cited by 345 · see citing works
Different Subsets of Enteric Bacteria Induce and Perpetuate Experimental Colitis in Rats and Mice
Rath, H. C., Schultz, M., Freitag, R., Dieleman, L. A., Li, F., Linde, H., Schölmerich, J., & Sartor, R. B. (2001) · Infection and Immunity · doi:10.1128/iai.69.4.2277-2285.2001 · Cited by 342 · see citing works
Højberg, O., Canibe, N., Poulsen, H. D., Hedemann, M. S., & Jensen, B. B. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.5.2267-2277.2005 · Cited by 318 · see citing works
Mechanisms of Disease: the hygiene hypothesis revisited
Guarner, F., Bourdet‐Sicard, R., Brandtzæg, P., Gill, H. S., McGuirk, P., van Eden, W., Versalovic, J. A., Weinstock, J. V., & Rook, G. A. W. (2006) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0471 · Cited by 315 · see citing works
Resistance of germfree rats to indomethacin-induced intestinal lesions
Robert, A., & Asano, T. (1977) · Prostaglandins · doi:10.1016/0090-6980(77)90178-2 · Cited by 312 · see citing works
Alterations in the gut microbiome of children with severe ulcerative colitis
Michail, S. K., Durbin, M. D., Turner, D., Griffiths, A. M., Mack, D. R., Hyams, J., LeLeiko, N. S., Kenche, H., Stolfi, A., & Wine, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22860 · Cited by 283 · see citing works
Kitts, C. L. (2001) · PubMed · Cited by 281 · see citing works
Xu, D., Gao, J., Gillilland, M., Wu, X., Song, I., Kao, J. Y., & Owyang, C. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.10.026 · Cited by 271 · see citing works
The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept
den Abbeele, P. V., de Wiele, T. V., Verstraete, W., & Possemiers, S. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00270.x · Cited by 263 · see citing works
Salzman, N. H., de Jong, H., Paterson, Y. Y. W., Harmsen, H. J. M., Welling, G. W., & Bos, N. A. (2002) · Microbiology · doi:10.1099/00221287-148-11-3651 · Cited by 253 · see citing works
Watanabe, T., Higuchi, K., Kobata, A., Nishio, H., Tanigawa, T., Shiba, M., Tominaga, K., Fujiwara, Y., Oshitani, N., Asahara, T., et al. (2007) · Gut · doi:10.1136/gut.2007.125963 · Cited by 227 · see citing works
Heimesaat, M. M., Fischer, A., Siegmund, B., Kupz, A., Niebergall, J., Fuchs, D., Jahn, H.-K., Freudenberg, M., Loddenkemper, C., Batra, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000662 · Cited by 213 · see citing works
Fukata, M., Shang, L., Santaolalla, R., Sotolongo, J. P., Pastorini, C., España, C., Ungaro, R. C., Harpaz, N., Cooper, H. S., Elson, G., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21527 · Cited by 199 · see citing works
Szebeni, B., Veres, G., Dezsőfi, A., Rusai, K., Vannay, Á., Mráz, M., Majorová, E., & Arató, A. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03531.x · Cited by 194 · see citing works
Frolová, L., Drastich, P., Rossmann, P., Kostovcikova, K., & Tlaskalová‐Hogenová, H. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.7a7303.2007 · Cited by 167 · see citing works
Watanabe, T., Nishio, H., Tanigawa, T., Yamagami, H., Okazaki, H., Watanabe, K., Tominaga, K., Fujiwara, Y., Oshitani, N., Asahara, T., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90553.2008 · Cited by 160 · see citing works
Reduced Diversity and Imbalance of Fecal Microbiota in Patients with Ulcerative Colitis
Nemoto, H., Kataoka, K., Ishikawa, H., Ikata, K., Arimochi, H., Iwasaki, T., Ohnishi, Y., Kuwahara, T., & Yasutomo, K. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2236-y · Cited by 152 · see citing works
Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat
Jacobson, K., McHugh, K., & Collins, S. M. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90378-x · Cited by 144 · see citing works
Erridge, C., Duncan, S. H., Bereswill, S., & Heimesaat, M. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009125 · Cited by 119 · see citing works
Aguilera, M., Vergara, P., & Martínez, V. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12154 · Cited by 119 · see citing works
Self-citationSatoh, H., Guth, P. H., & Grossman, M. I. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90071-9 · Cited by 114 · see citing works
Construction of lactose-utilizing Xanthomonas campestris and production of xanthan gum from whey
Fu, J. F., & Tseng, Y. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.4.919-923.1990 · Cited by 111 · see citing works
Uejima, M., Kinouchi, T., Kataoka, K., Hiraoka, I., & Ohnishi, Y. (1996) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1996.tb01108.x · Cited by 110 · see citing works
Incrimination of anaerobic bacteria in the induction of experimental colitis
Garcia-Lafuente, A. M., Antolı́n, M., Guarner, F., Crespo, E., Salas, A., Forcada, P., Laguarda, M. V., Gavaldà, J., Baena, J. A., Vilaseca, J., et al. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.1.g10 · Cited by 100 · see citing works
Microbiota–immune system interaction: an uneasy alliance
Salzman, N. H. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.09.018 · Cited by 96 · see citing works
Magrone, T., & Jirillo, E. (2012) · Current Pharmaceutical Design · doi:10.2174/138161213804805793 · Cited by 89 · see citing works
Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice
Larmonier, C. B., Laubitz, D., Hill, F. M., Shehab, K. W., Lipiński, L., Midura‐Kiela, M. T., McFadden, R.-M. T., Ramalingam, R., Hassan, K., Gołębiewski, M., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00189.2013 · Cited by 86 · see citing works
Probiotics and prebiotics : scientific aspects
Tannock, G. W. (2005) · Caister Academic Press eBooks · Cited by 72 · see citing works
Weissenborn, U., Maedge, S., Buettner, D., & Sewing, K. ‐. (2008) · Pharmacology · doi:10.1159/000138047 · Cited by 70 · see citing works
Schepper, H. U. D., Man, J. G. D., Moreels, T. G., Pelckmans, P. A., & Winter, B. Y. D. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03624.x · Cited by 61 · see citing works
Oligonucleotide probe for detecting Enterobacteriaceae byin situhybridization
Ootsubo, M., Shimizu, T., Tanaka, R., Sawabe, T., Tajima, K., Yoshimizu, M., Ezura, Y., Ezaki, T., & Oyaizu, H. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2002.01668.x · Cited by 60 · see citing works
Correlation of Cecal Microflora of HLA-B27 Transgenic Rats with Inflammatory Bowel Disease
Onderdonk, A. B., Richardson, J. A., Hammer, R. E., & Taurog, J. D. (1998) · Infection and Immunity · doi:10.1128/iai.66.12.6022-6023.1998 · Cited by 57 · see citing works
Dalby, A. B., Frank, D. N., Amand, A. L. S., Bendele, A. M., & Pace, N. R. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.00378-06 · Cited by 56 · see citing works
Membrane TLR signaling mechanisms in the gastrointestinal tract during sepsis
Buchholz, B. M., & bauer, A. J. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01464.x · Cited by 54 · see citing works
Tanigawa, T., Watanabe, T., Otani, K., Nadatani, Y., Ohkawa, F., Sogawa, M., Yamagami, H., Shiba, M., Watanabe, K., Tominaga, K., et al. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.02.010 · Cited by 54 · see citing works
Vaahtovuo, J., Korkeamäki, M., Munukka, E., Viljanen, M. K., & Toivanen, P. (2005) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2005.03.017 · Cited by 44 · see citing works
Messages from the Inside. The Dynamic Environment that Favors Intestinal Homeostasis
Eri, R. D., & Chieppa, M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00323 · Cited by 36 · see citing works
Intestinal motor disorders associated with cyclical bacterial overgrowth in a rat model of enteritis
Porras, M., Martín, M. T., Soler, M., & Vergara, P. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00513.2003 · Cited by 32 · see citing works
Self-citationBarada, K. A., Mourad, F. H., Sawah, S. I., Khoury, C. I., Safieh‐Garabedian, B., Nassar, C. F., & Saadé, N. E. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.047 · Cited by 24 · see citing works
Tanaka, K. (2008) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2.2.193 · Cited by 24 · see citing works
Aguilera, M., Vergara, P., & Martı́nez, V. (2013) · Microbial Ecology · doi:10.1007/s00248-013-0241-0 · Cited by 22 · see citing works
Self-citationTerán-Ventura, E., Roca, M., Martín, M. T., Abarca, M. L., Martı́nez, V., & Vergara, P. (2010) · Microbial Ecology · doi:10.1007/s00248-010-9737-z · Cited by 21 · see citing works
Self-citationImaeda, H., Fujimoto, T., Takahashi, K., Kasumi, E., Fujiyama, Y., & Andoh, A. (2012) · Digestion · doi:10.1159/000341508 · Cited by 20 · see citing works
Silva, M. A., Jury, J., Porras, M., Vergara, P., & Perdue, M. H. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20379 · Cited by 19 · see citing works
Self-citationMolecular methods in microbial ecology.
Zoetendal, E. G., Mackie, R. I., & Tannock, G. W. (2005) · Cited by 14 · see citing works
Neomycin prevents indomethacin-induced gastric peristalsis and mucosal injury in the rat
Mersereau, W. A., & Hinchey, E. J. (1989) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y89-162 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [17]17. Salzman NH, de Jong H, Paterson Y, Harmsen HJ, Welling GW, Bos NA. Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology 2002;148:3651-60.
- [18]18. Ootsubo M, Shimizu T, Tanaka R, Sawabe T, Tajima K, Yoshimizu M, et al. Oligonucleotide probe for detecting Enterobacteriaceae by in situ hybridization. J Appl Microbiol 2002;93:60-8.
Cited by
Sorted by citations
Etxeberria, U., Arias, N., Boqué, N., Macarulla, M. T., Portillo, M. P., Martínez, J. A., & Milagro, F. I. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.01.002 · Cited by 446 · see citing works
The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options
Wang, Q., Luo, Y., Ray Chaudhuri, K., Reynolds, R., Tan, E.-K., & Pettersson, S. (2021) · Brain · doi:10.1093/brain/awab156 · Cited by 281 · see citing works
Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications
Le Bastard, Q., Al‐Ghalith, G. A., Grégoire, M., Chapelet, G., Javaudin, F., Dailly, E., Batard, E., Knights, D., & Montassier, E. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14451 · Cited by 263 · see citing works
Li, H., Lŭ, L., Wang, X., Qin, L., Wang, P., Qiu, S., Wu, H., Huang, F., Zhang, B., Shi, H., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00455 · Cited by 184 · see citing works
Simpson, C. A., Mu, A., Haslam, N., Schwartz, O., & Simmons, J. G. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.124 · Cited by 164 · see citing works
Aguilera, M., Cerdà-Cuéllar, M., & Martínez, V (2015) · Gut Microbes · doi:10.4161/19490976.2014.990790 · Cited by 162 · see citing works
Self-citationNSAID–Gut Microbiota Interactions
Maseda, D., & Ricciotti, E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01153 · Cited by 166 · see citing works
Donoso, F., Cryan, J. F., Olavarría‐Ramírez, L., Nolan, Y. M., & Clarke, G. A. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2581 · Cited by 147 · see citing works
Watanabe, T., Fujiwara, Y., & Chan, F. K. L. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-019-01657-8 · Cited by 135 · see citing works
Fijlstra, M., Ferdous, M., Koning, A. M., Rings, E. H. H. M., Harmsen, H. J. M., & Tissing, W. J. E. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-014-2487-6 · Cited by 97 · see citing works
Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases
Constantino-Jonapa, L. A., Espinoza-Palacios, Y., Escalona‐Montaño, A. R., Hernández-Ruiz, P., Amezcua-Guerra, L. M., Amedei, A., & Aguirre‐García, M. M. (2023) · Biomedicines · doi:10.3390/biomedicines11020431 · Cited by 97 · see citing works
Zádori, Z., Király, K. P., Al‐Khrasani, M., & Gyires, K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108327 · Cited by 90 · see citing works
Role of colonic microbiota in the pathogenesis of ulcerative colitis
Pei, L.-Y., Ke, Y.-S., Zhao, H., Wang, L., Jia, C., Liu, W., Fu, Q.-H., Shi, M.-N., Cui, J., & Li, S. (2019) · BMC Gastroenterology · doi:10.1186/s12876-019-0930-3 · Cited by 80 · see citing works
Gut Microbiota in NSAID Enteropathy: New Insights From Inside
Wang, X., Tang, Q., Hou, H., Zhang, W., Li, M., Chen, D., Gu, Y., Wang, B., Hou, J., Liu, Y., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.679396 · Cited by 69 · see citing works
Gut Microbiota Mediates Protection Against Enteropathy Induced by Indomethacin
Xiao, X., Nakatsu, G., Jin, Y., Wong, S. H., Yu, J. Q., & Lau, J. Y. W. (2017) · Scientific Reports · doi:10.1038/srep40317 · Cited by 59 · see citing works
The Gut Microbiome–Brain Crosstalk in Neurodegenerative Diseases
Ghezzi, L., Cantoni, C., Rotondo, E., & Galimberti, D. (2022) · Biomedicines · doi:10.3390/biomedicines10071486 · Cited by 58 · see citing works
Chiu, C.-C., Ching, Y., Wang, Y., Liu, J.-Y., Li, Y.-P., Huang, Y.-T., & Chuang, H.-L. (2014) · BioMed Research International · doi:10.1155/2014/675786 · Cited by 52 · see citing works
Yang, B. K., Li, M., Wang, S., Ross, R. P., Stanton, C., Zhao, J., Zhang, H., & Chen, W. (2021) · Foods · doi:10.3390/foods10061349 · Cited by 48 · see citing works
Liu, H., Fu, S., Zhang, S., Ding, M., & Wang, A. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735573 · Cited by 46 · see citing works
Ijaz, U. Z., Quince, C., Hanske, L., Loman, N. J., Calus, S., Bertz, M., Edwards, C. A., Gaya, D. R., Hansen, R., McGrogan, P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172605 · Cited by 44 · see citing works
Maurer, L. H., Cazarin, C. B. B., Quatrin, A., Minuzzi, N. M., Nichelle, S. M., Lamas, C. D. A., Cagnon, V. H. A., Morari, J., Velloso, L. A., Maróstica, M. R., et al. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.01.006 · Cited by 40 · see citing works
Qi, R., Zhang, Z., Wang, J., Qiu, X., Wang, Q., Yang, F., Huang, J., & Liu, Z. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.623673 · Cited by 37 · see citing works
Lázár, B., László, S. B., Hutka, B., Tóth, A. S., Mohammadzadeh, A., Berekméri, E., Ágg, B., Balogh, M., Sajtos, V., Király, K. P., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114590 · Cited by 37 · see citing works
Zhang, M., Xia, F., Xia, S., Zhou, W., Zhang, Y., Han, X., Zhao, K., Feng, L. L., Dong, R., Tian, D., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.818877 · Cited by 34 · see citing works
Yang, P., Hu, H., Li, Y., Ai, Q., Zhang, W., Zhang, Y., & Mai, K. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.734361 · Cited by 32 · see citing works
Rekatsina, M., Paladini, A., Cifone, M. G., Lombardi, F., Pergolizzi, J. V., & Varrassi, G. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01338-6 · Cited by 24 · see citing works
