Cited by 159Neuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress ResearchHeart Rate Variability and Autonomic Control

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Increases in plasma neuropeptide Y concentrations during sympathetic activation in man

Morris, M.J., Russell, A.E., Kapoor, V., Cain, M.D., Elliott, J.M., West, M.J., Wing, L.M.H., Chalmers, J.P.·1986·Journal of the Autonomic Nervous System

DOI 10.1016/0165-1838(86)90089-5

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Abstract

Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons. In order to test the hypothesis that NPY may be released along with catecholamines by activation of the sympathoadrenal system we measured plasma NPY-like immunoreactivity (NPY-LI) concentrations during cold pressor test, head up tilt and bicycle exercise in healthy volunteers. All 3 manoeuvres resulted in elevation of blood pressure, heart rate and plasma noradrenaline and adrenaline concentrations. These were accompanied by increases in plasma NPY-LI concentrations on cold pressor test and exercise, but not with head up tilt. The increases in both NPY-LI and catecholamines were greatest with exercise. These findings suggest that NPY is released at the same time as noradrenaline when sympathetic noradrenergic nerves are activated.

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Some statistical methods useful in circulation research.
Wallenstein, S., Zucker, C. L., & Fleiss, J. L. (1980) · Circulation Research · doi:10.1161/01.res.47.1.1 · Cited by 3,867
Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254
Neuropeptide Y (NPY)‐like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function
Lundberg, J. M., Terenius, L. Y., Hökfelt, T. G. M., Martling, C., Tatemoto, K., Mutt, V., Polak, J. M., Bloom, S. R., & Goldstein, M. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb07171.x · Cited by 1,199
Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat
Everitt, B. J., Hökfelt, T. G. M., Terenius, L. Y., Tatemoto, K., Mutt, V., & Goldstein, M. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90036-8 · Cited by 871
Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers
Ekblad, E., Edvinsson, L. I., Wahlestedt, C., Uddman, R., Håkanson, R., & Sundler, F. (1984) · Regulatory Peptides · doi:10.1016/0167-0115(84)90064-8 · Cited by 741
High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man
Lundberg, J. M., Terenius, L. Y., Hökfelt, T. G. M., & Goldstein, M. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90401-9 · Cited by 616
Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.
Robertson, D., Johnson, G., Robertson, R. M., Nies, A. S., Shand, D. G., & Oates, J. A. (1979) · Circulation · doi:10.1161/01.cir.59.4.637 · Cited by 467
Simple and fast solvent extraction system for selective and quantitative isolation of adrenaline, noradrenaline and dopamine from plasma and urine
Smedes, F., Kraak, J. C., & Poppe, H. (1982) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)80506-x · Cited by 421
Evidence for differential localization of noradrenaline and neuropeptide Y in neuronal storage vesicles isolated from rat vas deferens
Fried, G. M., Terenius, L. Y., Hökfelt, T. G. M., & Goldstein, M. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-02-00450.1985 · Cited by 261
Co-release of neuropeptide Y and catecholamines during physical exercise in man
Lundberg, J. M., Martinsson, A., Hemsén, A., Theodorsson, E., Svedenhag, J., Ekblom, B. T., & Hjemdahl, P. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91837-6 · Cited by 223

