Cited by 1,237DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentEffects of Radiation Exposure

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

Bohr, V·1985·Cell

Open this paper in CoChat — free account

Abstract

DNA repair was measured in the dihydrofolate reductase gene in Chinese hamster ovary cells, amplified for the gene, by quantitating pyrimidine dimers with a specific UV-endonuclease. More than two thirds of the dimers had been removed from a 14.1 kb restriction fragment of the gene by 26 hr after irradiation (20 J/m2), while little removal was detected in fragments upstream of the gene and only 15% were removed from the genome overall. This suggests that damage processing can vary according to function or activity of affected sequences, which has general implications for correlations of DNA repair with survival and mutagenesis. Perhaps preferential repair of vital sequences facilitates UV-resistance of these cells despite low overall repair levels.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(85)90150-3

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245
A rapid alkaline extraction procedure for screening recombinant plasmid DNA
Birnboim, H. C., & Doly, J. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.6.1513 · Cited by 14,686
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.
Wahl, G. M., Stern, M., & Stark, G. R. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3683 · Cited by 3,159
Calcium-dependent bacteriophage DNA infection
Mandel, M., & Higa, A. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90051-3 · Cited by 2,521
[29] Analysis of repeating DNA sequences by reassociation
Britten, R. J., Graham, D. E., & Neufeld, B. R. (1974) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(74)29033-5 · Cited by 1,041
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.
Alt, F. W., Kellems, R. E., Bertino, J. R., & SCHIMKE, R. T. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34875-5 · Cited by 934
DNA Repair in Bacteria and Mammalian Cells
Hanawalt, P. C., Cooper, P. K., Ganesan, A. K., & Smith, C. A. (1979) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.48.070179.004031 · Cited by 837
Gene amplification in cultured animal cells
SCHIMKE, R. T. (1984) · Cell · doi:10.1016/0092-8674(84)90406-9 · Cited by 635
Practical Methods in Molecular Biology
Schleif, R., & Wensink, P. C. (1981) · Springer eBooks · doi:10.1007/978-1-4612-5956-5 · Cited by 473
Sequence organization of the human genome
Schmid, C. W., & Deininger, P. L. (1975) · Cell · doi:10.1016/0092-8674(75)90184-1 · Cited by 301

Show all 34 references

Sorted by citations

Items 401–500 of 1,001

Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes
Baik, A. H., Haribowo, A. G., Chen, X., Queliconi, B. B., Barrios, A. M., Garg, A., Maishan, M., Campos, A. R., Matthay, M. A., & Jain, I. H. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.02.013 · Cited by 57
DNA damage in normally and prematurely aged mice
Maslov, A. Y., Ganapathi, S. S., Westerhof, M., Quispe‐Tintaya, W., White, R. R., Houten, B. V., Reiling, E., Dollé, M. E. T., STEEG, H. V., Hasty, P., et al. (2013) · Aging Cell · doi:10.1111/acel.12071 · Cited by 53
Increasing the resolution of the comet assay using fluorescent in situ hybridization--a review
Shaposhnikov, S. A., Frengen, E., & Collins, A. R. (2009) · Mutagenesis · doi:10.1093/mutage/gep021 · Cited by 53
Epigenetic Theories of Cancer Initiation
Jaffe, L. F. (2003) · Advances in cancer research · doi:10.1016/s0065-230x(03)90007-8 · Cited by 53
Complete Replication of Plasmid DNA Containing a Single UV-induced Lesion in Human Cell Extracts
Carty, M. P., Lawrence, C. W., & Dixon, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9637 · Cited by 53
Distribution of X-ray-induced G2 chromatid damage among Chinese hamster chromosomes: influence of chromatin conformation
Slijepčević, P., & Natarajan, A. T. (1994) · Mutation Research Letters · doi:10.1016/0165-7992(94)90084-1 · Cited by 53
Lack of Gene- and Strand-Specific DNA Repair in RNA Polymerase III-Transcribed Human tRNA Genes
Dammann, R., & Pfeifer, G. P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.219 · Cited by 53
“Slow repair was observed at positions corresponding to binding sites of RNA polymerase II transcription factors (16, 64), and transcription-coupled repair was reported for many different RNA polymerase II transcribed genes (5, 16, 20, 34, 64).”
