Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training
Open accessAbstract
High-intensity interval training (HIT) has been proposed as a time-efficient alternative to traditional cardiorespiratory exercise training, but is very fatiguing. In this study, we investigated the effects of a reduced-exertion HIT (REHIT) exercise intervention on insulin sensitivity and aerobic capacity. Twenty-nine healthy but sedentary young men and women were randomly assigned to the REHIT intervention (men, n = 7; women, n = 8) or a control group (men, n = 6; women, n = 8). Subjects assigned to the control groups maintained their normal sedentary lifestyle, whilst subjects in the training groups completed three exercise sessions per week for 6 weeks. The 10-min exercise sessions consisted of low-intensity cycling (60 W) and one (first session) or two (all other sessions) brief ‘all-out’ sprints (10 s in week 1, 15 s in weeks 2–3 and 20 s in the final 3 weeks). Aerobic capacity (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \dot{V}{\text{O}}{}_{ 2}{\text{peak}} $$\end{document}) and the glucose and insulin response to a 75-g glucose load (OGTT) were determined before and 3 days after the exercise program. Despite relatively low ratings of perceived exertion (RPE 13 ± 1), insulin sensitivity significantly increased by 28% in the male training group following the REHIT intervention (P < 0.05). \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \dot{V}{\text{O}}{}_{ 2}{\text{peak}} $$\end{document} increased in the male training (+15%) and female training (+12%) groups (P < 0.01). In conclusion we show that a novel, feasible exercise intervention can improve metabolic health and aerobic capacity. REHIT may offer a genuinely time-efficient alternative to HIT and conventional cardiorespiratory exercise training for improving risk factors of T2D.
AI snapshot
Written from the paper’s full text.
TL;DR
A 6-week reduced-exertion high-intensity interval training (REHIT) program—3 sessions/week, 10 minutes each, totaling 30 minutes/week—improved insulin sensitivity in sedentary young men and aerobic capacity in both men and women. The authors conclude REHIT may be a time-efficient alternative to classic HIT and conventional cardiorespiratory training for improving type 2 diabetes risk factors.
Key findings
- Insulin sensitivity increased by 28% in the male REHIT group following training (P<0.05), but not in female subjects.
- VO₂peak increased by 15% in men and 12% in women after REHIT (P<0.01), with no significant gender difference in this effect.
- No changes in weight or BMI occurred in any group; mean adherence to the REHIT program was 97%, and 10 of 15 training participants completed all 18 sessions.
- Mean RPE peaked at session 12 (week 4) at about 14 (“somewhat hard”); no participant gave an RPE higher than 15, though women found the program significantly harder than men.
Methods
- Twenty-nine healthy but sedentary young men (n=13) and women (n=16) were randomized to REHIT or control; training groups were men n=7 and women n=8, control groups were men n=6 and women n=8.
- REHIT consisted of 3 supervised sessions/week for 6 weeks; each 10-minute session included low-intensity cycling at 60 W plus one (first session) or two all-out sprints, with sprint duration increasing from 10 s in week 1 to 15 s in weeks 2–3 and 20 s in the final 3 weeks.
- Insulin sensitivity was assessed by OGTT with 75 g glucose and the Cederholm index; aerobic capacity was assessed by a graded cycling VO₂peak test before and 3 days after training; three-way mixed-model ANOVAs tested gender × group × time effects.
Limitations
- Stated in the paper: the study had low statistical power, especially for the female REHIT group (n=8); possible non-responders may explain the lack of insulin-sensitivity improvement in women; the post-intervention OGTT was 3 days after the final session, so earlier improvements in women cannot be ruled out; glycogen depletion and sprint power output were not measured; some women struggled to increase pedal frequency/power during sprints, possibly reducing glycogen depletion; and the RPE scale may not validly capture exertion during interval exercise and may underestimate sprint effort.
- Evident from the text: the gender-specific insulin-sensitivity finding rests on very small subgroups, and the control condition was maintenance of a sedentary lifestyle rather than an active comparison intervention.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
0 of 40 cited sources checked · 0 supported · 0 flagged
- Findingown data
Following reduced-exertion high-intensity interval training, peak oxygen uptake increased by 12% in women.
“2 peak increased in the male training (+15%) and female training (+12%) groups (P<0.01).”
Quote in the paperSubstantial claim - Findingown data
No significant changes in insulin area under the curve were observed following reduced-exertion high-intensity interval training.
“No significant changes in insulin AUC were observed (Table 2).”
Quote in the paperNot a substantial claim - Findingown data
There was no significant gender difference in the effect of reduced-exertion high-intensity interval training on peak oxygen uptake.
“following REHIT 2 peak was increased by 15% in men and by 12% in women with no significant gender difference in this effect ( able 2).”
Quote in the paperNot a substantial claim - Findingown data
There were no changes in weight or body mass index following the reduced-exertion high-intensity interval training program in any of the groups.
“There were no changes in weight or BMI following the REHIT training program in any of the groups (Table 2).”
Quote in the paperSubstantial claim - Findingown data
Following reduced-exertion high-intensity interval training, peak oxygen uptake increased by 15% in men.
“2 peak increased in the male training (+15%) and female training (+12%) groups (P<0.01).”
Quote in the paperSubstantial claim
- Findingown data
Following reduced-exertion high-intensity interval training, insulin sensitivity did not significantly improve in female subjects.
“Following REHIT, insulin sensitivity significantly improved by 28% in male subjects (P<0.05),but not in female subjects (Figure 3).”
Quote in the paperNot a substantial claim - Findingown data
No significant effects were observed for men on glucose area under the curve following reduced-exertion high-intensity interval training.
“No significant effects were observed for men.”
Quote in the paperNot a substantial claim - Findingown data
Following reduced-exertion high-intensity interval training, insulin sensitivity significantly improved by 28% in male subjects.
“insulin sensitivity significantly increased by 28% in the male training group following the REHIT intervention (P<0.05).”
Quote in the paperSubstantial claim - Findingown data
The training sessions were well tolerated by all participants.
“On the whole, despite the incorporation of brief but intense sprints, the training sessions were well tolerated by all of the participants.”
Quote in the paperNot a substantial claim - Findingown data
Insulin sensitivity was increased by 28% in men following REHIT.
“Insulin sensitivity was increased by 28% in men following REHIT.”
Quote in the paperSubstantial claim - Findingown data
Mean insulin sensitivity was not improved in female subjects after the REHIT training program.
“mean insulin sensitivity was not improved in the female subjects after the training program”
Quote in the paperSubstantial claim - Findingcitation
Average RPE values reported on immediate completion of the REHIT training sessions were comparable with RPE values obtained during prolonged moderate intensity cardiorespiratory exercise at 50-75% VO2max.
“Average RPE values reported on immediate completion of the REHIT training sessions were comparable with RPE values obtained during prolonged moderate intensity cardiorespiratory exercise at 50-75% 2 max (Borg 1982).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Borg 1982
Not checked in the free run.
- Findingown data
Aerobic capacity increased by 15% in men and 12% in women after the REHIT intervention.
“Aerobic capacity increased by 15% and 12% in men and women respectively after the REHIT intervention”
Quote in the paperSubstantial claim - Premisecitation
A single 30-second Wingate sprint can reduce muscle glycogen stores in the vastus lateralis by 20-30%.
“It has consistently been shown that a single 30-second Wingate sprint can reduce muscle glycogen stores in the vastus lateralis by 20-30% (Esbjornsson-Liljedahl et al. 1999;Parolin et al. 1999;Esbjornsson-Liljedahl et al. 2002;Gibala et al. 2009).”
Quote in the paperSubstantial claim0 of 3 sources checked - Study design and conductown data
There were no significant differences in total energy, carbohydrate, fat or protein content over the 3 days before the pre- and post-intervention oral glucose tolerance tests in any of the subject groups.
