Cited by 1,237DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentEffects of Radiation Exposure

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

Bohr, V·1985·Cell

Open this paper in CoChat — free account

Abstract

DNA repair was measured in the dihydrofolate reductase gene in Chinese hamster ovary cells, amplified for the gene, by quantitating pyrimidine dimers with a specific UV-endonuclease. More than two thirds of the dimers had been removed from a 14.1 kb restriction fragment of the gene by 26 hr after irradiation (20 J/m2), while little removal was detected in fragments upstream of the gene and only 15% were removed from the genome overall. This suggests that damage processing can vary according to function or activity of affected sequences, which has general implications for correlations of DNA repair with survival and mutagenesis. Perhaps preferential repair of vital sequences facilitates UV-resistance of these cells despite low overall repair levels.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(85)90150-3

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245
A rapid alkaline extraction procedure for screening recombinant plasmid DNA
Birnboim, H. C., & Doly, J. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.6.1513 · Cited by 14,686
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.
Wahl, G. M., Stern, M., & Stark, G. R. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3683 · Cited by 3,159
Calcium-dependent bacteriophage DNA infection
Mandel, M., & Higa, A. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90051-3 · Cited by 2,521
[29] Analysis of repeating DNA sequences by reassociation
Britten, R. J., Graham, D. E., & Neufeld, B. R. (1974) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(74)29033-5 · Cited by 1,041
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.
Alt, F. W., Kellems, R. E., Bertino, J. R., & SCHIMKE, R. T. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34875-5 · Cited by 934
DNA Repair in Bacteria and Mammalian Cells
Hanawalt, P. C., Cooper, P. K., Ganesan, A. K., & Smith, C. A. (1979) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.48.070179.004031 · Cited by 837
Gene amplification in cultured animal cells
SCHIMKE, R. T. (1984) · Cell · doi:10.1016/0092-8674(84)90406-9 · Cited by 635
Practical Methods in Molecular Biology
Schleif, R., & Wensink, P. C. (1981) · Springer eBooks · doi:10.1007/978-1-4612-5956-5 · Cited by 473
Sequence organization of the human genome
Schmid, C. W., & Deininger, P. L. (1975) · Cell · doi:10.1016/0092-8674(75)90184-1 · Cited by 301

Show all 34 references

Sorted by citations

Items 501–600 of 1,001

Physical and functional interaction between DDB and XPA in nucleotide excision repair
Wakasugi, M., Kasashima, H., Fukase, Y., Imura, M., Imai, R., Yamada, S., Cleaver, J. E., & Matsunaga, T. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn964 · Cited by 40
Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B
Boetefuer, E. L., Lake, R. J., & Fan, H.-Y. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky660 · Cited by 38
Transcription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: Implications for Cockayne's syndrome
Lommel, L., Bucheli, M. E., & Sweder, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150130197 · Cited by 38
Transcription-coupled and global genome repair in the Saccharomyces cerevisiae RPB2 gene at nucleotide resolution
Tijsterman, M. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.18.3499 · Cited by 38
Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea.
Shaver-Walker, P., Urlando, C., Tao, K., Zhang, X. B., & Heddle, J. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11470 · Cited by 38
Gene-specific DNA repair in terminally differentiating rat myoblasts
Ho, L., & Hanawalt, P. C. (1991) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(91)90047-s · Cited by 38
Equal rates of repair of DNA photoproducts in transcribed and non‐transcribed strands in Sulfolobus solfataricus
Dorazi, R., Götz, D., Munro, S., Bernander, R., & White, M. F. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05516.x · Cited by 39
“Soon after the delineation of the NER pathway in E. coli, it became apparent that NER was completed more quickly in regions of the genome rich in open reading frames (ORFs) (Bohr et al., 1985).”
Background
New applications of the Comet assay: Comet–FISH and transcription-coupled DNA repair
Spivak, G., COX, R., & Hanawalt, P. C. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2007.12.003 · Cited by 37
Yeast RNA Polymerase II Transcription In Vitro Is Inhibited in the Presence of Nucleotide Excision Repair: Complementation of Inhibition by Holo-TFIIH and Requirement for RAD26
You, Z., Feaver, W. J., & Friedberg, E. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2668 · Cited by 37
Isolation and characterization of the human uracil DNA glycosylase gene.
