Cited by 177biodegradable polymer synthesis and propertiesSurgical Sutures and AdhesivesAdvanced Drug Delivery Systems

Biocompatibility of Resorbable Polymers: A Historical Perspective and Framework for the Future

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Pappalardo, Daniela, Mathisen, Torbjörn, Finne-Wistrand, Anna·2019·Biomacromolecules

Abstract

The history of resorbable polymers containing glycolide, lactide, ε-caprolactone and trimethylene carbonate, with a special emphasis being placed on the time frame of the 1960s-1990s is described. Reviewing the history is valuable when looking into the future perspectives regarding how and where these monomers should be used. This story includes scientific evaluations indicating that these polymers are safe to use in medical devices, while the design of the medical device is not considered in this report. In particular, we present the data regarding the tissue response to implanted polymers, as well as the toxicity and pharmacokinetics of their degradation products. In the translation of these polymers from "the bench to the bedside," various challenges have been faced by surgeons, medical doctors, biologists, material engineers and polymer chemists. This Perspective highlights the visionary role played by the pioneers, addressing the problems that occurred on a case by case basis in translational medicine.

Integrity signals

Registry

Crossref · 10.1021/acs.biomac.9b00159

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94 of 94 references verified0 citation errors · 0 not checkable

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Authors
Pappalardo, D., Mathisen, T., & Finne-Wistrand, A.
Affiliations
  • University of Sannio (IT)
  • Novus Scientific AB , Virdings allé 2 , ,
  • KTH Royal Institute of Technology , , ,
Venue
Biomacromolecules
Published
2019-03-11
Volume
20
Issue
4
Pages
1465-1477
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W2921533698
Cited by
177
References
94
Citations by year
2026: 15 · 2025: 30 · 2024: 27 · 2023: 24 · 2022: 26 · 2021: 25 · 2020: 23 · 2019: 7
FWCI
1.29
Type
journal article
Language
en
Open access
Locations
  • Biomacromolecules (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Funders
Stiftelsen f?r?Strategisk Forskning (RMA15-0010)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
resorbable polymers, biocompatibility, glycolide, lactide, ε-caprolactone, trimethylene carbonate, tissue response to implants, degradation products, toxicity, pharmacokinetics, medical devices, translational medicine
MeSH terms
Biocompatible Materials, Humans, Materials Testing, History, 20th Century, History, 21st Century, Biodegradable Plastics

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