Cited by 604Hair Growth and DisordersFibroblast Growth Factor Researchdental development and anomalies

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FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

Hébert, Jean M., Rosenquist, Thomas, Götz, Jürgen, Martin, Gail R.·1994·Cell

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Abstract

Fibroblast growth factor 5 (FGF5) is a secreted signaling protein. Mice homozygous for a predicted null allele of the Fgf5 gene, fgf5neo, produced by gene targeting in embryonic stem cells, have abnormally long hair. This phenotype appears identical to that of mice homozygous for the spontaneous mutation angora (go). The fgf5neo and go mutations fail to complement one another, and exon 1 of Fgf5 is deleted in DNA from go homozygotes, demonstrating that go is a mutant allele of Fgf5. Expression of Fgf5 is detected in hair follicles from wild-type mice and is localized to the outer root sheath during the anagen VI phase of the hair growth cycle. These findings provide evidence that FGF5 functions as an inhibitor of hair elongation, thus identifying a molecule whose normal function is apparently to regulate one step in the progression of the follicle through the hair growth cycle.

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Genomic sequencing.
Church, G. M., & Gilbert, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1991 · Cited by 8,213
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., & Roder, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8424 · Cited by 2,328
Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Altering the Genome by Homologous Recombination
Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037
The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium
Doetschman, T., Eistetter, H. R., Katz, M., Schmidt, W., & Kemler, R. (1985) · Development · doi:10.1242/dev.87.1.27 · Cited by 1,962
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
McMahon, A. P., & Bradley, A. (1990) · Cell · doi:10.1016/0092-8674(90)90385-r · Cited by 1,519
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281

Show all 67 references

Research works printed but not linked: 2

Dickie, 1963, New mutations. I. Angora, Mouse News Lett., 29, 39
Konyukhov, 1990, Analysis of the angora-Y gene expression, Mouse Genome, 87, 94

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Yamaguchi, T. P., & Rossant, J. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)90053-j · Cited by 182
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Chow, R. L., Diez‐Roux, G., Roghani, M., Palmer, M. A. J., Rifkin, D. B., Moscatelli, D., & Lang, R. A. (1995) · Development · doi:10.1242/dev.121.12.4383 · Cited by 154
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Millar, S. E., Miller, M. W., Stevens, M. E., & Barsh, G. S. (1995) · Development · doi:10.1242/dev.121.10.3223 · Cited by 146
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Vauclair, S., Nicolas, M., Barrandon, Y., & Radtke, F. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.018 · Cited by 145
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The generation and interpretation of positional information within the vertebrate myotome
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Wang, X., Tredget, E. E., & Wu, Y. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0230 · Cited by 80
Signaling through FGF receptor‐2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation
Garcia, C. M., Yu, K., Zhao, H., Ashery‐Padan, R., Ornitz, D. M., Robinson, M. L., & Beebe, D. C. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20356 · Cited by 77
Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle
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Authors: Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R.
Affiliations: University of California, San Francisco (US)
ORCID: Hébert, Jean M.
Rosenquist, Thomas
Götz, Jürgen
Venue: Cell
Publisher: Elsevier BV
Published: 1994-09
Volume: 78
Issue: 6
Pages: 1017-1025
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90276-3
OpenAlex: W2056016311
Cited by: 589
References: 67
Citations by year: 2026: 12 · 2025: 14 · 2024: 9 · 2023: 21 · 2022: 24 · 2021: 15 · 2020: 23 · 2019: 15 · 2018: 10 · 2017: 21 · 2016: 22 · 2015: 12 · 2014: 18 · 2013: 16 · 2012: 20
FWCI: 35.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Lucille P. Markey Charitable Trust (8814)
National Institutes of Health (CA 09043, PO1 HL 43821, ROl HD22731)
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Dentistry › General Dentistry › dental development and anomalies
Keywords: FGF5, hair cycle, anagen, outer root sheath, hair follicle, gene targeting, spontaneous mutation, complementation
MeSH terms: Alleles, Animals, Base Sequence, Fibroblast Growth Factors, Genetic Complementation Test, Hair, Homozygote, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Mutant Strains, Molecular Sequence Data, Phenotype, RNA, Messenger, Tissue Distribution, Transforming Growth Factor alpha, In Situ Hybridization, Mice, Knockout, Mice, Fibroblast Growth Factor 5

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FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

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