Vollberg, T. M., Siegler, K., Cool, B. L., & Sirover, M. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8693 · Cited by 37
Chemie und Biologie der DNA‐Reparatur
Schärer, O. D. (2003) · Angewandte Chemie · doi:10.1002/ange.200200523 · Cited by 37
Negative superhelicity promotes ATP-dependent binding of yeast RAD3 protein to ultraviolet-damaged DNA.
Sung, P., Watkins, J. F., Prakash, L., & Prakash, S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37193-4 · Cited by 37
Preferential DNA repair of alkali-labile sites within the active insulin gene.
LeDoux, S. P., Patton, N. J., Nelson, J. W., Bohr, W., & Wilson, G. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77196-2 · Cited by 37
CYCLOBUTANE DIMERS AND (6‐4)PHOTOPRODUCTS IN HUMAN CELLS ARE MENDED WITH THE SAME PATCH SIZES
Cleaver, J. E., Jen, J., Charles, W. C., & Mitchell, D. L. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02033.x · Cited by 37
Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain 1 1Edited by K. Yamamoto
Mazur, S. J., Sakaguchi, K., Appella, E., Wang, X. W., Harris, C. C., & Bohr, V. A. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3064 · Cited by 38
Self-citation
Repair mechanisms of UV-induced DNA damage in soybean chloroplasts
Cannon, G. C., Hedrick, L. A., & Heinhorst, S. (1995) · Plant Molecular Biology · doi:10.1007/bf00020467 · Cited by 36
“While this might simply be a consequence of the high growth rate of the cultured cells or be due to slightly different repair mechanisms in the two plant species, the rapid removal of UV-induced lesions from chloroplast and organellar DNA of the soybean cells might also reflect the previously observed higher repair ra…”
Result
Spatial organization of nucleotide excision repair proteins after UV-induced DNA damage in the human cell nucleus
Solimando, L., Luijsterburg, M. S., Vecchio, L., Vermeulen, W., van Driel, R., & Fakan, S. (2009) · Journal of Cell Science · doi:10.1242/jcs.031062 · Cited by 37
“If lesions are indeed translocated to the perichromatin region, this might explain in part why TCR is much faster than GGR (Bohr et al., 1985; Mellon et al., 1987), because active genes are predominantly located in the perichromatin area and do not need translocation.”
Background
Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction
Wang, Y.-C., Lee, P.-J., Shih, C., Chen, H., Lee, C.-C., Chang, Y., Hsu, Y.-T., Liang, Y.-J., Wang, L., Han, W.-H., et al. (2003) · Analytical Biochemistry · doi:10.1016/s0003-2697(03)00330-0 · Cited by 36
The bacterial transcription repair coupling factor
Deaconescu, A. M., Savery, N. J., & Darst, S. A. (2007) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2007.01.005 · Cited by 39
“DNA repair asymmetry in genomes has long been linked to transcription [1].”
Background
Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
Ghodke, H. B., Ho, H. N., & van Oijen, A. M. (2020) · Nature Communications · doi:10.1038/s41467-020-15179-y · Cited by 36
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover
Chakraborty, A., Tapryal, N., Islam, A., MITRA, S. P., & Hazra, T. K. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103204 · Cited by 39
Nucleotide excision repair: a versatile and smart toolkit
Zhang, X., Yin, M., & Hu, J. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022054 · Cited by 42
The pleiotropic roles of SPT5 in transcription
Song, A., & Chen, F. (2022) · Transcription · doi:10.1080/21541264.2022.2103366 · Cited by 36
Elongating RNA Polymerase II Is Disassembled through Specific Degradation of Its Largest but Not Other Subunits in Response to DNA Damage in Vivo
Malik, S., Bagla, S., Chaurasia, P., Duan, Z., & Bhaumik, S. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707649200 · Cited by 36
Analysis of gene- and strand-specific repair in the moderately UV-sensitive Saccharomyces cerevisiae rad23 mutant
Verhage, R. A., Zeeman, A., Lombaerts, M., van de Putte, P., & Brouwer, J. (1996) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(95)00045-3 · Cited by 36
Genetic analysis of Saccharomyces cerevisiae chromosome I: on the role of mutagen specificity in delimiting the set of genes identifiable using temperature-sensitive-lethal mutations.