“There were no significant differences in total energy, carbohydrate, fat or protein content over the 3 days before the pre-and post-intervention OGTTs in any of the subject groups.”
Quote in the paperNot a substantial claim - Interpretationown data
The beneficial effects of reduced-exertion high-intensity interval training occurred independently of changes in body mass.
“The beneficial effects occurred independently of changes in body mass”
Quote in the paperSubstantial claim - Premisecitation
Upregulation of key metabolic genes initiated by release of glycogen-bound proteins may explain how glycogen depletion affects insulin-dependent muscle glucose uptake.
“The upregulation of key metabolic genes initiated by the release of glycogen-bound proteins may, at least in part, explain how glycogen depletion affects insulin-dependent muscle glucose uptake (Steinberg et al. 2006;Graham et al. 2010).”
Quote in the paperSubstantial claim0 of 2 sources checked - Interpretationreasoning
The beneficial effects may represent a chronic training adaptation because post-training measurements were taken 3 days after the final exercise bout.
“may represent a chronic training adaptation since post-training measurements were taken 3 days after the final exercise bout.”
Quote in the paperSubstantial claim - Premisecitation
The primary defect underlying the development of type 2 diabetes is skeletal muscle insulin resistance.
“The primary defect underlying the development of T2D is skeletal muscle insulin resistance (DeFronzo and Tripathy 2009).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites DeFronzo and Tripathy 2009 source
Not checked in the free run.
- Study design and conductown data
There were no significant differences between the reduced-exertion high-intensity interval training and control groups at baseline.
“No significant differences existed between the REHIT and control groups at baseline (Tables 12).”
Quote in the paperSubstantial claim - Study design and conductcitation
The Cederholm Index has previously been shown to correlate well with the gold standard insulin clamp method.
“The Cederholm Index has previously been shown to correlate well with the gold standard insulin clamp method (Piche et al. 2007).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Piche et al. 2007 source
Not checked in the free run.
- Premisecitation
High-intensity interval training has beneficial effects on insulin sensitivity.
“we have recently demonstrated the beneficial effects of HIT on insulin sensitivity (Babraj et al. 2009), a finding that has since been confirmed by others (Little et al. 2011;Richards et al. 2010;Whyte et al. 2010).”
Quote in the paperSubstantial claim0 of 3 sources checked - Interpretationown data
The improvements were observed despite a low time commitment totalling 30 minutes per week.
“Importantly, the improvements were observed despite the low time commitment (totalling 30 minutes per week) and low required effort: RPE peaked at an average of 14 ('somewhat hard') in week 4 which is comparable with RPE scores reported with prolonged cycling at 50-75% 2 max (Borg 1982).”
Quote in the paperSubstantial claim - Premisecitation
Physical inactivity may be the major initiating factor in the metabolic causes of insulin resistance.
“there is accumulating evidence that physical inactivity may be the major initiating factor (Thyfault and Krogh-Madsen 2011)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Thyfault and Krogh-Madsen 2011
Not checked in the free run.
- Premisecitation
Activation of glycogenolysis is inhibited in subsequent repeated sprints.
“activation of glycogenolysis is inhibited in subsequent repeated sprints (Parolin et al. 1999).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Parolin et al. 1999
Not checked in the free run.
- Interpretationown data
To date, the training program used in the current study represents the smallest volume of exercise, when considered per session, that has been shown to induce positive effects on health.
“To date, the training program utilised in the current study represents the smallest volume of exercise (when considered per session) that has been shown to induce positive effects on health.”
Quote in the paperSubstantial claim - Interpretationown data
The REHIT protocol may offer a genuinely time-efficient alternative to HIT and conventional cardiorespiratory exercise training for improving risk factors of T2D.
“Our findings suggest that this REHIT protocol may offer a genuinely time-efficient alternative to HIT and conventional cardiorespiratory exercise training for improving risk factors of T2D.”
Quote in the paperSubstantial claim - Interpretationown data
This study extends previous literature showing beneficial effects of high-intensity interval training by showing that sprint number and duration can be substantially reduced whilst still maintaining positive effects.
“This study extends the previous literature showing the beneficial effects of HIT (Burgomaster et al. 2007;Babraj et al. 2009;Richards et al. 2010;Whyte et al. 2010;Rakobowchuk et al. 2008;Trilk et al. 2010) by showing that the sprint number and duration can be substantially reduced whilst still maintaining positive effects.”
Quote in the paperSubstantial claim0 of 3 sources checked - Interpretationown data
The improvements in insulin sensitivity after REHIT appear to be gender-specific.
“The improvements in insulin sensitivity after REHIT appear to be gender-specific as mean insulin sensitivity was not improved in the female subjects after the training program.”
Quote in the paperSubstantial claim- Rests on an assumption: No other study has investigated the effects of HIT on insulin sensitivity in women.
- Interpretationcitation
The magnitude of the increase in insulin sensitivity in men following REHIT is comparable to responses to 2 weeks of classic HIT in recreationally active men and women and in obese men.
“The magnitude of this change is comparable with responses to 2 weeks of classic HIT in recreationally active men and women (Babraj et al. 2009;Richards et al. 2010) and in obese men (Whyte et al. 2010).”
Quote in the paperSubstantial claim0 of 3 sources checked - Interpretationown data
Reduced-exertion high-intensity interval training may offer a genuinely time-efficient alternative to high-intensity interval training and conventional cardiorespiratory exercise training for improving risk factors of type 2 diabetes.
“REHIT may offer a genuinely time-efficient alternative to HIT and conventional cardiorespiratory exercise training for improving risk factors of T2D.”
Quote in the paperSubstantial claim - Premisecitation
A high aerobic capacity is associated with a lower risk of cardiometabolic disease.
“a high aerobic capacity is associated with a lower risk of cardiometabolic disease (Church et al. 2005;Wei et al. 1999).”
Quote in the paperSubstantial claim0 of 2 sources checked - Premisecitation
A rating of perceived exertion of 14 is comparable with ratings reported with prolonged cycling at 50-75% peak oxygen uptake.
“RPE peaked at an average of 14 ('somewhat hard') in week 4 which is comparable with RPE scores reported with prolonged cycling at 50-75% 2 max (Borg 1982).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Borg 1982
Not checked in the free run.
- Premisecitation
A previous study did not observe gender differences in the improvements in insulin sensitivity in 12 recreationally active subjects after 2 weeks of classic HIT.
“This is in contrast to a previous study which did not observe gender differences in the improvements in insulin sensitivity in 12 recreationally active subjects after 2 weeks of classic HIT (Richards et al. 2010).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Richards et al. 2010 source
Not checked in the free run.
- May combine two claims. 20
- Classified as probably not a substantial claim. 7
May combine two claims.
Findingown dataFor women, post-intervention glucose area under the curve was increased, but there was no significant difference between the female reduced-exertion high-intensity interval training and control groups.
“A significant main effect for time for women (P<0.05)indicated that postintervention values for glucose AUC were increased, but there was no significant difference between the female REHIT and control groups.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataMean ratings of perceived exertion peaked at the end of session 12 in week 4, corresponding to somewhat hard in men and between somewhat hard and hard in women.
“Mean RPE values peaked at the end of session 12 (week 4; 2x20 s), corresponding to 'somewhat hard' and between 'somewhat hard' and 'hard' in men and women respectively (Figure 4A).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataNone of the participants gave a rating of perceived exertion score higher than 15.
“None of the participants gave an RPE score higher than 15.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataFemale participants found the training program significantly harder than male participants.
“When mean RPE values over the whole training program were calculated, female participants found the training program significantly harder than male participants (Figure 4B).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataSome female volunteers struggled with the transition from 60 W to the all-out sprints and were unable to substantially increase their pedal frequency and power output during the sprints.
