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Cited by 79Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorEating Disorders and Behaviors

Control of sensorimotor function by dopaminergic nigrostriatal neurons: Influence on eating and drinking

White, Norman M.·1986·Neuroscience & Biobehavioral Reviews
DOI 10.1016/0149-7634(86)90030-8
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Abstract

The literature on the effects of lesions of the lateral hypothalamic area (LHA) on eating and drinking is reviewed in an effort to understand the function of the neural substrate destroyed. The data suggest that damage to the dopaminergic nigrostriatal neurons that course through the LHA results in a decrease in sensorimotor facilitation; that is, an increase in the threshold for responding to stimuli that elicit orientation, approach and consumption. This increase results in decreased consumption of food and water. Evidence is also reviewed suggesting the possibility that striatal dopaminergic activity may mediate a negative feedback signal related to blood glucose level that influences responsiveness to food, and therefore eating. There is no evidence that the nigrostriatal system mediates a similar signal related to water balance and drinking. A second deficit associated with LHA lesions, caused by damage to the pallidofugal neurons that descend through this area, is a dysfunction of motor control of the head and mouth. This results in an increase in the effort required to consume food and water, also leading to decreased consumption. These two behavioral factors: an increased threshold for responding to the sensory properties of food and water and an increase in the effort required to eat and drink are used to explain the symptoms making up the lateral hypothalamic syndrome without postulating changes in physiological regulatory (set point) mechanisms.

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Authors
White, N. M.
Affiliations
McGill University (CA)
Corresponding author
White, Norman M.
ORCID
White, Norman M.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1986
Volume
10
Issue
1
Pages
15-36
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/0149-7634(86)90030-8
OpenAlex
W2017452805
Cited by
79
References
187
Citations by year
2026: 1 · 2024: 1 · 2018: 1 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 1
FWCI
2.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
lateral hypothalamus, dietary habits, drinking behavior, dietary intake, water intake, striatal dopamine
MeSH terms
Animals, Blood Glucose, Body Weight, Brain Mapping, Corpus Striatum, Dopamine, Drinking Behavior, Electric Stimulation, Feedback, Feeding Behavior, Homeostasis, Hydroxydopamines, Hypothalamic Area, Lateral, Insulin, Male, Motor Activity, Neural Pathways, Synaptic Transmission, Receptors, Dopamine, Satiety Response, Sensation, Substantia Nigra, Taste, Oxidopamine, Rats

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