Harris, S. D., & Pringle, J. R. (1991) · Genetics · doi:10.1093/genetics/127.2.279 · Cited by 36
Transcription-Coupled Repair of Psoralen Cross-Links but Not Monoadducts in Chinese Hamster Ovary Cells
Islas, Á. L., Baker, F. J., & Hanawalt, P. C. (1994) · Biochemistry · doi:10.1021/bi00201a029 · Cited by 36
Ligation-Mediated PCR for Analysis of UV Damage
Tornaletti, S., & Pfeifer, G. P. (1996) · Springer eBooks · doi:10.1007/978-1-4899-0301-3_15 · Cited by 36
Mechanistic insights in transcription-coupled nucleotide excision repair of ribosomal DNA
Daniel, L., Cerutti, E., Donnio, L., Nonnekens, J., Carrat, C., Zahova, S. K., Mari, P., & Giglia‐Mari, G. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716581115 · Cited by 34
Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1
Sabatella, M., Thijssen, K. L., Davó-Martínez, C., Vermeulen, W., & Lans, H. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108608 · Cited by 36
“Also, standard TC-NER assays used in mammalian cell biology, such as strand-specific repair (Bohr et al., 1985) or recovery of RNA synthesis (RRS) (Mayne and Lehmann, 1982; Nakazawa et al.”
MethodResult
Interactions between DNA damage, repair, and transcription
Khobta, A., & Epe, B. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.07.014 · Cited by 38
Role of DNA Excision Repair Gene Defects in the Etiology of Cancer
Ford, J. M., & Hanawalt, P. C. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60505-5_5 · Cited by 35
Recombinational and Mutagenic Repair of Psoralen Interstrand Cross-links in Saccharomyces cerevisiae
Greenberg, R. B., Alberti, M., Hearst, J. E., Chua, M. A., & Saffran, W. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103588200 · Cited by 35
Repair of benzo(a)pyrene diol epoxide- and UV-induced DNA damage in dihydrofolate reductase and adenine phosphoribosyltransferase genes of CHO cells.
Tang, M. S., Pao, A., & Zhang, X. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99939-4 · Cited by 35
The mammalian dihydrofolate reductase locus
Hamlin, J. L., & Ma, C. (1990) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(90)90195-8 · Cited by 35
UVB-induced DNA and photosystem II damage in two intertidal green macroalgae: Distinct survival strategies in UV-screening and non-screening Chlorophyta
Pescheck, F., Lohbeck, K. T., Roleda, M. Y., & Bilger, W. (2014) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2014.02.006 · Cited by 34
“The rate of NER and BER depends on factors as type of lesion, methylation, transcription, condensation degree and DNA–histone interaction [9,29,17,40].”
Background
Interaction of nucleotide excision repair factors XPC-HR23B, XPA, and RPA with damaged DNA
Krasikova, Y. S., Rechkunova, N. I., Maltseva, E. A., Petruseva, I. O., Silnikov, V. N., Zatsepin, T. S., Oretskaya, T. S., Schärer, O. D., & Lavrik, O. I. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908080063 · Cited by 34
Kinetics of pyrimidine(6-4)pyrimidone photoproduct repair in Escherichia coli
Koehler, D. R., Courcelle, J., & Hanawalt, P. C. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1347-1350.1996 · Cited by 34
Repair of aflatoxin B1 DNA adducts by the UvrABC endonuclease of Escherichia coli.
Oleykowski, C. A., Mayernik, J. A., Lim, S., Groopman, J. D., Grossman, L. I., Wogan, G. N., & Yeung, A. T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53055-6 · Cited by 34
Differential Regulation of a Fibroblast Growth Factor-Binding Protein during Skin Carcinogenesis and Wound Healing
Kurtz, A., Aigner, A. M., Cabal-Manzano, R. H., Butler, R. E., Hood, D. R., Sessions, R. B., Czubayko, F., & Wellstein, A. (2004) · Neoplasia · doi:10.1593/neo.04214 · Cited by 35
Subfamily relationships and clustering of rabbit C repeats.