“we observed that some of the female volunteers struggled with the transition from 60 W to the all-out sprints, and were unable to substantially increase their pedal frequency, and thus their power output during the sprints.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductreasoningParticipants were asked to maintain their normal lifestyle patterns throughout the study period to control for changes in diet and physical activity.
“the potentially confounding effect of changes in diet and physical activity patterns was fully explained to all participants and they were asked to maintain their normal lifestyle patterns throughout the study period.”
Quote in the paperSubstantial claim- Rests on an assumption: Participants in both groups did not change their physical activity patterns outside the intervention during the study.
May combine two claims.
PremisecitationA typical high-intensity interval training session requires more than 20 minutes total time commitment including warm-up, recovery intervals and cool-down, reducing time-efficiency.
“although a typical HIT session requires only 2-3 minutes of actual sprint exercise, when considered as a feasible exercise session including a warm-up, recovery intervals and cool-down, the total time commitment is more than 20 minutes, reducing the timeefficiency (Garber et al. 2011).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Garber et al. 2011 source
Not checked in the free run.
May combine two claims.
Study design and conductown dataTen out of fifteen training group participants completed all 18 training sessions, with a mean adherence to the reduced-exertion high-intensity interval training program of 97% for all subjects combined.
“Ten out of fifteen training group participants completed all 18 training sessions (100% adherence), with a mean adherence to the REHIT training program of 97% for all subjects combined.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationExercise is essential for good metabolic and cardiovascular function, of which insulin action is a key component.
“exercise, rather than just being a useful strategy for improving health, is actually essential for good metabolic and cardiovascular function, of which insulin action is a key component (Thyfault and Krogh-Madsen 2011;Booth et al. 2002).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Thyfault and Krogh-Madsen 2011
Not checked in the free run.
- cites Booth et al. 2002 source
Not checked in the free run.
Classified as probably not a substantial claim.
PremisecitationLack of time is often cited as a barrier to being physically active.
“'Lack of time' is often cited as a barrier to being physically active (Korkiakangas et al. 2009;Reichert et al. 2007)”
Quote in the paperSubstantial claim0 of 2 sources checkedMay combine two claims.
InterpretationreasoningThe traditional high-intensity interval training protocol of 4-6 by 30 seconds may be unnecessarily strenuous because similar glycogen depletion may be achieved using 1-2 sprints of shorter duration of 15-20 seconds.
“This suggests that the traditional HIT protocol (4-6×30 seconds) may be unnecessarily strenuous as similar glycogen depletion may be achieved using 1-2 sprints of shorter duration (15-20 seconds).”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
PremisecitationHigh levels of glycogen depletion during repeated 30-second Wingate sprints may play an important role in mediating improvements in insulin sensitivity following high-intensity interval training.
“We (Babraj et al. 2009) and others (Whyte et al. 2010) have suggested that high levels of glycogen depletion observed during repeated 30-second Wingate sprints may play an important role in mediating improvements in insulin sensitivity following HIT.”
Quote in the paperSubstantial claim0 of 2 sources checkedMay combine two claims.
PremisecitationRegular exercise is associated with improved muscle insulin sensitivity and represents an effective strategy to prevent type 2 diabetes.
“regular exercise is associated with improved muscle insulin sensitivity and thus represents an effective strategy to prevent T2D (Hawley and Gibala 2009).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Hawley and Gibala 2009 source
Not checked in the free run.
May combine two claims.
PremisecitationGlycogenolysis is only activated during the first 15 seconds of a 30-second Wingate sprint and is then strongly attenuated during the final 15 seconds.
“glycogenolysis is only activated during the first 15 seconds of the sprint and is then strongly attenuated during the final 15 seconds (Parolin et al. 1999).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Parolin et al. 1999
Not checked in the free run.
May combine two claims.
InterpretationreasoningUsing 1-2 shorter sprints would make training sessions more time-efficient, less strenuous and more applicable to the largely sedentary general population.
“In turn, this would make the training sessions more time-efficient, less strenuous and more applicable to the largely sedentary general population.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataA 6-week reduced-exertion high-intensity interval training intervention consisting of very brief, manageable sessions is associated with improved insulin sensitivity in sedentary young men and improved aerobic capacity in men and women.
“In the present study we show that a 6-week novel exercise intervention consisting of very brief, manageable sessions is associated with improved insulin sensitivity in sedentary young men, and improved aerobic capacity in men and women.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationMuscle glycogen availability is inversely related to muscle cell membrane GLUT4 content during insulin stimulation, glycogen synthase activity, GLUT4 mRNA expression, and hence insulin sensitivity.
“This hypothesis is based on evidence that muscle glycogen availability is inversely related to muscle cell membrane GLUT4 content during insulin stimulation (Derave et al. 2000), glycogen synthase activity (Jensen et al. 2006), the expression of GLUT4 mRNA (Steinberg et al. 2006), and hence insulin sensitivity (Derave et al. 2000;Jensen et al. 2006;Kawanaka et al. 2000;Laurent et al. 2000;Lither”
Quote in the paperSubstantial claim0 of 3 sources checkedClassified as probably not a substantial claim.
Study design and conductown dataTwenty-nine healthy but sedentary young men and women were randomly assigned to the reduced-exertion high-intensity interval training intervention or a control group.
“Twenty-nine healthy but sedentary young men and women were randomly assigned to the REHIT intervention (men: n=7, women n=8) or a control group (men n=6; women n=8).”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationThe relatively high exertion associated with classic high-intensity interval training sessions requires strong motivation and may be perceived as too strenuous for many sedentary individuals.
“the relatively high exertion associated with 'classic' HIT sessions requires strong motivation and may be perceived as too strenuous for many sedentary individuals (Hawley and Gibala 2009).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Hawley and Gibala 2009 source
Not checked in the free run.
May combine two claims.
Interpretationown dataThe improvements were observed despite low required effort, with ratings of perceived exertion peaking at an average of 14, somewhat hard, in week 4.
“Importantly, the improvements were observed despite the low time commitment (totalling 30 minutes per week) and low required effort: RPE peaked at an average of 14 ('somewhat hard') in week 4 which is comparable with RPE scores reported with prolonged cycling at 50-75% 2 max (Borg 1982).”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataThere is a dissociation between changes in aerobic capacity and changes in insulin sensitivity, since women improved their aerobic capacity but not their insulin sensitivity.
“Interestingly, since women improved their aerobic capacity but not their insulin sensitivity, it appears that there is a dissociation between changes in aerobic capacity and changes in insulin sensitivity.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningThe post-intervention OGTT was scheduled three days following the final exercise session, and the study cannot rule out that insulin sensitivity was improved in female subjects at an earlier time-point.
“Furthermore, the post-intervention OGTT was scheduled three days following the final exercise session, and we cannot rule out that insulin sensitivity was improved in female subjects at an earlier time-point.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationCurrent exercise guidelines remain largely ineffective at a societal level, partly because they fail to sufficiently consider key barriers such as lack of time.
“However, whilst these guidelines may be effective in people who adhere to them, they remain largely ineffective at a societal level (Allender et al. 2008), partly because they fail to sufficiently consider the key barriers which prevent people from performing regular exercise, such as 'lack of time'.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Allender et al. 2008
Not checked in the free run.
May combine two claims.
InterpretationcitationRPE values obtained in this manner may underestimate exertion during the sprints; other studies where RPE has been obtained following a 20 second all out sprint have reported higher values of ~16-18.
“RPE values obtained in this manner may underestimate exertion during the sprints; indeed, other studies where RPE has been obtained following a 20 second all out sprint have reported higher values of ~16-18 (Baker et al. 2001;Gearhart et al. 2005).”
Quote in the paperNot a substantial claim0 of 2 sources checkedMay combine two claims.
