Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies
Abstract
Background While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear.Aims To review recent structural magnetic resonance imaging (MRI) research findings in MDD while considering the potential influence of key clinical and demographic variables.Method A selective review of all T1-weighted structural MRI studies published between 2000 and 2007 in adult samples of MDD patients.Results Volumetric reductions of the hippocampus, basal ganglia and OFC and SGPFC are consistently found in MDD patients, with more persistent forms of MDD (e.g., multiple episodes or repeated relapses, longer illness duration) being associated with greater impact on regional brain volumes. Gender, medication, stage of illness, and family history all affect the nature of the findings in a regionally specific manner.Limitations Overall, differences between the samples in factors such as illness severity, medication, gender and family history of mental illness makes difficult to identify their confounding effects on the observed neuroanatomical changes. Also, the tracing protocols used for particular brain regions were different amongst the reviewed studies, making difficult to compare their findings.Conclusions The data support the notion that MDD involves pathological alterations of limbic and cortical structures, and that they are generally more apparent in patients with more severe or persistent forms of the illness.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Meta-analyses revealed that depressed patients showed large volume reductions in frontal regions, especially in the anterior cingulate and orbitofrontal cortex.
“Meta-analyses revealed that depressed patients showed large volume reductions in frontal regions, especially in the anterior cingulate and OFC (Koolschijn et al., 2009; Lorenzetti et al., 2009).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Lorenzetti et al., 2009
Cites
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007 · see citing works
Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826 · see citing works
Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews
Shea, B. J., Grimshaw, J. M., Wells, G. A., Boers, M., Andersson, N., Hamel, C., Porter, A. C., Tugwell, P., Moher, D., & Bouter, L. M. (2007) · BMC Medical Research Methodology · doi:10.1186/1471-2288-7-10 · Cited by 4,374 · see citing works
Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D., & Acker, J. D. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi044 · Cited by 2,875 · see citing works
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works
Evidence-based health policy—lessons from the Global Burden of Disease Study
Murray, C. J. L., & Lopez, A. D. (1996) · Science · doi:10.1126/science.274.5288.740 · Cited by 2,178 · see citing works
Neurobiology of emotion perception I: the neural basis of normal emotion perception
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00168-9 · Cited by 2,173 · see citing works
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736 · see citing works
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670 · see citing works
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works
Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain
Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03295.2003 · Cited by 1,425 · see citing works
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182 · see citing works
Untreated Depression and Hippocampal Volume Loss
Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180 · see citing works
Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis
Campbell, S., Marriott, M., Nahmias, C., & MacQueen, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.598 · Cited by 1,156 · see citing works
Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151 · see citing works
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984 · see citing works
Course of illness, hippocampal function, and hippocampal volume in major depression
MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980 · see citing works
小野, 道., Kubik, S., & Abernathey, C. D. (1990) · Medical Entomology and Zoology · Cited by 850 · see citing works
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works
Childhood trauma associated with smaller hippocampal volume in women with major depression
Vythilingam, M., Heim, C., Newport, J., Miller, A. H., Anderson, E., Bronen, R., Brummer, M., Staib, L., Vermetten, E., Charney, D. S., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.12.2072 · Cited by 812 · see citing works
The anatomy of mood disorders—review of structural neuroimaging studies
Soares, J. C., & Mann, J. J. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00006-6 · Cited by 760 · see citing works
The prefrontal cortex as a key target of the maladaptive response to stress
Cerqueira, J. J., Mailliet, F., Almeida, O. F. X., Jay, T. M., & Sousa, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4372-06.2007 · Cited by 599 · see citing works
Reduced volume of orbitofrontal cortex in major depression
Bremner, J. D., Vythilingam, M., Vermetten, E., Nazeer, A., Adil, J., Khan, S., Staib, L. H., & Charney, D. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01336-1 · Cited by 537 · see citing works
Hippocampal Changes in Patients With a First Episode of Major Depression
Frodl, T., Meisenzahl, E. M., Zetzsche, T., Born, C., Groll, C., Jäger, M., Leinsinger, G. L., Ronald Bottlender, A., Hahn, K. M., & Möller, H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1112 · Cited by 525 · see citing works
Low glial numbers in the amygdala in major depressive disorder
Bowley, M. P., Drevets, W. C., Öngür, D., & Price, J. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01404-x · Cited by 503 · see citing works
Sheline, Y. I. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00994-x · Cited by 485 · see citing works
Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment
Vythilingam, M., Vermetten, E., Anderson, G. M., Luckenbaugh, D., Anderson, E. R., Snow, J., Staib, L. H., Charney, D. S., & Bremner, J. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.002 · Cited by 477 · see citing works
Amygdala core nuclei volumes are decreased in recurrent major depression
Sheline, Y. I., Gado, M. H., & Price, J. L. (1998) · NeuroReport · doi:10.1097/00001756-199806220-00021 · Cited by 472 · see citing works
Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.
Gold, P., Chrousos, G., Kellner, C., Post, R., Roy, A., Augerinos, P., Schulte, H., Oldfield, E., & Loriaux, D. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.5.619 · Cited by 460 · see citing works
Differential aging of the medial temporal lobe
Raz, N., Rodrigue, K., Head, D., Kennedy, K. M., & Acker, J. D. (2004) · Neurology · doi:10.1212/01.wnl.0000106466.09835.46 · Cited by 453 · see citing works
Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression
Hickie, I., Naismith, S., Ward, P. B., Turner, K., Scott, E., Mitchell, P., Wilhelm, K., & Parker, G. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.186.3.197 · Cited by 437 · see citing works
Barden, N., Reul, J. M., & Holsboer, F. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93942-q · Cited by 410 · see citing works
Steffens, D. C., & Krishnan, K. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00084-5 · Cited by 392 · see citing works
Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression
Hastings, R. S., Parsey, R. V., Oquendo, M. A., Arango, V., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300371 · Cited by 378 · see citing works
Sullivan, R. M., & Gratton, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02834.1999 · Cited by 377 · see citing works
Volumetric reduction in left subgenual prefrontal cortex in early onset depression
Botteron, K. N., Raichle, M. E., Drevets, W. C., Heath, A. C., & Todd, R. D. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01280-x · Cited by 371 · see citing works
Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study
Vakili, K., Pillay, S. S., Lafer, B., D, M. F. M., Renshaw, P. F., Bonello, C. M., & Yurgelun-Todd, D. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00296-6 · Cited by 360 · see citing works
Drevets, W. C., Öngür, D., & Price, J. L. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000370 · Cited by 352 · see citing works
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia
Pizzagalli, D. A., Oakes, T. R., Fox, A. S., Chung, M. K., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Benca, R. M., & Davidson, R. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001501 · Cited by 331 · see citing works
Monkul, E. S., Hatch, J. P., Nicoletti, M. A., Spence, S., Brambilla, P., Lacerda, A. L. T., Sassi, R. B., Mallinger, A. G., Keshavan, M. S., & Soares, J. C. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001919 · Cited by 321 · see citing works
Enlargement of the Amygdala in Patients with a First Episode of Major Depression
Frodl, T., Meisenzahl, E., Zetzsche, T., Bottlender, R., Born, C., Groll, C., Jäger, M., Leinsinger, G., Hahn, K., & Möller, H.-J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01359-2 · Cited by 316 · see citing works
Loss of Glucocorticoid Fast Feedback in Depression
Young, E. A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320017003 · Cited by 299 · see citing works
Reduced hippocampal volume correlates with executive dysfunctioning in major depression
Frodl, T., Schaub, A., Banac, S., Charypar, M., Jäger, M., Kümmler, P., Ronald Bottlender, A., Zetzsche, T., Born, C., Leinsinger, G. L., et al. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0636 · Cited by 280 · see citing works
Frodl, T., Meisenzahl, E. M., Zetzsche, T., Born, C., Jäger, M., Groll, C., Bottlender, R., Leinsinger, G., & Möller, H.-J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01474-9 · Cited by 278 · see citing works
Neumeister, A., Wood, S. E., Bonne, O. B., Nugent, A. C., Luckenbaugh, D. A., Young, T. A., Bain, E., Charney, D. S., & Drevets, W. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.016 · Cited by 276 · see citing works
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia
Pizzagalli, D. A., Oakes, T. R., Fox, A. S., Chung, M. K., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Benca, R. M., & Davidson, R. J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001469 · Cited by 255 · see citing works
Depression, Stress and the Adrenal axis
(2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01058.x · Cited by 242 · see citing works
Volumetric brain imaging findings in mood disorders
Beyer, J. L., & Krishnan, K. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01157.x · Cited by 231 · see citing works
Enlarged amygdala volume and reduced hippocampal volume in young women with major depression
Lange, C., & Irle, E. (2004) · Psychological Medicine · doi:10.1017/s0033291703001806 · Cited by 225 · see citing works
Yucel, M., Stuart, G. W., Maruff, P., Velakoulis, D., Crowe, S. F., Savage, G., & Pantelis, C. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.1.17 · Cited by 222 · see citing works
Glucocorticoid and Mineralocorticoid Receptor mRNA Expression in Rat Brain
Chao, H. M., Choo, P. H., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000125250 · Cited by 217 · see citing works
Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
Lacerda, A. L. T., Keshavan, M. S., Hardan, A. Y., Yorbık, Ö., Brambilla, P., Sassi, R. B., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., et al. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.021 · Cited by 212 · see citing works
Caetano, S. C., Hatch, J. P., Brambilla, P., Sassi, R. B., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.08.002 · Cited by 206 · see citing works
High-Dimensional Mapping of the Hippocampus in Depression
Posener, J. A., Wang, L., Price, J. L., Gado, M. H., Province, M. A., Miller, M. I., Babb, C. M., & Csernansky, J. G. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.83 · Cited by 200 · see citing works
An update on regional brain volume differences associated with mood disorders
Campbell, S., & MacQueen, G. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000194371.47685.f2 · Cited by 198 · see citing works
Subgenual anterior cingulate activation to valenced emotional stimuli in major depression
Gotlib, I. H., Sivers, H., Gabrieli, J. D. E., Whitfield-Gabrieli, S., Goldin, P., Minor, K. L., & Canli, T. (2005) · NeuroReport · doi:10.1097/01.wnr.0000183901.70030.82 · Cited by 194 · see citing works
Frodl, T., Meisenzahl, E. M., Zill, P., Baghai, T. C., Rujescu, D., Leinsinger, G. L., Ronald Bottlender, A., Schüle, C., Zwanzger, P., Engel, R. R., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.2.177 · Cited by 175 · see citing works
Raz, N., Rodrigue, K. M., & Haacke, E. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.018 · Cited by 172 · see citing works
Cerqueira, J., Taipa, R. J. F., Uylings, H. B. M., Almeida, O. F. X., & Sousa, N. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl108 · Cited by 171 · see citing works
Stress and hippocampal abnormalities in psychiatric disorders
Sala, M. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.12.005 · Cited by 169 · see citing works
Hippocampal volume change in depression: Late- and early-onset illness compared
Lloyd, A. J., Ferrier, I. N., Barber, R., Gholkar, A. R., Young, A. H., & O'Brien, J. T. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.6.488 · Cited by 165 · see citing works
Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects
Brambilla, P. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00352-4 · Cited by 164 · see citing works
Inhibition of glucocorticoid secretion by the hippocampal formation in the primate
Sapolsky, R., Zola-Morgan, S. M., & Squire, L. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-12-03695.1991 · Cited by 151 · see citing works
Smaller Cingulate Volumes in Unipolar Depressed Patients
Caetano, S. C., Kaur, S., Brambilla, P., Nicoletti, M., Hatch, J. P., Sassi, R. B., Mallinger, A. G., Keshavan, M. S., Kupfer, D. J., Frank, E., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.011 · Cited by 147 · see citing works
Hippocampal morphometry in depressed patients and control subjects: relations to anxiety symptoms
Rusch, B. D., Abercrombie, H. C., Oakes, T. R., Schaefer, S. M., & Davidson, R. J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01248-3 · Cited by 139 · see citing works
Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder
WENIGER, G., LANGE, C., & IRLE, E. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.04.017 · Cited by 135 · see citing works
Chronic, treatment-resistant depression and right fronto-striatal atrophy
Shah, P. J., Glabus, M. F., Goodwin, G. M., & Ebmeier, K. P. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.5.434 · Cited by 134 · see citing works
Hickie, I. B., Naismith, S. L., Ward, P. B., Scott, E. M., Mitchell, P. B., Schofield, P. R., Scimone, A., Wilhelm, K. A., & Parker, G. B. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.010 · Cited by 126 · see citing works
Distribution of messenger RNA for the vasopressin V1a receptor in the CNS of male and female rats
Szot, P., Bale, T. L., & Dorsa, D. M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90111-2 · Cited by 125 · see citing works
Anatomical MRI study of basal ganglia in major depressive disorder
Lacerda, A. L. T., Nicoletti, M., Brambilla, P., Sassi, R. B., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00123-9 · Cited by 121 · see citing works
Towards a neuropathology of emotion and mood
Damásio, A. R. (1997) · Nature · doi:10.1038/386769a0 · Cited by 119 · see citing works
Fornito, A., Whittle, S., Wood, S. J., Velakoulis, D., Pantelis, C., & Yücel, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.06.061 · Cited by 118 · see citing works
Cerqueira, J., Catania, C., Sotiropoulos, I., Schubert, M. I., Kalisch, R., Almeida, O. F. X., Auer, D. P., & Sousa, N. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.01.003 · Cited by 106 · see citing works
Anatomical MRI findings in mood and anxiety disorders
Brambilla, P., Barale, F., Caverzasi, E., & Soares, J. C. (2002) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00005558 · Cited by 104 · see citing works
Reduced hippocampal volume in drug-free depressed patients
Saylam, C., Üçerler, H., Kitiş, Ö., Ozand, E., & Gönül, A. S. (2006) · Surgical and Radiologic Anatomy · doi:10.1007/s00276-005-0050-3 · Cited by 97 · see citing works
Cicero, T. J., Cowan, W. M., & Moore, B. W. (1970) · Brain Research · doi:10.1016/0006-8993(70)90270-2 · Cited by 97 · see citing works
Blunted aldosterone and ACTH release after human CRH administration in depressed patients
Holsboer, F., Gerken, A., Stalla, G. K., & Müller, O. A. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.2.229 · Cited by 85 · see citing works
Steiner, H., & Gerfen, C. R. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961223)376:4 · Cited by 81 · see citing works
Pillay, S. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00048-1 · Cited by 76 · see citing works
A major depression prognosis calculator based on episode duration.
Patten, S. B. (2006) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-2-13 · Cited by 45 · see citing works
Basal ganglia volumetric studies in affective disorder: what did we learn in the last 15 years?
Bonelli, R. M., Kapfhammer, H., Pillay, S. S., & Yurgelun-Todd, D. A. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0372-7 · Cited by 34 · see citing works
A magnetic resonance volumetric study of the temporal lobe structures in depression.
Moryś, J. M., Bobek‐Billewicz, B., Dziewíatkowski, J., Ratajczak, I., Pankiewicz, P., Narkiewicz, O., & Moryś, J. (2003) · PubMed · Cited by 17 · see citing works
The conduct of successful multi-site EU collaborative research: the Epsilon Study
Thornicroft, G., Becker, T. M., Knapp, M. R. J., Knudsen, H. C., Schene, A. H., Tansella, M., Vázquez‐Barquero, J. L., & The Epsilon Study Group (2002) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00010071 · Cited by 5 · see citing works
Yeterian (1998) · doi:10.1002/(sici)1096-9861(19980928)399:3
Flagged first, then by citations
Cited by
Sorted by citations
The root of all value: a neural common currency for choice
Levy, D. J., & Glimcher, P. W. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.06.001 · Cited by 1,342 · see citing works
for the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.69 · Cited by 1,172 · see citing works
Towards a glutamate hypothesis of depression
Sanacora, G., Treccani, G., & Popoli, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.036 · Cited by 1,036 · see citing works
Single subject prediction of brain disorders in neuroimaging: Promises and pitfalls
Arbabshirani, M. R., Plis, S., Sui, J., & Calhoun, V. D. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.079 · Cited by 912 · see citing works
Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
Pizzagalli, D. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.166 · Cited by 945 · see citing works
Zhang, F., & O’Donnell, L. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815739-8.00007-9 · Cited by 827 · see citing works
Bora, E., Fornito, A., Pantelis, C., & Yücel, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.049 · Cited by 763 · see citing works
Whole brain resting-state analysis reveals decreased functional connectivity in major depression
Veer, I. M. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00041 · Cited by 753 · see citing works
A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder
Lee, R. S. C., Hermens, D. F., Porter, M. A., & Redoblado-Hodge, M. A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.10.023 · Cited by 737 · see citing works
Postpartum depression: Etiology, treatment and consequences for maternal care
Brummelte, S., & Galea, L. A. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.008 · Cited by 567 · see citing works
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529 · see citing works
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
The orbitofrontal cortex: reward, emotion and depression
Rolls, E. T., Cheng, W., & Feng, J. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa196 · Cited by 474 · see citing works
Avery, J. A., Drevets, W. C., Moseman, S. E., Bodurka, J., Barcalow, J. C., & Simmons, W. K. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.027 · Cited by 442 · see citing works
Sex differences in depression: Insights from clinical and preclinical studies
Eid, R. S., Gobinath, A. R., & Galea, L. A. M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.006 · Cited by 458 · see citing works
Dendritic Spines in Depression: What We Learned from Animal Models
Qiao, H., Li, M.-X., Xu, C. S., Chen, H.-B., An, S.-C., & Ma, X. (2016) · Neural Plasticity · doi:10.1155/2016/8056370 · Cited by 442 · see citing works
Sacher, J., Neumann, J., Fünfstück, T., Soliman, A., Villringer, A., & Schroeter, M. L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.001 · Cited by 410 · see citing works
Delay Discounting as a Transdiagnostic Process in Psychiatric Disorders
Amlung, M. T., Marsden, E., Holshausen, K., Morris, V. L., Patel, H., Vedelago, L., Naish, K. R., Reed, D. D., & McCabe, R. E. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.2102 · Cited by 395 · see citing works
Brakowski, J., Spinelli, S., Doerig, N., Bosch, O. G., Manoliu, A., Holtforth, M. G., & Seifritz, E. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.04.007 · Cited by 326 · see citing works
Joshi, S. H., Espinoza, R. T., Pirnia, T., Shi, J., Wang, Y., Ayers, B., Leaver, A., Woods, R. P., & Narr, K. L. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.029 · Cited by 320 · see citing works
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works
Cheng, W., Rolls, E. T., Qiu, J., Liu, W., Tang, Y., Huang, C.-C., Wang, X., Zhang, J., Lin, W., Zheng, L., et al. (2016) · Brain · doi:10.1093/brain/aww255 · Cited by 294 · see citing works
Post‐stroke depression: mechanisms, translation and therapy
Loubinoux, I., Kronenberg, G., Endres, M., Schumann‐Bard, P., Fréret, T., Filipkowski, R. K., Kaczmarek, L., & Popa‐Wagner, A. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01555.x · Cited by 317 · see citing works
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
Levy, M. J. F., Boulle, F., Steinbusch, H. W., van den Hove, D. L. A., Kenis, G., & Lanfumey, L. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4950-4 · Cited by 308 · see citing works
Neuroimaging-based markers of bipolar disorder: Evidence from two meta-analyses
Houenou, J., Frommberger, J., Carde, S., Glasbrenner, M., Diener, C., Leboyer, M., & Wessa, M. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.016 · Cited by 291 · see citing works
Where in the Brain Is Depression?
Pandya, M. A., Altinay, M. I., Malone, D. A., & Anand, A. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0322-7 · Cited by 302 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
Positive parenting predicts the development of adolescent brain structure: a longitudinal study
Whittle, S., Simmons, J. G., Dennison, M., Vijayakumar, N., Schwartz, O., Yap, M. B. H., Sheeber, L., & Allen, N. B. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.10.006 · Cited by 279 · see citing works
Self-citationAntidepressants Normalize the Default Mode Network in Patients With Dysthymia
Posner, J., Hellerstein, D. J., Gat, I., Mechling, A., Klahr, K., Wang, Z., McGrath, P. J., Stewart, J. W., & Peterson, B. S. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.455 · Cited by 268 · see citing works
Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.009 · Cited by 269 · see citing works
A wavelet-based technique to predict treatment outcome for Major Depressive Disorder
Mumtaz, W., Xia, L., Yasin, M. A. M., Ali, S. S. A., & Malik, A. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171409 · Cited by 273 · see citing works
Cobb, J. A., O’Neill, K., Milner, J., Mahajan, G. J., Lawrence, T. J., May, W. L., Miguel-Hidalgo, J., Rajkowska, G., & Stockmeier, C. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.044 · Cited by 254 · see citing works
Haeussinger, F. B., Heinzel, S., Hahn, T., Schecklmann, M., Ehlis, A., & Fallgatter, A. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026377 · Cited by 261 · see citing works
Sterner, E. Y., & Kalynchuk, L. E. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.005 · Cited by 259 · see citing works
Neighborhood matters: divergent patterns of stress-induced plasticity across the brain
Chattarji, S., Tomar, A., Suvrathan, A., Ghosh, S., & Rahman, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4115 · Cited by 248 · see citing works
Localized connectivity in depression: A meta-analysis of resting state functional imaging studies
Iwabuchi, S. J., Krishnadas, R., Li, C., Auer, D. P., Raduà, J., & Palaniyappan, L. K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.006 · Cited by 257 · see citing works
Role of Metabotropic Glutamate Receptors in Neurological Disorders
Crupi, R., Impellizzeri, D., & Cuzzocrea, S. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00020 · Cited by 257 · see citing works
Dendritic spines: Revisiting the physiological role
Chidambaram, S. B., Rathipriya, A. G., Bolla, S. R., Bhat, A., Ray, B., Mahalakshmi, A. M., Manivasagam, T., Thenmozhi, A. J., Essa, M. M., Guillemin, G. J., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.005 · Cited by 255 · see citing works
Wagner, G., Koch, K., Schachtzabel, C., Schultz, C. C., Sauer, H., & Schlösser, R. G. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.082 · Cited by 230 · see citing works
Mwangi, B., Ebmeier, K. P., Matthews, K., & Steele, J. D. (2012) · Brain · doi:10.1093/brain/aws084 · Cited by 207 · see citing works
Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms
Mahmoud, R., Wainwright, S. R., & Galea, L. A. M. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.002 · Cited by 201 · see citing works
Childhood Maltreatment and Psychopathology Affect Brain Development During Adolescence
Whittle, S., Dennison, M., Vijayakumar, N., Simmons, J. G., Yücel, M., Lubman, D. I., Pantelis, C., & Allen, N. B. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.06.007 · Cited by 187 · see citing works
A non-reward attractor theory of depression
Rolls, E. T. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.007 · Cited by 180 · see citing works
Diagnosis, Pathophysiology, and Management of Mood Disorders in Pregnant and Postpartum Women
Yonkers, K. A., Vigod, S. N., & Ross, L. E. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31821187a7 · Cited by 183 · see citing works
Wang, L., Dai, W., Su, Y., Wang, G., Tan, Y., Jin, Z. H., Zeng, Y., Yu, X., Chen, W., Wang, X., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048658 · Cited by 178 · see citing works
Musazzi, L., Treccani, G., Mallei, A., & Popoli, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.009 · Cited by 172 · see citing works
Ma, C., Ding, J., Li, J., Guo, W., Long, Z., Liu, F., Gao, Q. C., Zeng, L., Zhao, J., & Chen, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045263 · Cited by 165 · see citing works
Mood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus
Soczynska, J. K., Kennedy, S. H., Woldeyohannes, H. O., Liauw, S. S. L., Alsuwaidan, M. T., Yim, C. Y., & McIntyre, R. S. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8140-8 · Cited by 162 · see citing works
Soriano‐Mas, C., Hernández‐Ribas, R., Pujol, J., Urretavizcaya, M., Deus, J., Harrison, B. J., Ortiz, H., López‐Solà, M., Menchón, J. M., & Cardoner, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.029 · Cited by 152 · see citing works
Ahmadlou, M., Adeli, H., & Adeli, A. (2013) · Clinical EEG and Neuroscience · doi:10.1177/1550059413480504 · Cited by 151 · see citing works
Zhang, H., Li, L., Wu, M. C., Chen, Z., Hu, X., Chen, Y., Zhu, H., Jia, Z., & Gong, Q. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.011 · Cited by 147 · see citing works
Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia
John, C. S., Smith, K. L., Van'T Veer, A., Gompf, H. S., Carlezon, W. A., Cohen, B. M., Öngür, D., & Bechtholt-Gompf, A. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.105 · Cited by 136 · see citing works
Lyden, H. M., Espinoza, R. T., Pirnia, T., Clark, K., Joshi, S. K., Leaver, A. M., Woods, R. P., & Narr, K. L. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.21 · Cited by 141 · see citing works
Apfel, B. A., Ross, J., Hlavin, J., Meyerhoff, D. J., Metzler, T. J., Marmar, C. R., Weiner, M. W., Schuff, N., & Neylan, T. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.044 · Cited by 139 · see citing works
Pretreatment Brain States Identify Likely Nonresponse to Standard Treatments for Depression
McGrath, C. L., Kelley, M. E., Dunlop, B. W., Holtzheimer III, P. E., Craighead, W. E., & Mayberg, H. S. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.005 · Cited by 139 · see citing works
Hing, B., Sathyaputri, L., & Potash, J. B. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32616 · Cited by 137 · see citing works
Epilepsy Identification using Hybrid CoPrO-DCNN Classifier
Birajadar, G., Mulani, A. O., Khalaf, O. I., Farhah, N. S., Gawande, P. G., Kinage, K. S., & Mohamad, A. A. H. (2024) · International Journal of Computing and Digital Systems · doi:10.12785/ijcds/160157 · Cited by 138 · see citing works
Bertocci, M. A., Bebko, G. M., Mullin, B. C., Langenecker, S. A., Ladouceur, C. D., Almeida, J., & Phillips, M. L. (2011) · Psychological Medicine · doi:10.1017/s003329171100242x · Cited by 137 · see citing works
Liang, M.-J., Zhou, Q., Yang, K.-R., Yang, X.-L., Fang, J., Chen, W.-L., & Huang, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079999 · Cited by 135 · see citing works
Njau, S. N., Joshi, S. H., Espinoza, R. T., Leaver, A. M., Vasavada, M. M., Marquina, A., Woods, R. P., & Narr, K. L. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150177 · Cited by 134 · see citing works
Binary Classification of Alzheimer’s Disease Using sMRI Imaging Modality and Deep Learning
Tufail, A. B., Ma, Y.-K., & Zhang, Q.-N. (2020) · Journal of Imaging Informatics in Medicine · doi:10.1007/s10278-019-00265-5 · Cited by 134 · see citing works
Brain Structural Effects of Antidepressant Treatment in Major Depression
Dusi, N., Barlati, S., Vita, A., & Brambilla, P. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831121909 · Cited by 129 · see citing works
Beblo, T., Sinnamon, G., & Baune, B. T. (2011) · Neuropsychology Review · doi:10.1007/s11065-011-9171-0 · Cited by 128 · see citing works
Rigucci, S., Serafini, G., Pompili, M., Kotzalidis, G., & Tatarelli, R. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970903131571 · Cited by 154 · see citing works
Lifetime major depression and grey-matter volume
Ancelin, M., Carrière, I., Artéro, S., Maller, J. J., Meslin, C., Ritchie, K. A., Ryan, J. L., & Chaudieu, I. (2018) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.180026 · Cited by 128 · see citing works
Neuroimaging-based biomarkers for treatment selection in major depressive disorder
Dunlop, B. W., & Mayberg, H. S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.4/bdunlop · Cited by 127 · see citing works
Steffens, D. C., McQuoid, D. R., Payne, M. E., & Potter, G. G. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181d6c245 · Cited by 125 · see citing works
Kendler, K. S. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.70 · Cited by 125 · see citing works
Jacobsen, J. P. R., Siesser, W. B., Sachs, B. D., Peterson, S. M., Cools, M. J., Setola, V., Folgering, J. H. A., Flik, G., & Caron, M. G. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.50 · Cited by 125 · see citing works
Pirnia, T., Joshi, S. H., Leaver, A. M., Vasavada, M., Njau, S., Woods, R. P., Espinoza, R., & Narr, K. L. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.102 · Cited by 122 · see citing works
Alterations in brain structure in adults with anorexia nervosa and the impact of illness duration
Fonville, L., Giampietro, V., Williams, S., Simmons, A., & Tchanturia, K. (2013) · Psychological Medicine · doi:10.1017/s0033291713002389 · Cited by 117 · see citing works
Qiu, S., Chang, G. H., Panagia, M., Gopal, D. M., Au, R., & Kolachalama, V. B. (2018) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.08.013 · Cited by 110 · see citing works
Stress, glucocorticoids and glutamate release: Effects of antidepressant drugs
Musazzi, L., Racagni, G., & Popoli, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.05.002 · Cited by 113 · see citing works
Brain Network Dysfunction in Late-Life Depression
Tadayonnejad, R., & Ajilore, O. (2013) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988713516539 · Cited by 114 · see citing works
Sundermann, B., Beverborg, M. O. L., & Pfleiderer, B. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00692 · Cited by 109 · see citing works
MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder
Qi, S., Yang, X., Zhao, L.-S., Calhoun, V., Perrone-Bizzozero, N., Liu, S., Jiang, R.-T., Jiang, T., Sui, J., & Ma, X.-H. (2018) · Brain : a journal of neurology · doi:10.1093/brain/awx366 · Cited by 102 · see citing works
Reduced thalamic volumes in major depressive disorder
Nugent, A. C., Davis, R., Zarate, C. A., & Drevets, W. C. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.05.004 · Cited by 105 · see citing works
Carvalho, D. Z., Louis, E. K. S., Boeve, B. F., Mielke, M. M., Przybelski, S. A., Knopman, D. S., Machulda, M. M., Roberts, R. O., Geda, Y. E., Petersen, R. C., et al. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.08.023 · Cited by 102 · see citing works
Gobinath, A. R., Mahmoud, R., & Galea, L. A. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00420 · Cited by 105 · see citing works
Volumetric MRI study of the insular cortex in individuals with current and past major depression
Takahashi, T., Yücel, M., Lorenzetti, V., Tanino, R., Whittle, S., Suzuki, M., Walterfang, M., Pantelis, C., & Allen, N. B. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.003 · Cited by 104 · see citing works
Neurobiology of depression: A neurodevelopmental approach
Lima‐Ojeda, J. M., Rupprecht, R., & Baghai, T. C. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1289240 · Cited by 102 · see citing works
Booij, S. H., Bouma, E., de Jonge, P., Ormel, J., & Oldehinkel, A. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.004 · Cited by 101 · see citing works
Neuroplasticity and major depression, the role of modern antidepressant drugs
Serafini, G. (2012) · World Journal of Psychiatry · doi:10.5498/wjp.v2.i3.49 · Cited by 103 · see citing works
Animal models for the study of depressive disorder
Song, J., & Kim, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13622 · Cited by 104 · see citing works
Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview
Rasmus, P., & Kozłowska, E. (2023) · Antioxidants · doi:10.3390/antiox12030676 · Cited by 101 · see citing works
Tu, P., Chen, L., Hsieh, J., Bai, Y.-M., Li, C., & Su, T. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.07.011 · Cited by 98 · see citing works
Lee, H.-Y., Tae, W., Yoon, H.-K., Lee, B.-T., Paik, J., Son, K.-R., Oh, Y., Lee, M.-S., & Ham, B. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.006 · Cited by 98 · see citing works
Sensorimotor modulation of mood and depression: An integrative review
Canbeyli, R. S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.002 · Cited by 98 · see citing works
Lener, M. S., & Iosifescu, D. V. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12759 · Cited by 96 · see citing works
An MRI study of the superior temporal subregions in patients with current and past major depression
Takahashi, T., Yücel, M., Lorenzetti, V., Walterfang, M., Kawasaki, Y., Whittle, S., Suzuki, M., Pantelis, C., & Allen, N. B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.10.005 · Cited by 93 · see citing works
Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95 · see citing works
Lorenzetti, V., Solowij, N., Fornito, A., Lubman, D. I., & Yücel, M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990435 · Cited by 96 · see citing works
Han, K., Won, E., Sim, Y., Kang, J. C., Han, C., Kim, Y., Kim, S., Joe, S.-H., Lee, M.-S., Tae, W., et al. (2017) · Scientific Reports · doi:10.1038/srep42621 · Cited by 96 · see citing works
Smith, R., Chen, K., Baxter, L., Fort, C., & Lane, R. D. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.07.029 · Cited by 95 · see citing works
Sacchet, M. D., Livermore, E. E., Iglesias, J. E., Glover, G. H., & Gotlib, I. H. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.06.002 · Cited by 94 · see citing works
Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder
Wade, B., Joshi, S. H., Njau, S. N., Leaver, A. M., Vasavada, M. M., Woods, R. P., Gutman, B. A., Thompson, P. M., Espinoza, R. T., & Narr, K. L. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.48 · Cited by 95 · see citing works
Bavato, F., Barro, C., Schnider, L. K., Simrén, J., Zetterberg, H., Seifritz, E., & Quednow, B. B. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02524-6 · Cited by 92 · see citing works
Kvarta, M. D., Bradbrook, K. E., Dantrassy, H. M., Bailey, A. M., & Thompson, S. M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00359.2015 · Cited by 86 · see citing works
Prediction of illness severity in patients with major depression using structural MR brain scans
Mwangi, B., Matthews, K., & Steele, J. D. (2011) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22806 · Cited by 90 · see citing works
Musazzi, L., Treccani, G., & Popoli, M. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00060 · Cited by 83 · see citing works
- Authors
- Lorenzetti, V., Allen, N. B., Fornito, A., & Yücel, M.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Yücel, Murat
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 117
- Issue
- 1-2
- Pages
- 1-17
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W1980508260
- Cited by
- 553
- References
- 91
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 22 · 2023: 21 · 2022: 22 · 2021: 29 · 2020: 37 · 2019: 34 · 2018: 22 · 2017: 42 · 2016: 35 · 2015: 56 · 2014: 43 · 2013: 45 · 2012: 52
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- major depressive disorder, structural brain abnormalities, hippocampal volume, basal ganglia, orbitofrontal cortex, brain atrophy, dysthymia, disease duration, relapse, gender differences, antipsychotic drugs, family history of mental illness, limbic system, cortical structure
- MeSH terms
- Adult, Amygdala, Basal Ganglia, Brain, Major Depressive Disorder, Female, Frontal Lobe, Hippocampus, Humans, Limbic System, Magnetic Resonance Imaging, Male, Severity of Illness Index, Sex Factors, Temporal Lobe, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review