Cited by 1,237DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentEffects of Radiation Exposure

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DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

Bohr, V·1985·Cell

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Abstract

DNA repair was measured in the dihydrofolate reductase gene in Chinese hamster ovary cells, amplified for the gene, by quantitating pyrimidine dimers with a specific UV-endonuclease. More than two thirds of the dimers had been removed from a 14.1 kb restriction fragment of the gene by 26 hr after irradiation (20 J/m2), while little removal was detected in fragments upstream of the gene and only 15% were removed from the genome overall. This suggests that damage processing can vary according to function or activity of affected sequences, which has general implications for correlations of DNA repair with survival and mutagenesis. Perhaps preferential repair of vital sequences facilitates UV-resistance of these cells despite low overall repair levels.

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Method
THE RELATIVE BIOLOGICAL IMPORTANCE OF CYCLOBUTANE AND(6–4) PYRIMIDINE‐PYRIMIDONE DIMER PHOTOPRODUCTS IN HUMAN CELLS: EVIDENCE FROM A XERODERMA PIGMENTOSUM REVERTANT*
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Untitled work
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Background
Nucleotide Excision Repair of the 5 S Ribosomal RNA Gene Assembled into a Nucleosome
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Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer
Jans, J., Garinis, G. A., Schul, W., van Oudenaren, A., Moorhouse, M., Smid, M., Sert, Y.-G., van der Velde, A., Rijksen, Y., de Gruijl, F. R., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00807-06 · Cited by 56
Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region
Pastukh, V. M., Gorodnya, O. M., Gillespie, M. N., & Ruchko, M. V. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.011 · Cited by 57
“This method of calculation is based on the application of a Poisson equation for the undamaged sequences and has been traditionally used for the analyses of DNA damage by Southern blot and quantitative PCR [33,48].”
Method
Studies on chromosome aberration induction: What can they tell us about DNA repair?
Bailey, S. M., & Bedford, J. S. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.033 · Cited by 56
The Yeast RAD7 and RAD16 Genes Are Required for Postincision Events during Nucleotide Excision Repair
Reed, S. H., You, Z., & Friedberg, E. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29481 · Cited by 56
The RAD7 and RAD16 Genes, Which Are Essential for Pyrimidine Dimer Removal from the Silent Mating Type Loci, Are Also Required for Repair of the Nontranscribed Strand of an Active Gene in Saccharomyces cerevisiae
Verhage, R. A., Zeeman, A., de Groot, N., Gleig, F., Bang, D. D., van de Putte, P., & Brouwer, J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.6135-6142.1994 · Cited by 56
“For UV-induced cyclobutane pyrimidine dimers, this differential repair has been described for organisms ranging from Escherichia coli to humans (3, 5, 13, 17, 18, 33, 34, 38, 39).”
Background
Translesion DNA synthesis in the dihydrofolate reductase domain of UV-irradiated CHO cells
Spivak, G., & Hanawalt, P. C. (1992) · Biochemistry · doi:10.1021/bi00144a021 · Cited by 56
Mammalian nucleotide excision repair
Ma, L., Hoeijmakers, J. H. J., & van der Eb, A. J. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(95)00008-4 · Cited by 56
Increased UV Resistance of a Xeroderma Pigmentosum Revertant Cell Line is Correlated with Selective Repair of the Transcribed Strand of an Expressed Gene
Lommel, L., & Hanawalt, P. C. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.2.970 · Cited by 56
Cockayne Syndrome: The many challenges and approaches to understand a multifaceted disease
Vessoni, A. T., Guerra, C. C. C., Kajitani, G. S., Nascimento, L. L. S., & Garcia, C. C. M. (2020) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2019-0085 · Cited by 57
“In TC-NER, as shown in Figure 1, the triggering event is the arrest of RNA polymerase II (RNA pol II) owing to the presence of a lesion in the actively transcribed strand of a gene (Bohr et al., 1985; Hanawalt and Spivak, 2008).”
DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer’s Disease
Wang, H., Lautrup, S., Caponio, D., Zhang, J., & Fang, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136748 · Cited by 55
“In the case of TC-NER, it is primed by transcribing RNA polymerase II [25].”
Background
Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance
Dantas, T. J., Daly, O. M., & Morrison, C. G. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0961-1 · Cited by 55
In vivo formation and repair of cyclobutane pyrimidine dimers and 6-4 photoproducts measured at the gene and nucleotide level in Escherichia coli
Chandrasekhar, D., & Houten, B. V. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00014-2 · Cited by 55
Nucleotide Excision Repair Activity Varies Among Murine Spermatogenic Cell Types1
Xu, G., Spivak, G., Mitchell, D. L., Mori, T., McCarrey, J. R., McMahan, C. A., Walter, R. B., Hanawalt, P. C., & Walter, C. A. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.039123 · Cited by 55
Reduced global genomic repair of ultraviolet light-induced cyclobutane pyrimidine dimers in simian virus 40-transformed human cells
Bowman, K. K., Sicard, D., Ford, J. M., & Hanawalt, P. C. (2000) · Molecular Carcinogenesis · doi:10.1002/1098-2744(200009)29:1 · Cited by 56
Preferential repair of damage in actively transcribed DNA sequences in vivo
Hanawalt, P. C. (1989) · Genome · doi:10.1139/g89-113 · Cited by 54
The genetic defect in the Chinese hamster ovary cell mutant UV61 permits moderate selective repair of cyclobutane pyrimidine dimers in an expressed gene
Lommel, L., & Hanawalt, P. C. (1991) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(91)90052-q · Cited by 54
H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage
Wang, S., Meyer, D. H., & Schumacher, B. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-00513-1 · Cited by 49

Authors: Bohr, V
Affiliations: Stanford University (US)
Corresponding author: Bohr, V
ORCID: Bohr, V
Venue: Cell
Publisher: Elsevier BV
Published: 1985-02
Volume: 40
Issue: 2
Pages: 359-369
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(85)90150-3
OpenAlex: W1984353960
Cited by: 1,237
References: 34
Citations by year: 2026: 11 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 12 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 18 · 2017: 13 · 2016: 23 · 2015: 9 · 2014: 24 · 2013: 24 · 2012: 22
FWCI: 15.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 09901)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: DNA repair, pyrimidine dimers, dihydrofolate reductase gene, UV-induced DNA damage, UV endonuclease, UV resistance, CHO cells, mutagenesis, cell survival
MeSH terms: Animals, Base Sequence, Cell Line, Cell Survival, Cricetulus, DNA Repair, Endodeoxyribonucleases, Female, Cricetinae, Multienzyme Complexes, N-Glycosyl Hydrolases, Pyrimidine Dimers, Tetrahydrofolate Dehydrogenase

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DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

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