Study design and conductreasoningThere are limitations to the use of the RPE scale in the current study, as the RPE scale is designed for use during continuous exercise at a constant intensity and may not be a valid measure of exertion during interval based exercises, especially when values are given retrospectively of the most intense exercise.
“However, there are limitations to the use of the RPE scale in the current study, as the RPE scale is designed for use during (or immediately following) continuous exercise at a constant intensity and may not be a valid measure of exertion during interval based exercises, especially when values are given retrospective of the most intense exercise, as was the case in this study.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationFollowing a traditional aerobic exercise intervention in a large cohort, insulin sensitivity improved to a greater degree in men when compared with women, but the female participants had a higher baseline level of insulin sensitivity which may have impacted on the subsequent training response.
“Following a traditional aerobic exercise intervention in a large cohort, insulin sensitivity improved to a greater degree in men when compared with women but (similar to our study) the female participants had a higher baseline level of insulin sensitivity which may have impacted on the subsequent training response (Boule et al. 2005).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Boule et al. 2005 source
Not checked in the free run.
May combine two claims.
Interpretationown dataIn this study, a very brief and feasible exercise intervention is associated with improvements in metabolic health and aerobic capacity.
“In conclusion, in this study we have shown that a very brief and feasible exercise intervention is associated with improvements in metabolic health and aerobic capacity.”
Quote in the paperSubstantial claim
The paper relies on this without support.
Participants in both groups did not change their physical activity patterns outside the intervention during the study.
“the potentially confounding effect of changes in diet and physical activity patterns was fully explained to all participants and they were asked to maintain their normal lifestyle patterns throughout the study period.”
The paper relies on this without support.
No other study has investigated the effects of HIT on insulin sensitivity in women.
“No other study has investigated the effects of HIT on insulin sensitivity in women.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Very brief SIT protocols involving ≤10 min per session elicit adaptations similar to longer SIT protocols and MICT.
“Recent studies have shown that very brief SIT protocols involving ≤10 min per session elicit adaptations similar to longer SIT protocols and MICT [15–17].”
From Twelve weeks of sprint interval training improves indices of cardiometabolic health similar to traditional endurance training despite a five-fold lower exercise volume and time commitment (2016) · cites this paper as [15]
The Discussion (page unavailable) reports that 10-minute sessions improved aerobic capacity in men and women, and that the insulin-sensitivity improvement in men was comparable in magnitude to responses reported for classic HIT. It does not establish that the brief protocol produced adaptations similar to moderate-intensity continuous training (MICT); insulin sensitivity did not improve in the women studied. (LLM, conf=0.87)
Experimental — accuracy not yet measuredHigh-intensity interval training (HIIT) increases aerobic capacity in both men and women, but its ability to enhance insulin sensitivity appears to be blunted in women.
“while high-intensity interval training (HIIT; for the purpose of this review including both sprint-and high-intensity interval training) increases aerobic capacity in both men and women, its ability to enhance insulin sensitivity appears to be blunted in women (Metcalfe et al. 2012;Gillen et al. 2013).”
From Sex‐based differences in endurance exercise muscle metabolism: impact on exercise and nutritional strategies to optimize health and performance in women (2016) · cites this paper as Metcalfe et al. 2012
The Results and Discussion report that REHIT increased aerobic capacity in both sexes, while insulin sensitivity improved in men but not women. The claim extends this finding to HIIT generally; the Discussion notes that a previous study of classic HIT did not find a sex difference, and says larger studies are needed to confirm the REHIT observation. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMetcalfe et al. reported that a 10 min low-intensity cycling protocol that included 2×20 s all-out sprints, performed 18 times over 6 wk, improved insulin sensitivity measured by OGTTs in men but not women.
“Metcalfe et al. [10] recently reported that a 10 min low-intensity cycling protocol that included 2×20 s all-out sprints, performed 18 times over 6 wk, improved insulin sensitivity measured by OGTTs in men but not women [10].”
From Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health (2014) · cites this paper as [10]
Insulin sensitivity based on oral glucose tolerance tests was improved after training in men but not women.
“Metcalfe et al. [10] also reported that insulin sensitivity based on oral glucose tolerance tests was improved after training in men but not women, highlighting the potential for sex-based differences in the adaptive response.”
From Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health (2014) · cites this paper as [10]
A 10 min training protocol involving low-intensity cycling except for 2, 20 sec all out sprints improved cardiorespiratory fitness (VO2 peak) in previously sedentary adults when performed 3 times per week for 6 weeks.
“Metcalfe and colleagues [10] reported that a 10 min training protocol, involving low-intensity cycling except for 2, 20 sec all out sprints, improved cardiorespiratory fitness (VO2 peak) in previously sedentary adults when performed 3x/wk for 6 wk.”
From Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health (2014) · cites this paper as [10]
Using CGM, 24 h average blood glucose concentration, glucose AUC and Gmax, measured under standard dietary conditions from 48-72 h after the final training session, were improved in men but not women.
“Consistent with the observations of Metcalfe et al. [10], we found using CGM that 24 h average blood glucose concentration, glucose AUC and Gmax, measured under standard dietary conditions from 48–72 h after the final training session, were improved in men but not women.”
From Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health (2014) · cites this paper as [10]
The lack of change in peripheral glucose control in women in the present study is consistent with recent reports by others.
“The lack of change in peripheral glucose control in women in the present study is consistent with recent reports by others [10], [15], although this is not a universal finding [2].”
From Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health (2014) · cites this paper as [10]
Cites
International physical activity questionnaire: 12-country reliability and validity
CRAIG, C. L., MARSHALL, A. L., SJ??STR??M, M., BAUMAN, A. E., BOOTH, M. L., AINSWORTH, B. E., PRATT, M., EKELUND, U., YNGVE, A., SALLIS, J. F., et al. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000078924.61453.fb · Cited by 21,619 · see citing works
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580 · see citing works
Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., Nieman, D. C., & Swain, D. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318213fefb · Cited by 9,319 · cited 3× · see citing works
“Secondly, although a typical HIT session requires only 2-3 minutes of actual sprint exercise, when considered as a feasible exercise session including a warm-up, recovery intervals and cool-down, the total time commitment is more than 20 minutes, reducing the time-efficiency (Garber et al. 2011).”
BackgroundPerceived exertion as an indicator of somatic stress
Borg, G. (1970) · Journal of Rehabilitation Medicine · doi:10.2340/1650197719702239298 · Cited by 4,723 · see citing works
Danaei, G., Finucane, M. M., Lu, Y., Singh, G. M., Cowan, M. J., Paciorek, C. J., Lin, J. K., Farzadfar, F., Khang, Y.-H., Stevens, G. A., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60679-x · Cited by 3,568 · see citing works
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-s302 · Cited by 2,102 · cited 1× · see citing works
“The primary defect underlying the development of T2D is skeletal muscle insulin resistance (DeFronzo and Tripathy 2009).”
BackgroundRevision of the Physical Activity Readiness Questionnaire (PAR-Q).
Thomas, S. G., Reading, J., & Shephard, R. J. (1992) · PubMed · Cited by 1,952 · see citing works
Economic costs of diabetes in the U.S. in 2007
American Diabetes Association (2008) · Diabetes Care · doi:10.2337/dc08-9017 · Cited by 1,323 · see citing works
Burgomaster, K. A., Howarth, K. R., Phillips, S. M., Rakobowchuk, M., MacDonald, M. J., McGee, S. L., & Gibala, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142109 · Cited by 1,257 · see citing works
Cohen, L. S., ELLIOTT, W., KLEIN, M. D., & Gorlin, R. (1966) · The American Journal of Cardiology · doi:10.1016/0002-9149(66)90347-x · Cited by 1,223 · see citing works
Wei, M. (1999) · JAMA · doi:10.1001/jama.282.16.1547 · Cited by 1,168 · see citing works
Gibala, M. J., Little, J. P., Van Essen, M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., Raha, S., & Tarnopolsky, M. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.112094 · Cited by 1,082 · see citing works
Individual differences in response to regular physical activity
BOUCHARD, C., & RANKINEN, T. (2001) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200106001-00013 · Cited by 939 · see citing works
Coronary heart disease statistics.
Allender, S. E., Peto, V., Scarborough, P., Kaur, A., & Rayner, M. (2008) · Deakin Research Online (Deakin University) · Cited by 928 · see citing works
Burgomaster, K. A., Hughes, S. C., Heigenhauser, G. J. F., Bradwel, S. N., & Gibala, M. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01095.2004 · Cited by 856 · see citing works
Little, J. P., Gillen, J. B., Percival, M. E., Safdar, A., Tarnopolsky, M. A., Punthakee, Z., Jung, M. E., & Gibala, M. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00921.2011 · Cited by 787 · see citing works
Economic Costs of Diabetes in the U.S. in 2007
Leahy, J. L. (2008) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)79219-9 · Cited by 781 · see citing works
The Role of Perceived Personal Barriers to Engagement in Leisure-Time Physical Activity
Reichert, F. F., Barros, A. J. D., Domingues, M. R., & Hallal, P. C. (2007) · American Journal of Public Health · doi:10.2105/ajph.2005.070144 · Cited by 507 · see citing works
Lerner, D. A., & Lindsay, R. B. (1961) · Cited by 455 · see citing works
Church, T. S., LaMonte, M. J., Barlow, C. E., & Blair, S. N. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.18.2114 · Cited by 445 · see citing works
Gibala, M. J., McGee, S. L., Garnham, A. P., Howlett, K. F., Snow, R. J., & Hargreaves, M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90880.2008 · Cited by 427 · see citing works
Whyte, L. J., Gill, J. M. R., & Cathcart, A. J. (2010) · Metabolism · doi:10.1016/j.metabol.2010.01.002 · Cited by 424 · see citing works
Babraj, J. A., Vollaard, N. B., Keast, C., Guppy, F. M., Cottrell, G., & Timmons, J. A. (2009) · BMC Endocrine Disorders · doi:10.1186/1472-6823-9-3 · Cited by 374 · see citing works
Self-citationEffects of Exercise Training on Glucose Homeostasis
Boulé, N. G., Weisnagel, S. J., Lakka, T. A., Tremblay, A., Bergman, R. N., Rankinen, T., Leon, A. S., Skinner, J. S., Wilmore, J. H., Rao, D. C., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.108 · Cited by 356 · see citing works
Rakobowchuk, M., Tanguay, S., Burgomaster, K. A., Howarth, K. R., Gibala, M. J., & MacDonald, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00069.2008 · Cited by 335 · see citing works
Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise
Parolin, M. L., Chesley, A., Matsos, M. P., Spriet, L. L., Jones, N. L., & Heigenhauser, G. J. F. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.5.e890 · Cited by 334 · see citing works
Trends in the prevalence and incidence of diabetes in the UK: 1996–2005
Gonzalez, E., Johansson, S., Wallander, M. ‐., & Rodríguez, L. A. G. (2009) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2008.080382 · Cited by 295 · see citing works
Exercise and gene expression: physiological regulation of the human genome through physical activity
Booth, F. W., Chakravarthy, M. V., & Spangenburg, E. E. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.019265 · Cited by 277 · see citing works
Korkiakangas, E. E., Alahuhta, M. A., & Laitinen, J. H. (2009) · Health Promotion International · doi:10.1093/heapro/dap031 · Cited by 276 · see citing works
Insulin release and peripheral sensitivity at the oral glucose tolerance test
Cederholm, J., & Wibell, L. (1990) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(90)90040-z · Cited by 264 · see citing works
Glucose, exercise and insulin: emerging concepts
Richter, E. A., Derave, W., & Wojtaszewski, J. F. P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-2-00313.x · Cited by 258 · see citing works
Burgomaster, K. A., Cermak, N. M., Phillips, S. M., Benton, C. R., Bonen, A., & Gibala, M. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00503.2006 · Cited by 255 · see citing works
Vollaard, N. B. J., Constantin-Teodosiu, D., Fredriksson, K., Rooyackers, O., Jansson, E., Greenhaff, P. L., Timmons, J. A., & Sundberg, C. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91453.2008 · Cited by 205 · cited 2× · see citing works
“Previous studies have comprehensively demonstrated that following a period of exercise training part of the population will not adapt for specific parameters (non-responders), and for insulin sensitivity this has been shown to be the case for up to 40% of the population (Boule et al. 2005; Vollaard et al. 2009; Boucha…”
BackgroundSelf-citationMetabolic response in type I and type II muscle fibers during a 30-s cycle sprint in men and women
Esbjörnsson-Liljedahl, M., Sundberg, C. J., Norman, B., & Jansson, E. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.4.1326 · Cited by 199 · see citing works
Richards, J. C., Johnson, T. K., Kuzma, J. N., Lonac, M. C., Schweder, M. M., Voyles, W. F., & Bell, C. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.189886 · Cited by 187 · see citing works
Smaller muscle ATP reduction in women than in men by repeated bouts of sprint exercise.
Esbjörnsson-Liljedahl, M., Bodin, K., & Jansson, E. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00732.1999 · Cited by 142 · see citing works
Trilk, J. L., Singhal, A., Bigelman, K. A., & Cureton, K. J. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1777-z · Cited by 130 · see citing works
Jensen, J., Jebens, E., Brennesvik, E. O., Ruzzin, J., Soos, M. A., Engebretsen, E. M. L., O'Rahilly, S., & Whitehead, J. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2005 · Cited by 114 · see citing works
Steinberg, G. R., Watt, M. J., McGee, S. L., Chan, S., Hargreaves, M., Febbraio, M. A., Stapleton, D., & Kemp, B. E. (2006) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-003 · Cited by 104 · see citing works
Muscle glycogen content affects insulin-stimulated glucose transport and protein kinase B activity
Derave, W., Hansen, B. F., Lund, S., Kristiansen, S., & Richter, E. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e947 · Cited by 102 · see citing works
Kawanaka, K., Nolte, L. A., Han, D., Hansen, P. A., & Holloszy, J. O. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.6.e1311 · Cited by 98 · see citing works
Metabolic disruptions induced by reduced ambulatory activity in free-living humans
Thyfault, J. P., & Krogh‐Madsen, R. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00478.2011 · Cited by 93 · see citing works
Baker, J. S., Bailey, D. M., & Davies, B. (2001) · Journal of Science and Medicine in Sport · doi:10.1016/s1440-2440(01)80002-5 · Cited by 80 · see citing works
The regulation of muscle glycogen: the granule and its proteins
Graham, T. E., Yuan, Z., Hill, A. K., & Wilson, R. J. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02131.x · Cited by 69 · see citing works
Mechanism of muscle glycogen autoregulation in humans
Laurent, D., Hundal, R. S., Dresner, A., Price, T. B., Vogel, S. M., Petersen, K. F., & Shulman, G. I. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.4.e663 · Cited by 58 · see citing works
Trends in the Prevalence and Incidence of Diabetes in the UK
González, E., González, E., Johansson, S., Wallander, M.-A. A., & Rodríguez, L. A. G. (2009) · Cited by 46 · see citing works
Exercise intensity and insulin sensitivity: how low can you go?
