Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)

Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

Bottenstein, J. E., & SATO, G. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.514 · Cited by 2,268

Identification of a receptor for the morphogen retinoic acid

Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965

Purification of a new neurotrophic factor from mammalian brain.

Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822

Physiology of nerve growth factor.

Thoenen, H., & Barde, Y. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1284 · Cited by 1,573

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

Hefti, F. F. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,445

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

Strickland, S., & Mahdavi, V. (1978) · Cell · doi:10.1016/0092-8674(78)90008-9 · Cited by 1,420

Actions of Insulin-Like Growth Factors

Froesch, E. R., Schmid, C., Schwander, J., & Zapf, J. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002303 · Cited by 1,154

THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS

Shute, C. C. D., & Lewis, P. R. (1967) · Brain · doi:10.1093/brain/90.3.497 · Cited by 1,120

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa‐Komaroff, L., Gusella, J. F., & Neve, R. L. (1988) · Nature · doi:10.1038/331528a0 · Cited by 1,093

Neurotrophins in the Central Nervous System

Lapchak, P. A., Araujo, D. M., & Hefti, F. F. (1992) · Reviews in the Neurosciences · doi:10.1515/revneuro.1992.3.1.1 · Cited by 39

Role of the cholinergic system in the regulation of neurotrophin synthesis

Yu, J., Pizzo, D. P., Hutton, L. A., & Perez-Polo, J. R. (1995) · Brain Research · doi:10.1016/0006-8993(95)01169-2 · Cited by 38

Staurosporine, K‐252a, and K‐252b Stabilize Calcium Homeostasis and Promote Survival of CNS Neurons in the Absence of Glucose

Cheng, B., Barger, S. W., & Mattson, M. P. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62041319.x · Cited by 38

Chapter 32: Trophic responses of forebrain cholinergic neurons: a discussion

Cuello, A. C. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62408-5 · Cited by 38

Neurotrophic factors: From physiology to pharmacology?

Vantini, G. (1992) · Pharmacological Research · doi:10.1016/1043-6618(92)90701-c · Cited by 37

Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats

Montero‐Menei, C. N., & Hefti, F. F. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90011-0 · Cited by 37

Neuroprotective potential of choline alfoscerate against β‐amyloid injury: Involvement of neurotrophic signals

Catanesi, M., d’Angelo, M., Antonosante, A., Castelli, V., Alfonsetti, M., Benedetti, E., Desideri, G., Ferri, C., & Cimini, A. (2020) · Cell Biology International · doi:10.1002/cbin.11369 · Cited by 36

NGF increases neuritic complexity of cholinergic interneurons in organotypic cultures of neonatal rat striatum

Studer, L., Spenger, C., Luthman, J., & Seiler, R. W. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903400212 · Cited by 37

Nerve growth factor receptor‐immunoreactive neurons within the developing human cortex

Kordower, J. H., & Mufson, E. J. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903230104 · Cited by 36

Amyotrophic Lateral Sclerosis: Current and Future Treatment Strategies

Festoff, B. W. (1996) · Drugs · doi:10.2165/00003495-199651010-00004 · Cited by 35

GM1 ganglioside enhances cholinergic parameters in the brain of senescent rats

Hadjiconstantinou, M., Karadsheh, N. S., Rattan, A. K., Tejwani, G. A., Fitkin, J. G., & Neff, N. H. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90154-t · Cited by 35

Nitric oxide modulates retinal ganglion cell axon arbor remodelingin vivo

Cogen, J., & Cohen‐Cory, S. (2000) · Journal of Neurobiology · doi:10.1002/1097-4695(20001105)45:2 · Cited by 42

Roles for calcium signaling in structural plasticity and pathology in the hippocampal system.

Mattson, M. P., & Barger, S. W. (1993) · PubMed · Cited by 35

Chapter 31: Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections

Hefti, F. F., Knüsel, B., & Lapchak, P. A. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62407-3 · Cited by 35

Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness

Mizumura, K., & Taguchi, T. (2024) · The Journal of Physiological Sciences · doi:10.1186/s12576-023-00896-y · Cited by 33

The α7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice

Ren, K., King, M. A., Liu, J., Siemann, J. K., Altman, M., Meyers, C., Hughes, J. A., & Meyer, E. M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.013 · Cited by 34

Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells

Dong-Ruyl, L., Sawada, M., & Nakano, K. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00120-7 · Cited by 33

Acidic FGF induces NGF and its mRNA in the injured neocortex of adult animals

de Figueiredo, B. C., Plüss, K., Skup, M., Otten, U., & Cuello, A. C. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00099-e · Cited by 33

Evaluation of neuritogenic activity of cultivated, wild and commercial roots of Gentiana lutea L.

Mustafa, A. M., Caprioli, G., Dikmen, M., Tilki, E. K., Maggi, F., Sagratini, G., Vittori, S., & Öztürk, Y. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.09.018 · Cited by 31

Trophic Actions of IGF-I, IGF-II and Insulin on Cholinergic and Dopaminergic Brain Neurons

Knüsel, B., & Hefti, F. F. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5949-4_31 · Cited by 32

Structure–activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata

Han, C., Qi, J., & Ojika, M. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.02.032 · Cited by 32

Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neurons

Widmer, H. R., Ohsawa, F., Knüsel, B., & Hefti, F. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91051-s · Cited by 32

Issues regarding gene therapy products for Parkinson's disease: The development of CERE-120 (AAV-NTN) as one reference point

Bartus, R. T., Herzog, C. D., Bishop, K. M., Ostrove, J. M., Tuszynski, M. H., Kordower, J. H., & Gasmi, M. (2007) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(08)70052-x · Cited by 31

Neurotrophic factors in neurodegenerative disorders: Model of parkinson’s disease

de Yébenes, J. G., & Mena, M. A. (2000) · Neurotoxicity Research · doi:10.1007/bf03033789 · Cited by 31

Encapsulated genetically engineered fibroblasts: Release of nerve growth factor and effects in vivo on recovery of cholinergic markers after devascularizing cortical lesions

Maysinger, D., Piccardo, P., Liberini, P., Jalšenjak, I., & Cuello, A. C. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90097-3 · Cited by 31

Basic fibroblast growth factor high and low affinity binding sites in developing mouse brain, hippocampus and cerebellum

Fayein, N. A., Courtois, Y., & Jeanny, J. (1992) · Biology of the Cell · doi:10.1016/0248-4900(92)90189-8 · Cited by 31

Monoclonal antibody 14F7, which recognizes a stage-specific immature oligodendrocyte surface molecule, inhibits oligodendrocyte differentiation mediated in co-culture with astrocytes

Yoshimura, K., Sakurai, Y., Nishimura, D., Tsuruo, Y., Nomura, M., Kawato, S., Seiwa, C., Iguchi, T., Itoh, K., & Asou, H. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981001)54:1 · Cited by 15

Effect of Ganglioside (GM1) on Memory in Senescent Rats

Silva, R. H., Felício, L. F., Nasello, A. G., Vital, M. A. B. F., & Frussa‐Filho, R. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00065-6 · Cited by 30

Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures

Lorenzi, M. V., Knüsel, B., Hefti, F. F., & Strauss, W. L. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90098-r · Cited by 30

Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseases

Herzog, C. D., Bishop, K. M., Brown, L., Wilson, A., Kordower, J. H., & Bartus, R. T. (2011) · Drug Delivery and Translational Research · doi:10.1007/s13346-011-0037-z · Cited by 29

Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption

Solà, E., Moyano, P. M., Flores, A., García, J., García, J. M., Anadón, M. J., Frejo, M. T., Pelayo, A., Fernández, M. D. L. C., & del Pino, J. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103791 · Cited by 29

Trophic factor effects on cholinergic innervation in the cerebral cortex of the adult rat brain

Cuello, A. C., Maysinger, D., & Garofalo, L. (1992) · Molecular Neurobiology · doi:10.1007/bf02757946 · Cited by 29

Linckosides C–E, three new neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata

Qi, J., Ojika, M., & Sakagami, Y. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.04.049 · Cited by 29

Rationale for the Planned Clinical Trials with Nerve Growth Factor in Alzheimer’s Disease

Hefti, F. F., & Schneider, L. S. (1990) · Advances in behavioral biology · doi:10.1007/978-1-4684-5847-3_70 · Cited by 29

Stability of septohippocampal neurons following excitotoxic lesions of the rat hippocampus

Kordower, J. H., Burke, M. A., Roback, J. D., & Wainer, B. H. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90105-y · Cited by 29

Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae)

Mustafa, A. M., Maggi, F., Papa, F., Tilki, E. K., Dikmen, M., & Öztürk, Y. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.07.079 · Cited by 28

Translating the therapeutic potential of neurotrophic factors to clinical ‘proof of concept’: A personal saga achieving a career-long quest

Bartus, R. T. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.04.004 · Cited by 28

Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms

Chadi, G., & Fuxé, K. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998000200007 · Cited by 28

Microencapsulation of genetically engineered fibroblasts secreting nerve growth factor

Maysinger, D., Piccardo, P., Filipović‐Grčić, J., & Cuello, A. C. (1993) · Neurochemistry International · doi:10.1016/0197-0186(93)90089-n · Cited by 28

Roles for calcium signaling in structural plasticity and pathology in the hippocampal system

Mattson, M. P., & Barger, S. W. (1993) · Hippocampus · doi:10.1002/hipo.1993.4500030711 · Cited by 36

The role of estrogen replacement therapy in Alzheimer’s disease

Panidis, D., Matalliotakis, I., Rousso, D., Kourtis, A., & Koumantakis, E. E. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00373-0 · Cited by 27

Medial-to-lateral gradient of neostriatal NGF receptors: relationship to cholinergic neurons and NGF-like immunoreactivity

Altar, C. A., Dugich‐Djordjevic, M. M., Armanini, M. P., & Bakhit, C. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00828.1991 · Cited by 27

Gangliosides prevent MPTP toxicity in mice - an immunocytochemical study

Gupta, M., Schwarz, J., Chen, X. L., & Roisen, F. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)91154-9 · Cited by 27

Dose-dependent responses to nerve growth factor by adult rat cholinergic medial septum and neostriatum neurons

Vahlsing, H. L., Hagg, T., Spencer, M., Conner, J. M., Manthorpe, M., & Varon, S. S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90098-g · Cited by 28

An Update on Gene Therapy in Parkinson’s Disease

Witt, J. L., & Marks, W. J. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0197-8 · Cited by 30

Characterization of a neurotrophic factor produced by cultured astrocytes involved in the regulation of subcortical cholinergic neurons

Gray, C. W., & Patel, A. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)90825-t · Cited by 26

Nerve Growth Factor Systems in Alzheimer’s Disease

Mufson, E. J., & Kordower, J. H. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_19 · Cited by 25

Detection and Quantitation of Perlecan mRNA Levels in Alzheimer's Disease and Normal Aged Hippocampus by Competitive Reverse Transcription‐Polymerase Chain Reaction

Maresh, G. A., Erezyilmaz, D. F., Murry, C. E., Nochlin, D., & Snow, A. D. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031132.x · Cited by 25

Analysis of Mutant Platelet-Derived Growth Factor Receptors Expressed in PC12 Cells Identifies Signals Governing Sodium Channel Induction during Neuronal Differentiation

Fanger, G. R., Vaillancourt, R. R., Heasley, L. E., Montmayeur, J., Johnson, G. L., & Maue, R. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.89 · Cited by 25

Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease

Kerwin, J. M., Morris, C. M., Perry, R. H., & Perry, E. K. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90242-y · Cited by 25

Peptide growth factors but not ganglioside protect against excitotoxicity in rat retinal neurons in vitro

Heidinger, V., Hicks, D., Sahel, J., & Dreyfus, H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00605-7 · Cited by 25

Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

(1995) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7218-8 · Cited by 25

Exenatide upregulates gene expression of glucagon‐like peptide‐1 receptor and nerve growth factor in streptozotocin/nicotinamide‐induced diabetic mice

Gümüşlü, E., Çine, N., Ertan, M., Mutlu, O., Celikyurt, I. K., & Ulak, G. (2017) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12329 · Cited by 24

Thermoresponsive-co-Biodegradable Linear–Dendritic Nanoparticles for Sustained Release of Nerve Growth Factor To Promote Neurite Outgrowth

Kim, Y. S., Gulfam, M., & Lowe, T. L. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b01044 · Cited by 24

Long Term Effects of Toki-shakuyaku-san on Brain Dopamine and Nerve Growth Factor in Olfactory-Bulb-Lesioned Mice

Song, Q.-H., Toriizuka, K., Jin, G., Yabe, T., & Cyong, J. (2001) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.86.183 · Cited by 24

Basic fibroblast growth factor prevents neuronal death and atrophy of retrogradely labeled preganglionic neurons in vivo

Blottner, D., & Baumgarten, H. G. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90020-q · Cited by 24

A Novel Fungal Metabolite NG-061 Enhances and Mimics Neurotrophic Effect of Nerve Growth Factor(NGF) on Neurite Outgrowth in PC12 Cells.

Ito, M., SAKAI, N., Ito, K., Mizobe, F., Hanada, K., Mizoue, K., Bhandari, R., Eguchi, T., & Kakinuma, S. (1999) · The Journal of Antibiotics · doi:10.7164/antibiotics.52.224 · Cited by 23

Growth factor effects on survival and development of calbindin immunopositive cultured septal neurons

Silva, A., Montague, J. R., Lopez, T. F., & Mudd, L. M. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00188-4 · Cited by 24

Basal Forebrain Cholinergic System Is Involved in Rapid Nerve Growth Factor (NGF)-Induced Plasticity in the Barrel Cortex of Adult Rats

Prakash, N., Cohen‐Cory, S., Penschuck, S., & Frostig, R. D. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00489.2003 · Cited by 23

Nerve growth factor and the neostriatum

Altar, C. A. (1991) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(91)90077-e · Cited by 23

Diagnostic and Pharmacological Approaches in Alzheimer??s Disease

Hermann, C. R., Stern, R. G., Losonzcy, M. F., Jaff, S., & Davidson, M. (1991) · Drugs & Aging · doi:10.2165/00002512-199101020-00006 · Cited by 23

Reduced density of neuropeptide Y neurons in the somatosensory cortex of old male and female rats: Relation to cholinergic depletion and recovery after nerve growth factor treatment

Cardoso, A., Paula-Barbosa, M. M., & Lukoyanov, N. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.027 · Cited by 24

NGF receptor (p75)‐immunoreactivity in the developing primate basal ganglia

Kordower, J. H., & Mufson, E. J. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903270305 · Cited by 22

Chapter 27 Trophic factor therapy in the adult CNS: remodelling of injured basalo-cortical neurons

Cuello, A. C. (1994) · Progress in brain research · doi:10.1016/s0079-6123(08)60788-8 · Cited by 22

The effects of NGF and fetal cell transplants on spatial learning after intradentate administration of colchicine

Barone, S., Tandon, P., McGinty, J. F., & Tilson, H. A. (1991) · Experimental Neurology · doi:10.1016/0014-4886(91)90161-5 · Cited by 22

Use of a digital brain atlas to compare the distribution of NGF‐ and bFGF‐protected cholinergic neurons

Schwaber, J. S., Due, B. E., Rogers, W. T., Junard, E. O., Sharma, A., & Hefti, F. F. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903090104 · Cited by 22

Specificity versus Redundancy of Melanocortins in Nerve Regeneration

Antonawich, F. J., Azmitia, E. C., Kramer, H. K., & Strand, F. L. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb19807.x · Cited by 21

GM1 and NGF synergism on choline acetyltransferase and choline uptake in aged brain

Fong, T. G., Vogelsberg, V., Neff, N. H., & Hadjiconstantinou, M. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00088-7 · Cited by 21

Tyrosine kinase A, galanin and nitric oxide synthase within basal forebrain neurons in the rat

Sobreviela, T., Jaffar, S., & Mufson, E. J. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00153-5 · Cited by 21

Decreased insulin-like growth factor I-mediated protein tyrosine phosphorylation in human olivopontocerebellar atrophy and lurcher mutant mouse

Vig, P. J. S., Desaiah, D., Joshi, P., Subramony, S. H., Fratkin, J. D., & Currier, R. D. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90008-6 · Cited by 21

Growth Factors and Lymphokines: Modulators of Cholinergic Neuronal Activity

Quirion, R., Araujo, D. M., Lapchak, P. A., Seto, D., & Chabot, J. (1991) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100032510 · Cited by 21

Expression of neuronal nitric oxide synthase in spinal motoneurons in aged rats

Kanda, K. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13170-0 · Cited by 20

Pharmacology of Nerve Growth Factor in the Brain

Hefti, F. F., & Lapchak, P. A. (1993) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60939-4 · Cited by 20

Plasticity following neonatal visual cortex damage in cats

Spear, P. D. (1995) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y95-194 · Cited by 20

The pharmacological potential of neurotrophins: A perspective

Vantini, G. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90045-9 · Cited by 20

Inhibition of nuclear factor kappa B (NF?B) activity induces nerve growth factor-resistant apoptosis in PC12 cells

Taglialatela, G., Robinson, R. C., & Perez-Polo, J. R. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970115)47:2 · Cited by 170

A low-affinity nerve growth factor receptor antibody is internalized and retrogradely transported selectively into cholinergic neurons of the rat basal forebrain

Kiss, J., Shooter, E. M., & Patel, A. J. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90063-l · Cited by 20

Neuropathobiology of Senile Dementia and Mechanism of Action of Nootropic Drugs

Benešová, O. (1994) · Drugs & Aging · doi:10.2165/00002512-199404040-00002 · Cited by 18

Phosphorylation of mitogen-activated protein kinase is altered in neuroectodermal cells overexpressing the human amyloid precursor protein 751 isoform

Grant, S. M., Morinville, A., Maysinger, D., Szyf, M., & Cuello, A. C. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00157-6 · Cited by 19

Transplants of NGF-Secreting Fibroblasts Restore Stimulus-Evoked Activity in Barrel Cortex of Basal-Forebrain-Lesioned Rats

Rahimi, O. B., & Juliano, S. L. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.4.2081 · Cited by 19

NGF and Alzheimer's disease: Unfulfilled promise and untapped potential

Kordower, J. H., & Mufson, E. J. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90123-1 · Cited by 19

Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation

Yu, C., & Crutcher, K. A. (1995) · Brain Research · doi:10.1016/0006-8993(94)01344-h · Cited by 18

Attenuation of IGF-1 antinociceptive action and a reduction in spinal cord gene expression of its receptor in experimental diabetes

Bitar, M. S., & Pilcher, T. C. W. (1998) · Pain · doi:10.1016/s0304-3959(97)00206-6 · Cited by 18

Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice

Ohnishi, K., Tomimoto, H., Akiguchi, I., Seriu, N., Kawamata, T., Nakamura, S., Kimura, J., Nishio, T., Higuchi, K., & Hosokawa, M. (1995) · Acta Neuropathologica · doi:10.1007/bf00294454 · Cited by 18

Nerve Growth Factor in CNS Repair and Regeneration

Varon, S. S., Hagg, T., & Manthorpe, M. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-8047-4_25 · Cited by 18

Glucocorticoid modulation of neurotrophin expression in immortalized mouse hippocampal neurons

Scully, J. L., & Otten, U. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90662-5 · Cited by 18

Developmental changes of acidic fibroblast growth factor (aFGF) transcription and expression in mouse brain

Thomas, D., Muscatelli‐Groux, B., Raes, M., Caruelle, J. P., Stéhelin, D., Barritault, D., & Boilly, B. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90091-v · Cited by 18

Neuroprotection in alzheimer’s disease — new strategies for treatment

Nordberg, A. K. (2000) · Neurotoxicity Research · doi:10.1007/bf03033791 · Cited by 17

Pyritinol facilitates the recovery of cortical cholinergic deficits caused by nucleus basalis lesions

Tolédano, A., & Bentura, M. L. (1994) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02253438 · Cited by 17

Regulation of ion channel expression in neural cells by hormones and growth factors

Chew, L., & Gallo, V. (1998) · Molecular Neurobiology · doi:10.1007/bf02741300 · Cited by 17

Synthetic neovibsanes and their ability to induce neuronal differentiation in PC12 cells

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