Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS
Open accessAbstract
The third meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) focused on selecting promising measures for each of the cognitive constructs selected in the first CNTRICS meeting. In the domain of perception, the 2 constructs of interest were gain control and visual integration. CNTRICS received 5 task nominations for gain control and three task nominations for visual integration. The breakout group for perception evaluated the degree to which each of these tasks met prespecified criteria. For gain control, the breakout group for perception believed that 2 of the tasks (prepulse inhibition of startle and mismatch negativity) were already mature and in the process of being incorporated into multisite clinical trials. However, the breakout group recommended that steady-state visual-evoked potentials be combined with contrast sensitivity to magnocellular vs parvocellular biased stimuli and that this combined task and the contrast-contrast effect task be recommended for translation for use in clinical trial contexts in schizophrenia research. For visual integration, the breakout group recommended the Contour Integration and Coherent Motion tasks for translation for use in clinical trials. This manuscript describes the ways in which each of these tasks met the criteria used by the breakout group to evaluate and recommend tasks for further development.
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Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia
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Self-citation
- Authors
- Green, M. F., Butler, P. D., Chen, Y., Geyer, M. A., Silverstein, S., Wynn, J. K., Yoon, J. H., & Zemon, V.
- Affiliations
- University of California, Los Angeles (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Harvard University (US)
- University of California San Diego (US)
- University of California, Davis (US)
- Yeshiva University (US)
- Corresponding author
- Green, M. F.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-01
- Volume
- 35
- Issue
- 1
- Pages
- 163-181
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC2635893
- OpenAlex
- W2104383152
- Cited by
- 113
- References
- 174
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 9 · 2013: 16 · 2012: 7
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- Dainippon Sumitomo Pharma
- Astellas Pharma
- Otsuka Pharmaceutical
- H. Lundbeck A/S
- National Institute of Mental Health (MH 52885, MH 61824, R01MH066374, R01MH052885, MH 43292, MH66374, R01MH061824)
- National Institute on Drug Abuse (DA 02925, R01DA002925)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, perception
- MeSH terms
- Animals, Clinical Trials as Topic, Evoked Potentials, Visual, Humans, Magnetic Resonance Imaging, Perceptual Disorders, Psychometrics, Schizophrenia, Reflex, Startle, Visual Perception
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