Hawley, J. A., & Gibala, M. J. (2009) · Diabetologia · doi:10.1007/s00125-009-1425-5 · Cited by 41 · see citing works
Piché, M.-È., Lemieux, S., Corneau, L., Nadeau, A., Bergeron, J., & Weisnagel, S. J. (2007) · Metabolism · doi:10.1016/j.metabol.2007.04.002 · Cited by 31 · see citing works
Role of glycogen content in insulin resistance in human muscle cells
Litherland, G. J., Morris, N. J., Walker, M., & Yeaman, S. J. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20942 · Cited by 16 · see citing works
Rating Perceived Exertion during Short Duration, Very High Intensity Cycle Exercise
Gearhart, R. F., Becque, M. D., Palm, C. M., & Hutchins, M. D. (2005) · Perceptual and Motor Skills · doi:10.2466/pms.100.3.767-773 · Cited by 13 · see citing works
[Skeletal muscle insulin resistance].
Ohno, H., & Asano, T. (2011) · PubMed · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Buchheit, M., & Laursen, P. B. (2013) · Sports Medicine · doi:10.1007/s40279-013-0029-x · Cited by 1,490 · see citing works
Milanović, Z., Sporiš, G., & Weston, M. (2015) · Sports Medicine · doi:10.1007/s40279-015-0365-0 · Cited by 923 · see citing works
High-Intensity Interval Training, Solutions to the Programming Puzzle
Buchheit, M., & Laursen, P. B. (2013) · Sports Medicine · doi:10.1007/s40279-013-0066-5 · Cited by 899 · see citing works
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 919 · see citing works
Jelleyman, C., Yates, T., O'Donovan, G., Gray, L. J., King, J. A., Khunti, K., & Davies, M. J. (2015) · Obesity Reviews · doi:10.1111/obr.12317 · Cited by 588 · see citing works
Gillen, J. B., & Gibala, M. J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0187 · Cited by 506 · see citing works
Gillen, J. B., Martin, B. J., MacInnis, M. J., Skelly, L. E., Tarnopolsky, M. A., & Gibala, M. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154075 · Cited by 363 · see citing works
“Recent studies have shown that very brief SIT protocols involving 10 min per session elicit adaptations similar to longer SIT protocols and MICT [15–17].”
BackgroundBiddle, S. J. H., & Batterham, A. M. (2015) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-015-0254-9 · Cited by 355 · see citing works
Effects of Physical Activity and Inactivity on Muscle Fatigue
Bogdanis, G. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00142 · Cited by 356 · see citing works
Fyfe, J. J., Bishop, D. J., & Stepto, N. K. (2014) · Sports Medicine · doi:10.1007/s40279-014-0162-1 · Cited by 347 · see citing works
Racil, G., Ounis, O. B., Hammouda, O., Kallel, A., Zouhal, H., Chamari, K., & Amri, M. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2689-5 · Cited by 335 · see citing works
Sloth, M., Sloth, D., Overgaard, K., & Dalgas, U. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12092 · Cited by 314 · see citing works
Sultana, R. N., Sabag, A., Keating, S. E., & Johnson, N. A. (2019) · Sports Medicine · doi:10.1007/s40279-019-01167-w · Cited by 286 · see citing works
ATAKAN, M. M., Li, Y., Koşar, Ş. N., Turnagöl, H. H., & Yan, X. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18137201 · Cited by 291 · see citing works
Gillen, J. B., Percival, M. E., Ludzki, A., Tarnopolsky, M. A., & Gibala, M. J. (2013) · Obesity · doi:10.1002/oby.20379 · Cited by 222 · see citing works
Gibala, M. J., Gillen, J. B., & Percival, M. E. (2014) · Sports Medicine · doi:10.1007/s40279-014-0259-6 · Cited by 223 · see citing works
McRae, G., Payne, A., Zelt, J. G. E., Scribbans, T. D., Jung, M. E., Little, J. P., & Gurd, B. J. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-093 · Cited by 206 · see citing works
Ito, S. (2019) · World Journal of Cardiology · doi:10.4330/wjc.v11.i7.171 · Cited by 195 · see citing works
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00484.x · Cited by 184 · see citing works
Gillen, J. B., Percival, M. E., Skelly, L. E., Martin, B. J., Tan, R. B., Tarnopolsky, M. A., & Gibala, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111489 · Cited by 181 · see citing works
Tjønna, A. E., Leinan, I. M., Bartnes, A. T., Jenssen, B. M., Gibala, M. J., Winett, R. A., & Wisløff, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065382 · Cited by 167 · see citing works
Effectiveness and Safety of High-Intensity Interval Training in Patients With Type 2 Diabetes
François, M. E., & Little, J. P. (2015) · Diabetes Spectrum · doi:10.2337/diaspect.28.1.39 · Cited by 153 · see citing works
Mann, S., Beedie, C., Balducci, S., Zanuso, S., Allgrove, J. E., Bertiato, F., & Jiménez, A. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2488 · Cited by 150 · see citing works
Devries, M. C. (2016) · Experimental Physiology · doi:10.1113/ep085369 · Cited by 151 · see citing works
Scribbans, T. D., Vecsey, S. P., Hankinson, P. B., Foster, W. S., & Gurd, B. J. (2016) · International journal of exercise science · doi:10.70252/hhbr9374 · Cited by 139 · see citing works
Shepherd, S. O., Wilson, O. J., Taylor, A. S., Thøgersen‐Ntoumani, C., Adlan, A., Wagenmakers, A. J. M., & Shaw, C. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139056 · Cited by 133 · see citing works
Vollaard, N. B. J., & Metcalfe, R. S. (2017) · Sports Medicine · doi:10.1007/s40279-017-0727-x · Cited by 131 · see citing works
Self-citationKong, Z., Sun, S., Liu, M., & Shi, Q. (2016) · Journal of Diabetes Research · doi:10.1155/2016/4073618 · Cited by 126 · see citing works
Multidimensional Physical Activity
Thompson, D., Peacock, O. J., Western, M. J., & Batterham, A. M. (2015) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000039 · Cited by 120 · see citing works
Brief Intense Stair Climbing Improves Cardiorespiratory Fitness
ALLISON, M. K., BAGLOLE, J. H., MARTIN, B. J., MACINNIS, M. J., GURD, B. J., & GIBALA, M. J. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001188 · Cited by 116 · see citing works
Barathi, S. C., Finnegan, D. J., Farrow, M. T., Whaley, A., Heath, P., Buckley, J., Dowrick, P. W., Wuensche, B. C., Bilzon, J., O'Neill, E. J., et al. (2018) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3173574.3173982 · Cited by 113 · see citing works
Ruffino, J. S., Songsorn, P., Haggett, M., Edmonds, D., Robinson, A. M., Thompson, D., & Vollaard, N. B. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0497 · Cited by 111 · see citing works
Self-citationEffect of Number of Sprints in an SIT Session on Change in V˙O2max
Vollaard, N. B. J., Metcalfe, R. S., & Williams, S. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001204 · Cited by 110 · see citing works
Self-citationCan High-Intensity Interval Training Promote Skeletal Muscle Anabolism?
Callahan, M. J., Parr, E. B., Hawley, J. A., & Camera, D. M. (2021) · Sports Medicine · doi:10.1007/s40279-020-01397-3 · Cited by 106 · see citing works
Forrest, L. J., Ferguson, C., Wilson, J., Scott, R. A., & Gill, J. M. R. (2012) · Metabolism · doi:10.1016/j.metabol.2012.07.019 · Cited by 106 · see citing works
Metcalfe, R. S., Koumanov, F., Ruffino, J. S., Stokes, K., Holman, G. D., Thompson, D., & Vollaard, N. B. J. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3217-6 · Cited by 104 · see citing works
Self-citationHigh-intensity interval training improves insulin sensitivity in older individuals.
Søgaard, D., Lund, M. T., Scheuer, C. M., Dehlbæk, M. S., Dideriksen, S. G., Abildskov, C. V., Christensen, K. K., Dohlmann, T. L., Larsen, S., Vigelsø, A. H., et al. (2018) · Acta Physiologica · doi:10.1111/apha.13009 · Cited by 98 · see citing works
Phillips, B. E., Kelly, B. M., Lilja, M. R., Ponce‐González, J. G., Brogan, R. J., Morris, D. L., Gustafsson, T. P., Kraus, W. E., Atherton, P. J., Vollaard, N. B. J., et al. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00229 · Cited by 98 · see citing works
Self-citationBoyd, J. C., Simpson, C. A., Jung, M. E., & Gurd, B. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068091 · Cited by 99 · see citing works
Modified sprint interval training protocols. Part II. Psychological responses
Townsend, L. K., Islam, H., Dunn, E., Eys, M., Robertson‐Wilson, J., & Hazell, T. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0479 · Cited by 93 · see citing works
Physiological basis of brief vigorous exercise to improve health
Gibala, M. J., & Little, J. P. (2019) · The Journal of Physiology · doi:10.1113/jp276849 · Cited by 90 · see citing works
ROY, M., WILLIAMS, S. M., BROWN, R. C., MEREDITH-JONES, K. A., OSBORNE, H., JOSPE, M., & TAYLOR, R. W. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001642 · Cited by 86 · see citing works
Mohr, M., Nordsborg, N. B., Lindenskov, A., Steinholm, H., Nielsen, H. P., Mortensen, J., Weihe, P., & Krustrup, P. (2014) · BioMed Research International · doi:10.1155/2014/728289 · Cited by 86 · see citing works
Running sprint interval training induces fat loss in women
Hazell, T. J., Hamilton, C. D., Olver, T. D., & Lemon, P. W. R. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0503 · Cited by 86 · see citing works
Palma, S., Hasenoehrl, T., Jordakieva, G., Ramazanova, D., & Crevenna, R. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05834-x · Cited by 87 · see citing works
Moore, J., Merchant, Z., Rowlinson‐Groves, K., McEwan, K., Evison, M., Faulkner, G., Sultan, J., McPhee, J. S., & Steele, J. (2020) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2020.04.042 · Cited by 83 · see citing works
Scott, J. P. R., Weber, T., & Green, D. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00173 · Cited by 86 · see citing works
Psychological and Behavioral Responses to Interval and Continuous Exercise
Stork, M., Gibala, M. J., & Ginis, K. A. M. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001671 · Cited by 81 · see citing works
Cockcroft, E., Williams, C. A., Tomlinson, O. W., Vlachopoulos, D., Jackman, S. R., Armstrong, N., & Barker, A. R. (2014) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2014.10.001 · Cited by 79 · see citing works
Exercise and diabetes: relevance and causes for response variability
Böhm, A., Weigert, C., Staiger, H., & Häring, H. (2015) · Endocrine · doi:10.1007/s12020-015-0792-6 · Cited by 79 · see citing works
Sprint exercise snacks: a novel approach to increase aerobic fitness
Little, J. P., Langley, J. E., Lee, M., Myette‐Côté, É., Jackson, G. S., Durrer, C. G., Gibala, M. J., & Jung, M. E. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04110-z · Cited by 74 · see citing works
Yin, M., Li, H., Bai, M., Liu, H., Chen, Z., Deng, J., Deng, S., Chuan, M., Vollaard, N. B. J., Little, J. P., et al. (2023) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2023-0329 · Cited by 74 · see citing works
Self-citationWeston, M., Weston, K. L., Prentis, J. M., & Snowden, C. P. (2016) · Perioperative Medicine · doi:10.1186/s13741-015-0026-8 · Cited by 74 · see citing works
Metcalfe, R. S., Tardif, N., Thompson, D., & Vollaard, N. B. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0253 · Cited by 68 · see citing works
Self-citationMetcalfe, R. S., Atef, H., Mackintosh, K. A., McNarry, M. A., Ryde, G. C., Hill, D. M., & Vollaard, N. B. J. (2020) · BMC Public Health · doi:10.1186/s12889-020-8444-z · Cited by 67 · see citing works
Self-citationZelt, J. G. E., Hankinson, P. B., Foster, W. S., Williams, C. B., Reynolds, J., Garneys, E., Tschakovsky, M. E., & Gurd, B. J. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2960-4 · Cited by 64 · see citing works
Skleryk, J. R., Karagounis, L. G., Hawley, J. A., Sharman, M. J., Laursen, P. B., & Watson, G. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12150 · Cited by 63 · see citing works
Dohlmann, T. L., HINDSØ, M. G., Dela, F., Helge, J. W., & Larsen, S. (2018) · Physiological Reports · doi:10.14814/phy2.13857 · Cited by 62 · see citing works
Santos, A., Braaten, K., MacPherson, M., Vasconcellos, D., Vis-Dunbar, M., Lonsdale, C., Lubans, D., & Jung, M. E. (2023) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-023-01535-w · Cited by 59 · see citing works
Modified sprint interval training protocols. Part I. Physiological responses
Islam, H., Townsend, L. K., & Hazell, T. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0478 · Cited by 59 · see citing works
Cuddy, T. F., Ramos, J. S., & Dalleck, L. C. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16030483 · Cited by 57 · see citing works
Forbes, S. C., Candow, D. G., Smith‐Ryan, A. E., Hirsch, K. R., Roberts, M. D., VanDusseldorp, T. A., Stratton, M. T., Kaviani, M., & Little, J. P. (2020) · Nutrients · doi:10.3390/nu12020390 · Cited by 60 · see citing works
Toohey, K. L., Pumpa, K. L., Arnolda, L., Cooke, J., Yip, D., Craft, P., & Semple, S. (2016) · PeerJ · doi:10.7717/peerj.2613 · Cited by 57 · see citing works
Edwards, J. J., Griffiths, M., Deenmamode, A. H. P., & O’Driscoll, J. M. (2023) · Sports Medicine · doi:10.1007/s40279-023-01863-8 · Cited by 55 · see citing works
Effects of low-volume high-intensity interval training in a community setting: a pilot study
Reljic, D., Wittmann, F., & Fischer, J. E. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3845-8 · Cited by 56 · see citing works
Toohey, K. L., Pumpa, K. L., McKune, A. J., Cooke, J., & Semple, S. (2017) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-017-2552-x · Cited by 54 · see citing works
Extremely short duration interval exercise improves 24-h glycaemia in men with type 2 diabetes
Metcalfe, R. S., Fitzpatrick, B., Fitzpatrick, S., McDermott, G., Brick, N., McClean, C. M., & Davison, G. W. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3980-2 · Cited by 54 · see citing works
Self-citationTowards Integrated Physical Activity Profiling
Thompson, D., & Batterham, A. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056427 · Cited by 53 · see citing works
Mitochondrial adaptations to high intensity interval training in older females and males.
Chrøis, K. M., Dohlmann, T. L., Søgaard, D., Hansen, C. V., Dela, F., Helge, J. W., & Larsen, S. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2019.1615556 · Cited by 50 · see citing works
Nicolini, C., Fahnestock, M. L., Gibala, M. J., & Nelson, A. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.013 · Cited by 50 · see citing works
Tan, R., Nederveen, J. P., Gillen, J. B., Joanisse, S., Parise, G., Tarnopolsky, M. A., & Gibala, M. J. (2018) · Physiological Reports · doi:10.14814/phy2.13597 · Cited by 48 · see citing works
Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity
Zanou, N., Dridi, H., Reiken, S. R., de Lima, T. I., Donnelly, C., Marchi, U. D., Ferrini, M., Vidal, J., Sittenfeld, L. R., Feige, J. N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27422-1 · Cited by 46 · see citing works
Jiménez‐Maldonado, A., García‐Suárez, P. C., Rentería, I., Moncada‐Jiménez, J., & Plaisance, E. P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165820 · Cited by 52 · see citing works
O’Brien, K. V., Stewart, L. K., Forney, L. A., Aryana, K. J., Prinyawiwatkul, W., & Boeneke, C. A. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9392 · Cited by 46 · see citing works
Extremely short duration sprint interval training improves vascular health in older adults
Adamson, S., Kavaliauskas, M., Yamagishi, T., Phillips, S., Lorimer, R., & Babraj, J. (2018) · Sport Sciences for Health · doi:10.1007/s11332-018-0498-2 · Cited by 44 · see citing works
Self-citationIntensity and temporal patterns of physical activity and cardiovascular disease risk in midlife
Niemelä, M., Kangas, M., Farrahi, V., Kiviniemi, A. M., Leinonen, A., Ahola, R., Puukka, K. S., AUVINEN, J. P., Korpelainen, R., & Jämsä, T. J. (2019) · Preventive Medicine · doi:10.1016/j.ypmed.2019.04.023 · Cited by 42 · see citing works
Attributes of Physical Activity and Gut Microbiome in Adults: A Systematic Review
Tzemah-Shahar, R., Koren, O., Greenfeld, S. M., Shochat, T., Magzal, F., & Agmon, M. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1157-9257 · Cited by 43 · see citing works
Military Applicability of Interval Training for Health and Performance
Gibala, M. J., Gagnon, P. J., & Nindl, B. C. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001119 · Cited by 50 · see citing works
Aquatic High Intensity Interval Training for Cardiometabolic Health
Nagle, E. F., Sanders, M. E., & Franklin, B. A. (2015) · American Journal of Lifestyle Medicine · doi:10.1177/1559827615583640 · Cited by 46 · see citing works
Mora-González, J., López, I. J. P., Esteban‐Cornejo, I., & Delgado‐Fernández, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17030877 · Cited by 42 · see citing works
High Intensity Training Improves Health and Physical Function in Middle Aged Adults
Adamson, S., Lorimer, R., Cobley, J. N., Lloyd, R., & Babraj, J. (2014) · Biology · doi:10.3390/biology3020333 · Cited by 41 · see citing works
Self-citationEffect of sex on the acute skeletal muscle response to sprint interval exercise
Skelly, L. E., Gillen, J. B., MacInnis, M. J., Martin, B. J., Safdar, A., Akhtar, M., MacDonald, M. J., Tarnopolsky, M. A., & Gibala, M. J. (2017) · Experimental Physiology · doi:10.1113/ep086118 · Cited by 39 · see citing works
McKie, G. L., Islam, H., Townsend, L. K., Robertson‐Wilson, J., Eys, M., & Hazell, T. J. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0595 · Cited by 42 · see citing works
Whole body heat exposure modulates acute glucose metabolism
Kimball, A., McCue, P. M., Petrie, M. A., & Shields, R. K. (2018) · International Journal of Hyperthermia · doi:10.1080/02656736.2018.1516303 · Cited by 37 · see citing works
Hall, A. J., Aspe, R., Craig, T. P., Kavaliauskas, M., Babraj, J., & Swinton, P. A. (2022) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004257 · Cited by 41 · see citing works
Self-citationStern, G., Psycharakis, S. G., & Phillips, S. (2023) · Sports Medicine - Open · doi:10.1186/s40798-023-00551-1 · Cited by 37 · see citing works
Nalçakan, G. R., Songsorn, P., Fitzpatrick, B., Yüzbaşıoğlu, Y., Brick, N., Metcalfe, R. S., & Vollaard, N. B. J. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0597 · Cited by 36 · see citing works
Self-citationExercise Training Reduces Intrathoracic Fat Regardless of Defective Glucose Tolerance
Honkala, S. M., Motiani, K. K., Eskelinen, J., Savolainen, A., Saunavaara, V., Virtanen, K. A., Löyttyniemi, E., Kapanen, J., Knuuti, J. M., Kalliokoski, K. K., et al. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001232 · Cited by 35 · see citing works
Hu, M., Kong, Z., Sun, S., Zou, L., Shi, Q., Chow, B. C., & Nie, J. (2021) · Journal of Sports Sciences · doi:10.1080/02640414.2021.1892946 · Cited by 34 · see citing works
Metcalfe, R. S., Williams, S., Fernandes, G., Astorino, T. A., Stork, M., Phillips, S., Niven, A. G., & Vollaard, N. B. J. (2022) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.815555 · Cited by 35 · see citing works
Self-citationGuo, L., Chen, J., & Yuan, W. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1095328 · Cited by 42 · see citing works
Khalafi, M., Ravasi, A. A., Malandish, A., & Rosenkranz, S. K. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.109815 · Cited by 30 · see citing works
Wan, K., Dai, Z., Wong, P., Huang, Y., Lei, E. F., Little, J. P., Lin, F., & Tam, B. T. (2025) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.70114 · Cited by 31 · see citing works
Benítez‐Flores, S., Medeiros, A. R., Voltarelli, F. A., Iglesias‐Soler, E., Doma, K., Simões, H. G., Rosa, T. D. S., & Boullosa, D. A. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04125-6 · Cited by 33 · see citing works
Effects of three low-volume, high-intensity exercise conditions on affective valence
Haines, M. R., Broom, D. R., Gillibrand, W. P., & Stephenson, J. R. (2019) · Journal of Sports Sciences · doi:10.1080/02640414.2019.1684779 · Cited by 33 · see citing works
Wang, J., Qiu, J., Yi, L., Hou, Z., Benardot, D., & Cao, W. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0285-8 · Cited by 32 · see citing works
Mcleod, J. C., Diana, H., & Hicks, A. L. (2019) · Spinal Cord · doi:10.1038/s41393-019-0345-6 · Cited by 31 · see citing works
No effect of acute and chronic supramaximal exercise on circulating levels of the myokine SPARC
Songsorn, P., Ruffino, J. S., & Vollaard, N. B. J. (2016) · European Journal of Sport Science · doi:10.1080/17461391.2016.1266392 · Cited by 30 · see citing works
Self-citationGerber, T., Borg, M. L., Hayes, A., & Stathis, C. G. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2878-x · Cited by 29 · see citing works
Evaluation of a Laughter-based Exercise Program on Health and Self-efficacy for Exercise
Greene, C. M., Morgan, J. C., Traywick, L. S., & Mingo, C. A. (2016) · The Gerontologist · doi:10.1093/geront/gnw105 · Cited by 29 · see citing works
- Authors
- Metcalfe, R. S., Babraj, J. A., Fawkner, S. G., & Vollaard, N. B. J.
- Affiliations
- Heriot-Watt University (GB)
- Abertay University (GB)
- Corresponding author
- Vollaard, Niels B. J.
- Venue
- European Journal of Applied Physiology
- Published
- 2011-11-29
- Volume
- 112
- Issue
- 7
- Pages
- 2767-2775
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W2070323514
- Semantic Scholar
- 68782c041fc1329362729634e4547a4ea4aa1fea
- Cited by
- 294
- References
- 51
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 12 · 2023: 23 · 2022: 17 · 2021: 19 · 2020: 19 · 2019: 22 · 2018: 21 · 2017: 20 · 2016: 23 · 2015: 19 · 2014: 16 · 2013: 41 · 2012: 5
- FWCI
- 53.82
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- The University of Bath Online Publications Store (The University of Bath) (submittedVersion)
- Pure (University of Bath) (submittedVersion, other-oa)
- Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
- Funders
- Heriot-Watt University
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- high-intensity interval training, insulin sensitivity, cardiorespiratory fitness, metabolic health, type 2 diabetes risk, all-out sprints, sedentary lifestyle, time-efficient exercise, glucose tolerance
- MeSH terms
- Adult, Physical Exertion, Female, Humans, Insulin, Insulin Resistance, Male, Oxygen Consumption, Physical Fitness, Exercise Tolerance, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-10.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-10.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review