Cited by 1,237DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentEffects of Radiation Exposure

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DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

Bohr, V·1985·Cell

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Abstract

DNA repair was measured in the dihydrofolate reductase gene in Chinese hamster ovary cells, amplified for the gene, by quantitating pyrimidine dimers with a specific UV-endonuclease. More than two thirds of the dimers had been removed from a 14.1 kb restriction fragment of the gene by 26 hr after irradiation (20 J/m2), while little removal was detected in fragments upstream of the gene and only 15% were removed from the genome overall. This suggests that damage processing can vary according to function or activity of affected sequences, which has general implications for correlations of DNA repair with survival and mutagenesis. Perhaps preferential repair of vital sequences facilitates UV-resistance of these cells despite low overall repair levels.

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Komura, J., Mitani, H., Nemoto, N., Ishikawa, T., & Shima, A. (1991) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(91)90056-u · Cited by 23
DNA‐Directed Mutations: Leading and Lagging Strand Specificity
Sinden, R. R., Hashem, V. I., & Rosche, W. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08878.x · Cited by 23
Deoxyuridine Is Generated Preferentially in the Nontranscribed Strand of DNA from Cells Expressing Activation-Induced Cytidine Deaminase
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“To detect dU in a specific gene, we modified an established Southern blot technique, which has been used previously to study genespecific DNA repair in mammalian cells (26, 27).”
Method
Temperature dependence of adriamycin-induced DNA damage in L1210 cells.
Vichi, P., Robison, S., & Tritton, T. R. (1989) · PubMed · Cited by 23
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences
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RAD7 Gene of Saccharomyces cerevisiae: Transcripts, Nucleotide Sequence Analysis, and Functional Relationship between the RAD7 and RAD23 Gene Products
Perozzi, G., & Prakash, S. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.5.1497-1507.1986 · Cited by 23
Heat-shock enhanced reactivation of a UV-damaged reporter gene in human cells involves the transcription coupled DNA repair pathway
McKay, B. C., & Rainbow, A. J. (1996) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(96)00013-4 · Cited by 23
Two Distinct Compositional Classes of Vertebrate Gene-Bearing DNA Stretches, Their Structures and Possible Evolutionary Origin
Filipski, J., Salinas, J., & RODIER, F. (1987) · DNA · doi:10.1089/dna.1987.6.109 · Cited by 23
“Part of the regional differences in composition may be explained by different rates of repair in active genes versus the overall genome (Bohr et al., 1985).”
Excision repair of UV-damaged plasmid DNA inXenopusoocytes is mediated by DNA polymerase α (and/or δ)
Saxena, J. K., Hays, J. B., & Ackerman, E. J. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.24.7425 · Cited by 23
Transcription Blockage by DNA Damage in Nucleotide Excision Repair-Related Neurological Dysfunctions
Kajitani, G. S., Nascimento, L. L. D. S., Neves, M. R. D. C., Leandro, G. D. S., Garcia, C. C. M., & Menck, C. F. M. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.10.009 · Cited by 22
Photobiological Origins of the Field of Genomic Maintenance
Ganesan, A., & Hanawalt, P. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12542 · Cited by 22
A half century of exploring DNA excision repair in chromatin
Smerdon, M. J., Wyrick, J. J., & Delaney, S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105118 · Cited by 25
Relationship between chromatin structure, DNA damage and repair following X-irradiation of human lymphocytes
Mosesso, P., Palitti, F., Pepe, G., Piñero, J., Bellacima, R., Ahnström, G., & Natarajan, A. T. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.03.005 · Cited by 22
New discoveries linking transcription to DNA repair and damage tolerance pathways
Cohen, S., & Walker, G. C. (2011) · Transcription · doi:10.4161/trns.2.1.14228 · Cited by 22
Base Excision Repair and Nucleotide Excision Repair
Izumi, T., & Mellon, I. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00017-3 · Cited by 22
Damage removal and gap filling in nucleotide excision repair
Kemp, M. G. (2019) · The Enzymes · doi:10.1016/bs.enz.2019.06.001 · Cited by 27
Induction and removal of interstrand crosslinks in the ribosomal RNA genes of lymphoblastoid cell lines from patients with Fanconi anemia
Rey, J.-P., Scott, R. J., & Müller, H. (1993) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(93)90067-p · Cited by 22
Defective nucleotide excision repair in yeast hpr1 and tho2 mutants
González‐Barrera, S. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.2193 · Cited by 22
Deletion of the CSB homolog, RAD26, yields Spt- strains with proficient transcription-coupled repair
Gregory, S. M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.14.3080 · Cited by 22
“(6,19, 22 ). Equal amounts of purified, restricted DNA were either mock treated (10 mM Tris–HCl, pH 7.5, 0.1 M NaCl, 10 mM EDTA, 1 mg/ml BSA) or treated with the enzyme T4 endonuclease V in mock buffer for 30 min at 37°C.”
MethodInfluential
Two-Wavelength Fluorescence Assay for DNA Repair
Roguev, A., & Russev, G. C. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4865 · Cited by 22
Transcription-coupled and Transcription-independent Repair of Cyclobutane Pyrimidine Dimers in the Dihydrofolate Reductase Gene
Hu, W., Feng, Z., Chasin, L. A., & Tang, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206375200 · Cited by 22
Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N′-nitro-N-nitrosoguanidine and promoted by mezerein†This article is a US Government work and, as such, is in the public domain in the United States of America.
Rehman, I., Lowry, D. T., Adams, C., Abdel‐Fattah, R., Holly, A. J., Yuspa, S. H., & Hennings, H. (2000) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(200004)27:4 · Cited by 29

Authors: Bohr, V
Affiliations: Stanford University (US)
Corresponding author: Bohr, V
ORCID: Bohr, V
Venue: Cell
Publisher: Elsevier BV
Published: 1985-02
Volume: 40
Issue: 2
Pages: 359-369
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(85)90150-3
OpenAlex: W1984353960
Cited by: 1,237
References: 34
Citations by year: 2026: 11 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 12 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 18 · 2017: 13 · 2016: 23 · 2015: 9 · 2014: 24 · 2013: 24 · 2012: 22
FWCI: 15.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 09901)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: DNA repair, pyrimidine dimers, dihydrofolate reductase gene, UV-induced DNA damage, UV endonuclease, UV resistance, CHO cells, mutagenesis, cell survival
MeSH terms: Animals, Base Sequence, Cell Line, Cell Survival, Cricetulus, DNA Repair, Endodeoxyribonucleases, Female, Cricetinae, Multienzyme Complexes, N-Glycosyl Hydrolases, Pyrimidine Dimers, Tetrahydrofolate Dehydrogenase

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DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

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