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury
Xu, N., Zhang, C., Jing, L., Mou, S.-J., Cao, X., & Yu, Z. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107136 · Cited by 23 · see citing works
Jia, X., Chen, Q., Zhang, Y., & Asakawa, T. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1296713 · Cited by 22 · see citing works
Samer, A., Toumi, R., Soufli, I., & Touil–Boukoffa, C. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-00996-y · Cited by 22 · see citing works
Thipart, K., Gruneck, L., Phunikhom, K., Sharpton, T. J., Sattayasai, J., & Popluechai, S. (2022) · International Microbiology · doi:10.1007/s10123-022-00309-x · Cited by 19 · see citing works
Chi, T., Zhao, Q., & Wang, P. (2021) · BioMed Research International · doi:10.1155/2021/8848686 · Cited by 18 · see citing works
Chen, Y., Wang, Z., Chen, X., Chao, G., & Zhang, S. (2023) · Journal of Applied Microbiology · doi:10.1093/jambio/lxad032 · Cited by 16 · see citing works
Hutka, B., Lázár, B., Tóth, A. S., Ágg, B., László, S. B., Makra, N., Ligeti, B., Scheich, B., Király, K. P., Al‐Khrasani, M., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.664177 · Cited by 15 · see citing works
Gut microbiota and inflammation in Parkinson’s disease: Pathogenetic and therapeutic insights
Guo, T., & Chen, L. (2022) · European Journal of Inflammation · doi:10.1177/1721727x221083763 · Cited by 14 · see citing works
Lázár, B., Brenner, G. B., Makkos, A., Balogh, M., László, S. B., Al‐Khrasani, M., Hutka, B., Bató, E., Ostorházi, E., Juhász, J., et al. (2019) · Cells · doi:10.3390/cells8030251 · Cited by 12 · see citing works
The Intricate Interplay: Microbial Metabolites and the Gut‐Liver‐Brain Axis in Parkinson's Disease
Kishanchand, D. K., A., A. K. K., Chandrababu, K., Philips, C. A., Sivan, U., & Chakrapani, P. S. B. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70016 · Cited by 11 · see citing works
Microbiota and Mitochondrial Sex-Dependent Imbalance in Fibromyalgia: A Pilot Descriptive Study
Ramírez‐Tejero, J. A., Durán‐González, E., Martínez‐Lara, A., del Amo, L. L., Sepúlveda, I., Huancas-Díaz, A., Carvajal, M., & Cotán, D. (2023) · Neurology International · doi:10.3390/neurolint15030055 · Cited by 10 · see citing works
Ocaña, J. S., Bayard, N. U., & Zackular, J. P. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.11.011 · Cited by 8 · see citing works
Effects of Rifaximin on Luminal and Wall-Adhered Gut Commensal Microbiota in Mice
Ferrer, M., Aguilera, M., & Martı́nez, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020500 · Cited by 7 · see citing works
Self-citationInteraction of microbiome and immunity in tumorigenesis and clinical treatment
Yu, Y., & Zhong, W. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113894 · Cited by 7 · see citing works
Zhu, L., Guo, J., Liu, Q., Luo, Y., Zhao, J., Zhong, W., Sun, S., Xu, X., Liang, H., Lou, C., et al. (2023) · Pharmacology · doi:10.1159/000529879 · Cited by 7 · see citing works
Characteristics of gut microbiota in male periadolescent rats with irritable bowel syndrome
Lin, W., Wu, D., Zeng, Y., Liu, Y., Yu, D., Wei, J., Cai, Y., Lin, Y., Wu, B., & Huang, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18995 · Cited by 6 · see citing works
Mathis, S., Bodduluri, S. R., & Haribabu, B. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158982 · Cited by 6 · see citing works
O’Brien, E. S., Robert, A., Gauthier, D., Cavorzin, A. L., Planchais, J., Roux, X., Verleye, M., & Castagné, V. (2023) · Beneficial Microbes · doi:10.3920/bm2023.0003 · Cited by 5 · see citing works
