Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

Morse, JK; Wiegand, SJ; Anderson, K; You, Y; Cai, N; Carnahan, J; Miller, J; DiStefano, PS; Altar, CA; Lindsay, RM

doi:10.1523/jneurosci.13-10-04146.1993

Cited by 251Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsNuclear Receptors and Signaling

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

Open access

Morse, JK, Wiegand, SJ, Anderson, K, You, Y, Cai, N, Carnahan, J, Miller, J, DiStefano, PS +2 more·1993·The Journal of Neuroscience

DOI 10.1523/jneurosci.13-10-04146.1993PMC PMC6576390

Open this paper in CoChat — free account Open PDF

Abstract

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, supports the survival of developing basal forebrain cholinergic neurons in vitro and is retrogradely transported by cholinergic neurons of the medial septum and diagonal band following intrahippocampal injections in vivo. To substantiate a potential role for BDNF in the maintenance of forebrain cholinergic neurons in the adult brain, we assessed the ability of BDNF to sustain the phenotype of medial septal cholinergic neurons following a unilateral transection of the fimbria. BDNF, NGF, or vehicle solutions were infused continuously in adult female rats either into the lateral ventricle (intracerebroventricularly) or directly into the septum for 2 weeks beginning at the time of the transection. In vehicle-infused animals, only 28% of the ChAT-immunoreactive neurons remained on the side ipsilateral to the lesion compared to the contralateral intact side. When infused intracerebroventricularly, both BDNF and NGF reduced the extent of the phenotypic loss, in that 44% and 68%, respectively, of the ChAT-immunopositive neurons remained on the lesioned side. Intraseptal infusion proved even more effective, in that following BDNF and NGF treatment 60% and 86%, respectively, of the normal complement of ChAT-immunopositive neurons were apparent on the side ipsilateral to the lesion. Similar results were obtained when an antibody to the low- affinity NGF receptor was used to identify the cholinergic neurons. To determine if the apparent greater efficacy of NGF compared to BDNF might be related to differences in delivery, we examined the patterns of distribution of radiolabeled BDNF and NGF injected into the lateral ventricle. 125I-BDNF showed only very little diffusion from the ventricles into the adjacent neural tissue and negligible retrograde labeling of the neurons within the basal forebrain. 125I-NGF, however, diffused readily into the brain, resulting in widespread retrograde labeling of basal forebrain neurons. A similarly limited distribution pattern was observed where BDNF was detected immunohistochemically in animals infused intracerebroventricularly (12 micrograms/d) for 2 weeks. In contrast, when delivered intraseptally, the same dose of BDNF exhibited a widespread diffusion within the surrounding neuropil and retrograde labeling of neurons in the medial septum and the vertical limb of the diagonal band. Thus, when delivered effectively, BDNF has a substantial capacity to rescue axotomized cholinergic neurons.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.13-10-04146.1993