Krane, D. E., Clark, A. G., Cheng, J., & Hardison, R. C. (1991) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040631 · Cited by 34
Mechanisms associated with the expression of cisplatin resistance in a human ovarian tumor cell line following exposure to fractionated X-irradiation in vitro
Dempke, W. C. M., Shellard, S. A., Hosking, L. K., Fichtinger-Schepman, A. M. J., & Hill, B. T. (1992) · Carcinogenesis · doi:10.1093/carcin/13.7.1209 · Cited by 34
“Bohr and Hanawalt have developed a molecular technique to study DNA repair processes in individual genes ( 74-76 ).”
Method
Heterogeneous repair of methylnitrosourea-induced alkali-labile sites in different DNA sequences.
LeDoux, S. P., Thangada, M., Bohr, V. A., & Wilson, G. L. (1991) · PubMed · Cited by 34
Self-citation
The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase
Musk, S., & Steel, G. G. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.298 · Cited by 34
Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells
Vélez-Cruz, R., Zadorin, A. S., Coin, F., & Egly, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213076110 · Cited by 34
A Peek Inside the Machines of Bacterial Nucleotide Excision Repair
Kraithong, T., Hartley, S., Jeruzalmi, D., & Pakotiprapha, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020952 · Cited by 35
Versatile protection from mutagenic DNA lesions conferred by bipartite recognition in nucleotide excision repair
Maillard, O., Camenisch, U., Blagoev, K. B., & Naegeli, H. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.01.007 · Cited by 36
Transcription‐blocking DNA damage in aging: a mechanism for hormesis
Schumacher, B. (2009) · BioEssays · doi:10.1002/bies.200900107 · Cited by 33
Protection from Ultraviolet Damage and Photocarcinogenesis by Vitamin D Compounds
Gordon‐Thomson, C., Tongkao‐on, W., Song, E. J., Carter, S. E., Dixon, K. M., & Mason, R. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0437-2_17 · Cited by 33
Identifying transcription start sites and active enhancer elements using BruUV-seq
Magnuson, B., Veloso, A., Kirkconnell, K. S., Lima, L. C. D. A., Paulsen, M. T., Ljungman, E. A., Bedi, K., Prasad, J., Wilson, T. E., & Ljungman, M. E. (2015) · Scientific Reports · doi:10.1038/srep17978 · Cited by 34
DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice
Wijnhoven, S., Kool, H., Mullenders, L. H. F., Slater, R. M., van Zeeland, A. A., & Vrieling, H. (2001) · Carcinogenesis · doi:10.1093/carcin/22.7.1099 · Cited by 33
Transcription, nucleosome stability, and DNA repair in a yeast minichromosome.
Bedoyan, J. K., Gupta, R., Thoma, F., & Smerdon, M. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42653-1 · Cited by 33
Pyrimidine Dimer Induction and Repair in Cultured Human Skin Keratinocytes or Melanocytes After Irradiation with Monochromatic Ultraviolet Radiation
Schothorst, A. A., Evers, L. M., Noz, K. C., Filon, R., & van Zeeland, A. A. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12475443 · Cited by 33
Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis
Xu, L., Da, L., Plouffe, S. W., Chong, J. P. C., Kool, E. T., & Wang, D. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.024 · Cited by 32
Transcription-coupled DNA double-strand break repair
Guha, S., & Bhaumik, S. R. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103211 · Cited by 34
Mitochondria, oxidative DNA damage, and aging
Anson, R. M., & Bohr, V. A. (2000) · AGE · doi:10.1007/s11357-000-0020-y · Cited by 32
Self-citation
DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice.
Beecham, E. J., Mushinski, J. F., Shacter, E. B., Potter, M., & Bohr, V. A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3095 · Cited by 32
Self-citation
Role of DNA repair in carcinogen-induced ras mutation
Engelbergs, J., Thomale, J., & Rajewsky, M. F. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00021-x · Cited by 32
Posttreatment with sodium arsenite alters the mutational spectrum induced by ultraviolet light irradiation in chinese hamster ovary cells
Yang, J., Chen, M., Wu, C., & Lee, T. (1992) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850200304 · Cited by 32
Impaired nucleotide excision repair in UV-irradiated human oral keratinocytes immortalized with type 16 human papillomavirus genome
Rey, O., Lee, S., & Park, N. (1999) · Oncogene · doi:10.1038/sj.onc.1203180 · Cited by 32
“Strand-speci®c removal of UV-induced cyclobutane pyramidine dimers (CPDs) was analysed from a 16 kb EcoRI fragment of the active p53 gene using single-stranded labeled riboprobes speci®c for p53 (Bohr et al., 1985; van der Horst et al., 1997).”
