The DOI matches its Crossref record; 43 of the 45 references it cites were found in a registry or an index.
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
Open accessAbstract
Mice carrying a mutation in the synaptotagmin I gene were generated by homologous recombination. Mutant mice are phenotypically normal as heterozygotes, but die within 48 hr after birth as homozygotes. Studies of hippocampal neurons cultured from homozygous mutant mice reveal that synaptic transmission is severely impaired. The synchronous, fast component of Ca(2+)-dependent neurotransmitter release is decreased, whereas asynchronous release processes, including spontaneous synaptic activity (miniature excitatory postsynaptic current frequency) and release triggered by hypertonic solution or alpha-latrotoxin, are unaffected. Our findings demonstrate that synaptotagmin I function is required for Ca2+ triggering of synchronous neurotransmitter release, but is not essential for asynchronous or Ca(2+)-independent release. We propose that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2+ regulation of synchronous neurotransmitter release in hippocampal neurons.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among these isoforms, synaptotagmin-1 (Syt1) is a Ca2+ sensor for evoked synchronous neurotransmitter release7.”
From Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis (2015) · cites this paper as [7]
In the citing paper
“As expected7, removal of Syt1 abolished synchronous release monitored by recording evoked inhibitory postsynaptic currents (eIPSCs), a phenotype that can be rescued by re-introduction of WT but not mutant Syt1 cDNA (Figs. 4a, b).”
From Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis (2015) · cites this paper as [7]
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
SNAP receptors implicated in vesicle targeting and fusion
Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997
Spontaneous subthreshold activity at motor nerve endings
Fatt, P., & Katz, B. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004735 · Cited by 1,835
Co‐operative action of calcium ions in transmitter release at the neuromuscular junction
Dodge, F. A., & Rahamimoff, R. (1967) · The Journal of Physiology · doi:10.1113/jphysiol.1967.sp008367 · Cited by 1,315
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
Brose, N., Petrenko, A. G., Südhof, T. C., & Jahn, R. (1992) · Science · doi:10.1126/science.1589771 · Cited by 979
Self-citation
Research works printed but not linked: 1
- Shirataki, 1993, Rabphillin-3A, a putative target protein for smg p25Arab3A small GTP-binding protein related to synaptotagmin, Mol. Cell. Biol., 13, 2061, 10.1128/MCB.13.4.2061 · DOI
Cited by
Sorted by citations
Items 1,001–1,005 of 1,005
Small, C., Harper, C., Jiang, A., Kontaxi, C., Pronot, M., Yak, N., Malapaka, A., Davenport, E. C., Wallis, T. P., Gormal, R. S., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16186 · Cited by 14
Turecek, J., & Regehr, W. G. (2020) · eLife · doi:10.7554/elife.61672 · Cited by 13
A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release
Jaczynska, K., Esser, V., Xu, J., Sari, L., Lin, M. M., Rosenmund, C., & Rizo, J. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2417941121 · Cited by 13
“The function of Syt1 as the Ca 2+ sensor that triggers neurotransmitter release and its essential nature for fast, synchronous release ( 28 , 66 ) are well established, but its mechanism of action has remained enigmatic despite intense research for over three decades.”
Hogg, J. A., & Cousin, M. A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.16308 · Cited by 5
Small, C., Harper, C., Jiang, A., Kontaxi, C., Yak, N., Malapaka, A., Davenport, E. C., Wallis, T. P., Gormal, R. S., Joensuu, M., et al. (2022) · doi:10.1101/2022.12.12.520075 · Cited by 4
Metadata
- Authors
- Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Salk Institute for Biological Studies (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-11
- Volume
- 79
- Issue
- 4
- Pages
- 717-727
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2165302477
- Cited by
- 1,483
- References
- 45
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 34 · 2023: 36 · 2022: 41 · 2021: 42 · 2020: 47 · 2019: 49 · 2018: 43 · 2017: 41 · 2016: 31 · 2015: 41 · 2014: 51 · 2013: 33 · 2012: 59
- FWCI
- 20.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (5r01ns012961-22)
- National Institute of Neurological Disorders and Stroke (R0 NS 12961-17)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- synaptotagmin-1, calcium sensor, asynchronous release, calcium-independent release, hippocampal neurons, synaptic transmission, mouse mutants, alpha-latrotoxin, spontaneous synaptic activity
- MeSH terms
- Animals, Animals, Newborn, Base Sequence, Brain, Calcium, Calcium-Binding Proteins, Exons, Hippocampus, Homozygote, Hypertonic Solutions, Membrane Glycoproteins, Mice, Neurologic Mutants, Molecular Sequence Data, Mutation, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Reference Values, Spider Venoms, Synapses, Restriction Mapping, Polymerase Chain Reaction, Mutagenesis, DNA Primers, Neurotransmitter Agents, Synaptotagmins, Synaptotagmin I, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
