CoChat
Sign Up
Cited by 164Regulation of Appetite and ObesitySmoking Behavior and CessationAdipose Tissue and Metabolism

Effect of Short-Term Cigarette Smoke Exposure on Body Weight, Appetite and Brain Neuropeptide Y in Mice

Chen, Hui, Vlahos, Ross, Bozinovski, Steve, Jones, Jessica, Anderson, Gary P, Morris, Margaret J·2005·Neuropsychopharmacology
DOI 10.1038/sj.npp.1300597
Open this paper in CoChat — free account

Abstract

Although nicotinic receptors have been demonstrated in hypothalamic appetite-regulating areas and nicotine administration alters food intake and body weight in both animals and humans, the mechanisms underlying the effects of smoking on appetite circuits remain unclear. Conflicting effects of nicotine on the major orexigenic peptide, neuropeptide Y (NPY), have been observed in the brain, but the effects of smoking are unknown. Thus, we aimed to investigate how cigarette smoking affects body weight, food intake, plasma leptin concentration, hypothalamic NPY peptide, adipose mass and mRNA expression of uncoupling proteins (UCP), and tumor necrosis factor (TNF) alpha. Balb/C mice (8 weeks) were exposed to cigarette smoke (three cigarettes, three times a day for 4 consecutive days) or sham exposed. Body weight and food intake were recorded. Plasma leptin and brain NPY were measured by radioimmunoassay. UCPs and TNF alpha mRNA were measured by real-time PCR. Food intake dropped significantly from the first day of smoking, and weight loss became evident within 2 days. Brown fat and retroperitoneal white fat masses were significantly reduced, and plasma leptin concentration was decreased by 34%, in line with the decreased fat mass. NPY concentrations in hypothalamic subregions were similar between two groups. UCP1 mRNA was decreased in white fat and UCP3 mRNA increased in brown fat in smoking group. Short-term cigarette smoke exposure led to reduced body weight, food intake, and fat mass. The reduction in plasma leptin concentration may have been too modest to increase NPY production; alternatively, change in NPY or its function might have been offset by nicotine or other elements in cigarette smoke.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300597

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Chen, H., Vlahos, R., Bozinovski, S., Jones, J., Anderson, G. P., & Morris, M. J.
Affiliations
  • The University of Melbourne (AU)
  • The Royal Melbourne Hospital (AU)
Corresponding author
Morris, Margaret J
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2004-10-27
Volume
30
Issue
4
Pages
713-719
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1300597
OpenAlex
W2037326512
Semantic Scholar
7b28eb4ddab8a09bfdc985dfb901e81fcdaf9837
Cited by
164
References
62
Citations by year
2026: 1 · 2025: 3 · 2024: 8 · 2023: 3 · 2022: 11 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 9
FWCI
1.48
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • UTS ePRESS (University of Technology Sydney) (submittedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
cigarette smoke exposure, nicotine, neuropeptide Y, appetite, dietary intake, body weight, leptin, hypothalamus, brown adipose tissue, white adipose tissue, uncoupling proteins, UCP1, UCP3, TNF-α, fat mass
MeSH terms
Uncoupling Protein 3, Uncoupling Protein 1, Adipose Tissue, Animals, Appetite Regulation, Body Weight, Brain, Carrier Proteins, Disease Models, Animal, Drug Administration Schedule, Energy Metabolism, Hypothalamus, Ion Channels, Male, Membrane Proteins, Mice, Inbred BALB C, Neuropeptide Y, Nicotine, RNA, Messenger, Smoking, Time Factors, Tobacco Use Disorder, Tumor Necrosis Factor-alpha, Down-Regulation, Leptin, Mitochondrial Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review