Method
Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair
Balajee, A. S., May, A., Dianova, I. I., & Bohr, V. A. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(98)00051-2 · Cited by 32
Self-citation
Assignment of orthologous relationships among mammalian alpha-globin genes by examining flanking regions reveals a rapid rate of evolution.
Hardison, R. C., & Gelinas, R. E. (1986) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040392 · Cited by 32
Measurement of the kinetics of DNA repair synthesis after uv irradiation using immunochemical staining of incorporated 5-bromo-2′-deoxyuridine and flow cytometry
Beisker, W., & Hittelman, W. N. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90151-6 · Cited by 32
The sensitivity of human fibroblasts to N-acetoxy-2-acetylaminofluorene is determined by the extent of transcription-coupled repair, and/or their capability to counteract RNA synthesis inhibition
van Oosterwijk, M. F. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.23.4653 · Cited by 32
STK19 is a transcription-coupled repair factor that participates in UVSSA ubiquitination and TFIIH loading
Tan, Y., Gao, M., Huang, Y., Zhan, D., Wu, S., An, J., Zhang, X., & Hu, J. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae787 · Cited by 31
“Although TCR was first discovered in mammalian cells nearly 40 years ago ( 61 ), the molecular mechanism of mammalian TCR still remains unclear.”
PostExcision Events in Human Nucleotide Excision Repair
Kemp, M. G., & Hu, J. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12641 · Cited by 30
Crosslinking of the NER damage recognition proteins XPC-HR23B, XPA and RPA to photoreactive probes that mimic DNA damages
Maltseva, E. A., Rechkunova, N. I., Gillet, L. C. J., Petruseva, I. O., Schärer, O. D., & Lavrik, O. I. (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.01.007 · Cited by 32
Nucleotide excision repair- and p53-deficient mouse models in cancer research
Hoogervorst, E. M., STEEG, H. V., & de Vries, A. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.01.018 · Cited by 31
Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA–/– mice
Klein, J. C., Beems, R. B., Zwart, P. E., Hamzink, M., Zomer, G., van Steeg, H., & van Kreijl, C. F. (2001) · Carcinogenesis · doi:10.1093/carcin/22.4.619 · Cited by 32
Evidence that the Transcription Elongation Function of Rpb9 Is Involved in Transcription-Coupled DNA Repair in Saccharomyces cerevisiae
Li, S., Ding, B., Chen, R., Ruggiero, C., & Chen, X. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01656-06 · Cited by 31
Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.
Fishel, M. L., Delaney, S. M., Friesen, L. D., Hansen, R. J., Zuhowski, E. G., Moschel, R. C., Egorin, M. J., & Dolan, M. E. (2003) · PubMed · Cited by 31
Fine structural analysis of DNA repair in mammalian cells
Balajee, A. S., May, A., & Bohr, V. A. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00088-8 · Cited by 31
Self-citation
Lack of a cell cycle-dependent strand bias for mutations induced in the HPRT gene by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in excision repair-deficient human cells.
Chen, R., Maher, V. M., & McCormick, J. J. (1991) · PubMed · Cited by 31
Photolyases: Capturing the Light to Battle Skin Cancer
Garinis, G. A., Jans, J., & van der Horst, G. T. (2006) · Future Oncology · doi:10.2217/14796694.2.2.191 · Cited by 30
“However, whilst GG-NER is efficient at removing 6-4PPs and other types of helix-distorting damage, CPDs are a poor substrate and are removed at substantially reduced rates in human cells [12], and virtually not at all in rodent cells [13].”
Background
DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water
Meier, S., Karlsen, Ø., Goff, J. L., Sørensen, L., Sørhus, E., Pampanin, D. M., Donald, C. E., Fjelldal, P. G., Dunaevskaya, E., Romano, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240307 · Cited by 30
“One explanation could be that the long-lived DNA adduct are located in the none-coding parts of the genome that are not so accessible to repair [51].”