Filaretova, L. P., Bagaeva, T. R., Morozova, O., & Zelena, D. (2014) · Endocrine Regulations · doi:10.4149/endo_2014_04_163 · Cited by 5 · see citing works
Arron, M. N. N., Bluiminck, S., ten Broek, R. P. G., Ederveen, T. H. A., Alpert, L., Zaborina, O. E., Alverdy, J. C., & van Goor, H. (2024) · Biomedicines · doi:10.3390/biomedicines12102170 · Cited by 3 · see citing works
Zhang, Q., Liu, W., Li, Q., Zeng, Y., Wu, M., Wu, T., Guo, S., Wang, L., Zhao, D., Yi, D., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115173 · Cited by 3 · see citing works
Sánchez‐Trigueros, M. I., Martínez‐Vieyra, I., Pineda‐Peña, E. A., Castañeda‐Hernández, G., Perez‐Cruz, C., Cerecedo, D., & Chávez‐Piña, A. E. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02881-z · Cited by 3 · see citing works
Oral indomethacin modifies small intestine biofilms and host-microbe interaction mediators
Haghighi, A., Tóth, A. S., Demeter, Z. O., Hutka, B., Zsidai, A., Lengyel, L., Haghighi, S., Pannier, M., Cosquer, G. L., Servanne-Meunier, E., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124114 · Cited by 2 · see citing works
Kumar, S., & Sarkar, B. (2026) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00345.2025 · Cited by 2 · see citing works
Guo, Y.-H., Luo, L., Cheng, M.-Y., Hu, Y., Jurutka, P. W., Hu, D., Cao, C.-J., Zhang, Y., & Cheng, S. (2026) · Food & medicine homology. · doi:10.26599/fmh.2026.9420139 · Cited by 2 · see citing works
Jardí, F., Aguilera, M., Vergara, P., & Martı́nez, V. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14136 · Cited by 2 · see citing works
Self-citationShao, W., Lian, T., Xie, W., Wang, Y., Li, H., Yang, D.-G., Nie, X., Zhou, M., Liu, F., Wei, S., et al. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202501198 · Cited by 1 · see citing works
Abd-Elbaky, R. F., Badr, S. M., Kandeel, S., & Zamzam, A.-E. M. F. (2023) · Tanta Medical Journal · doi:10.4103/tmj.tmj_30_23
Research Progress on the Relationship between Gut Microbiome and Parkinson’s Disease
力比奴尔·塞地尔丁, 克. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.14123217
Cui, J., Tang, L., Li, Z., Wang, S., Zhou, J., Yan, H., & Wang, X. Q. (2025) · Microorganisms · doi:10.3390/microorganisms13112533
Gut microbiota and non-steroidal anti-inflammatory drugs: mechanisms of interaction
Ермоленко, Е. И., Baryshnikova, N. V., & Suvorov, A. N. (2026) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-239-7-99-107
Zhong, X., Li, J. Z., Yu, Z. T., Cai, J., Wang, L., Li, P., Sen, L., Huang, Y., Yu, D. P., Wang, B., et al. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7674358
- Authors
- Terán-Ventura, E., Aguilera, M., Vergara, P., & Martínez, V.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-09-01
- Volume
- 8
- Issue
- 9
- Pages
- 1043-1054
- ISSN
- 1873-9946 (ISSN-L)
- 1876-4479
- OpenAlex
- W2021451372
- Semantic Scholar
- 0a65373149300868e585691ddae8abde2243ae3c
- Cited by
- 59
- References
- 55
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 6 · 2019: 4 · 2017: 5 · 2015: 2 · 2014: 4
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Crohn s and Colitis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Generalitat de Catalunya (2009SGR708)
- Ministerio de Ciencia e Innovación (BFU2009-08229, BFU2010-15401, BES-2010-037699)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- gut microbiota, intestinal inflammation
- MeSH terms
- Animals, Bacterial Adhesion, Disease Models, Animal, Indomethacin, Intestinal Mucosa, Male, Inflammatory Bowel Diseases, Rats, Sprague-Dawley, Toll-Like Receptors, Rats, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
