Photobiological Origins of the Field of Genomic Maintenance
Open accessAbstract
Although sunlight is essential for life on earth, the ultraviolet (UV) wavelengths in its spectrum constitute a major threat to life. Various cellular responses have evolved to deal with the damage inflicted in DNA by UV, and the study of these responses in model systems has spawned the burgeoning field of DNA repair. Although we now know of many types of deleterious alterations in DNA, the approaches for studying them and the early mechanistic insights have come in large part from pioneering research on the processing of UV‐induced bipyrimidine photoproducts in bacteria. It is also notable that UV was one of the first DNA damaging agents for which exposure was directly linked to cancer; the sun‐sensitive syndrome, xeroderma pigmentosum, was the first example of a cancer‐prone hereditary disease involving a defect in DNA repair. We provide a short history of advances in the broad field of genomic maintenance as they have emerged from research in photochemistry and photobiology.
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DNA and RNA are damaged by both ultraviolet and ionizing radiation.
“Both UV and ionizing radiation damage DNA and RNA.”
From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Ganesan and Hanawalt 2016
Radiation exposure would significantly challenge the development of an early nucleotide-based system because radiation damage harms the stability and fidelity of genetic material.
“Because radiation damage has strong negative consequences for the stability and fidelity of genetic material (Ganesan and Hanawalt 2016;Kladwang et al. 2012), radiation exposure would present a significant challenge in the development of an early nucleotide-based system.”
From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Ganesan and Hanawalt 2016
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Self-citationStrauss, B. S. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.9.1670 · Cited by 49 · see citing works
Ganesan, A. K. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.10.2753 · Cited by 49 · see citing works
Self-citationEstablishment of a monoclonal antibody recognizing ultraviolet light-induced (6-4) photoproducts
Mori, T., Matsunaga, T., Hirose, T., & Nikaido, O. (1988) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(88)90028-4 · Cited by 49 · see citing works
Effect of Sublethal Doses of Monochromatic Ultraviolet Radiation on Bacteria in Liquid Suspensions
Hollaender, A., & Curtis, J. T. (1935) · Experimental Biology and Medicine · doi:10.3181/00379727-33-8248p · Cited by 44 · see citing works
Endonuclease-sensitive sites in the DNA of irradiated bacteria: A rapid and sensitive assay
Wilkins, R. J. (1973) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(73)90049-x · Cited by 42 · see citing works
Ligation of oligonucleotides by pyrimidine dimers—a missing ‘link’ in the origin of life?
Lewis, R. J., & Hanawalt, P. C. (1982) · Nature · doi:10.1038/298393a0 · Cited by 42 · see citing works
Self-citationEmmons, C. W., & Hollaender, A. (1939) · American Journal of Botany · doi:10.1002/j.1537-2197.1939.tb09306.x · Cited by 42 · see citing works
Conversion of Biosynthetic Precursors of RNA to Those of DNA by Photoredox Chemistry
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Kinetics of pyrimidine(6-4)pyrimidone photoproduct repair in Escherichia coli
Koehler, D. R., Courcelle, J., & Hanawalt, P. C. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1347-1350.1996 · Cited by 34 · see citing works
Self-citationSur le mécanisme de la photodimérisation de la thymine
Mantione, M., & Pullman, B. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects · doi:10.1016/0926-6550(64)90068-4 · Cited by 32 · see citing works
Synthesis of nucleic acids in ultraviolet-treated Escherichia coli
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Differences in Pyrimidine Dimer Removal between Rat Skin Cells In Vitro and In Vivo
Mullaart, E., Lohman, P. H. M., & Vijg, J. (1988) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12456316 · Cited by 28 · see citing works
Cooper, P. K., & Hanawalt, P. C. (1971) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1971.tb06094.x · Cited by 27 · see citing works
Self-citationPhotosensitive human syndromes
Spivak, G., & Hanawalt, P. C. (2015) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2014.11.003 · Cited by 27 · see citing works
Self-citationHsu, P.-H., Hanawalt, P. C., & Nouspikel, T. P. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.06.008 · Cited by 26 · see citing works
Self-citationPrimordial soup that cooks itself
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Photoreactivation of macromolecular synthesis in Escherichia coli
Hanawalt, P. C., & Buehler, J. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90088-3 · Cited by 14 · see citing works
Self-citationOh, D. H., & Spivak, G. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6448-9_9 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [103]Mansbridge JN Hanawalt PC 1983 Domain-limited repair of DNA in ultraviolet irradiated fibroblasts from xeroderma pigmentosum complemetation group C Cellular Responses to DNA Damage, UCLA Symposium on Molecular and Cellular Biology 195 207
Cited by
Sorted by citations
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Transcription-coupled repair: An update
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Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor
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Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention
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Unbalanced Growth, the DNA Replication Cycle and Discovery of Repair Replication
Hanawalt, P. C. (2023) · Life · doi:10.3390/life13041052
Self-citationBarrera, C., & Fuentes, J. L. (2023) · FEMS Microbiology Letters · doi:10.1093/femsle/fnad108
- Authors
- Ganesan, A., & Hanawalt, P.
- Affiliations
- Stanford University (US)
- Corresponding author
- Hanawalt, Philip
- ORCID
- Hanawalt, Philip
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2015-12-16
- Volume
- 92
- Issue
- 1
- Pages
- 52-60
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- PMC
- PMC4720547
- OpenAlex
- W1858845501
- Cited by
- 22
- References
- 127
- Citations by year
- 2026: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Institutes of Health
- American Cancer Society
- U.S. Department of Energy
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- DNA repair, ultraviolet radiation, UV-induced DNA damage, xeroderma pigmentosum, photobiology, bacterial DNA repair
- MeSH terms
- Origin of Life, DNA Damage, DNA Repair, Humans, Neoplasms, Radiation-Induced, Ultraviolet Rays, Xeroderma Pigmentosum, Genome, Human, Genetic Predisposition to Disease
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