Background
UV irradiation induces a postreplication DNA damage checkpoint
Callegari, A. J., & Kelly, T. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607343103 · Cited by 51
Transcription-Coupled DNA Repair in Prokaryotes
Ganesan, A. K., Spivak, G., & Hanawalt, P. C. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-387665-2.00002-x · Cited by 53
Sequence-specific oxidative base modifications in hypoxia-inducible genes
Pastukh, V. M., Ruchko, M. V., Gorodnya, O. M., Wilson, G. L., & Gillespie, M. N. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.027 · Cited by 53
Excision repair of UV radiation-induced DNA damage in Caenorhabditis elegans.
Hartman, P. S., Hevelone, J. C., Dwarakanath, V. N., & Mitchell, D. L. (1989) · Genetics · doi:10.1093/genetics/122.2.379 · Cited by 52
Ultraviolet-induced movement of the human DNA repair protein, Xeroderma pigmentosum type G, in the nucleus.
Park, M. S., Knauf, J. A., Pendergrass, S. H., Coulon, C. H., Strniste, G. F., Marrone, B. L., & MacInnes, M. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8368 · Cited by 52
Biological and biochemical consequences of the human ERCC-1 repair gene after transfection into a repair-deficient CHO cell line
Zdzienicka, M. Z., Roza, L., Westerveld, A., & Bootsma, D. (1987) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(87)90047-2 · Cited by 52
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches
Duan, M., Speer, R. M., Ulibarri, J., Liu, K. J., & Mao, P. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103126 · Cited by 54
Review of the evidence for thresholds for DNA-Reactive and epigenetic experimental chemical carcinogens
Kobets, T., & Williams, G. M. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.11.011 · Cited by 52
A role for UV-light-induced c-Fos: stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis
Christmann, M., Tomicic, M. T., Aasland, D., & Kaina, B. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl119 · Cited by 51
“Rodent cells display a very low level of global genome repair (GGR) [23-25] which is due to decreased expression of DDB2, the main recognition factor for”
Influential
The ATPase Domain but Not the Acidic Region of Cockayne Syndrome Group B Gene Product Is Essential for DNA Repair
Brosh, R. M., Balajee, A. S., Selzer, R. R., Sunesen, M., Proietti‐De‐Santis, L., & Bohr, V. A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3583 · Cited by 51
“The presence of CPDs in DNA samples was measured in an enzymatic assay as described previously ( Bohr et al., 1985 ).”
MethodSelf-citation
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product
Sunesen, M., Stevnsner, T., Brosh, R. M., Dianov, G. L., & Bohr, V. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205443 · Cited by 52
“…excises primarily 8-oxoG and faPy lesions and cleaves the DNA backbone 3' of the base; thus, incisions in DNA at Fpg sensitive sites generates singlestranded breaks, which can readily be detected in the gene speci®c repair assay as described previously (Anson and Bohr, 1999; Bohr et al., 1985).”
Self-citation
Human genetic instability syndromes: single gene defects with increased risk of cancer
Digweed, M. (1993) · Toxicology Letters · doi:10.1016/0378-4274(93)90061-2 · Cited by 50
Somatic cell genetics approach to dissecting mammalian DNA repair
Thompson, L. H. (1989) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850140409 · Cited by 51
STK19 positions TFIIH for cell-free transcription-coupled DNA repair
Mevissen, T. E. T., Kümmecke, M., Schmid, E. W., Farnung, L., & Walter, J. C. (2024) · Cell · doi:10.1016/j.cell.2024.10.020 · Cited by 50
Sequence specificity for removal of uracil from U·A pairs and U·G mismatches by uracil‐DNA glycosylase from Escherichia coli , and correlation with mutational hotspots
Nilsen, H. L., Yazdankhah, S. P., Eftedal, I., & Krokan, H. E. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00244-4 · Cited by 50
Removal of UV-induced DNA lesions in mouse epidermis soon after irradiation
Vink, A. A., Henegouwen, J. B. A. B., Nikaido, O., Baan, R. A., & Roza, L. (1994) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(94)07005-9 · Cited by 50
Histone Post-Translational Modifications in DNA Damage Response
Méndez-Acuña, L., Tomaso, M. V. D., Palitti, F., & Martínez‐López, W. (2010) · Cytogenetic and Genome Research · doi:10.1159/000296275 · Cited by 49
Transcriptional induction of Ty recombination in yeast.
