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Cited by 104Treatment of Major DepressionMental Health Treatment and AccessBipolar Disorder and Treatment

First-Episode Major Depression: Few Sex Differences in Course

Simpson, H. Blair·1997·Archives of General Psychiatry
DOI 10.1001/archpsyc.1997.01830190059006
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Abstract

BACKGROUND: There is a sex difference in the prevalence of unipolar major depression. This study sought to determine whether there is a sex difference in its course. METHODS: The National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies provided data on 96 male and 101 female subjects who were diagnosed as having a first episode of unipolar major depressive disorder at intake and on whom prospective data were available. We looked for differences at intake in factors other than sex that might affect the course of illness: demographic factors, characteristic features of the first depressive episode, psychiatric history, and family history of depression. We then examined the course of depression of these subjects during the following 15 years. RESULTS: The subjects were similar at intake, enabling us to focus on sex when we looked for differences in the course. Most subjects recovered from their first episode of major depression, but the majority had at least 1 recurrence in the following 5 years. During the following 15 years, male and female subjects did not differ significantly in the time to recovery, the overall time to first recurrence, of the number or severity of recurrences of major depressive episodes. There was no evidence for a more chronic course of depression in women. CONCLUSION: There were few significant sex differences in the course of major depressive disorder in this study population.

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Crossref · 10.1001/archpsyc.1997.01830190059006

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  • In our study, age at onset of first MDE and gender did not predict subsequent episode of MDE.

    “In terms of age at onset and gender, the results of our study replicated results of several earlier studies showing that age at onset of first MDE [17, 18, 59–60] and gender [16, 18, 59–61] did not predict subsequent episode of MDE.”

    From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [61]

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Authors
Simpson, H. B.
Affiliations
Columbia University (US)
Corresponding author
Simpson, H. Blair
ORCID
Simpson, H. Blair
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1997-07-01
Volume
54
Issue
7
Pages
633
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1997.01830190059006
OpenAlex
W2156947831
Cited by
104
References
32
Citations by year
2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 4
FWCI
4.47
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH 23864, MH30906)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
sex differences, clinical course, depression recurrence, recovery time, unipolar major depression, chronicity of depression, family history of depression, psychiatric history
MeSH terms
Adult, Chronic Disease, Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Recurrence, Severity of Illness Index, Sex Factors, Prevalence, Survival Analysis, Outcome Assessment, Health Care, Age of Onset

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