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Cited by 848Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

The role of dopamine in locomotor activity and learning

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Beninger, Richard J.·1983·Brain Research Reviews
DOI 10.1016/0165-0173(83)90038-3
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Abstract

The discovery that the brain contains neurons utilizing dopamine (DA) as their transmitter has led to studies of the behavioral function of these neurons. Changes in overall level of activity of DA neurons appear to produce parallel changes in locomotor activity. Additionally, DA neurons seem to mediate in part the effects of biologically significant (reinforcing) stimuli on learning. One way in which reinforcing stimuli produce learning is to increase the incentive motivational (response-eliciting) properties of neutral stimuli associated with them; also, reinforcing stimuli maintain the incentive motivational properties of previously conditioned incentive stimuli. Normal DA functioning appears to be required for the establishment and maintenance of incentive learning in naive animals. Previous incentive learning in trained animals can influence behavior for a time even when the function of DA neurons is disrupted; however, with continued testing in the absence of normal DA functioning, previously established conditioned incentive stimuli cease to influence behavior. From these observations and recent physiological, anatomical and biochemical studies of DA systems it is suggested that the biological substrate of DA-mediated incentive learning is a heterosynaptic facilitation of muscarinic cholinergic synapses. This model has important clinical implications since it has been suggested that DA hyperfunctioning underlies the development of schizophrenia.

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Authors
Beninger, R. J.
Affiliations
Queen's University (CA)
Corresponding author
Beninger, Richard J.
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
1983-10
Volume
6
Issue
2
Pages
173-196
ISSN
0165-0173 (ISSN-L)
DOI
10.1016/0165-0173(83)90038-3
OpenAlex
W2157844171
Cited by
848
References
204
Citations by year
2026: 3 · 2025: 9 · 2024: 11 · 2023: 16 · 2022: 20 · 2021: 11 · 2020: 19 · 2019: 25 · 2018: 25 · 2017: 22 · 2016: 18 · 2015: 16 · 2014: 18 · 2013: 14 · 2012: 17
FWCI
2.52
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • QSpace (Queen's University Library) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
dopamine, locomotor activity, incentive learning, incentive motivation, heterosynaptic facilitation, schizophrenia, dopaminergic neurons
MeSH terms
Animals, Association Learning, Dopamine, Learning, Locomotion, Motivation

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