Intravenous vitamin C in the supportive care of cancer patients: A review and rational approach
Open accessAbstract
This article reviews intravenous vitamin C (IV C) in cancer care and offers a rational approach to enable medical oncologists and integrative practitioners to safely provide IV C combined with oral vitamin C to patients. The use of IV C is a safe supportive intervention to decrease inflammation in the patient and to improve symptoms related to antioxidant deficiency, disease processes, and side effects of standard cancer treatments. A proposed rationale, together with relevant clinical safety considerations for the application of IV C in oncologic supportive care, is provided.
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A significant number of clinical trials have indicated that vitamin C administered intravenously in high-doses (in most trials, 50-100 g twice or thrice weekly) as a treatment for various cancers including glioblastoma, ovarian, prostate, lung, or rectum cancer is well tolerated with minimal toxicity, improves the quality of life for patients, and has a synergistic therapeutic effect when combined
“A significant number of clinical trials have indicated that vitamin C administered intravenously in high-doses (in most trials, 50–100 g twice or thrice weekly) as a treatment for various cancers including glioblastoma, ovarian, prostate, lung, or rectum cancer is well tolerated with minimal toxicity, improves the quality of life for patients, and has a synergistic therapeutic effect when combined”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [184]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredMost of these studies were not designed as large-scale randomized clinical trials and clear verifications of the clinical efficacy of vitamin C are currently rather limited.
“However, most of these studies were not designed as large-scale randomized clinical trials and clear verifications of the clinical efficacy of vitamin C are currently rather limited [177,182,183,184].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [184]
Many clinical studies report that intravenous high-dose ascorbate is well tolerated, improves quality of life, and when combined with radiation or standard chemotherapy has synergistic effects and fewer side effects.
“a significant number of clinical studies to date have indicated that intravenous high-dose ascorbate is well tolerated in patients with minimal toxicity, improves the quality of life for patients and has demonstrated synergistic therapeutic effects as well as reduced side effects when combined with radiation and standard chemotherapies.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [99]
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- Authors
- Klimant, E., Wright, H., Rubin, D., Seely, D., & Markman, M.
- Affiliations
- Cancer Treatment Centers of America (US)
- ORCID
- Venue
- Current Oncology
- Publisher
- MDPI AG
- Published
- 2018-04-01
- Volume
- 25
- Issue
- 2
- Pages
- 139-148
- ISSN
- 1198-0052 (ISSN-L)
- 1718-7729
- PMC
- PMC5927785
- OpenAlex
- W2800392143
- Cited by
- 99
- References
- 83
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 10 · 2023: 8 · 2022: 13 · 2021: 25 · 2020: 16 · 2019: 11 · 2018: 3
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- creativecommons.org/licenses/by/4.0/ (vor)
- Locations
- Current Oncology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- intravenous vitamin C, vitamin C, cancer supportive care, integrative oncology, antioxidant deficiency, inflammation, chemotherapy side effects, clinical safety
- MeSH terms
- Administration, Oral, Antioxidants, Ascorbic Acid, Humans, Neoplasms, Quality of Life, Vitamin D Deficiency, Oxidative Stress, Administration, Intravenous
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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