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

BDNF regulates neuron survival, plasticity, and synaptic function, plays an integral role in differentiation during development, is affected by stress, and is associated with major depression and suicidal behavior.
“Brain-derived neurotrophic factor (BDNF) regulates neuron survival, plasticity, and synaptic function (169-174), plays an integral role in differentiation during development (175, 176), is affected by stress (177), and is associated with major depression and suicidal behavior (178).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [174]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329 · see citing works
Molecular cloning and expression of brain-derived neurotrophic factor
Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H., & Barde, Y. (1989) · Nature · doi:10.1038/341149a0 · Cited by 1,458 · see citing works
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
Hefti, F. F. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,455 · see citing works
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Science · doi:10.1126/science.2321006 · Cited by 1,322 · see citing works
Self-citation
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression
Maisonpierre, P. C., Belluscio, L., Friedman, B., Alderson, R. F., Wiegand, S. J., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Neuron · doi:10.1016/0896-6273(90)90089-x · Cited by 1,234 · see citing works
Self-citation
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
Hohn, A., Leibrock, J., Bailey, K., & Barde, Y.-A. (1990) · Nature · doi:10.1038/344339a0 · Cited by 1,145 · see citing works
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.
Williams, L. R., Varon, S. S., Peterson, G. M., Wictorin, K., Fischer, W., Björklund, A., & Gage, F. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.9231 · Cited by 1,055 · see citing works
Regional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.
Hofer, M., Pagliusi, S. R., Hohn, A., Leibrock, J., & Barde, Y. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07423.x · Cited by 1,017 · see citing works
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary
Hallböök, F., Ibáñez, C. F., & Persson, H. (1991) · Neuron · doi:10.1016/0896-6273(91)90180-8 · Cited by 834 · see citing works
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
Squinto, S. P., Stitt, T. N., Aldrich, T. H., Davis, S. H., Blanco, S. M., Radziejewski, C. H., Glass, D. J., Masiakowski, P., Furth, M. E., Valenzuela, D. M., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90395-f · Cited by 830 · see citing works
Self-citation
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Raid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90396-g · Cited by 820 · see citing works
Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
Ernfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819 · see citing works
The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons
DiStefano, P. S., Friedman, B., Radziejewski, C. H., Alexander, C., Boland, P. S., Schick, C., Lindsay, R. M., & Wiegand, S. J. (1992) · Neuron · doi:10.1016/0896-6273(92)90213-w · Cited by 742 · see citing works
Self-citation
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
Klein, R., Conway, D., Parada, L. F., & Barbacid, M. (1990) · Cell · doi:10.1016/0092-8674(90)90476-u · Cited by 740 · see citing works
Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
Alderson, R. F., Alterman, A. L., Barde, Y., & Lindsay, R. M. (1990) · Neuron · doi:10.1016/0896-6273(90)90166-d · Cited by 685 · see citing works
Self-citation
Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.
Knüsel, B., Winslow, J. W., Rosenthal, A., Burton, L. E., Seid, D. P., Nikolics, K., & Hefti, F. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.961 · Cited by 603 · see citing works
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
Klein, R., Parada, L. F., Coulier, F., & Barbacid, M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08545.x · Cited by 598 · see citing works
Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat
Seiler, M. J., & Schwab, M. E. (1984) · Brain Research · doi:10.1016/0006-8993(84)91338-6 · Cited by 592 · see citing works
Primary structure and biological activity of a novel human neurotrophic factor
Rosenthal, A., Goeddel, D. V., Nguyen, T., Lewis, M., Shih, A., Laramee, G. R., Nikolics, K., & Winslow, J. W. (1990) · Neuron · doi:10.1016/0896-6273(90)90203-r · Cited by 556 · see citing works
Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons
PHILLIPS, H. S., Hains, J. M., Laramee, G. R., Rosenthal, A., & Winslow, J. W. (1990) · Science · doi:10.1126/science.1688328 · Cited by 532 · see citing works
The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
Cordon‐Cardo, C., Tapley, P. M., Jing, S., Nanduri, V., O’Rourke, E. C., Lamballe, F., Kovary, K., Klein, R., Jones, K. R., Reichardt, L. F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90149-s · Cited by 520 · see citing works
A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.
Chandler, C. E., Parsons, L. M., Hosang, M., & Shooter, E. M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39810-1 · Cited by 496 · see citing works
Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system
McKinney, M., Coyle, J. T., & Hedreen, J. C. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902170109 · Cited by 463 · see citing works
A modified histochemical technique to visualize acetylcholinesterase-containing axons.
Hedreen, J. C., Bacon, S. J., & Price, D. L. (1985) · Journal of Histochemistry & Cytochemistry · doi:10.1177/33.2.2578498 · Cited by 434 · see citing works
Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra
Schwab, M. E., Otten, U., Agid, Y., & Thoenen, H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90303-2 · Cited by 416 · see citing works
Cellular localization of nerve growth factor synthesis by in situ hybridization.
Bandtlow, C. E., Heumann, R., Schwab, M. E., & Thoenen, H. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb04835.x · Cited by 343 · see citing works
Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease
Goedert, M., Fine, A., Hunt, S. P., & Ullrich, A. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90023-9 · Cited by 338 · see citing works
Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF
Ip, N. Y., Li, Y., Yancopoulos, G. D., & Lindsay, R. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03394.1993 · Cited by 330 · see citing works
Self-citation
Development of Septal Cholinergic Neurons in Culture: Plating Density and Glial Cells Modulate Effects of NGF on Survival, Fiber Growth, and Expression of Transmitter-Specific Enzymes
Hartikka, J., & Hefti, F. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02967.1988 · Cited by 317 · see citing works
Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures
Honegger, P., & Lenoir, D. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90023-2 · Cited by 293 · see citing works
Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo.
Altar, C. A., Boylan, C. B., Jackson, C., Hershenson, S., Miller, J., Wiegand, S. J., Lindsay, R. M., & Hyman, C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11347 · Cited by 275 · see citing works
Self-citation
Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria‐fornix transection
Batchelor, P., Armstrong, D. M., Blaker, S. N., & Gage, F. H. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840204 · Cited by 251 · see citing works
Nerve growth factor in mouse and rat serum: correlation between bioassay and radioimmunoassay determinations.
Suda, K., Barde, Y., & Thoenen, H. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.8.4042 · Cited by 245 · see citing works
Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neurons
Hagg, T., Fass-Holmes, B., Vahlsing, H. L., Manthorpe, M., Conner, J. M., & Varon, S. S. (1989) · Brain Research · doi:10.1016/0006-8993(89)90112-1 · Cited by 193 · see citing works
Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy
Springer, J. E., Koh, S., Tayrien, M. W., & Loy, R. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490170204 · Cited by 191 · see citing works
Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease
Hefti, F. F., & Mash, D. C. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80014-4 · Cited by 168 · see citing works
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
Maisonpierre, P. C., Belluscio, L., Squinto, S. P., et al. (1990) · Science · doi:10.1126/science.247.4949.1446 · Cited by 167 · see citing works
NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease
Higgins, G. A., & Mufson, E. J. (1989) · Experimental Neurology · doi:10.1016/0014-4886(89)90155-6 · Cited by 158 · see citing works
Two‐color immunoperoxidase staining: Visualization of anatomic relationships between immunoreactive neural elements
Hancock, M. B. (1986) · American Journal of Anatomy · doi:10.1002/aja.1001750216 · Cited by 141 · see citing works
Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies.
Wetmore, C., Cao, Y. H., Pettersson, R. F., & Olson, L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9843 · Cited by 140 · see citing works
Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease
Goedert, M., Fine, A., Dawbarn, D., Wilcock, G. K., & Chao, M. V. (1989) · Molecular Brain Research · doi:10.1016/0169-328x(89)90011-9 · Cited by 130 · see citing works
Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment.
Ceccatelli, S., Ernfors, P., Villar, M. J., Persson, H., & Hökfelt, T. G. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10352 · Cited by 126 · see citing works
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients
Kordower, J. H., Gash, D. M., Bothwell, M. A., Hersh, L. B., & Mufson, E. J. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80013-2 · Cited by 117 · see citing works
Receptor‐mediated retrograde transport in CNS neurons after intraventricular administration of NGF and growth factors
Ferguson, I. A., Schweitzer, J. B., Bartlett, P. F., & Johnson, E. M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130411 · Cited by 100 · see citing works
Fine structure of rat septohippocampal neurons: II. A time course analysis following axotomy
Naumann, T., Peterson, G. M., & Frotscher, M. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903250207 · Cited by 87 · see citing works
Characterization and topography of high-affinity 125I-neurotrophin-3 binding to mammalian brain
Altar, C. A., Criden, M., Lindsay, R. M., & DiStefano, P. S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00733.1993 · Cited by 58 · see citing works
Self-citation
Brain-Derived Neurotrophic Factor: An NGF-Related Neurotrophin
Lindsay, R. M. (1993) · Elsevier eBooks · doi:10.1016/b978-0-08-057132-4.50012-5 · Cited by 48 · see citing works
Self-citation
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients
Kordower, J. H., Gash, D. M., Bothwell, M. A., Hersh, L. B., & Mufson, E. J. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90068-7 · Cited by 40 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Ip NY, Li Y, Yancopoulos GD, Lindsay RM (1993) Cultured hip- pocampal neurons show responses to BDNF, NT3, and NT4 but not NGF. J Neurosci, in press.

Sorted by citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
Holash, J. A., Maisonpierre, P. C., Compton, D. L., Boland, P., Alexander, C., Zagzag, D., Yancopoulos, G. D., & Wiegand, S. J. (1999) · Science · doi:10.1126/science.284.5422.1994 · Cited by 2,181 · see citing works
Self-citation
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works
Excitotoxicity and stroke: Identifying novel targets for neuroprotection
Lai, T. W., Zhang, S., & Wang, Y. T. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.006 · Cited by 1,106 · see citing works
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works
Neurotrophic factors: from molecule to man
Lindsay, R. M., Wiegand, S. J., Altar, C. A., & DiStefano, P. S. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90099-x · Cited by 789 · see citing works
Self-citation
Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
Mufson, E. J., Counts, S., Perez, S. E., & Ginsberg, S. D. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.11.1703 · Cited by 589 · see citing works
Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor.
Sohrabji, F., Miranda, R. C., & Toran‐Allerand, C. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11110 · Cited by 560 · see citing works
Delivery of Neurotrophic Factors to the Central Nervous System: Pharmacokinetic Considerations
Thorne, R. G., & Frey, W. H. (2001) · Clinical Pharmacokinetics · doi:10.2165/00003088-200140120-00003 · Cited by 487 · see citing works
Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling
Eide, F. F., Vining, E. R., Eide, B. L., Zang, K., Wang, X., & Reichardt, L. F. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03123.1996 · Cited by 473 · see citing works
Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain
Mamounas, L., Blue, M., Siuciak, J. A., & Altar, C. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07929.1995 · Cited by 471 · see citing works
Self-citation
Immunocytochemical localization of TrkB in the central nervous system of the adult rat
Yan, Q., Radeke, M. J., Matheson, C. R., Talvenheimo, J., Welcher, A. A., & Felnstein, S. C. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970203)378:1 · Cited by 428 · see citing works
Noradrenergic mechanisms in neurodegenerative diseases: a theory
Marien, M. R., Colpaert, F. C., & Rosenquist, A. C. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.02.002 · Cited by 411 · see citing works
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J. N., Nehama, D., Rajadas, J., & Longo, F. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41356 · Cited by 406 · see citing works
Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF
Mitsumoto, H., Ikeda, K., Klinkosz, B., Cedarbaum, J. M., Wong, V., & Lindsay, R. M. (1994) · Science · doi:10.1126/science.8066451 · Cited by 386 · see citing works
Self-citation
Quantitative analysis of the olfactory pathway for drug delivery to the brain
Thorne, R. G., Emory, C. R., Ala, T. A., & Frey, W. H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00637-6 · Cited by 352 · see citing works
Characteristics of BDNF-induced weight loss
Pelleymounter, M. A., Cullen, M. J., & Wellman, C. L. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90045-4 · Cited by 321 · see citing works
Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex
Croll, S. D., Suri, C., Compton, D. L., Simmons, M. V., Yancopoulos, G. D., Lindsay, R. M., Wiegand, S. J., Rudge, J., & Scharfman, H. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00296-1 · Cited by 310 · see citing works
Self-citation
Brain-Derived Neurotrophic Factor Triggers Transcription-Dependent, Late Phase Long-Term PotentiationIn Vivo
Messaoudi, E., Ying, S., Kanhema, T., Croll, S. D., & Bramham, C. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07453.2002 · Cited by 297 · see citing works
Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases
Mufson, E. J., Kroin, J. S., Sendera, T. J., & Sobreviela, T. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00059-8 · Cited by 296 · see citing works
Estrogen–BDNF interactions: Implications for neurodegenerative diseases
Sohrabji, F., & Lewis, D. K. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.09.003 · Cited by 284 · see citing works
Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats
Mu, J.-S., Li, W., Yao, Z., & Zhou, X. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01592-9 · Cited by 282 · see citing works
Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson’s disease
Levivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274 · see citing works
TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders
Gupta, V., You, Y., Gupta, V. B., Klistorner, A. I., & Graham, S. L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510122 · Cited by 259 · see citing works
Self-citation
The Role of Estrogen in Brain and Cognitive Aging
Russell, J. K., Jones, C. K., & Newhouse, P. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00766-9 · Cited by 257 · see citing works
Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain
Nawa, H., Pelleymounter, M., & Carnahan, J. F. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03751.1994 · Cited by 235 · see citing works
Self-citation
A brain-centric model of suicidal behavior
Mann, J. J., & Rizk, M. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20081224 · Cited by 214 · see citing works
Regulation of Neuropeptides in Adult Rat Forebrain by the Neurotrophins BDNF and NGF
Croll, S. D., Wiegand, S. J., Anderson, K. D., Lindsay, R. M., & Nawa, H. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00325.x · Cited by 209 · see citing works
Self-citation
Distribution of nerve growth factor following direct delivery to brain interstitium
Krewson, C. E., Klarman, M. L., & Saltzman, W. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00261-n · Cited by 201 · see citing works
Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer’s dementia
Wang, R., & Holsinger, R. M. D. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.10.002 · Cited by 194 · see citing works
In Situ Hybridization of trkB and trkC Receptor mRNA in Rat Forebrain and Association with High‐affinity Binding of [125I]BDNF, [125I]NT‐4/5 and [125I]NT‐3
Altar, C. A., Siuciak, J. A., Wright, P., Ip, N. Y., Lindsay, R. M., & Wiegand, S. J. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb01001.x · Cited by 189 · see citing works
Self-citation
Marked age‐dependent neuroprotection by brain‐derived neurotrophic factor against neonatal hypoxic—ischemic brain injury
Cheng, Y. D., Gidday, J. M., Yan, Q., Shah, A. R., & Holtzman, D. M. (1997) · Annals of Neurology · doi:10.1002/ana.410410416 · Cited by 185 · see citing works
VEGF-mediated inflammation precedes angiogenesis in adult brain
Croll, S. D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.02.010 · Cited by 184 · see citing works
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide
Youssef, M. M., Underwood, M. D., Huang, Y.-Y., Hsiung, S.-C., Liu, Y., Simpson, N. R., Bakalian, M. J., Rosoklija, G. B., Dwork, A. J., Arango, V., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy008 · Cited by 183 · see citing works
An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease
Murer, M. G., Boissière‐Michot, F., Yan, Q., Hunot, S., Villares, J., Faucheux, B. A., Agid, Y., Hirsch, É. C., & Raisman‐Vozari, R. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00219-x · Cited by 176 · see citing works
Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor.
Fischer, W., Sirevaag, A. M., Wiegand, S. J., Lindsay, R. M., & Björklund, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8607 · Cited by 170 · see citing works
Self-citation
Differential distribution of exogenous BDNF, NGF, and NT‐3 in the brain corresponds to the relative abundance and distribution of high‐affinity and low‐affinity neurotrophin receptors
Anderson, K. D., Alderson, R. F., Altar, C. A., DiStefano, P. S., Corcoran, T. L., Lindsay, R. M., & Wiegand, S. J. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903570209 · Cited by 169 · see citing works
Self-citation
Targeting synapse function and loss for treatment of neurodegenerative diseases
Dejanovic, B., Sheng, M., & Hanson, J. E. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00823-1 · Cited by 168 · see citing works
Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system
Berhow, M. T., Russell, D., Terwilliger, R. Z., Beitner‐Johnson, D., Self, D. W., Lindsay, R. M., & Nestler, E. J. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00207-y · Cited by 163 · see citing works
Self-citation
Lesion-induced plasticity of central neurons: sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion
Deller, T., & Frotscher, M. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00044-0 · Cited by 162 · see citing works
Hyperexcitability in Combined Entorhinal/Hippocampal Slices of Adult Rat After Exposure to Brain-Derived Neurotrophic Factor
Scharfman, H. E. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.2.1082 · Cited by 162 · see citing works
Fluctuations in relative levels of choline acetyltransferase mRNA in different regions of the rat basal forebrain across the estrous cycle: effects of estrogen and progesterone
Gibbs, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01049.1996 · Cited by 161 · see citing works
HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice
Roy, A., Jana, M., Kundu, M., Corbett, G. T., Rangaswamy, S. B., Mishra, R. K., Luan, C., Gonzalez, F. J., & Pahan, K. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.022 · Cited by 160 · see citing works
Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain
Martı́nez-Serrano, A., Fischer, W., & Björklund, A. (1995) · Neuron · doi:10.1016/0896-6273(95)90051-9 · Cited by 157 · see citing works
Neurotrophic factor therapy for Parkinson’s disease
Rangasamy, S. B., Soderstrom, K. E., Bakay, R. A. E., & Kordower, J. H. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)84013-0 · Cited by 155 · see citing works
TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury
Wang, Y., Liang, J., Xu, B., Yang, J., Wu, Z., & Cheng, L. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122282 · Cited by 152 · see citing works
Endogenous BDNF Protein Is Increased in Adult Rat Hippocampus after a Kainic Acid Induced Excitotoxic Insult but Exogenous BDNF Is Not Neuroprotective
Rudge, J. S., Mather, P. E., Pasnikowski, E. M., Cai, N., Corcoran, T. L., Acheson, A. L., Anderson, K., Lindsay, R. M., & Wiegand, S. J. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6737 · Cited by 147 · see citing works
Self-citation
Target Identification for CNS Diseases by Transcriptional Profiling
Altar, C. A., Vawter, M. P., & Ginsberg, S. D. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.172 · Cited by 139 · see citing works
Self-citation
COMPARATIVE STUDY OF BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER RNA AND PROTEIN AT THE CELLULAR LEVEL SUGGESTS MULTIPLE ROLES IN HIPPOCAMPUS, STRIATUM AND CORTEX
Schmidt‐Kastner, R., Wetmore, C., & OLSON, L. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00093-0 · Cited by 139 · see citing works
Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain
Kawamoto, Y., Nakamura, S., Nakano, S., Oka, N., Akiguchi, I., & Kimura, J. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00245-x · Cited by 137 · see citing works
Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease
Salehi, A., Verhaagen, J., Dijkhuizen, P. A., & Swaab, D. F. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00273-4 · Cited by 135 · see citing works
Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine
French, S. J., Humby, T., Horner, C. H., Sofroniew, M. V., & Rattray, M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00048-0 · Cited by 134 · see citing works
The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology
Nemoto, K., Ohnishi, T., Mori, T., Moriguchi, Y., Hashimoto, R., Asada, T., & Kunugi, H. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.067 · Cited by 131 · see citing works
TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice
Qin, X., Zhao, Y., Zhang, T., Yin, C., Qiao, J., Guo, W., & Lu, B. (2022) · Nature Communications · doi:10.1038/s41467-022-28611-2 · Cited by 129 · see citing works
Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer
Klein, R. L., Lewis, M. H., Muzyczka, N., & Meyer, E. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02116-2 · Cited by 128 · see citing works
Neurotrophic factors and Alzheimer’s disease: are we focusing on the wrong molecule?
Fahnestock, M. L., Garzón, D. V., Holsinger, R. M. D., & Michalski, B. (2002) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6139-5_22 · Cited by 125 · see citing works
THE ACTION OF NEUROTROPHINS IN THE DEVELOPMENT AND PLASTICITY OF THE VISUAL CORTEX
Cellerino, A., & Maffei, L. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(96)00008-1 · Cited by 122 · see citing works
Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts
Sauer, H., Fischer, W., Nikkhah, G., Wiegand, S. J., Brundin, P., Lindsay, R. M., & Björklund, A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90560-a · Cited by 121 · see citing works
Self-citation
Expression and function of TrkB variants in developing sensory neurons.
Ninkina, N. N., Adu, J., Fischer, A., Piñón, L. G. P., Buchman, V. L., & Davies, A. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01029.x · Cited by 112 · see citing works
Profound and Selective Loss of Catalytic TrkB Immunoreactivity in Alzheimer's Disease
Allen, S. J., Wilcock, G. K., & Dawbarn, D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1561 · Cited by 111 · see citing works
Actions of Brain-Derived Neurotrophic Factor in Slices from Rats with Spontaneous Seizures and Mossy Fiber Sprouting in the Dentate Gyrus
Scharfman, H. E., Goodman, J. H., & Sollas, A. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05619.1999 · Cited by 110 · see citing works
Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine
Ando, S., Kobayashi, S., Waki, H., Kon, K., Fukui, F., Tadenuma, T., Iwamoto, M., Takeda, Y., Izumiyama, N., Watanabe, K., et al. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10443 · Cited by 110 · see citing works
THE FIMBRIA-FORNIX/CINGULAR BUNDLE PATHWAYS: A REVIEW OF NEUROCHEMICAL AND BEHAVIOURAL APPROACHES USING LESIONS AND TRANSPLANTATION TECHNIQUES
Cassel, J., Duconseille, E., Jeltsch‐David, H., & Will, B. E. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00009-9 · Cited by 110 · see citing works
Region- and peptide-specific regulation of the neurotrophins by estrogen
Jezierski, M., & Sohrabji, F. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00244-8 · Cited by 108 · see citing works
Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75
Peterson, D. A., Dickinson-Anson, H., Leppert, J. T., Lee, K., & Gage, F. H. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990201)404:1 · Cited by 107 · see citing works
BDNF Is Needed for Postnatal Maturation of Basal Forebrain and Neostriatum Cholinergic Neurons In Vivo
Ward, N. L., & Hagg, T. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7346 · Cited by 106 · see citing works
Neurotrophins as Mediators of Drug Effects on Mood, Addiction, and Neuroprotection
Ċastrén, E. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:3:289 · Cited by 105 · see citing works
Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and Schwann cells in vitro
Alderson, R. F., Curtis, R., Alterman, A. L., Lindsay, R. M., & DiStefano, P. S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02428-8 · Cited by 104 · see citing works
Self-citation
Fetal Spinal Cord Transplants Rescue Some Axotomized Rubrospinal Neurons from Retrograde Cell Death in Adult Rats
Mori, F., Himes, B. T., Kowada, M., Murray, M., & Tessler, A. R. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6318 · Cited by 104 · see citing works
Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice
Matsui, N., Takahashi, K., Takeichi, M., Kuroshita, T., Noguchi, K., Yamazaki, K., Tagashira, H., Tsutsui, K., Okada, H., Kido, Y., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.107 · Cited by 103 · see citing works
Chronic ethanol administration decreases brain-derived neurotrophic factor gene expression in the rat hippocampus
MacLennan, A. J., Leea, N., & Walker, D. W. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11922-j · Cited by 103 · see citing works
Effects of BDNF Infusion on the Regulation of TrkB Protein and Message in Adult Rat Brain
Frank, L., Wiegand, S. J., Siuciak, J. A., Lindsay, R. M., & Rudge, J. S. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6440 · Cited by 101 · see citing works
Self-citation
Possible Mechanisms of Neurodegeneration in Schizophrenia
Pérez‐Neri, I., Ramírez‐Bermúdez, J., Montes, S., & Rı́os, C. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9162-3 · Cited by 100 · see citing works
Transport and elimination of recombinant human NGF during long-term delivery to the brain
Krewson, C. E., & Saltzman, W. M. (1996) · Brain Research · doi:10.1016/0006-8993(96)00378-2 · Cited by 99 · see citing works
A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E ε4 allele
Riemenschneider, M. J., Schwarz, S., Wagenpfeil, S., Diehl, J., Müller, U., Förstl, H., & Kurz, A. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001073 · Cited by 98 · see citing works
Three‐dimensional reconstruction of the antennal lobe in Drosophila melanogaster
Laissue, P. P., Reiter, C., Hiesinger, P. R., Halter, S., Fischbach, K. F., & Stocker, R. F. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990322)405:4 · Cited by 421 · see citing works
Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults
Richter‐Schmidinger, T., Alexopoulos, P., Horn, M., Maus, S., Reichel, M., Rhein, C., Lewczuk, P., Sidiropoulos, C., Kneib, T., Perneczky, R., et al. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0539-8 · Cited by 93 · see citing works
IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice
Mellott, T. J., Pender, S. M., Burke, R. M., Langley, E. A., & Blusztajn, J. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094287 · Cited by 93 · see citing works
BDNF Up‐Regulates TrkB Protein and Prevents the Death of CA1 Neurons Following Transient Forebrain Ischemia
Ferrer, I., Ballabriga, J., Martı́, E., Pérez, E., Alberch, J., & Arenas, E. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00151.x · Cited by 91 · see citing works
Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase
Kim, S. H., Won, S. J., Sohn, S., Kwon, H. J., Lee, J. Y., Park, J.-H., & Gwag, B. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112131 · Cited by 90 · see citing works
Pegylated Brain-Derived Neurotrophic Factor Shows Improved Distribution into the Spinal Cord and Stimulates Locomotor Activity and Morphological Changes after Injury
Ankeny, D. P., McTigue, D. M., Guan, Z., Yan, Q., Kinstler, O. B., Stokes, B. T., & Jakeman, L. B. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7699 · Cited by 89 · see citing works
Neuroprotection of Spinal Motoneurons Following Targeted Transduction with an Adenoviral Vector Carrying the Gene for Glial Cell Line-Derived Neurotrophic Factor
Baumgartner, B. J., & Shine, H. D. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6878 · Cited by 89 · see citing works
BDNF Produces Analgesia in the Formalin Test and Modifies Neuropeptide Levels in Rat Brain and Spinal Cord Areas Associated With Nociception
Siuciak, J. A., Wong, V., Pearsall, D., Wiegand, S. J., & Lindsay, R. M. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00670.x · Cited by 88 · see citing works
Self-citation
Fluid Percussion Injury Causes Loss of Forebrain Choline Acetyltransferase and Nerve Growth Factor Receptor Immunoreactive Cells in the Rat
LEONARD, J. R., Maris, D. O., & Grady, M. S. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.379 · Cited by 87 · see citing works
Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferase and Trk receptor levels in the adult rat basal forebrain
Klein, R. L., Muir, D. F., King, M. A., Peel, A. L., Zolotukhin, S., Möller, J. C., Krüttgen, A., Heymach, J. V., Muzyczka, N., & Meyer, E. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00537-5 · Cited by 84 · see citing works
Cortical spreading depression induces long-term alterations of BDNF levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance
Kawahara, N., Croll, S. D., Wiegand, S. J., & KLATZO, I. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00069-2 · Cited by 83 · see citing works
Self-citation
Overexpression of neuropeptide Y induced by brain‐derived neurotrophic factor in the rat hippocampus is long lasting
Reibel, S., VIVIEN‐ROELS, B., Pham-Lê, B.-T., Larmet, Y., Carnahan, J. F., Marescaux, C., & Depaulis, A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00941.x · Cited by 82 · see citing works
Self-citation
Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits
Blaha, G. R., Raghupathi, R., Saatman, K. E., & McIntosh, T. K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00214-1 · Cited by 80 · see citing works
Aging-related magnification of genetic effects on cognitive and brain integrity
Papenberg, G., Lindenberger, U., & Bäckman, L. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.06.008 · Cited by 77 · see citing works
GDNF delivery for Parkinson’s disease
Patel, N. K., & Gill, S. S. (2007) · Springer eBooks · doi:10.1007/978-3-211-33081-4_16 · Cited by 77 · see citing works
Differential regulation of neurotrophin expression in basal forebrain astrocytes by neuronal signals
Wu, H., Friedman, W., & Dreyfus, C. F. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20060 · Cited by 76 · see citing works
Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript
Berchtold, N. C., Oliff, H. S., Isackson, P. J., & Cotman, C. W. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00137-0 · Cited by 75 · see citing works
Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis
Ranuh, R. G., Athiyyah, A. F., Darma, A., Risky, V. P., Riawan, W., SURONO, I. S., & Sudarmo, S. M. (2019) · Iranian Journal of Microbiology · doi:10.18502/ijm.v11i2.1077 · Cited by 74 · see citing works
Cell-Mediated Delivery of Brain-Derived Neurotrophic Factor Enhances Dopamine Levels in an Mpp+ Rat Model of Substantia Nigra Degeneration
Galpern, W. R., Frim, D. M., Tatter, S. B., Altar, C. A., Beal, M. F., & Isacson, O. (1996) · Cell Transplantation · doi:10.1016/0963-6897(95)02030-6 · Cited by 74 · see citing works
Self-citation
Diffusion of Nerve Growth Factor in Rat Striatum as Determined by Multiphoton Microscopy
Stroh, M., Zipfel, W. R., Williams, R. M., Webb, W. W., & Saltzman, W. M. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74502-0 · Cited by 73 · see citing works
Brain-derived neurotrophic factor-transduced fibroblasts: Production of BDNF and effects of grafting to the adult rat brain
Lucidi‐Phillipi, C. A., Gage, F. H., Shults, C. W., Jones, K. R., Reichardt, L. F., & Kang, U. J. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903540306 · Cited by 72 · see citing works
Recent Developments in the Drug Treatment of Alzheimer??s Disease
Sramek, J. J., & Cutler, N. R. (1999) · Drugs & Aging · doi:10.2165/00002512-199914050-00004 · Cited by 72 · see citing works
Inhibition of axonal growth from sensory neurons by excess nerve growth factor
Conti, A. M. F., Fischer, S. J., & Windebank, A. J. (1997) · Annals of Neurology · doi:10.1002/ana.410420604 · Cited by 70 · see citing works
Brain-derived neurotrophic factor prevents the loss of nigral neurons induced by excitotoxic striatal-pallidal lesions
Volpe, B. T., Wildmann, J., & Altar, C. A. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00424-7 · Cited by 70 · see citing works
Self-citation
Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic–Ischemic Stroke
Han, J., Pollak, J., Yang, T., Siddiqui, M. R., Doyle, K. P., Taravosh-Lahn, K., Cekanaviciute, E., Han, A., Goodman, J. Z., Jones, B., et al. (2012) · Stroke · doi:10.1161/strokeaha.111.641878 · Cited by 69 · see citing works

BDNF protection of basal forebrain cholinergic neurons after axotomy
Widmer, H. R., Knüsel, B., & Hefti, F. F. (1993) · Neuroreport · doi:10.1097/00001756-199304000-00005 · Cited by 58 · see citing works
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J Neurosci 6:2155–2162
Hefti, F. F. (1986)
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
Hefti, F. F. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,455 · see citing works
Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment
Montero‐Menei, C. N., & Hefti, F. F. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02986.1988 · Cited by 211 · see citing works
Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
Knüsel, B., Beck, K., Winslow, J. W., Rosenthal, A., Burton, L., Widmer, H., Nikolics, K., & Hefti, F. F. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04391.1992 · Cited by 278 · see citing works

Authors: Morse, J., Wiegand, S., Anderson, K., You, Y., Cai, N., Carnahan, J., Miller, J., DiStefano, P., Altar, C., & Lindsay, R.
Affiliations: Regeneron (United States) (US)
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1993-10-01
Volume: 13
Issue: 10
Pages: 4146-4156
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.13-10-04146.1993
PMC: PMC6576390
OpenAlex: W1565095682
Cited by: 251
References: 47
Citations by year: 2026: 2 · 2025: 1 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 4
FWCI: 7.44
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords: brain-derived neurotrophic factor, neurotrophins, medial septum, cholinergic neurons, neurodegeneration, nerve growth factor, choline acetyltransferase, low-affinity NGF receptor, intracerebroventricular infusion, retrograde transport, basal forebrain, neuroprotection
MeSH terms: Animals, Brain, Cerebral Ventricles, Choline O-Acetyltransferase, Female, Humans, Injections, Intraventricular, Nerve Degeneration, Nerve Growth Factors, Nerve Tissue Proteins, Neurons, Recombinant Proteins, Prosencephalon, Rats, Sprague-Dawley, Receptors, Nerve Growth Factor, Brain-Derived Neurotrophic Factor, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks