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IκB-β regulates the persistent response in a biphasic activation of NF-κB
Open accessAbstract
We have cloned the cDNA encoding I kappa B-beta, one of the two major I kappa B isoforms in mammalian cells. The recombinant I kappa B- beta protein interacts with equal affinity to p65 and c-Rel and does not exhibit a preference between these Rel proteins. Instead the primary difference between I kapp B-alpha and I kappa B-beta is in their response to different inducers of NF-kappa B activity. One class of inducers causes rapid but transient activation of NF-kappa B by primarily affecting I kappa B-alpha complexes, whereas another class of inducers causes persistent activation of NF-kapa B by affecting both I kappa B-alpha and I kappa B-beta complexes. Therefore, the overall activation of NF-kappa B consists of two overlapping phases, a transient phase mediated through I kappa B-alpha and a persistent phase mediated through I kappa B-beta.
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Metadata
- Authors
- Thompson, J. E., Phillips, R. J., Erdjument-Bromage, H., Tempst, P., & Ghosh, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 80
- Issue
- 4
- Pages
- 573-582
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2095019663
- Cited by
- 751
- References
- 1
- FWCI
- 32.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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