Nevo‐Caspi, Y., & Kupiec, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12711 · Cited by 49
Leading strand specific spontaneous mutation corrects a quasipalindrome by an intermolecular strand switch mechanism
Rosche, W. A., Trinh, T. Q., & Sinden, R. R. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1034 · Cited by 49
Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs
Chouteau, J. M., Obiako, B. O., Gorodnya, O. M., Pastukh, V. M., Ruchko, M. V., Wright, A. J., Wilson, G. L., & Gillespie, M. N. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00210.2011 · Cited by 48
New Vision in Photoprotection and Photorepair
Leccia, M. ‐., Lebbé, C., Claudel, J., Narda, M., & Basset‐Séguin, N. (2019) · Dermatology and Therapy · doi:10.1007/s13555-019-0282-5 · Cited by 50
The Association Between Neuronal Nitric Oxide Synthase and Neuronal Sensitivity in the Brain After Brain Injury
Liu, P. K., Robertson, C. S., & Valadka, A. B. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04071.x · Cited by 48
Human Transcription Release Factor 2 Dissociates RNA Polymerases I and II Stalled at a Cyclobutane Thymine Dimer
Hara, R., Selby, C. P., Liu, M., Price, D. H., & Sancar, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24779 · Cited by 50
Repair of (6-4)photoproducts correlates with split-dose recovery in UV-irradiated normal and hypersensitive rodent cells
Mitchell, D. L., Humphrey, R. M., Adair, G. M., Thompson, L. H., & Clarkson, J. M. (1988) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(88)90007-7 · Cited by 48
Preferential DNA Repair in Expressed Genes
Hanawalt, P. C. (1987) · Environmental Health Perspectives · doi:10.1289/ehp.87769 · Cited by 48
Transcription-Coupled DNA Repair
Sweder, K., & Hanawalt, P. C. (1993) · Science · doi:10.1126/science.8211165 · Cited by 48
RNA Polymerase Bypass at Sites of Dihydrouracil: Implications for Transcriptional Mutagenesis
Liu, J., Zhou, W., & Doetsch, P. W. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6729 · Cited by 47
The Use of Recombinant DNA Techniques to Study Radiation-induced Damage, Repair and Genetic Change in Mammalian Cells
Thacker, J. (1986) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008614550391 · Cited by 47
Demethylation Enhances Removal of Pyrimidine Dimers from the Overall Genome and from Specific DNA Sequences in Chinese Hamster Ovary Cells
Ho, L., Bohr, V. A., & Hanawalt, P. C. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1594 · Cited by 47
Self-citation
Methodologies for detecting environmentally induced DNA damage and repair
Li, W., & Sancar, A. (2020) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22365 · Cited by 45
“…restriction enzymes to cut off specific DNA fragments, creates strand breaks at DNA lesion sites within the DNA fragments by repair enzymes, and measures the frequency of DNA lesions by hybridization with radioactive probe after alkaline gel electrophoresis (Bohr et al. 1985; Thomas et al. 1988).”
