Intravenous cocaine-induced place preference: attenuation by haloperidol

Spyraki, Christina; Nomikos, George G.; Varonos, Denis D.

doi:10.1016/0166-4328(87)90016-7

Cited by 89Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Intravenous cocaine-induced place preference: attenuation by haloperidol

Spyraki, Christina, Nomikos, George G., Varonos, Denis D.·1987·Behavioural Brain Research

DOI 10.1016/0166-4328(87)90016-7

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Abstract

Cocaine reward was demonstrated by establishing a conditioned place preference (CPP) to a distinctive location paired with cocaine administered either intravenously (i.v., 0.5 mg/kg) or intraperitoneally (i.p., 10 mg/kg). Significant i.p. or i.v. cocaine CPP was observed following the second conditioning trial. Haloperidol (0.2 mg/kg) pretreatment disrupted CPP induced by i.v., but not i.p., cocaine. The haloperidol effect built up over successive trials. The involvement of dopaminergic transmission in i.v. cocaine-induced CPP is discussed.

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Intravenous administration of cocaine induces conditioned place preference mediated via a dopamine dependent mechanism, particularly that of the accumbens shell and olfactory tubercle.
“Whereas intravenous administration of cocaine induces conditioned place preference mediated via a dopamine dependent mechanism (Spyraki et al., 1987), particularly that of the accumbens shell and olfactory tubercle (Sellings et al., 2006b)”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Spyraki et al., 1987

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Authors: Spyraki, C., Nomikos, G. G., & Varonos, D. D.
Affiliations: National and Kapodistrian University of Athens (GR)
Corresponding author: Spyraki, Christina
ORCID: Nomikos, George G.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 1987-10
Volume: 26
Issue: 1
Pages: 57-62
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/0166-4328(87)90016-7
OpenAlex: W2007169577
Cited by: 87
References: 27
Citations by year: 2026: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 1
FWCI: 0.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: cocaine, conditioned place preference, intravenous administration, intraperitoneal administration, haloperidol, dopamine, drug reward, dopamine D1 receptor, route of administration
MeSH terms: Animals, Cocaine, Conditioning, Psychological, Haloperidol, Injections, Intraperitoneal, Injections, Intravenous, Male, Rats, Inbred Strains, Reward, Rats

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Intravenous cocaine-induced place preference: attenuation by haloperidol

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