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“NPY-like immunoreactivity in the various brain regions was measured by a specific radioimmunoassay developed in our laboratory using synthetic NPY as standard (10–1280 pg/tube, Auspep, Australia) (Morris et al, 1986).”
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“NPY-like immunoreactivity (NPY-LI) was measured using synthetic NPY as a standard (10 -1280 pg/tube, Auspep, Australia) and Bolton Hunter labelled 125 I-NPY (2000 Ci/mmol, Amersham Pharmacia Biotech UK, Buckinghamshire HP, England) (41).”
Method
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Background
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“radioimmunoassay developed in our laboratory (33) using synthetic NPY as standard (10-1280 pg/tube, Auspep, Australia).”
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“by physical exercise, a parallel increase in plasma concentrations of noradrenaline and NPY was observed, suggesting release of both transmitters from stimulated sympathetic nerve fibres (Lundberg et al. 1985a; Morris et al. 1986).”
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“However, in the brain NPY acts as an anxiolytic and inhibits sympathetic activity which results in lowering blood pressure and heart rate (Morris et al., 1986; Kuo et al., 2007), and inhibiting the production of cortisol in human adrenal cells (Kempna et al.”
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Background
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Method
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Background
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“Plasma leptin concentrations were measured using a commercially available radioimmunoassay kit (Linco, Missouri, USA) while NPY was measured using an in house assay utilising a rabbit antibody and 125I-NPY (2000 Ci/mmol, Amersham, Australia) as previously described [13].”
BackgroundMethod
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“NPY-like immunoreactivity (NPY-LI) was measured by a specific radioimmunoassay developed in our laboratory (Morris et al., 1986) using synthetic NPY as standard (10–1280 pg/tube, Auspep, Australia).”
Method
Neuropeptide Y: An overview
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Endogenous Mediators in Sepsis and Septic Shock
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“... brain [1], in postganglionic sympathetic noradrenergic nerves innervating the cardiovascular system, and in catecholamine-containing chromaffin cells of the adrenal medulla [2, 3]. NPY is stored in large densecore vesicles [4] and is coreleased with norepinephrine (NE), primarily during high-intensity sympathetic…”
Background
Is the CCK2 receptor essential for normal regulation of body weight and adiposity?
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“NPY-like immunoreactivity was measured by a specific radioimmunoassay developed in our laboratory (Morris et al., 1986) using synthetic NPY as standard (10–1280 pg ⁄ tube, Auspep, VIC,”
Method
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Increased concentrations of plasma neuropeptide Y in patients with eclampsia and preeclampsia
Khatun, S., Kanayama, N., Belayet, H. M., Bhuiyan, A. B., Jahan, S., Begum, A., Kobayashi, T., & Terao, T. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(00)70342-5 · Cited by 28
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Zoccali, C., Mallamaci, F., Tripepi, G. L., Benedetto, F. A., Parlongo, S., Cutrupi, S., Bonanno, G., Rapisarda, F., Fatuzzo, P. M., Seminara, G., et al. (2003) · Journal of Hypertension · doi:10.1097/00004872-200307000-00025 · Cited by 27
Involvement of neuropeptide Y in neuroendocrine stress responses. Central and peripheral studies
Mormède, P., Castagné, V., Rivet, J., Gaillard, R. C., & Corder, R. (1990) · Springer eBooks · doi:10.1007/978-3-7091-9050-0_8 · Cited by 27
Neuropeptide Y and [Leu31,Pro34]neuropeptide Y potentiate potassium-induced noradrenaline release in the paraventricular nucleus of the aged rat
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Increased immunoreactive neuropeptide Y in platelets of spontaneously hypertensive rats (SHR)
Ogawa, T., Kitamura, K., Kawamoto, M., Eto, T., & Tanaka, K. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92759-9 · Cited by 25
A Pilot Study of Potassium Supplementation in the Treatment of Hypokalemic Patients With Rheumatoid Arthritis: A Randomized, Double-Blinded, Placebo-Controlled Trial
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Regional Sympathetic Effects of Low-Dose Clonidine in Heart Failure
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Actions of neuropeptide Y on basal, cyclic AMP-induced and neurally evoked ion transport in porcine distal jejunum
Brown, D. R., Boster, S. L., Overend, M. F., Parsons, A. M., & Treder, B. G. (1990) · Regulatory Peptides · doi:10.1016/0167-0115(90)90107-8 · Cited by 24
Changes in plasma catecholamine and neuropeptide Y levels after sympathetic activation in dogs
Poncet, M., Damase‐Michel, C., Tavernier, G., Tran, M. A., Berlan, M., Montastruc, J., & Montastruc, P. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14232.x · Cited by 23
Effects of neuropeptide Y and agonists selective for neuropeptide Y receptor sub‐types on arterioles of the guinea‐pig small intestine and the rat brain
Xia, J., Neild, T. O., & Kotecha, N. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14522.x · Cited by 22
NEUROPEPTIDE Y RADIO‐IMMUNOASSAY: CHARACTERIZATION AND APPLICATION
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Plasma neuropeptide Y (NPY) and galanin before and during exercise in type 1 diabetic patients with autonomic dysfunction
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Effects of neuropeptide Y on the renal, mesenteric and hindlimb vascular beds of the conscious rabbit
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Renal and systemic plasma immunoreactive neuropeptide Y and calcitonin gene‐related peptide responses to mental stress and adrenaline in humans
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Neuroendocrine immune pathways in chronic arthritis
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“myocardial infarction, chronic heart failure or phaeochromocytoma [2,30,46,61,85].”
Background
Neuropeptide Y in the Sympathetic Control of Blood Pressure in Hypertensive Subjects
Chalmers, J. P., Morris, M. J., Kapoor, V., Cain, M., Elliott, J. M., Russell, A. E., Pilowsky, P. M., Minson, J. B., West, M., & Wing, L. M. H. (1989) · Clinical and Experimental Hypertension · doi:10.3109/10641968909045412 · Cited by 19
Post‐exercise depression of baroreflex slowing of the heart in humans
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Assessment of sympathoneural activity in clinical research
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Psychopharmacological possibilities in the acute disaster setting
Simon, A. B., & Gorman, J. M. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.03.004 · Cited by 18
Release of neuropeptide Y and hemodynamic changes during surgical removal of human pheochromocytomas
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Pharmacological characterization of the release of neuropeptide Y-like immunoreactivity from the rat hypothalamus
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Brislane, Á., Davenport, M. H., & Steinback, C. D. (2022) · Experimental Physiology · doi:10.1113/ep089665 · Cited by 17
“NPY is a potent vasoconstrictor peptide that is transmitted with noradrenaline at sympathetic nerve terminals after sympathetic stimulation (Morris et al., 1986; Wahlestedt et al., 1990).”
Background
Response of plasma neuropeptide Y and noradrenaline to dynamic exercise and ramipril treatment in patients with congestive heart failure
Ullman, B., Lindvall, K., Lundberg, J. M., Sigurðsson, A. F., & Swedberg, K. B. (1994) · Clinical Physiology · doi:10.1111/j.1475-097x.1994.tb00498.x · Cited by 17
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Sympathetic Neural Control in Humans with Anxiety‐Related Disorders
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Roles of nuclear NPY and NPY receptors in the regulation of the endocardial endothelium and heart functionThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.
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NEUROPEPTIDE Y IN CORTISOL‐INDUCED HYPERTENSION IN MALE VOLUNTEERS
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Age‐related changes of exercise‐induced plasma catecholamines and neuropeptide Y responses in normal human subjects
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Changes in cardiac neuropeptide Y after experimental myocardial infarction in rat
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Facilitating laser Doppler measurements of cutaneous adrenergic vasoconstriction: a comparison of methods
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“The systemic concentration of neuropeptide Y increases during sympathetic activation [23], and with its long plasma half-life [24], could have accumulated over the course of the experiment.”

Authors: Morris, M. J., Russell, A. E., Kapoor, V., Cain, M. D., Elliott, J. M., West, M. J., Wing, L. M. H., & Chalmers, J. P.
Affiliations: Flinders Medical Centre (AU)
ORCID: Morris, M.J.
Elliott, J.M.
West, M.J.
Chalmers, J.P.
Venue: Journal of the Autonomic Nervous System
Publisher: Elsevier BV
Published: 1986-10
Volume: 17
Issue: 2
Pages: 143-149
ISSN: 0165-1838 (ISSN-L)
DOI: 10.1016/0165-1838(86)90089-5
OpenAlex: W2001937802
Cited by: 159
References: 22
Citations by year: 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 1 · 2014: 4 · 2013: 2 · 2012: 3
FWCI: 2.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Autonomic Nervous System (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: neuropeptide Y, sympathetic activation, sympathoadrenal system, norepinephrine, catecholamines, epinephrine, cold pressor test, head-up tilt, physical activity, blood pressure, heart rate
MeSH terms: Adult, Blood Pressure, Chromatography, High Pressure Liquid, Cold Temperature, Epinephrine, Exercise Test, Female, Heart Rate, Humans, Immersion, Male, Middle Aged, Neuropeptide Y, Norepinephrine, Posture, Radioimmunoassay, Sympathetic Nervous System

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Increases in plasma neuropeptide Y concentrations during sympathetic activation in man

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