BackgroundMethod
Structural basis for transcription complex disruption by the Mfd translocase
Kang, J. Y., Llewellyn, E., Chen, J., Olinares, P. D. B., Brewer, J. J., Chait, B. T., Campbell, E. A., & Darst, S. A. (2021) · eLife · doi:10.7554/elife.62117 · Cited by 47
Inhibition of cyclobutane pyrimidine dimer formation in epidermal p53 gene of UV‐irradiated mice by α‐tocopherol
Chen, W., Barthelman, M., Martinez, J., Alberts, D. E., & Gensler, H. L. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514625 · Cited by 46
Location of the BCR‐ABL fusion gene on the 9q34 band in two cases of Ph‐positive chronic myeloid leukemia
Aurich, J., Dastugue, N., Duchayne, É., Schlaifer, D., Huguet, F., & Caballín, M. R. (1997) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199710)20:2 · Cited by 29
The Dose Dependence of Cyclobutane Dimer Induction and Repair in UVB-irradiated Human Keratinocytes¶
Greinert, R., Boguhn, O., Harder, D., Breitbart, E. W., Mitchell, D. L., & Volkmer, B. (2000) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2000)0720701tddocd2.0.co2 · Cited by 46
Roots: Mutation frequency decline revisited
Witkin, E. M. (1994) · BioEssays · doi:10.1002/bies.950160613 · Cited by 46
DNA Damage-induced Def1-RNA Polymerase II Interaction and Def1 Requirement for Polymerase Ubiquitylation in Vitro
Reid, J., & Svejstrup, J. Q. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400185200 · Cited by 46
The 26S proteasome negatively regulates the level of overall genomic nucleotide excision repair
Lommel, L. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.24.4839 · Cited by 46
“The incidence of cyclobutane pyrimidine dimers (CPDs) in each strand of the PvuI–PvuII restriction fragment of the RPB2 gene was determined by previously developed methods (30,31).”
Method
Hypersensitivity of skin fibroblasts from basal cell nevus syndrome patients to killing by ultraviolet B but not by ultraviolet C radiation.
Applegate, L. A., Goldberg, L. H., Ley, R. D., & Ananthaswamy, H. N. (1990) · PubMed · Cited by 46
DNA.RNA helicase activity of RAD3 protein of Saccharomyces cerevisiae.
Bailly, V., Sung, P., Prakash, L., & Prakash, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9712 · Cited by 46
Phenotypic heterogeneity within the first complementation group of UV-sensitive mutants of Chinese hamster cell lines
Zdzienicka, M. Z., van der Schans, G. P., Westerveld, A., van Zeeland, A. A., & Simons, J. W. I. M. (1988) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(88)90005-3 · Cited by 46
Reversible inhibition of gene expression by a psoralen functionalized triple helix forming oligonucleotide in intact cells
Degols, G., Clarenc, J. P., Lebleu, B., & Léonetti, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89479-6 · Cited by 46
RNA polymerase pausing, stalling and bypass during transcription of damaged DNA: from molecular basis to functional consequences
Agapov, A., Olina, A., & Kulbachinskiy, A. V. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac174 · Cited by 45
Initiation of DNA interstrand cross‐link repair in mammalian cells
Hlavin, E. M., Smeaton, M. B., & Miller, P. S. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20559 · Cited by 46
“…cells was initially identified by Hanawalt and coworkers in the mid 1980s with the observation of strand-preferential removal of pyrimidine dimers in the transcriptionally active DHFR gene [Bohr et al., 1985; Mellon et al., 1986], the mechanistic details of TC-NER are still being uncovered.”
When machines get stuck—obstructed RNA polymerase II: displacement, degradation or suicide
van den Boom, V., Jaspers, N. G. J., & Vermeulen, W. (2002) · BioEssays · doi:10.1002/bies.10150 · Cited by 45
Fast repair of O 6 -ethylguanine, but not O 6 -methylguanine, in transcribed genes prevents mutation of H- ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea
Engelbergs, J., Thomale, J., Galhoff, A., & Rajewsky, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1635 · Cited by 45
TATA Binding Protein Discriminates between Different Lesions on DNA, Resulting in a Transcription Decrease
Coin, F., Frit, P., Viollet, B., Salles, B., & Egly, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3907 · Cited by 45
Genetic complementation of UV-induced DNA repair in Chinese hamster ovary cells by the denV gene of phage T4.
Valerie, K. C., de Riel, J. K., & Henderson, E. E. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7656 · Cited by 45
Targeting Chromosomal Architectural HMGB Proteins Could Be the Next Frontier in Cancer Therapy
Mukherjee, A., & Vásquez, K. M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3066 · Cited by 43
STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
(2024) · doi:10.1016/j.cell.2024.10.018 · Cited by 44
Cross-Link Structure Affects Replication-Independent DNA Interstrand Cross-Link Repair in Mammalian Cells
Hlavin, E. M., Smeaton, M. B., Noronha, A. M., Wilds, C. J., & Miller, P. S. (2010) · Biochemistry · doi:10.1021/bi902169q · Cited by 44
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang, H., Dharmalingam, P., Vasquez, V., Mitra, J., Boldogh, I. R., Rao, K. S. J., Kent, T. A., MITRA, S. P., & Hegde, M. L. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.005 · Cited by 46
“[35], can be distinguished based on the difference in the initial DNA damage recognition, but utilizing the same excision and repair synthesis steps subsequently.”
Background
DNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells
Grimaldi, K. A., McAdam, S. R., Souhami, R. L., & Hartley, J. A. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.12.2311 · Cited by 44
Nucleotide Excision Repair
Thompson, L. H. (1998) · Humana Press eBooks · doi:10.1007/978-1-59259-455-9_18 · Cited by 44
Transcription-dependent and independent DNA excision repair pathways in human cells
Carreau, M., & Hunting, D. J. (1992) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(92)90043-3 · Cited by 44
Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage
Sweder, K., Verhage, R. A., Crowley, D. J., Crouse, G. F., Brouwer, J., & Hanawalt, P. C. (1996) · Genetics · doi:10.1093/genetics/143.3.1127 · Cited by 44
Rethinking transcription coupled DNA repair
Kamarthapu, V., & Nudler, E. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.12.005 · Cited by 42
Cockayne syndrome group B protein has novel strand annealing and exchange activities
Müftüoğlu, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj410 · Cited by 44
“Transcription blocking DNA lesions act as signals of DNA damage and recruit NER proteins to damaged regions of the genome (2,3).”
Background
Nucleotide distribution in gymnosperm nuclear sequences suggests a model for GC-content change in land-plant nuclear genomes
Jansson, S., Meyer-Gauen, G., Cerff, R., & Martin, W. F. (1994) · Journal of Molecular Evolution · doi:10.1007/bf00178247 · Cited by 43
“Though it has been known for some time that DNA repair in prokaryotes (Mellon and Hanawalt 1989) and eukaryotes ( Bohr et al. 1985 ) is more efficient in transcribed than in nontranscribed DNA, unequivocal evidence for the existence of transcriptionally coupled DNA repair synthesis in yeast and animals has only recent…”
Background
Do we know the cause of xeroderma pigmentosum?
Cleaver, J. E. (1990) · Carcinogenesis · doi:10.1093/carcin/11.6.875 · Cited by 42
Inhibition of transient gene expression in Chinese hamster ovary cells by cyclobutane dimers and (6-4) photoproducts in transfected ultraviolet-irradiated plasmid DNA
Mitchell, D. L., Vaughan, J. E., & Nairn, R. S. (1989) · Plasmid · doi:10.1016/0147-619x(89)90083-8 · Cited by 43
Examination of vectors with two dominant, selectable genes for DNA repair and mutation studies in mammalian cells
Debenham, P. G., Webb, M. B. T., Stretch, A., & Thacker, J. (1988) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(88)90240-0 · Cited by 43
Genes controlling nucleotide excision repair in eukaryotic cells
Weeda, G., Hoeijmakers, J. H. J., & Bootsma, D. (1993) · BioEssays · doi:10.1002/bies.950150405 · Cited by 43
Xeroderma Pigmentosum: A Model for Human Premature Aging
Rizza, E. R. H., DiGiovanna, J. J., Khan, S. G., Tamura, D., Jeskey, J., & Kraemer, K. H. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.012 · Cited by 43
“The functional TC-NER, on the other hand, promotes normal cell survival and aging by protecting against DNA damage-mediated disruption of transcription within actively transcribed genes, thus preventing loss of proliferation and cell death(Bohr et al., 1985; Marteijn et al., 2014; Mullenders, 2015; Spivak and Hanawalt…”
Background
A cassette of N-terminal amino acids of histone H2B are required for efficient cell survival, DNA repair and Swi/Snf binding in UV irradiated yeast
Chaudhuri, R. N., Kyriss, M., Smerdon, J. W., Wyrick, J. J., & Smerdon, M. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1074 · Cited by 42
Nucleotide Sequence Context Effect of a Cyclobutane Pyrimidine Dimer upon RNA Polymerase II Transcription
Tornaletti, S., Donahue, B. A., Reines, D., & Hanawalt, P. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31719 · Cited by 42
Repair of rDNA in Saccharomyces cerevisiae: RAD4-independent strand- specific nucleotide excision repair of RNA polymerase I transcribed genes
Verhage, R. A. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.6.1020 · Cited by 42
The molecular basis of nucleotide excision repair syndromes
Bootsma, D., & Hoeijmakers, J. H. J. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90273-9 · Cited by 42
Poly(ADP-ribosyl)ation, DNA strand breaks, chromatin and cancer
Boulikas, T. (1993) · Toxicology Letters · doi:10.1016/0378-4274(93)90051-x · Cited by 42
Molecular Cloning and Biological Characterization of a Human Gene, ERCC2, that Corrects the Nucleotide Excision Repair Defect in CHO UV5 Cells
Weber, C. A., Salazar, E. P., Stewart, S. A., & Thompson, L. H. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.3.1137-1146.1988 · Cited by 42
Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality
Yonemasu, R., Minami, M., Nakatsu, Y., TAKEUCHI, M., Kuraoka, I., Matsuda, Y., Higashi, Y., Kondoh, H., & Tanaka, K. (2005) · DNA repair · doi:10.1016/j.dnarep.2004.12.004 · Cited by 42
The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B mice.
Wijnhoven, S., Kool, H., van Oostrom, C. T. M., Beems, R. B., Lh, M., van Zeeland, A. A., van der Horst, G. T. J., Vrieling, H., & STEEG, H. V. (2000) · PubMed · Cited by 42
Repair in ribosomal RNA genes is deficient in xeroderma pigmentosum group C and in Cockayne's syndrome cells
Christians, F. C., & Hanawalt, P. C. (1994) · Mutation Research Letters · doi:10.1016/0165-7992(94)90031-0 · Cited by 41
Analysis and modulation of DNA repair in aging
Walter, C. A., Grabowski, D. T., Street, K. A., Conrad, C. C., & Richardson, A. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00108-5 · Cited by 40
Repair of Single-Stranded DNA Nicks, Gaps, and Loops in Mammalian Cells
Ayares, D., Ganea, D., Chekuri, L., Campbell, C., & Kucherlapati, R. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.5.1656 · Cited by 41
Carcinogenesis in human skin grafted to SCID mice.
Soballe, P. W., Montone, K. T., Satyamoorthy, K., Nesbit, M., & Herlyn, M. (1996) · PubMed · Cited by 41
Clues to the Organization of DNA Repair Systems Gained from Studies of Intragenomic Repair Heterogeneity
Smith, C. A., & Mellon, I. (1990) · Advances in mutagenesis research · doi:10.1007/978-3-642-74955-1_6 · Cited by 41
The Cartography of UV ‐induced DNA Damage Formation and DNA Repair
Hu, J., & Adar, S. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12668 · Cited by 41
“Using these sensitive and specific enzymatic approaches, Hanawalt and colleagues were able to first identify transcriptioncoupled repair in the DHFR gene locus (12), and the effect of”
Method
Polymerase Stalling during Replication, Transcription and Translation
Edenberg, E. R., Downey, M., & Toczyski, D. P. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.060 · Cited by 42
Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo[ a,l ]pyrene or its diol epoxides
Melendez-Colon, V. J., Smith, C. A., Seidel, A., Luch, A., Platt, K. L., & Baird, W. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13542 · Cited by 40
Adaptive enhancement and kinetics of nucleotide excision repair in humans
Ye, N., de Bianchi, M. S. A., Bianchi, N. O., & Holmquist, G. P. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00022-1 · Cited by 40
Use of the Comet-FISH Assay to Demonstrate Repair of theTP53Gene Region in Two Human Bladder Carcinoma Cell Lines
McKenna, D. J., Rajab, N. F., McKEOWN, S. R., McKerr, G., & McKelvey‐Martin, V. J. (2003) · Radiation Research · doi:10.1667/0033-7587(2003)159[0049:uotcfa]2.0.co;2 · Cited by 40
Genomic Heterogeneity of DNA Repair
Hanawalt, P. C., Gee, P., Ho, L., HSU, R. K., & Kane, C. J. M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38644.x · Cited by 40
DNA base changes and RNA levels in N-acetoxy-2-acetylaminofluorene-induced dihydrofolate reductase mutants of Chinese hamster ovary cells
Carothers, A. M., Steigerwalt, R. W., Urlaub, G., Chasin, L. A., & Grünberger, D. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90506-8 · Cited by 39
DNA Repair in Specific Sequences in Mammalian Cells
Smith, C. A. (1987) · Journal of Cell Science · doi:10.1242/jcs.1984.supplement_6.16 · Cited by 40
DNA repair at the level of the gene
Bohr, V. A., & Wassermann, K. (1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90216-2 · Cited by 40
Self-citation
Reprogramming transcription after DNA damage: recognition, response, repair, and restart
Lu, H., Yang, M., & Zhou, Q. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.11.010 · Cited by 40
The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61
Orren, D. K. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.17.3317 · Cited by 39
Cellular Resistance to Cancer Chemotherapy
Skovsgaard, T., Nielsen, D., Maare, C., & Wassermann, K. (1994) · International review of cytology · doi:10.1016/s0074-7696(08)62253-6 · Cited by 39
The genetic defect in DNA repair deficiency syndromes
Bootsma, D. (1993) · European Journal of Cancer · doi:10.1016/0959-8049(93)90026-c · Cited by 39
Preferential repair of ultraviolet light‐induced dna damage in the transcribed strand of the human p53 gene
Ford, J. M., Lommel, L., & Hanawalt, P. C. (1994) · Molecular Carcinogenesis · doi:10.1002/mc.2940100208 · Cited by 39
Gene-Specific and Strand-Specific DNA Repair in the G 1 and G 2 Phases of the Cell Cycle
Petersen, L. N., Orren, D. K., & Bohr, V. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3731 · Cited by 39
Self-citation
XPA-Mediated Regulation of Global Nucleotide Excision Repair by ATR Is p53-Dependent and Occurs Primarily in S-Phase
Li, Z., Musich, P. R., Serrano, M. A., Dong, Z., & Zou, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028326 · Cited by 38
DETECTION OF UVR‐INDUCED DNA DAMAGE IN MOUSE EPIDERMIS in vivo USING ALKALINE ELUTION
Kinley, J. S., Brunborg, G., Moan, J. E., & Young, A. R. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb03953.x · Cited by 36

Authors: Bohr, V
Affiliations: Stanford University (US)
Corresponding author: Bohr, V
ORCID: Bohr, V
Venue: Cell
Publisher: Elsevier BV
Published: 1985-02
Volume: 40
Issue: 2
Pages: 359-369
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(85)90150-3
OpenAlex: W1984353960
Cited by: 1,237
References: 34
Citations by year: 2026: 11 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 12 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 18 · 2017: 13 · 2016: 23 · 2015: 9 · 2014: 24 · 2013: 24 · 2012: 22
FWCI: 15.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 09901)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: DNA repair, pyrimidine dimers, dihydrofolate reductase gene, UV-induced DNA damage, UV endonuclease, UV resistance, CHO cells, mutagenesis, cell survival
MeSH terms: Animals, Base Sequence, Cell Line, Cell Survival, Cricetulus, DNA Repair, Endodeoxyribonucleases, Female, Cricetinae, Multienzyme Complexes, N-Glycosyl Hydrolases, Pyrimidine Dimers, Tetrahydrofolate Dehydrogenase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks