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Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
Open accessAbstract
Mice carrying a mutation in the synaptotagmin I gene were generated by homologous recombination. Mutant mice are phenotypically normal as heterozygotes, but die within 48 hr after birth as homozygotes. Studies of hippocampal neurons cultured from homozygous mutant mice reveal that synaptic transmission is severely impaired. The synchronous, fast component of Ca(2+)-dependent neurotransmitter release is decreased, whereas asynchronous release processes, including spontaneous synaptic activity (miniature excitatory postsynaptic current frequency) and release triggered by hypertonic solution or alpha-latrotoxin, are unaffected. Our findings demonstrate that synaptotagmin I function is required for Ca2+ triggering of synchronous neurotransmitter release, but is not essential for asynchronous or Ca(2+)-independent release. We propose that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2+ regulation of synchronous neurotransmitter release in hippocampal neurons.
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“Among these isoforms, synaptotagmin-1 (Syt1) is a Ca2+ sensor for evoked synchronous neurotransmitter release7.”
From Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis (2015) · cites this paper as [7]
In the citing paper
“As expected7, removal of Syt1 abolished synchronous release monitored by recording evoked inhibitory postsynaptic currents (eIPSCs), a phenotype that can be rescued by re-introduction of WT but not mutant Syt1 cDNA (Figs. 4a, b).”
From Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis (2015) · cites this paper as [7]
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
SNAP receptors implicated in vesicle targeting and fusion
Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997
Spontaneous subthreshold activity at motor nerve endings
Fatt, P., & Katz, B. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004735 · Cited by 1,835
Co‐operative action of calcium ions in transmitter release at the neuromuscular junction
Dodge, F. A., & Rahamimoff, R. (1967) · The Journal of Physiology · doi:10.1113/jphysiol.1967.sp008367 · Cited by 1,315
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
Brose, N., Petrenko, A. G., Südhof, T. C., & Jahn, R. (1992) · Science · doi:10.1126/science.1589771 · Cited by 979
Self-citation
Research works printed but not linked: 1
- Shirataki, 1993, Rabphillin-3A, a putative target protein for smg p25Arab3A small GTP-binding protein related to synaptotagmin, Mol. Cell. Biol., 13, 2061, 10.1128/MCB.13.4.2061 · DOI
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Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
Self-citationMembrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Self-citationThe synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Self-citationSynaptic assembly of the brain in the absence of neurotransmitter secretion.
Verhage, M., Maia, A., Plomp, J., Brussaard, A., Heeroma, J., Vermeer, H., Toonen, R., Hammer, R., van den Berg, T. K., Missler, M., et al. (2000) · Science · doi:10.1126/science.287.5454.864 · Cited by 1,387
Self-citationFast-spiking, parvalbumin + GABAergic interneurons: From cellular design to microcircuit function
Hu, H., Gan, J., & Jonas, P. (2014) · Science · doi:10.1126/science.1255263 · Cited by 1,197
Membrane fusion and exocytosis.
Jahn, R., & Südhof, T. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.863 · Cited by 1,253
Self-citationNeurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197
Self-citationControl of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Definition of the readily releasable pool of vesicles at hippocampal synapses.
Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084
Self-citationBiomarkers for Alzheimer's disease: current status and prospects for the future
Blennow, K., & Zetterberg, H. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12816 · Cited by 1,000
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Mohn, F., Weber, M., Rebhan, M., Roloff, T. C., Richter, J., Stadler, M. B., Bibel, M., & Schübeler, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.007 · Cited by 970
C2-domains, Structure and Function of a Universal Ca2+-binding Domain*
Rizo, J., & Südhof, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.15879 · Cited by 825
Self-citationSynaptotagmin I functions as a calcium regulator of release probability
Fernández-Chacón, R., Königstorfer, A., Gerber, S. H., García, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., & Südhof, T. C. (2001) · Nature · doi:10.1038/35065004 · Cited by 961
Self-citationThe C2 domain calcium‐binding motif: Structural and functional diversity
Nalefski, E. A., & Falke, J. J. (1996) · Protein Science · doi:10.1002/pro.5560051201 · Cited by 832
Roux, I., Safieddine, S., Nouvian, R., Grati, M., Simmler, M., Bahloul, A., Perfettini, I., Gall, M. L., Rostaing, P., Hamard, G., et al. (2006) · Cell · doi:10.1016/j.cell.2006.08.040 · Cited by 753
Mechanisms of membrane fusion: disparate players and common principles
Martens, S., & McMahon, H. T. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2417 · Cited by 733
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
Sutton, R. B., Davletov, B. A., Berghuis, A. M., Südhof, T. C., & Sprang, S. R. (1995) · Cell · doi:10.1016/0092-8674(95)90296-1 · Cited by 693
Self-citationMunc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787
Self-citationSNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
Schoch, S., Deák, F., Königstorfer, A., Mozhayeva, M. G., Sara, Y., Südhof, T. C., & Kavalali, E. T. (2001) · Science · doi:10.1126/science.1064335 · Cited by 664
Self-citationCalcium Channel Regulation and Presynaptic Plasticity
Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647
Hong, W. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.03.014 · Cited by 648
Mitochondria at the neuronal presynapse in health and disease
Devine, M. J., & Kittler, J. T. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.170 · Cited by 636
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
Li, C., Ullrich, B., Zhang, J. Z., Anderson, R. G. W., Brose, N., & Südhof, T. C. (1995) · Nature · doi:10.1038/375594a0 · Cited by 599
Self-citationHata, Y., Butz, S., & Sudhof, T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02488.1996 · Cited by 553
Self-citationHow Does Synaptotagmin Trigger Neurotransmitter Release?
Chapman, E. R. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.062005.101135 · Cited by 547
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
Washbourne, P., Thompson, P. M., Carta, M., da Costa, E. T., Mathews, J. R., López‐Bendito, G., Molnár, Z., Bêcher, M. W., Valenzuela, C. F., Partridge, L. D., et al. (2001) · Nature Neuroscience · doi:10.1038/nn783 · Cited by 535
Gibson, J. R., Bartley, A. F., Hays, S. A., & Huber, K. M. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90752.2008 · Cited by 529
Generation, Control, and Processing of Cellular Calcium Signals
Carafoli, E., Santella, L., Branca, D., & Brini, M. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074183 · Cited by 524
Clark, J., Schievella, A., Nalefski, E. A., & Lin, L. (1995) · Journal of Lipid Mediators and Cell Signalling · doi:10.1016/0929-7855(95)00012-f · Cited by 515
Mechanisms of Synaptic Vesicle Exocytosis
Lin, R. C.-S., & Scheller, R. H. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.19 · Cited by 512
Calcium Control of Neurotransmitter Release
Sudhof, T. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011353 · Cited by 502
Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release
Reim, K., Mansour, M., Varoqueaux, F., McMahon, H. T., Südhof, T. C., Brose, N., & Rosenmund, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00192-1 · Cited by 500
Self-citationComplexins: Cytosolic proteins that regulate SNAP receptor function
McMahon, H. T., Missler, M., Li, C., & Südhof, T. C. (1995) · Cell · doi:10.1016/0092-8674(95)90239-2 · Cited by 500
Self-citationSüdhof, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100052200 · Cited by 503
Self-citationHow Synaptotagmin Promotes Membrane Fusion
Martens, S., Kozlov, M. M., & McMahon, H. T. (2007) · Science · doi:10.1126/science.1142614 · Cited by 528
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
Chapman, E. R. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm855 · Cited by 492
The mechanisms and functions of spontaneous neurotransmitter release
Kavalali, E. T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3875 · Cited by 486
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
Tang, J., Maximov, A., Shin, O., Dai, H., Rizo, J., & Südhof, T. C. (2006) · Cell · doi:10.1016/j.cell.2006.08.030 · Cited by 474
Self-citationMolecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release
Kaeser, P. S., & Regehr, W. G. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170338 · Cited by 447
Imaging exocytosis and endocytosis
Betz, W. J., Mao, F., & Smith, C. B. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80121-8 · Cited by 446
The neuronal calcium sensor family of Ca2+-binding proteins
Burgoyne, R. D., & Weiss, J. L. (2000) · Biochemical Journal · doi:10.1042/bj3530001 · Cited by 456
A genetic selection for Caenorhabditis elegans synaptic transmission mutants.
Miller, K. G., Alfonso, A., Nguyen, M., Crowell, J. A., Johnson, C. D., & Rand, J. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12593 · Cited by 437
Synaptotagmins: C2-domain proteins that regulate membrane traffic.
Südhof, T., & Rizo, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80171-3 · Cited by 450
Self-citationThe small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion
Geppert, M., Goda, Y., Stevens, C., & Südhof, T. (1997) · Nature · doi:10.1038/42954 · Cited by 422
Self-citationSNARE Complex Formation Is Triggered by Ca 2+ and Drives Membrane Fusion
Chen, Y. A., Scales, S. J., Patel, S. M., Doung, Y.-C., & Scheller, R. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80727-8 · Cited by 417
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
Crowder, K. M., Gunther, J. M., Jones, T. A., Hale, B. D., Zhang, H. Z., Peterson, M. R., Scheller, R. H., Chavkin, C., & Bajjalieh, S. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15268 · Cited by 415
Munc18-1 Promotes Large Dense-Core Vesicle Docking
Voets, T., Toonen, R. F., Brian, E. C., de Wit, H., Moser, T., Rettig, J., Südhof, T. C., Neher, E., & Verhage, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00391-9 · Cited by 396
Self-citationAn Isolated Pool of Vesicles Recycles at Rest and Drives Spontaneous Neurotransmission
Sara, Y., Virmani, T., Deák, F., Liu, X., & Kavalali, E. T. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.056 · Cited by 399
Cell biology of Ca2+-triggered exocytosis
Pang, Z. P., & Südhof, T. C. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.05.001 · Cited by 406
Self-citationThe Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones
Imig, C., Min, S.-W., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T. C., Rhee, J., Brose, N., & Cooper, B. H. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.009 · Cited by 389
Self-citationStructure and function of neuronal Ca2+ channels and their role in neurotransmitter release.
Catterall, W. (1998) · Cell Calcium · doi:10.1016/s0143-4160(98)90055-0 · Cited by 397
Membrane Repair: Mechanisms and Pathophysiology
Cooper, S. T., & McNeil, P. L. (2015) · Physiological Reviews · doi:10.1152/physrev.00037.2014 · Cited by 400
Syntaxin and synaptobrevin function downstream of vesicle docking in drosophila
Broadie, K. S., Prokop, A., Bellen, H. J., O’Kane, C. J., Schulze, K. L., & Sweeney, S. T. (1995) · Neuron · doi:10.1016/0896-6273(95)90154-x · Cited by 379
Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1 (*)
Chapman, E., Hanson, P., An, S. J., & Jahn, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23667 · Cited by 363
Aghajanian, G. K., & Marek, G. J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01224-x · Cited by 376
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
Sun, J., Pang, Z. P., Qin, D., Fahim, A. T., Adachi, R., & Südhof, T. C. (2007) · Nature · doi:10.1038/nature06308 · Cited by 357
Self-citationA Clamping Mechanism Involved in SNARE-Dependent Exocytosis
Giraudo, C. G., Eng, W. S., Melia, T. J., & Rothman, J. E. (2006) · Science · doi:10.1126/science.1129450 · Cited by 368
SV2A and SV2B Function as Redundant Ca2+ Regulators in Neurotransmitter Release
Janz, R., Goda, Y., Geppert, M., Missler, M., & Südhof, T. C. (1999) · Neuron · doi:10.1016/s0896-6273(00)81046-6 · Cited by 372
Self-citationDifferential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23
Sørensen, J. B., Nagy, G., Varoqueaux, F., Nehring, R. B., Brose, N., Wilson, M. C., & Neher, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00477-x · Cited by 364
Calcium Dependence of Exocytosis and Endocytosis at the Cochlear Inner Hair Cell Afferent Synapse
Beutner, D., Voets, T., Neher, E., & Moser, T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00243-4 · Cited by 352
Xu, J., Mashimo, T., & Südhof, T. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.004 · Cited by 336
Self-citationArchitecture of the synaptotagmin–SNARE machinery for neuronal exocytosis
Zhou, Q., Lai, Y., Bacaj, T., Zhao, M., Lyubimov, A. Y., Uervirojnangkoorn, M., Zeldin, O. B., Brewster, A. S., Sauter, N. K., Cohen, A. E., et al. (2015) · Nature · doi:10.1038/nature14975 · Cited by 348
Self-citationCalcium-dependent interaction of N-type calcium channels with the synaptic core complex
Sheng, Z.-H., Rettig, J., Cook, T., & Catterall, W. (1996) · Nature · doi:10.1038/379451a0 · Cited by 363
Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A
Fernández, I., Ubach, J., Dulubova, I., Zhang, X., Südhof, T. C., & Rizo, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81742-0 · Cited by 345
Self-citationThe calcium sensor synaptotagmin 7 is required for synaptic facilitation
Jackman, S. L., Turecek, J., Belinsky, J. E., & Regehr, W. G. (2016) · Nature · doi:10.1038/nature16507 · Cited by 336
Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins
Brose, N., Hofmann, K., Hata, Y., & Südhof, T. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.25273 · Cited by 412
Self-citationNovel aspects of calmodulin target recognition and activation
Vetter, S. W., & Leclerc, E. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03414.x · Cited by 348
Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion
Maximov, A., Tang, J., Yang, X., Pang, Z. P., & Südhof, T. C. (2009) · Science · doi:10.1126/science.1166505 · Cited by 339
Self-citationDrosophila Unc-13 is essential for synaptic transmission
Aravamudan, B., Fergestad, T., Davis, W. S., Rodesch, C. K., & Broadie, K. S. (1999) · Nature Neuroscience · doi:10.1038/14764 · Cited by 335
Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells
Parsons, T. D., Coorssen, J. R., Horstmann, H., & Almers, W. (1995) · Neuron · doi:10.1016/0896-6273(95)90097-7 · Cited by 333
C ELL B IOLOGY OF THE P RESYNAPTIC T ERMINAL
Murthy, V. N., & Camilli, P. V. D. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131445 · Cited by 337
YONEKAWA, Y., Harada, A., Okada, Y., Funakoshi, T., Kanai, Y., Takei, Y., Terada, S., Noda, T., & Hirokawa, N. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.431 · Cited by 327
Exocytosis: A Molecular and Physiological Perspective
Zucker, R. S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80238-x · Cited by 320
Stevens, C., & Wesseling, J. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80550-4 · Cited by 327
Self-citationClathrin-mediated endocytosis: membrane factors pull the trigger
Takei, K., & Haucke, V. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02082-7 · Cited by 311
Neurogenic inflammation and its role in migraine
Ramachandran, R. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0676-y · Cited by 311
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2‐domain?
Ubach, J., Zhang, X., Shao, X., Südhof, T. C., & Rizo, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.3921 · Cited by 316
Self-citationBacaj, T., Wu, D., Yang, X., Morishita, W., Zhou, P., Xu, W., Malenka, R. C., & Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.026 · Cited by 308
Self-citationBipartite Ca2+-Binding Motif in C2 Domains of Synaptotagmin and Protein Kinase C
Shao, X., Davletov, B., Sutton, R. B., Südhof, T., & Rizo, J. (1996) · Science · doi:10.1126/science.273.5272.248 · Cited by 303
Self-citationStructure and function of SNARE and SNARE-interacting proteins
Brünger, A. T. (2005) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583505004051 · Cited by 308
Miller, R. J. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.201 · Cited by 304
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release
Meir, A., Ginsburg, S., Butkevich, A., Kachalsky, S. G., Kaiserman, I., Ahdut-HaCohen, R., Demirgören, S., & Rahamimoff, R. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.3.1019 · Cited by 299
Kraszewski, K., Mundigl, O., DANIELL, L. W., Verderio, C., Matteoli, M., & Camilli, P. V. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04328.1995 · Cited by 298
Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin.
Schiavo, G., Gu, Q.-M., Prestwich, G., Söllner, T. H., & Rothman, J. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.23.13327 · Cited by 304
The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis
Zhou, Q., Zhou, P., Wang, A. L., Wu, D., Zhao, M., Südhof, T. C., & Brünger, A. T. (2017) · Nature · doi:10.1038/nature23484 · Cited by 293
Self-citationDoc2b Is a High-Affinity Ca 2+ Sensor for Spontaneous Neurotransmitter Release
Groffen, A. J., Martens, S., Arazola, R. D., Cornelisse, L. N., Lozovaya, N., de Jong, A. P. H., Goriounova, N. A., Habets, R. L. P., Takai, Y., Borst, J. G., et al. (2010) · Science · doi:10.1126/science.1183765 · Cited by 313
Modeling Buffered Ca2+ Diffusion Near the Membrane
Klingauf, J., & Neher, E. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78704-6 · Cited by 291
Calcium-regulated exocytosis is required for cell membrane resealing.
Bi, G., Alderton, J. M., & Steinhardt, R. A. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.6.1747 · Cited by 285
Synaptic Vesicle Pools and Dynamics
Alabi, A. A., & Tsien, R. W. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013680 · Cited by 284
Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
Lang, J. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00043.x · Cited by 347
Synaptotagmins form a hierarchy of exocytotic Ca2+ sensors with distinct Ca2+ affinities
Sugita, S., Shin, O., Han, W., Lao, Y., & Südhof, T. (2002) · EMBO Journal · doi:10.1093/emboj/21.3.270 · Cited by 280
Self-citationSynaptotagmin-1 functions as a Ca2+ sensor for spontaneous release
Xu, J., Pang, Z. P., Shin, O.-H., & Südhof, T. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2320 · Cited by 274
Self-citationKinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes.
Davis, A. F., Bai, J.-H., Fasshauer, D., Wolowick, M. J., Lewis, J. L., & Chapman, E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80850-8 · Cited by 271
The WNKs: Atypical Protein Kinases With Pleiotropic Actions
McCormick, J. A., & Ellison, D. H. (2011) · Physiological Reviews · doi:10.1152/physrev.00017.2010 · Cited by 277
Mechanisms Underlying Phasic and Sustained Secretion in Chromaffin Cells from Mouse Adrenal Slices
Voets, T., Neher, E., & Moser, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80812-0 · Cited by 276
Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals
Marks, B., & McMahon, H. T. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70297-0 · Cited by 271
Takahashi, T., Kajikawa, Y., & Tsujimoto, T. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03138.1998 · Cited by 268
Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo
Poskanzer, K. E., Marek, K. W., Sweeney, S. T., & Davis, G. W. (2003) · Nature · doi:10.1038/nature02184 · Cited by 265
Metadata
- Authors
- Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Salk Institute for Biological Studies (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-11
- Volume
- 79
- Issue
- 4
- Pages
- 717-727
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2165302477
- Cited by
- 1,483
- References
- 45
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 34 · 2023: 36 · 2022: 41 · 2021: 42 · 2020: 47 · 2019: 49 · 2018: 43 · 2017: 41 · 2016: 31 · 2015: 41 · 2014: 51 · 2013: 33 · 2012: 59
- FWCI
- 20.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (5r01ns012961-22)
- National Institute of Neurological Disorders and Stroke (R0 NS 12961-17)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- synaptotagmin-1, calcium sensor, asynchronous release, calcium-independent release, hippocampal neurons, synaptic transmission, mouse mutants, alpha-latrotoxin, spontaneous synaptic activity
- MeSH terms
- Animals, Animals, Newborn, Base Sequence, Brain, Calcium, Calcium-Binding Proteins, Exons, Hippocampus, Homozygote, Hypertonic Solutions, Membrane Glycoproteins, Mice, Neurologic Mutants, Molecular Sequence Data, Mutation, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Reference Values, Spider Venoms, Synapses, Restriction Mapping, Polymerase Chain Reaction, Mutagenesis, DNA Primers, Neurotransmitter Agents, Synaptotagmins, Synaptotagmin I, Mice
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