Background
DNA damage-dependent recruitment of nucleotide excision repair and transcription proteins to Escherichia coli inner membranes
Lin, C. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.3151 · Cited by 30
DNA-sequence specificity of mutations at the human thymidine kinase locus
Grosovsky, A. J., Walter, B. N., & Giver, C. R. (1993) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(93)90074-p · Cited by 30
Equal G and C contents in histone genes indicate selection pressures on mRNA secondary structure
Huynen, M. A., Konings, D. A. M., & Hogeweg, P. (1992) · Journal of Molecular Evolution · doi:10.1007/bf00160235 · Cited by 30
“Another explanation for differences in G+C level may be differential repair of regions with active genes versus regions without active genes ( Bohr et al. 1985 ).”
Background
Functional Nucleotide Excision Repair Is Required for the Preferential Removal of N-Ethylpurines from the Transcribed Strand of the Dihydrofolate Reductase Gene of Chinese Hamster Ovary Cells
Sitaram, A., Plitas, G., Wang, W., & Scicchitano, D. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.564 · Cited by 30
N-methyl-N-nitrosourea-induced mutations in human cells
Palombo, F., Kohfeldt, E., Calcagnile, A. S., Nehls, P., & Eugenia Dogliotti, Y. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90974-o · Cited by 30
Use of DNA Repair-Deficient XPA Transgenic Mice in Short-Term Carcinogenicity Testing
STEEG, H. V., Klein, H., Beems, R. B., & van Kreijl, C. F. (1998) · Toxicologic Pathology · doi:10.1177/019262339802600605 · Cited by 31
A yeast whole cell extract supports nucleotide excision repair and RNA polymerase II transcription in vitro
Wang, Z., Wu, X., & Friedberg, E. C. (1996) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(96)00019-5 · Cited by 30
Concepts and models for DNA repair: FromEscherichia coli to mammalian cells
Hanawalt, P. C. (1989) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850140617 · Cited by 30
Differential repair of DNA damage in specific nucleotide sequences in monkey cells
Leadon, S. A. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.22.8979 · Cited by 30
Transcriptional coupling of DNA repair in sporulating B acillus subtilis cells
Ramírez‐Guadiana, F. H., Barajas‐Ornelas, R. D. C., Ayala‐García, V. M., Yasbin, R. E., Robleto, E. A., & Pedraza‐Reyes, M. (2013) · Molecular Microbiology · doi:10.1111/mmi.12417 · Cited by 29
“In several species, a specialized DNA repair mechanism called transcription-coupled repair (TCR) is responsible for mediating the repair of DNA damage in actively transcribed genes (Bohr et al., 1985; Mellon and Hanawalt, 1989).”
Background
The oxidatively induced DNA lesions 8,5′-cyclo-2′-deoxyadenosine and 8-hydroxy-2′-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond
Theruvathu, J. A., Jaruga, P., Dizdaroğlu, M., & Brooks, P. J. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.06.006 · Cited by 29
“In dividing cells, the rate of NER of cyclobutane pyrimidine dimers (CPDs) is highest in transcribed DNA sequences (Bohr et al., 1985), and specifically on the transcribed strand of active genes (Mellon et al.”
Background
RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications
Xu, L., Wang, W., Chong, J. P. C., Shin, J. H., Xu, J., & Wang, D. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1087960 · Cited by 28
“…2008; Lagerwerf et al., 2011; Saxowsky & Doetsch, 2006; Tornaletti & Hanawalt, 1999), which preferentially removes DNA lesions in the transcribed strand (Bohr et al., 1985; Fousteri & Mullenders, 2008; Hanawalt & Spivak, 2008; Lagerwerf et al., 2011; Mellon et al., 1986, 1987; Sarker et al., 2005).”
Background
Transcription-coupled homologous recombination after oxidative damage
Wei, L., Levine, A. S., & Lan, L. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.009 · Cited by 29
Mitochondrial DNA Damage Mediates Hyperoxic Dysmorphogenesis in Rat Fetal Lung Explants
Gebb, S. A., DeCoux, A., Waggoner, A., Wilson, G. L., & Gillespie, M. N. (2012) · Neonatology · doi:10.1159/000342632 · Cited by 29
Amplification of unscheduled DNA synthesis signal enables fluorescence-based single cell quantification of transcription-coupled nucleotide excision repair
Wienholz, F., Vermeulen, W., & Marteijn, J. A. F. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1360 · Cited by 30
Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair
Steurer, B., der Velden, Y. T.-V., van Toorn, M., van Leeuwen, W., Escudero-Ferruz, P., & Marteijn, J. A. F. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz035 · Cited by 29
“Alternatively, TC-NER can be measured in a direct manner by strand-specific repair assays (38), or by more recently developed single-cell assays, such as the modified COMET-FISH procedure (39), or the TC-NER specific UDS assay (40).”
Method
A single amino acid change in histone H4 enhances UV survival and DNA repair in yeast
Nag, R., Gong, F., Fahy, D., & Smerdon, M. J. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn311 · Cited by 29
Evidence that Localized Variation in Primate Sequence Divergence Arises from an Influence of Nucleosome Placement on DNA Repair
Ying, H., Epps, J., Williams, R. B. H., & Huttley, G. A. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp253 · Cited by 29
“The evolution of intronic regions are likely affected by the operation of transcription coupled DNA repair (Bohr et al. 1985; Green et al. 2003).”
Background
Repair of Radiation-Induced DNA Strand Breaks Does Not Occur Preferentially in Transcriptionally Active DNA
Ljungman, M. E. (1999) · Radiation Research · doi:10.2307/3580230 · Cited by 29
Loss of intragenomic DNA repair heterogeneity with cellular differentiation.
Bill, C. A., Grochan, B. M., Meyn, R. E., Bohr, V. A., & Tofilon, P. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54711-6 · Cited by 29
Self-citation
A modified quantitative polymerase chain reaction assay for measuring gene-specific repair of UV photoproducts in human cells
McCarthy, M. J., Rosenblatt, J. I., & Lloyd, R. S. (1996) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(95)00061-5 · Cited by 29
Transcription and DNA Damage: A Link to a Kink
Scicchitano, D. A., & Mellon, I. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s1145 · Cited by 29
Postirradiation Alterations of Neuronal Chromatin Structure
Jaberaboansari, A., Nelson, G. B., Roti, J. L. R., & Wheeler, K. T. (1988) · Radiation Research · doi:10.2307/3577147 · Cited by 29
DNA-Protein Cross-Links: New Insights into their Formation and Repair in Irradiated Mammalian Cells
Oleinick, N. L., Chiu, S., Friedman, L. R., Xue, L.-Y., & Ramakrishnan, N. (1986) · Springer eBooks · doi:10.1007/978-1-4615-9462-8_19 · Cited by 29
UV-induced endonuclease III-sensitive sites at the mating type loci inSaccharomyces cerevisiae are repaired by nucleotide excision repair: RAD7 and RAD16 are not required for their removal fromHMLα
Reed, S. H., Waters, R., & Boiteux, S. (1996) · Molecular and General Genetics MGG · doi:10.1007/bf02174039 · Cited by 29
“The Southern blot method of assaying for the removal of endonuclease-sensitive sites was developed by Bohr et al. (1985) .”
Method

Authors: Bohr, V
Affiliations: Stanford University (US)
Corresponding author: Bohr, V
ORCID: Bohr, V
Venue: Cell
Publisher: Elsevier BV
Published: 1985-02
Volume: 40
Issue: 2
Pages: 359-369
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(85)90150-3
OpenAlex: W1984353960
Cited by: 1,237
References: 34
Citations by year: 2026: 11 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 12 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 18 · 2017: 13 · 2016: 23 · 2015: 9 · 2014: 24 · 2013: 24 · 2012: 22
FWCI: 15.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 09901)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: DNA repair, pyrimidine dimers, dihydrofolate reductase gene, UV-induced DNA damage, UV endonuclease, UV resistance, CHO cells, mutagenesis, cell survival
MeSH terms: Animals, Base Sequence, Cell Line, Cell Survival, Cricetulus, DNA Repair, Endodeoxyribonucleases, Female, Cricetinae, Multienzyme Complexes, N-Glycosyl Hydrolases, Pyrimidine Dimers, Tetrahydrofolate Dehydrogenase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks