Cited by 213Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyOpioid Use Disorder Treatment

The DOI matches its Crossref record; 140 of the 142 references it cites were found in a registry or an index.

Participation of Noradrenergic Pathways in the Expression of Opiate Withdrawal: Biochemical and Pharmacological Evidence

MALDONADO, RAFAEL·1997·Neuroscience & Biobehavioral Reviews

DOI 10.1016/0149-7634(95)00061-5

Open this paper in CoChat — free account

Abstract

Several lines of biochemical and pharmacological evidence provide support for the involvement of the noradrenergic system in the expression of the somatic symptoms of opiate withdrawal. Early studies reported changes in brain noradrenaline and metabolite levels during opiate dependence. The significance of these changes has been clarified in recent microdialysis studies indicating that acute morphine decreases the extraneuronal levels of noradrenaline, whereas an increase in release of the neurotransmitter occurs during opiate withdrawal in several brain areas. Changes in the sensitivity and density of alpha 2- and beta-adrenoceptors have also been reported, probably as a consequence of the decreased presynaptic noradrenergic activity induced during morphine dependence. In addition, the administration of alpha 2-agonists, such as clonidine, or beta-antagonists, such as propranolol, has been reported to attenuate some manifestations of opiate withdrawal. The noradrenergic structure mediating the expression of opioid abstinence seems to be the locus coeruleus. However, the activation of the locus coeruleus during morphine withdrawal seems to be primarily due to the afferent projections containing excitatory amino acids and derived from the nucleus paragigantocellularis, although intrinsic modifications, consisting of an up-regulation of the cAMP pathway, seem also to be involved in this activation. The participation of the mesolimbic dopaminergic system in opiate dependence and its relation with the changes produced in the noradrenergic system are also discussed.

Integrity signals

Registry

Crossref · 10.1016/0149-7634(95)00061-5

Cites

140 of 140 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901
Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin
Sesack, S. R., Deutch, A. Y., Roth, R. H., & Bunney, B. S. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902900205 · Cited by 1,568
Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems
Moore, R. Y., & Bloom, F. E. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.000553 · Cited by 1,118
Molecular mechanisms of drug addiction
Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108
The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs
Vogt, M. L. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005064 · Cited by 1,017
Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine
Aghajanian, G. K. (1978) · Nature · doi:10.1038/276186a0 · Cited by 800
Clonidine blocks acute opiate-withdrawal symptoms
Gold, M., Redmond, D. E., & Kleber, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92823-4 · Cited by 710
II. New evidence for a locus coeruleus-norepinephrine connection with anxiety
Redmond, D. E., & Huang, Y. H. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90087-0 · Cited by 662

Show all 142 references

Research works printed but not linked: 4

Dahlstrom, 1965, Evidence for the existence of monoamine-containing neurons in the central nervous system., Acta Physiol. Scand., 232, 1
Kimes, 1993, Injections of methylnaloxonium into the locus coeruleus produce cerebral hypermetabolism in morphine-dependent rats, Society for Neuroscience Abstracts, 19, 1022
Nestler, 1988, Chronic morphine treatment increases cyclic AMP-dependent protein kinase in the rat locus coeruleus, Molec. Pharmac., 33, 127
Redmond, D.E. Jr. Studies of the locus coeruleus in monkeys and hypotheses for neuropsychopharmacology. In: Psychopharmacology: The Third Generation of Progress, H.Y. Meltzer (Ed.) Raven Press, New York, pp. 967–975; 1987.

Sorted by citations

The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Molecular and Cellular Basis of Addiction
Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,295
Reward Processing by the Opioid System in the Brain
Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Williams, J. T., Christie, M. J., & Manzoni, O. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.299 · Cited by 853
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Walker, D. L., Toufexis, D. J., & Davis, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01282-2 · Cited by 838
Understanding polydrug use: review of heroin and cocaine co‐use
Leri, F., Bruneau, J., & Stewart, J. (2002) · Addiction · doi:10.1046/j.1360-0443.2003.00236.x · Cited by 807
Noradrenergic pain modulation
Pertovaara, A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.08.001 · Cited by 597
Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion
Delfs, J. M., Zhu, Y., Druhan, J. P., & Aston-Jones, G. (2000) · Nature · doi:10.1038/35000212 · Cited by 462
There and Back Again: A Tale of Norepinephrine and Drug Addiction
Weinshenker, D., & Schroeder, J. P. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301263 · Cited by 347
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
Profile of Executive and Memory Function Associated with Amphetamine and Opiate Dependence
Ersche, K. D., Clark, L., London, M., Robbins, T. W., & Sahakian, B. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300889 · Cited by 311
Neurobiology of the nicotine withdrawal syndrome
Kenny, P. J., & Markou, A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00651-7 · Cited by 310
Consensus guidelines on sedation and analgesia in critically ill children
PLAYFOR, S. D., Jenkins, I., Boyles, C. E., Choonara, I., Davies, G. E., Haywood, T., Hinson, G., Mayer, A., Morton, N. S., Ralph, T., et al. (2006) · Intensive Care Medicine · doi:10.1007/s00134-006-0190-x · Cited by 278
Origin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat
Delfs, J. M., Zhu, Y., Druhan, J. P., & Aston‐Jones, G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00672-6 · Cited by 267
The Bed Nucleus of the Stria Terminalis: A Target Site for Noradrenergic Actions in Opiate Withdrawal
Aston‐Jones, G., Delfs, J. M., Druhan, J. P., & Zhu, Y. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09284.x · Cited by 251
EEG biofeedback as a treatment for substance use disorders: review, rating of efficacy, and recommendations for further research
Sokhadze, T. M., Cannon, R. L., & Trudeau, D. L. (2008) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-007-9047-5 · Cited by 222
Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal
Scavone, J. L., Sterling, R. C., & Van Bockstaele, E. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.034 · Cited by 209
Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence
Liu, J. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00057-1 · Cited by 209
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence
Smith, R. J., & Aston-Jones, G. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0191-3 · Cited by 206
Hindbrain noradrenergic A2 neurons: diverse roles in autonomic, endocrine, cognitive, and behavioral functions
Rinaman, L. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00556.2010 · Cited by 201
Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome
Hildebrand, B. E., Nomikos, G. G., Hertel, P., Schilström, B., & Svensson, T. H. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01135-9 · Cited by 200
Release of neurotransmitters in the locus coeruleus
Singewald, N. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00039-2 · Cited by 197
Endocrine withdrawal syndromes
Hochberg, Z., Pacak, K., & Chrousos, G. P. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0014 · Cited by 181
Neural correlates of the motivational and somatic components of naloxone‐precipitated morphine withdrawal
Frenois, F., Cador, M., Caillé, S., Stinus, L., & Moine, C. L. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02187.x · Cited by 179
The Neuropsychology of Amphetamine and Opiate Dependence: Implications for Treatment
Ersche, K. D., & Sahakian, B. J. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9033-y · Cited by 175
α1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol
Walker, B. M., Rasmussen, D. D., Raskind, M. A., & Koob, G. F. (2008) · Alcohol · doi:10.1016/j.alcohol.2007.12.002 · Cited by 170
Impaired Emotional-Like Behavior and Serotonergic Function During Protracted Abstinence from Chronic Morphine
Goeldner, C., Lutz, P.-E., Darcq, E., Halter, T., Clesse, D., Ouagazzal, A.-M., & Kieffer, B. L. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.021 · Cited by 163
Noradrenaline Triggers GABAAInhibition of Bed Nucleus of the Stria Terminalis Neurons Projecting to the Ventral Tegmental Area
Dumont, É. C., & Williams, J. T. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0425-04.2004 · Cited by 137
Brain-Derived Neurotrophic Factor Is Essential for Opiate-Induced Plasticity of Noradrenergic Neurons
Akbarian, S., Rios, M., Liu, R.-J., Gold, S. J., Fong, H., Zeiler, S., Coppola, V., Tessarollo, L., Jones, K. R., Nestler, E. J., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-04153.2002 · Cited by 129
Role of Noradrenergic Signaling by the Nucleus Tractus Solitarius in Mediating Opiate Reward
Olson, V. G., Heusner, C. L., Bland, R. J., During, M. J., Weinshenker, D., & Palmiter, R. D. (2006) · Science · doi:10.1126/science.1119311 · Cited by 126
Prefrontal Cortical Norepinephrine Release Is Critical for Morphine-induced Reward, Reinstatement and Dopamine Release in the Nucleus Accumbens
Ventura, R., Alcaro, A., & Puglisi‐Allegra, S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi066 · Cited by 119
Δ9‐tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice
Balerio, G. N., Aso, E., Berrendero, F., Murtra, P., & Maldonado, R. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03714.x · Cited by 118
Self-citation
Noradrenaline in the bed nucleus of the stria terminalis is critical for stress-induced reactivation of morphine-conditioned place preference in rats
Wang, X., Cen, X., & Lü, L. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01487-x · Cited by 112
PRECLINICAL STUDY: Corticotropin‐releasing factor‐1 receptor antagonists decrease heroin self‐administration in long‐ but not short‐access rats
Greenwell, T. N., Funk, C. K., Cottone, P., Richardson, H. N., Chen, S. A., Rice, K. C., Zorrilla, E. P., & Koob, G. F. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00142.x · Cited by 87
Total Neurochemical Lesion of Noradrenergic Neurons of the Locus Ceruleus Does Not Alter Either Naloxone-Precipitated or Spontaneous Opiate Withdrawal nor Does It Influence Ability of Clonidine To Reverse Opiate Withdrawal
Caillé, S., Fernández‐Espejo, E., Rénéric, J.-P., Cador, M., Koob, G. F., & Stinus, L. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)34977-8 · Cited by 87
Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell
Paterson, N. E., Balfour, D. J. K., & Markou, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05546.x · Cited by 80
Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety
Harris, A. C., & Gewirtz, J. C. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1573-0 · Cited by 81
Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis
Fuentealba, J. A., Forray, M. I., & Gysling, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750741.x · Cited by 74
Absence and Rescue of Morphine Withdrawal in GIRK/Kir3 Knock-out Mice
Cruz, H. G., Berton, F., Sollini, M., Blanchet, C., Pravetoni, M., Wickman, K. D., & Lüscher, C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0267-08.2008 · Cited by 73
Chronic CRF1receptor blockade reduces heroin intake escalation and dependence‐induced hyperalgesia
Park, P. E., Schlosburg, J. E., Vendruscolo, L. F., Schulteis, G., Edwards, S., & Koob, G. F. (2015) · Addiction Biology · doi:10.1111/adb.12120 · Cited by 69
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats
Watanabe, T., Nakagawa, T., Yamamoto, R., Maeda, A., Minami, M., & Satoh, M. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1504-0 · Cited by 71
The α1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
Greenwell, T. N., Walker, B. M., Cottone, P., Zorrilla, E. P., & Koob, G. F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.07.012 · Cited by 69
Catechol-O-Methyltransferase and Pain
Kambur, O., & Männistö, P. T. (2010) · International review of neurobiology · doi:10.1016/b978-0-12-381326-8.00010-7 · Cited by 70
EEG spectral power and mean frequencies in early heroin abstinence
Polunina, A. G., & Davydov, D. M. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.022 · Cited by 66
Opiate physical dependence and N-methyl-d-aspartate receptors
Noda, Y., & Nabeshima, T. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.017 · Cited by 65
Endogenous opiates: 1997
Olson, G. A., Olson, R. D., Vaccarino, A. L., & Kastin, A. J. (1998) · Peptides · doi:10.1016/s0196-9781(98)00137-5 · Cited by 64
Acute opioid dependence: characterizing the early adaptations underlying drug withdrawal
Harris, A. C., & Gewirtz, J. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2155-0 · Cited by 63
Roles of α1- and α2-Adrenoceptors in the Nucleus Raphe Magnus in Opioid Analgesia and Opioid Abstinence-Induced Hyperalgesia
Bie, B., Fields, H. L., Williams, J. T., & Pan, Z. Z. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07950.2003 · Cited by 63
Morphine state-dependent learning: interactions with α2-adrenoceptors and acute stress
Homayoun, H., Khavandgar, S., & Zarrindast, M. (2003) · Behavioural Pharmacology · doi:10.1097/00008877-200302000-00004 · Cited by 63
Autoradiographic evidence that prenatal morphine exposure sex-dependently alters μ-opioid receptor densities in brain regions that are involved in the control of drug abuse and other motivated behaviors
Vathy, I., Šlamberová, R., Rimanóczy, Á., Riley, M. A., & Bar, N. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00355-x · Cited by 60
Effects of chronic oral nicotine treatment and its withdrawal on locomotor activity and brain monoamines in mice
Gäddnäs, H., Pietilä, K., & Ahtee, L. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00201-1 · Cited by 60
Punishment Induces Risky Decision-Making in Methadone-Maintained Opiate Users but not in Heroin Users or Healthy Volunteers
Ersche, K. D., Roiser, J. P., Clark, L., London, M., Robbins, T. W., & Sahakian, B. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300812 · Cited by 60
Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin
Weinshenker, D., & Holmes, P. V. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.025 · Cited by 63
p38 MAPK and β-Arrestin 2 Mediate Functional Interactions between Endogenous μ-Opioid and α2A-Adrenergic Receptors in Neurons
Tan, M., Walwyn, W. M., Evans, C. J., & Xie, C.-W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806742200 · Cited by 56
Effects of Corticotropin-Releasing Factor Receptor-1 Antagonists on the Brain Stress System Responses to Morphine Withdrawal
Navarro‐Zaragoza, J., Núñez, C., Laorden, M. L., & Milanés, M. V. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.062463 · Cited by 56
Pregabalin for the Treatment of Drug and Alcohol Withdrawal Symptoms: A Comprehensive Review
Freynhagen, R., Bačkonja, M., Schug, S. A., Lyndon, G. J., Parsons, B., WATT, S. J., & Behar, R. (2016) · CNS Drugs · doi:10.1007/s40263-016-0390-z · Cited by 55
Morphine withdrawal‐induced c‐fos expression in the hypothalamic paraventricular nucleus is dependent on the activation of catecholaminergic neurones
Laorden, M. L., Núñez, C., Almela, P., & Milanés, M. V. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01123.x · Cited by 53
Elevated Glucocorticoid Levels Are Responsible for Induction of Tyrosine Hydroxylase mRNA Expression, Phosphorylation, and Enzyme Activity in the Nucleus of the Solitary Tract during Morphine Withdrawal
Núñez, C., Földes, A., Pérez-Flores, D., García-Borrón, J. C., Laorden, M. L., Kovács, K., & Milanés, M. V. (2009) · Endocrinology · doi:10.1210/en.2008-1732 · Cited by 51
Potentiated startle and hyperalgesia during withdrawal from acute morphine: effects of multiple opiate exposures
Harris, A. C., Hanes, S. L., & Gewirtz, J. C. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1889-4 · Cited by 46
Prolonged Activation of Mesolimbic Dopaminergic Neurons by Morphine Withdrawal Following Clonidine: Participation of Imidazoline and Norepinephrine Receptors
Georges, F. E., & Aston‐Jones, G. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300161 · Cited by 46
Addiction: the clinical interface
Nutt, D., & Lingford-Hughes, A. R. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.101 · Cited by 46
Agmatine Potentiates Morphine-Induced Conditioned Place Preference in Mice: Modulation by Alpha(2)-Adrenoceptors
Tahsili‐Fahadan, P., Yahyavi‐Firouz‐Abadi, N., Khoshnoodi, M. A., Motiei-Langroudi, R., Tahaei, S. A., Ghahremani, M. H., & Dehpour, A. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300929 · Cited by 43
Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice
Arıcıoğlu, F., Paul, I. A., & Regunathan, S. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.010 · Cited by 43
The involvement of α2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice
Özdoğan, Ü. K., Lähdesmäki, J., Hakala, K., & Scheinin, M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.06.051 · Cited by 42
The role of alpha-adrenoceptor mechanism(s) in morphine-induced conditioned place preference in female mice
Sahraei, H., Ghazzaghi, H., Zarrindast, M., Ghoshooni, H., Sepehri, H., & Haeri-Rohan, A. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.03.004 · Cited by 42
Regulation of Serine (Ser)-31 and Ser40 Tyrosine Hydroxylase Phosphorylation during Morphine Withdrawal in the Hypothalamic Paraventricular Nucleus and Nucleus Tractus Solitarius-A2 Cell Group: Role of ERK1/2
Núñez, C., Laorden, M. L., & Milanés, M. V. (2007) · Endocrinology · doi:10.1210/en.2007-0510 · Cited by 40
EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research
Sokhadze, T. M., Cannon, R. L., & Trudeau, D. L. (2008) · Journal of Neurotherapy · doi:10.1080/10874200802219855 · Cited by 40
The Role of α2‐Adrenoceptors in the Modulatory Effects of Morphine on Seizure Susceptibility in Mice
Homayoun, H., Khavandgar, S., & Dehpour, A. R. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.49701.x · Cited by 39
Subcellular localization of α‐2A‐adrenergic receptors in the rat medial nucleus tractus solitarius: Regional targeting and relationship with catecholamine neurons
Glass, M. J., Huang, J., Aicher, S. A., Milner, T. A., & Pickel, V. M. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1135 · Cited by 39
Tramadol Induced Paradoxical Hyperalgesia
Kim, W. M. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/41 · Cited by 38
Supersensitivity of 5-HT 1A -autoreceptors and α 2 -adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats
Sastre-Coll, A., Esteban, S., & Garcı́a-Sevilla, J. A. (2002) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-001-0508-8 · Cited by 38
Immunomodulatory effects of morphine withdrawal in the rat are time dependent and reversible by clonidine
West, J. P., Dykstra, L., & Lysle, D. T. (1999) · Psychopharmacology · doi:10.1007/s002130051123 · Cited by 38
Corticotropin-releasing factor (CRF) and α2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats
Park, P. E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Schulteis, G., & Koob, G. F. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000308 · Cited by 38
Morphine withdrawal syndrome and its prevention with baclofen: Autoradiographic study of μ‐opioid receptors in prepubertal male and female mice
Diaz, S. L., Barros, V. G., Antonelli, M. C., Rubio‐Terres, C., & Balerio, G. N. (2006) · Synapse · doi:10.1002/syn.20279 · Cited by 37
The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
Skelton, K. H., Oren, D., Gutman, D. A., Easterling, K. W., Holtzman, S. G., Nemeroff, C. B., & Owens, M. J. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.041 · Cited by 36
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal
Akbarian, S., Bates, B., Liu, R.-J., Skirboll, S. L., Pejchal, T., Coppola, V., Sun, L. D., Fan, G., Kučera, J., Wilson, M. A., et al. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000897 · Cited by 36
Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN
Benavides, M., Laorden, M. L., García-Borrón, J. C., & Milanés, M. V. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02434.x · Cited by 34
Noradrenergic modulation of the discriminative-stimulus effects of methamphetamine in rats
Munzar, P., & Goldberg, S. R. (1999) · Psychopharmacology · doi:10.1007/s002130050950 · Cited by 34
Stress and Drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function
Fox, M. E., Studebaker, R. I., Swofford, N. J., & Wightman, R. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.23 · Cited by 33
Sensitivity to naloxone of the behavioral signs of morphine withdrawal and c‐Fos expression in the rat CNS: A quantitative dose‐response analysis
Guen, S. L., Gestreau, C., & Besson, J. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1140 · Cited by 33
Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework
Greenwald, M. K. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.08.003 · Cited by 33
Opioid withdrawal results in an increased local and remote functional connectivity at EEG alpha and beta frequency bands
Fingelkurts, A. A., Fingelkurts, A. A., Kivisaari, R., Autti, T. H., Борисов, С., Puuskari, V., Jokela, O., & Kähkönen, S. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.01.011 · Cited by 33
Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice
Özdoğan, Ü. K., Lähdesmäki, J., & Scheinin, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02961-8 · Cited by 32
Chronic very low dose naltrexone administration attenuates opioid withdrawal expression
Mannelli, P., Gottheil, E., Peoples, J. F., Oropeza, V. C., & Bockstaele, E. J. V. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.05.013 · Cited by 30
CRF2mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in rats
Navarro‐Zaragoza, J., Núñez, C., Ruiz‐Medina, J., Laorden, M. L., Valverde, O., & Milanés, M. V. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01090.x · Cited by 29
Yokukansan inhibits morphine tolerance and physical dependence in mice: The role of α2A-adrenoceptor
Nakagawa, T., Nagayasu, K., Nishitani, N., Shirakawa, H., Sekiguchi, K., Ikarashi, Y., Kase, Y., & Kaneko, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.079 · Cited by 29
Morphine withdrawal is modified in pituitary adenylate cyclase-activating polypeptide type I-receptor-deficient mice
Martín, M., Otto, C., Santamarta, M. T., Torrecilla, M., Pineda, J., Schütz, G., & Maldonado, R. J. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00646-0 · Cited by 29
Self-citation
Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference
Lasheras, M. C., Laorden, M. L., Milanés, M. V., & Núñez, C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.021 · Cited by 28
Daily morphine injection and withdrawal disrupt 24-h wheel running and PERIOD2 expression patterns in the rat limbic forebrain
Hood, S., Cassidy, P., Mathewson, S. A., Stewart, J., & Amir, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.045 · Cited by 28
The effects of dopamine receptor agents on naloxone-induced jumping behaviour in morphine-dependent mice
Zarrindast, M., Habibi, M., sh., B., Fazli‐Tabaei, S., Yahyavi, S. H., & Rostamin, P. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02149-0 · Cited by 28
Prostaglandin E2 attenuates SR141716A-precipitated withdrawal in tetrahydrocannabinol-dependent mice
Anggadiredja, K., Yamaguchi, T., Tanaka, H., Shoyama, Y., Watanabe, S., & Yamamoto, T. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04169-0 · Cited by 28
Increase of tyrosine hydroxylase levels and activity during morphine withdrawal in the heart
Cuello, A. M. G., Milanés, M. V., & Laorden, M. L. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.11.009 · Cited by 27
Stress‐Induced Analgesia and Morphine Responses Are Changed in Catechol‐O‐methyltransferase‐Deficient Male Mice
Kambur, O., Männistö, P. T., Viljakka, K. M., Reenilä, I., Lemberg, K. K., Kontinen, V., Karayiorgou, M., Gogos, J. A., & Kalso, E. A. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00289.x · Cited by 25
A Quantitative Peptidomic Analysis of Peptides Related to the Endogenous Opioid and Tachykinin Systems in Nucleus Accumbens of Rats Following Naloxone-Precipitated Morphine Withdrawal
Rossbach, U. L., Nilsson, A., Fälth, M., Kultima, K., Zhou, Q., Hallberg, M., Gordh, T., Andrén, P. E., & Nyberg, F. (2009) · Journal of Proteome Research · doi:10.1021/pr800669g · Cited by 24
The Nucleus Paragigantocellularis and Opioid Withdrawal-Like Behavior
Rockhold, R. W., Liu, N., Coleman, D., Commiskey, S., Shook, J. F., & Ho, I. K. (2000) · Journal of Biomedical Science · doi:10.1007/bf02255476 · Cited by 24
Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus–pituitary–adrenal axis
Cerezo, M., Laorden, M. L., & Milanés, M. V. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02245-8 · Cited by 24
Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice
Gómez-Milanés, I., Almela, P., García-Carmona, J. A., García‐Gutiérrez, M. S., Aracil-Fernández, A., Manzanares, J., Milanés, M. V., & Laorden, M. L. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.06.011 · Cited by 23
Morphine-dependent and abstinent mice are characterized by a broader distribution of the neurons co-expressing mu and delta opioid receptors
Pierre, F., Ugur, M., Faivre, F., Doridot, S., Veinante, P., & Massotte, D. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.009 · Cited by 23
The α2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats
Semenova, S., & Markou, A. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.05.003 · Cited by 22
α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice
You, S., Li, X., Xiong, J., Zhu, X., Zhangsun, D., Zhu, X., & Luo, S. (2019) · Marine Drugs · doi:10.3390/md17090490 · Cited by 22

Authors: MALDONADO, R.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: MALDONADO, RAFAEL
ORCID: MALDONADO, RAFAEL
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 1997-01
Volume: 21
Issue: 1
Pages: 91-104
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/0149-7634(95)00061-5
OpenAlex: W1991473840
Cited by: 213
References: 142
Citations by year: 2026: 5 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 11 · 2012: 7
FWCI: 0.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords: opioid withdrawal, noradrenergic system, locus coeruleus, morphine dependence, norepinephrine, alpha2-adrenoceptors, beta-adrenergic receptors, clonidine, propranolol, nucleus paragigantocellularis, excitatory amino acids, cAMP pathway, mesolimbic dopamine system
MeSH terms: Adrenergic Fibers, Animals, Narcotics, Neural Pathways, Substance Withdrawal Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Participation of Noradrenergic Pathways in the Expression of Opiate Withdrawal: Biochemical and Pharmacological Evidence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks