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Cited by 264Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesDiabetes Management and Research

Insulin release and peripheral sensitivity at the oral glucose tolerance test

Cederholm, Jan, Wibell, Lars·1990·Diabetes Research and Clinical Practice
DOI 10.1016/0168-8227(90)90040-z
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Abstract

With the use of a 75 g oral glucose tolerance test, both insulin release (IRG) and the degree of peripheral sensitivity (SI) were evaluated simultaneously in groups with normal (NGT) and impaired (IGT) glucose tolerance as well as NIDDM. IRG was expressed as the ratio of the area under the insulin curve to that of the glucose curve above fasting levels. The peripheral glucose uptake rate (M) during the OGTT was measured as the difference between the glucose load and the increase in the amount of glucose in the glucose space during the oral glucose tolerance test (OGTT). SI was expressed as the ratio of the metabolic clearance rate (M/mean blood glucose) to log mean serum insulin. In the non-obese groups, both mean IRG and mean SI values were decreased with an increasing degree of hyperglycemia from NGT to NIDDM. Decreased mean SI values were also found in obese subjects. IGT-subjects given 3 months of diet and exercise achieved improved SI values. A non-obese NIDDM-group had higher mean IRG and mean SI values after 6 months of treatment with glipizide. The results were comparable to data obtained with more complicated techniques, such as the insulin clamp and suppression tests, and should be easy to apply on a large scale in epidemiological studies.

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  • Late-reactive hypoglycemia may be a predictor of diabetes.

    “For all these reasons, late-reactive hypoglycemia may be a predictor of diabetes.[30–32]”

    From Postprandial Reactive Hypoglycemia (2019) · cites this paper as [30]

  • The Cederholm index of peripheral insulin sensitivity has been validated against the hyperinsulinemic-euglycemic clamp.

    “Glucose and insulin concentrations during the OGTT were used to calculate the Cederholm index of peripheral insulin sensitivity (32), which has been validated against the hyperinsulinemic-euglycemic clamp (33).”

    From Simvastatin Effects on Skeletal Muscle (2013) · cites this paper as [32]

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Authors
Cederholm, J., & Wibell, L.
Affiliations
Uppsala University Hospital (SE)
Corresponding author
Cederholm, Jan
Venue
Diabetes Research and Clinical Practice
Publisher
Elsevier BV
Published
1990-10
Volume
10
Issue
2
Pages
167-175
ISSN
0168-8227 (ISSN-L)
DOI
10.1016/0168-8227(90)90040-z
OpenAlex
W2050110272
Cited by
264
References
28
Citations by year
2026: 2 · 2025: 7 · 2024: 11 · 2023: 3 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 14 · 2015: 14 · 2014: 12 · 2013: 11 · 2012: 2
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Diabetes Research and Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
insulin secretion, insulin sensitivity, oral glucose tolerance test, impaired glucose tolerance, type 2 diabetes, peripheral glucose uptake, hyperglycemia, obesity, diet and exercise therapy, glipizide
MeSH terms
Insulin Secretion, Aged, Blood Glucose, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Insulin, Male, Middle Aged, Obesity, Reference Values

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